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The non-smooth nonlinear energy sink (NSNES) is used to suppress the vibration of the rotor-blade system. Firstly, the structure and working principle of the NSNES for rotor-blade system are introduced. Then, the dynamics model of the rotor-blade-NSNES system is established by Lagrangian method. And then, numerical simulations are applied to evaluate the vibration suppression ability of the NSNES on rotor and blade. The results show that the suppression rates of NSNES on the rotor and the blade can reach 81% and 74% in steady state resonance under given parameters, respectively; and for transient vibration of blade, a 1.85 times dissipating speed is obtained in rotor-blade system with NSNES than that without NSNES. In particular, NSNES has better vibration suppression capability than linear dynamic vibration absorber (LDVA) when both have the same vibration absorption mass.

An efficient and low-cost method was developed for the preparation of pedunculoside from the dried barks of Ilex rotunda using crystallization combined with polyamide column chromatography. The kin...

A new cascade approach has been developed for the one-pot four-step divergent synthesis of polysubstituted benzofurans and 2H-chromenes, featuring a novel cascade aromatic Claisen rearrangement/Mei...

Naoxintong Capsule (NXT), a Chinese medicine, has been widely used for the treatment of cardiovascular diseases in clinic. The present study was designed to clarify the effects of NXT on haemorheology, blood coagulation, hepatic function, antioxidant capacity and inflammatory responses in a rat model of blood stasis syndrome. Rats were placed in ice-cold water for 5 min during the time interval of two adrenaline injections to induce blood circulation disorders after intragastric administration of 10 consecutive days. Blood was collected from abdominal aorta to determine whole blood viscosity (WBV), plasma viscosity (PV), activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), total antioxidant capacity (T-AOC), superoxide dismutase (SOD), malonaldehyde (MDA), alanine transaminase (ALT), aspartate transaminase (AST), interleukin-1β (IL-1β), interleukin-6 (IL-6), platelet activating factor (PAF). The results showed that NXT could significantly decrease the WBV, PV, FIB and prolong the APTT and PT. Meanwhile, NXT significantly decreased the serum contents of MDA, IL-1β, IL-6, ALT, AST and PAF, while elevating T-AOC and SOD levels. These results indicate that NXT could improve coagulation function, enhance antioxidant capacity and suppress inflammation, which might partly account for its mechanisms of action in preventing and treating cardiovascular diseases.

Context Naoxintong Capsule (NXT), a Chinese medicine, has been widely used for the treatment of coronary heart disease (CHD) in clinics. Objective This study evaluated the cardioprotective effects of NXT alone and in combination with ticagrelor (TIC) and atorvastatin (ATO). Materials and methods Qi deficiency and blood stasis rats were established by 8 weeks high fat diet feeding and 16 days exhaustive swimming and randomly divided into seven groups, that is, NXT (250, 500 and 1000 mg/kg/d), TIC (20 mg/kg/d), ATO (8 mg/kg/d), NXT (500 mg/kg/d)+TIC (20 mg/kg/d) and NXT (500 mg/kg/d)+ATO (8 mg/kg/d) group, with oral administration for 12 weeks. The contents of TC, TG, LDL-C, HDL-C, IL-1β, IL-6, IL-8, TNF-α, AST, ALT, SOD, MDA, CK-MB, LDH, TXA2, PGI2, IgA, IgG, IgM and C3 in serum were measured. Results NXT + TIC group was significantly superior to the TIC group in decreasing the levels of TC (4.34 vs. 5.54), TG (3.37 vs. 4.66), LDL-C (1.21 vs. 1.35), LDH (4919.71vs. 5367.19) and elevating SOD level (248.54 vs. 192.04). NXT + ATO group was significantly superior to the ATO group in decreasing the levels of AST (195.931 vs. 241.63), ALT (71.26 vs. 83.16), LDH (4690.05 vs. 5285.82), TXA2 (133.73 vs. 158.67), IgG (8.08 vs. 9.80), C3 (2.03 vs. 2.35) and elevating the levels of HDL-C (1.19 vs. 0.91), SOD (241.91vs. 209.49). Conclusions The present findings demonstrate that the combined use of NXT with TIC and ATO had better integrated regulating effects than TIC and ATO, respectively. The mechanism of action requires further research.

