Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC50 values of 29.4 &plusmn
0.35 &mu
M, 25.6 &plusmn
0.47 &mu
M, and 41.7 &plusmn
0.71 &mu
M, respectively, whereas compound 4 exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC50 values of 14.9 &plusmn
0.21 &mu
M and 26.7 &plusmn
1.1 &mu
M, respectively. In addition, compounds 4 and 5 displayed inhibitory activity against &alpha
glycosidase, with IC50 values of 78.2 &plusmn
2.1 &mu
M and 49.3 &plusmn
10.6 &mu
M, respectively.