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Reaction of 3-Amino-4,6-diarylthieno[2,3-b]pyridine-2-carboxamides with Ninhydrin
- Source :
- Russian Journal of General Chemistry. 90:948-960
- Publication Year :
- 2020
- Publisher :
- Pleiades Publishing Ltd, 2020.
-
Abstract
- The reaction of N-substituted amides of 3-amino-4,6-diarylthieno[2,3-b]pyridine-2-carboxylic acids with ninhydrin in the presence of catalytic amounts of sulfuric acid gave 1′-spiro[indene-2,2′-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine]-1,3,4′(3′H)-triones. Structure of a number of key compounds was studied using 2D NMR spectroscopy; the bioavailability parameters of the obtained compounds in silico were calculated. In a laboratory experiment, a moderate antidote effect was revealed with respect to the 2,4-D herbicide for one compound.
- Subjects :
- Pyrimidine
010405 organic chemistry
medicine.medical_treatment
Sulfuric acid
General Chemistry
010402 general chemistry
01 natural sciences
Medicinal chemistry
0104 chemical sciences
Bioavailability
Catalysis
chemistry.chemical_compound
chemistry
Ninhydrin
Pyridine
medicine
Antidote
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- ISSN :
- 16083350 and 10703632
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Russian Journal of General Chemistry
- Accession number :
- edsair.doi...........678d08261e8af0f7f9d83d82fa9e4dec