Naringin has been documented to possess various bioactivities. Due to thorny endogenous interferences, the metabolism pathways of naringin and exact amounts of derived phenolic catabolites have not been definitely assigned. In this work, stable isotope-labeling-based liquid chromatography-mass spectrometry methods were developed to eliminate the endogenous interferences. [2',3',5',6'-D4]-naringin was orally administrated to rats. Urine and feces samples were collected and then analyzed with ultrahigh-performance liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS). A total of 21 flavonoid metabolites and 11 phenolic catabolites were screened. The metabolism and catabolism pathways were proposed. Furthermore, deuterated naringin and its main metabolites were determined with rapid resolution liquid chromatography tandem triple quadrupole mass spectrometry (RRLC-QqQ-MS/MS). The overall recovery of ingested deuterated naringin was calculated as 56.9% without endogenous interferences. The obtained results provide essential information for further pharmacological studies of naringin.

Modern rotating machineries require vibration suppression devices with simple structure and wide band effective vibration suppression frequency range, so a grounded nonlinear energy sink (GNES) with piecewise linear stiffness is developed to satisfy the requirements. Firstly, the structure and working principles of the GNES is explained. Then, the piecewise linear stiffness characteristic of elastic rods is analyzed and the dynamic equations for the rotor-GNES system are established, in which the rotor system is assumed to be either isotropic or anisotropic; numerical simulations are then carried out to study the vibration suppression effect of the GNES, and the wide-band vibration suppression capability of the GNES is assessed; comparison is made between the vibration suppression effect of the GNES and that of the dynamic vibration absorbers. Finally, experiments are carried out on a rotor-GNES system test platform to verify the suppression effects. The results show that the GNES is effective at suppressing vibrations in terms of both transient and steady-state vibrations within a rotor system. In the numerical simulation an optimal vibration suppression rate of 78% is achieved and in the test a rate of 68% is achieved.

Microctis Folium is the dried leaves of a plant (Microcos paniculata L.) used to improve the digestive system, alleviate diarrhoea, and relieve fever, but information regarding its chemical composition has rarely been reported. The traditional research approach of determining chemical composition has included isolating, purifying, and identifying compounds with high-cost and time-consuming processes. In this study, molecular networking (MN) and fingerprint analysis were integrated as a comprehensive approach to study the chemical composition of Microctis Folium by an ultra fast liquid chromatography-photo diode array detector-triple-time of flight-tandem mass spectrometry (UFLC-DAD-Triple TOF-MS/MS). Large numbers of mass spectrometric data were processed to identify constituents, and the identified compounds and their unknown analogues were comprehensively depicted as visualized figures comprising distinct families by MN. A validated fingerprint methodology was established to quantitatively determine compounds in Microctis Folium. Ultimately, 165 constituents were identified in Microctis Folium for the first time and the identified compounds and approximately five hundred unknown analogues were applied to create visualized figures by MN, indicating compound groups and their chemical structure analogues in Microctis Folium. The validated fingerprint methodology was indicated to be specific, repeatable, precise, and stable and was used to determine 15 batches of samples during three seasons in three districts. Furthermore, seasonal or geographic environmental influences on the chemical profile were estimated by principal coordinate analysis. The results can be used to control the quality of Microctis Folium, observe seasonal or geographic environmental influences on the chemical profiles, and provide a reference for further exploitation of potential active unknown analogues in the future.

In this paper, a nonlinear energy sink with piecewise linear stiffness spring is proposed, and the fundamental characteristics of the nonlinear energy sink are investigated. Firstly, the structure of the piecewise linear stiffness spring is proposed and nonlinearity of the spring is analyzed. Then, the dynamic model of the primary vibration system with the nonlinear energy sink is built, and the responses and vibration suppression effects are studied by numerical simulations. Finally, the effectiveness of the NES is proved by experiment. The results show that the piecewise linear stiffness spring is effective; its structure is simple, compact and adjustable; the vibration attenuation performance of nonlinear energy sink is very good under moderate exciting force.

