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Hypoxia-inducible factors (HIFs) are key protein members in tumour acute and chronic hy poxia response with special biological functions. HIFs are highly expressed in a variety of tumors, including hepatocellular carcinoma (HCC), and can promote the epithelial-mesenchymal transition (EMT) process of tumor cells. HCC has the characteristic of typical aggressive growth, which are closely associated with EMT. The Notch signaling pathway is a highly conserved signal transduction pathway in biological evolution, which is involved in the EMT process of cells and plays an important role in the promotion of tumour growth and migration by HIFs. HIFs may exert effects directly or indirectly on tumor cell EMT processes including HCC through the Notch signaling pathway. This article provided a brief review of the regulatory effects of HIFs on tumor cell EMT, especially on HCC EMT, and the possible role of Notch signaling pathway in this process. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Biological scaffolds made from tissue or organ decellularization have been successfully applied to various tissue engineering and regenerative medicine. OBJECTIVE: To review the preparation methods of acellular scaffolds and their functions and applications in tissue engineering and regenerative medicine. METHODS: Databases of PubMed and CNKI were retrieved with the key words of “decellularization, scaffold, extracellular matrix, tissue regeneration and repair” in English and Chinese. Subjects and abstracts were initially screened to exclude documents that were not related to the subject of the article, and finally 66 articles were included for result analysis. RESULTS AND CONCLUSION: The decellularized scaffolds obtained by decellularizing tissues and organs through physical, chemical and biological methods can effectively retain the components of the extracellular matrix, are non-immunogenic, have good biocompatibility and mechanical properties, and can promote cell adhesion, proliferation, migration and differentiation, induce tissue repair, and reconstruct vascularized and functional tissues and organs. Acellular scaffolds have achieved ideal results in vitro and short-term in vivo experiments of many tissues and organs, such as heart, liver, kidney, lung, trachea, skin and bone, indicating that acellular scaffolds play an important role in tissue regeneration and repair, and have good application prospects. However, to be put into clinical use, more in-depth research and exploration are needed. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

宫颈恶性肿瘤除了常见的鳞癌、腺癌外，还有一些特殊病理类型， 如宫颈神经内分泌癌、宫颈淋巴痐、宫颈黑色素 瘤、宫颈肉瘤及宫颈透明细胞癌等。因为病例的罕见性， 目前尚无指南对这部分宫颈癌冶疗方案做出规范。该又回顾性分析了关 于宫颈神经内分必癌、宫颈淋巴疮、宫颈黑色素瘤治疗方式的文献，发现其恶性程度较高， 冶疗方式存在争议， 多借鉴发生于其他 器官相应病理类型的治疗方案，但预后相对较差，靶向冶疗及免疫冶疗的发展可能是这部分患者未来的新希望。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Remote Sensing is the property of Editorial Office of Journal of Remote Sensing & Science Publishing Co. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Recurrence after surgery for common bile duct stones has not been solved properly, and recurrence of calculi often requires reoperation, which brings patients great pain and economic burden. Various risk factors may mediate the recurrence of common bile duct stones, including biliary tract infection, bile duct stenosis, cholangiectasis, cholestasis, Oddi sphincter dysfunction, abnormal bile composition, and surgical procedure. These risk factors are analyzed and related preventive measures are summarized. Current research findings show that prevention and treatment of risk factors for recurrence of calculi can reduce the recurrence rate of calculi and play an important role in preventing the recurrence of common bile duct stones. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Phosphatidyl inositol 3 - kinase, Akt, and the mammalian target of rapamycin (PI3K/Akt/mTOK) signaling pathway is shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of hepatoeellular eareinoma (HCC) by regulating gene expression. The components and functions of PI3K/Akt/mTOK signaling pathway are briefly described, and the research advances in the action mechanism of PI3K/Akt/mTOK signaling pathway in the progression of HCC and related inhibitors are reviewed. It is disclosed that blocking the PI3K/Akt/mTOK signaling pathway may become a new therapy for HCC. [ABSTRACT FROM AUTHOR]