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Your search keyword '"α-glycosidase inhibitor"' showing total 2 results
Start Over Descriptor "α-glycosidase inhibitor" Topic 0104 chemical sciences
2 results on '"α-glycosidase inhibitor"'

1. Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl

Author

Jing-Zhe Yuan, Sheng-Zhuo Huang, Hao Wang, Guoliang Zhu, Cai-Hong Cai, Xing-Lian Xu, Xin Chen, Wen-Li Mei, Hao-Fu Dai, and Pei Wang

Subjects
Formamide, picrotoxane, Stereochemistry, Carbon skeleton, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Dendrobium nobile, HeLa, lcsh:Chemistry, chemistry.chemical_compound, sesquiterpenes, Bond cleavage, chemistry.chemical_classification, α-glycosidase inhibitor, biology, General Chemistry, Dendrobium nobile Lindl, 021001 nanoscience & nanotechnology, biology.organism_classification, 0104 chemical sciences, chemistry, lcsh:QD1-999, cytotoxicity, 0210 nano-technology, Lactone
Abstract

Four picrotoxane-type sesquiterpenes, dendroterpene A-D (1-4), together with four known compounds (5-8), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis, X-ray diffraction analysis, analysis of the ECD data according to the Klyne's lactone sector rule, and quantum ECD calculation. Compounds 1 and 2 are two new picrotoxane-type sesquiterpenes with a new carbon skeleton containing a formamide group, which may be derived from the previously reported dendrobiumane B skeleton by the C(9)-C(11) carbon bond cleavage. Compounds 3, 5, 6, and 8 exhibited inhibitory activity against α-glycosidase. Compounds 5 and 6 were cytotoxic against SGC-7901, K562, A549, BEL-7402, and Hela cell lines.

Published
2019

2. Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

Author

Peng-Wei Chen, Wen-Li Mei, Fan-Dong Kong, Hao-Fu Dai, Pei Wang, Hui-Qin Chen, Yu Dai, Xin-Ming Song, Jing-Zhe Yuan, Yan Cui, and Cai-Hong Cai

Subjects
Proton Magnetic Resonance Spectroscopy, Succinimides, Pharmaceutical Science, Antineoplastic Agents, succinimide-containing derivatives, Fungus, 010402 general chemistry, Plant Roots, 01 natural sciences, Anthraquinone, Article, HeLa, Inhibitory Concentration 50, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Glycoside Hydrolase Inhibitors, Cytotoxicity, lcsh:QH301-705.5, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Enzyme Assays, Cladosporium sp, α-glycosidase inhibitor, Biological Products, Molecular Structure, mangrove-derived fungus, biology, 010405 organic chemistry, Chemistry, alpha-Glucosidases, biology.organism_classification, Pyrone, 0104 chemical sciences, lcsh:Biology (General), Cell culture, Fermentation, Rhizophoraceae, cytotoxicity, Cladosporium, Two-dimensional nuclear magnetic resonance spectroscopy, Nuclear chemistry
Abstract

Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC50 values of 29.4 &plusmn, 0.35 &mu, M, 25.6 &plusmn, 0.47 &mu, M, and 41.7 &plusmn, 0.71 &mu, M, respectively, whereas compound 4 exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC50 values of 14.9 &plusmn, 0.21 &mu, M and 26.7 &plusmn, 1.1 &mu, M, respectively. In addition, compounds 4 and 5 displayed inhibitory activity against &alpha, glycosidase, with IC50 values of 78.2 &plusmn, 2.1 &mu, M and 49.3 &plusmn, 10.6 &mu, M, respectively.

Published
2018

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