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Your search keyword '"Svyatoslav Polovkovych"' showing total 3 results
Start Over Author "Svyatoslav Polovkovych" Topic [chim]chemical sciences
3 results on '"Svyatoslav Polovkovych"'

1. Novel Synthesis of 5-Substituted 5H-Benzo[b] carbazole-6,11-diones via Double Buchwald-Hartwig Reaction

Author

Khrystyna Bolibrukh, Patrice Vanelle, Thierry Terme, Svyatoslav Polovkovych, Volodymyr Novikov, Omar Khoumeri, Institut de Chimie Radicalaire (ICR), and Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
chemistry.chemical_compound, chemistry, Carbazole, Organic Chemistry, [CHIM]Chemical Sciences, Combinatorial chemistry, Coupling reaction, 3. Good health, Quinone
Abstract

International audience; 2-Bromo-3-(2-bromophenyl)naphthalene-1,4-dione was synthesized as a key precursor to obtain a number of functionalized benzo[b]carbazole-6,11-diones by double Buchwald-Hartwig coupling reaction.

Published
2014
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2. Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety

Author

Patrice Vanelle, Khrystyna Bolibrukh, Vira Lubenets, Volodymyr Novikov, Thierry Terme, Svyatoslav Polovkovych, T. I. Halenova, Irina Nikolaeva, Omar Khoumeri, Olexiy Savchuk, Institut de Chimie Radicalaire (ICR), and Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Anti-platelet activity, Chemistry, Stereochemistry, Thiosulfonate, Pharmaceutical Science, Moiety, [CHIM]Chemical Sciences, Quinone, Anti platelet, Research Article
Abstract

International audience; Thiosulfonate derivatives based on quinones were synthesized for studying "structure-activity relationship" compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was assessed.

Published
2014
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3. Synthesis and Conformational Analysis of [3-(6-Chloropyridazin-3-yl)-3,4-Dihydropyridazino[4,5-b]Quinoxalin-2(1De )-yl](Phenyl)Methanone

Author

A. I. Karkhut, Volodymyr Novikov, O. Solovyov, Patrice Vanelle, Khrystyna Bolibrukh, Thierry Terme, Svyatoslav Polovkovych, Omar Khoumeri, Institut de Chimie Radicalaire (ICR), and Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
chemistry.chemical_compound, Quinoxaline, chemistry, Computational chemistry, Organic Chemistry, [CHIM]Chemical Sciences, Density functional theory, Carbon-13 NMR, Polarizable continuum model, Conformational isomerism
Abstract

International audience; [3-(6-Chloropyridazin-3-yl)-3,4-dihydropyridazino[4,5-b]quinoxalin-2(1H) -yl](phenyl)methanone has been synthesized and its two stable forms were isolated. For the establishment of their structures, B3LYP geometry and energy and GIAO/B3LYP NMR calculations of possible conformers using the polarizable continuum model were performed. The differences in calculated spectra allow attributing calculated structures and obtained substances by their H-1 and C-13 NMR. The conformer ratio correlates with their calculated Gibbs energies.

Published
2014
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