A tunable dynamic vibration absorber for unbalanced rotor system which is made up of coil springs and magnetic spring is presented. The structure of the absorber is introduced and the stiffness tuning mechanism of the magnetic spring is explained. A finite element model of the rotor-absorber system was built and the influencing factors to the appearance of the absorber were studied numerically. Finally, experiments were carried out to verify the numerical results, and PID control strategy was tested. The numerical and experimental results show that the present absorber is effective for vibration suppression of an unbalanced rotor system, and the control strategy is effective.

The metabolism of flavonoids derived from orange juice in Chinese volunteers has not been well investigated. With the ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS) system, orange juice-derived flavonoids, as well as metabolites contained in urine collected from healthy Chinese volunteers after consumption of 250mL orange juice, were systematically identified and quantified. Finally, a total of 9 flavonoids and 30 metabolites were detected. Obtained results revealed that flavonoids derived from orange juice underwent extensive phase II metabolism in human, mainly comprising glucuronidation and sulfation. The overall recovery of the primary flavonoid aglycones, i.e., naringenin and hesperetin, were both approximately equivalent 22% of intake, primarily occurred in 4-12h post consumption. Meanwhile, additional 35 phenolic catabolites were identified in urine collected post consumption. However, it is difficult to determine the exact amounts of phenolic catabolites derived from specific flavonoid due to the interference of diets and other flavonoids. This work would be valuable for the clarification of metabolic profiles for flavonoids in Chinese population.

The major purpose of this study is to research the local rub fault transfer mechanism in rotor system, that is, the influence of local faults on the whole rotor system. The proposed rotor model is based on Euler-Bernoulli beam finite elements. The dynamic model takes into account the gyroscopic moment of rotor as well as the elastic support. The local rub fault is equivalent to external excitation in the equations of motion. The local rub fault transfer mechanism derives from the harmonic balance theory by the relationship between the harmonic components of vibration response and the frequency domain response matrices. The response of any other nodes in the rotor system is obtained by the transfer mechanism. Effectiveness and robustness of the transfer mechanism are verified by numerical simulation and experiments. The transfer mechanism has a good applicability for the main vibration faults in rotor system such as rub, misalignment and crack.

Ansellane-type sesterterpenoids including, ansellones A-G and (+)-phorbadione are structurally novel marine secondary metabolites which exhibit anticancer and anti-HIV activity. The first, asymmetric total syntheses of three structurally representative members, (-)-ansellones A and B and (+)-phorbadione, were accomplished in 16-23 steps from (+)-sclareolide. The route features the first regioselective cyclization of vinyl epoxides with internal alcohol nucleophiles in a 1,4-addition manner (SN 2'). Additionally, the allylic C-H oxidation was exploited at a late stage of the synthesis of (-)-ansellone A and (+)-phorbadione. This strategy is expected to be applicable to the synthesis of other ansellane sesterterpenoids.

This paper presents a study of a novel nonlinear damper on vibration control of rotor system with variable damping by using a smart material- shear thickening fluid (STF), whose viscosity and damping will dramatically increase with shear rate. A STF damper was self-developed and dynamic model of the STF damper-rotor system was established by using the Bouc-Wen model as mechanical model of the smart material damper. The incremental harmonic balance (IHB) method combined with the arc-length method was presented to investigate the dynamic response of rotor system with hysteresis nonlinear damping force theoretically. Experimental study of STF damper on suppressing vibration of rotor system was carried out by using a Bently rotor test rig with two STF dampers. The damping effect under different damper installation direction, vibration frequency and amplitude were investigated theoretically and experimentally. Study shows that the nonlinear damper exhibits larger damping force and fuller hysteresis characteristics, so it has better effect on resonance energy absorption compared with the traditional linear damper; and its output damping force can increase dramatically with the change of frequency and amplitude. It is verified that the unbalance vibration, especially the resonance amplitude of rotor system can be effectively suppressed by nonlinear damping of STF damper. The study shows the feasibility and advantages of using the STF damper for potential applications of adaptive or semi-active vibration control of rotating machinery.

Multifunctional nanoplatforms (MFNPs) have attracted increasing attention because of their ability to integrate diverse functional diagnostic and therapeutic agents in one system. MFNPs should be biocompatible and smart, have active targeted delivery, exhibit specific target recognition and controlled release properties, exert a high therapeutic effect, and have the excellent visual diagnosing and monitoring abilities for precision cancer theranostics. Numerous strategies have been recently developed to enhance the accuracy of MFNPs for cancer theranostics. The endogenous stimuli-responsive MFNP is one of the most effective strategies and can be classified into six types based on their usage: (1) for enhancing targeted delivery, (2) for improving specific recognition and affinity performance, (3) for enhancing controlled release, (4) for synergistic multimodal diagnosis in vivo, (5) for enhanced synergistic therapy, and (6) for real-time, in situ and visual tracking of delivery, release, and therapeutic effect. Herein, these strategies are reviewed in detail. Furthermore, challenges in enhancing the accuracy of MFNPs and suggestions for further improving the performance of MFNPs are discussed to achieve real precision cancer theranostics with fewer side effects.

Aculeatins, a growing family of natural products with potent antimalarial and/or anticancer activities, have been the targets for more than 20 total syntheses since the first members (aculeatins A–C) reported in 2000 partially due to their unprecedented and fascinating tricyclic 1,7-dioxadispiro[5.1.5.2]pentadecane (1,7-DODSP) skeleton. This Digest distills the two key strategies (POD/DSK and POD/DOMC) employed in all these syntheses for the construction of the 1,7-DODSP core and summarizes these total syntheses of aculeatins with the focus on different methods for the diastereo- and enantioselective preparation of the essential (5-keto-)1,3-diol substrates.

Development of two new protocols for oxa-[3 + 2] cycloaddition reactions of Achmatowicz products with 1,3-dicarbonyl compounds for rapid and highly efficient assembly of polycyclic furopyranones is described. Plausible mechanisms were proposed to involve either Pd-catalyzed Tsuji–Trost allylation and concomitant oxa-Michael cyclization or quinine-promoted cascade Michael addition and SN2-type cycloacetalization.

In this paper, a bi-stable nonlinear energy sink (BNES) with buckled beam is developed to suppress the vibration of unbalanced rotor system. The structure of the BNES is developed. The specific structures and working principles of the buckled beam are introduced. Based on these, the dynamic equations of the rotor-BNES system are established. Then, the transient and steady state responses of the rotor-BNES system are numerically studied and compared with the linear visco-elastic damper. In addition, the vibration suppression ability and frequency suppression range of the BNES are analyzed. Finally, experiments are carried out and compared with the simulations to confirm the vibration suppression effectiveness of the BNES. The numerical and experimental results show that the designed BNES has a strong vibration suppression effect on the rotor system and can withstand a wide range of energy.

Naringin has been documented to possess multiple pharmacological activities. Reported pharmacokinetic studies revealed that oral bioavailability of naringin was low, in contrast to its significant pharmacological effects. The in vivo distribution of naringin and derived metabolites might partly explain this discrepancy. In this study, an ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry system (UFLC-Q-TOF-MS/MS) was used for profiling the distribution of naringin and its metabolites in rat plasma and fourteen tissues after oral administration. Naringin was widely distributed and its concentrations in certain tissues were much higher than that in plasma, especially in trachea and lung. Moreover, a total of 23 flavonoid metabolites and 15 phenolic catabolites were screened. Naringenin glucuronides were principal metabolites in plasma, while free naringenin and naringenin-7-O-sulfate were the major molecular forms in most tissues. Meanwhile, phenolic catabolites derived from naringin were found to be abundant in liver and kidney. These pharmacokinetic results would be useful to explain the pharmacodynamics of naringin.

Widespread in citrus fruits, naringin, a natural 2,3-dihydroflavonoid, is of particular interest to scientists and has a broad range of beneficial bioactivities to health. Orally administered naringin remains in the gut tract for a relatively long time because of its low bioavailability. Under the metabolism mediated by human gut microbiota, naringin could be an active precursor for derived metabolites to play important physiological roles. However, naringin and its metabolites are hard to accurately quantify due to severe endogenic interference. In this study, an analytical rapid resolution liquid chromatography tandem mass spectrometry (RRLC-MS/MS) method coupled with stable isotope deuterium-labeling is developed and validated to simultaneously quantify naringin as well as its major human gut microbial metabolites naringenin and 3-(4&prime, hydroxyphenyl) propanoic acid. By eliminating the matrix interferences, this strategy not only confirms naringenin and 3-(4&prime, hydroxyphenyl) propanoic acid as the predominant metabolites which contribute to the pharmacological effects of naringin but also provides a suitable choice for other flavonoid pharmacokinetics study.

Discovery and identification of three bioactive compounds affecting endothelial function in Ginkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analysis results indicated that three bioactive compounds had close relevance to ET-1: Kaempferol-3-O-α-l-glucoside, 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Quercetin isomers, and 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Kaempferide. The discovery of bioactive compounds could provide references for the quality control and novel pharmaceuticals development of GRE. The present work proposes a feasible chromatogram-bioactivity correlation based approach to discover the compounds and define their bioactivities for the complex multi-component systems.

Although Aurantii Fructus (AF) and Aurantii Fructus Immaturus (AFI) are both the fruits of the same rutaceae plant at different stages of growth, they exert similar yet distinct clinical effects. The chemical composition is crucial for quality control as well as therapeutic application. To address this concern, it is significant to evaluate the similarities and differences of the constituents in both AF and AFI. The extract of AF and AFI were comprehensively analyzed by ultra fast liquid chromatography-photodiode array detector-triple-time of flight-tandem mass spectrometry (UFLC-DAD-Triple TOF-MS/MS). Among the 40 compounds detected, 19 metabolites were detected in both the AF and AFI; whereas 13 compounds were only detected in AF and five constituents were exclusively detected in AFI. In particular, even in AFI, three compounds were only identified in AFI (Citrus aurantium’ L. and its cultivar). Among the 18 compounds confirmed by standard database, 13 compounds were reported in AF and AFI for the first time. Furthermore, the distinction was also revealed by the content of naringin, hesperidin, neohesperidin, and synephrine. The study directly contributed to the similarities and differences of AF and AFI. Herein, similarities and the differences in chemical profiles of AF and AFI could explain the current clinical applications.

The dynamic vibration absorbers have been applied to attenuate the rotor unbalance and torsional vibrations. The major purpose of this paper is to research the elimination of the fluid-induced vibration in the rotor/seal system using the absorber. The simplified rotor model with the absorber is established, and the Muszynska fluid force model is employed for the nonlinear seal force. The numerical method is used for the solutions of the nonlinear differential equations. The nonlinear responses of the rotor/seal system without and with the absorber are obtained, and then the rotating speed ranges by which the fluid-induced instability can be eliminated completely and partially are presented, respectively. The absorber parameters ranges by which the instability vibration can be eliminated completely and partially are obtained. The results show that the natural frequency vibration due to the fluid-induced instability in the rotor/seal system can be eliminated efficiently using the absorber. The appropriate natural frequency and damping ratio of the absorber can extend the complete elimination region of the instability vibration and postpone the occurrence of the instability vibration.

Naringin is a flavanone that widely presents on daily diet and traditional medicinal materials. The ratios of naringin C-2 diastereomers are found different in reported samples, thus suspiciously leading to various functions. In this study, we measured the interconversion of C-2 diastereomers intensively with ultimate high-performance liquid chromatography and circular dichroism spectra. We examined the diastereomeric naringins in fresh citrus fruit, Huajuhong decoction pieces, and naringin tablet; evaluated the impact of tablet production procedures in factory; and monitored the rapid racemization in incubation. The results not only confirmed that enzyme, temperature, and pH condition could influence the interconversion but also demonstrated that diverse ratios of diastereomers showed limited influence on metabolic behaviors of naringin in the blood, which consequently cause comparable bioactivities. This study could provide comprehensive understanding of diastereomeric interconversion and provide useful reference for drug development.

The novel tricyclic spiroketal alotane-type sesterterpenoids showed strikingly different biological activities and potency with subtle structural alterations. Asymmetric total syntheses of the tricyclic sesterterpenoids (-)-alotaketals A-D and (-)-phorbaketal A were accomplished [29-31 steps from (-)-malic acid] in a collective way for the first time. The key features of the strategy included 1) a new cascade cyclization of vinyl epoxy δ-keto-alcohols to forge the common tricyclic spiroketal intermediate, 2) a late-stage allylic C-H oxidation, and 3) olefin cross-metathesis to install the different side chains.

The possible biogenetic connection of the 10-membered lactone (decanolide) and the tricyclic [5,5]-spiroacetal-cis-fused-γ-lactone (SAFL) natural products was proposed by Hanson in 1985. Mimicking such biosynthetic hypothesis led us to develop a general synthetic strategy for the total syntheses of both decanolide-type cephalosporolides and SAFL-type natural products. This biomimetic strategy features two key transformations: i) oxidative ring expansion of bicyclic β-hydroxy tetrahydropyrans to the decanolides and ii) ring contraction rearrangement of the decanolides to the tricyclic SAFLs. In particular, the phenol derivatives are exploited as the starting materials for the decanolides and then the SAFLs. The successful biomimetic total synthesis allows us to revise the structures and biosynthetic hypothesis of several natural products, along with development of an NMR analysis method for determination of the relative stereochemistry of SAFL-type compounds. In addition, this account will summarize recent synthetic work by other research groups.

A novel nonlinear energy sink (NES) consisting of permanent magnetic springs and coil springs is proposed, and the vibration attenuation performance of the NES for unbalanced rotor system is investigated. Firstly, the nonlinearity of the magnet spring is analyzed and the structure of the NES is introduced. Then, the dynamic model of the rotor system with the NES is built, and the responses and stabilities of the system are studied by applying Complexification-averaging method. The strongly modulated responses (SMR) behavior, which is the most important performance characteristic of the NES, is analytically studied by combining Complexification-averaging method and multiscale method and numerically verified by Runge-Kutta method. The results show that the NES is effective in attenuating the vibration of unbalanced rotor, and the SMR occurrence range can be broadened by increasing the nonlinearity of the NES. And also, the NES has better performance over a wider frequency range than the linear absorber.

To suppress the vibration of a rotor system, a vibration absorber combining negative stiffness with positive stiffness together is proposed in this paper. Firstly, the negative stiffness producing mechanism using ring type permanent magnets is presented and the characteristics of the negative stiffness are analyzed. Then, the structure of the absorber is proposed; the principles and nonlinear dynamic characteristics of the absorber-rotor system are studied numerically. Finally, experiments are carried out to verify the numerical conclusions. The results show that the proposed vibration absorber is effective to suppress the vibration of the rotor system, the nonlinearity of the negatives stiffness affects the vibration suppression effect little, and the negative stiffness can broaden the effective vibration control frequency range of the absorber.

This paper presents an experimental study of the dynamic performance of a self-developed shear thickening fluid (STF) damper and its mechanical model was proposed by nonlinear fitting. First, STF samples with different mass fraction and dispersion medium were fabricated by nano fumed silica and polyethylene glycol, and its rheological properties were investigated by a rheometer. Second, a smart STF damper was developed and manufactured. Its dynamic properties were experimentally investigated by establishing a vibration test bench, and results indicated that the STF damper can output variable damping force by controlling the loading frequency, loading amplitude and fluid gap. Third, the Bouc–Wen model was proposed to address the dynamic properties of STF damper, and mechanical model analysis was carried out by comparing several fitting functions. It verified that the Bouc–Wen hysteresis model can be better used to describe the nonlinear stiffness, nonlinear damping and rate-dependence characteristics of the STF damper. All these investigations can offer an effective guidance for further theoretical and application study of the smart STF damper in energy dissipation fields.

Exocarpium Citri grandis (ECG) is an important Traditional Chinese Medicine (TCM) for the treatment of cough and phlegm, and the flavonoids contained were considered the main effective components. To date, the systematic chemical profiling of these flavonoids and derived in vivo metabolites in human have not been well investigated. ECG was extracted using boiling water and then provided to volunteers for oral administration. Following the ingestion, urine samples were collected from volunteers over 48 h. The extract and urine samples were analyzed using ultra-fast liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS) system to screen and identify flavonoids and derived in vivo metabolites. A total of 18 flavonoids were identified in the ECG extract, and 20 metabolites, mainly glucuronide and sulfate conjugates, were screened in urine samples collected post consumption. The overall excretion of naringenin metabolites corresponded to 5.45% of intake and occurred mainly within 4–12 h after the ingestion. Meanwhile, another 29 phenolic catabolites were detected in urine. Obtained data revealed that flavonoids were abundant in the ECG extract, and these components underwent extensive phase II metabolism in humans. These results provided valuable information for further study of the pharmacology and mechanism of action of ECG.