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Background: Mantle cell lymphoma (MCL) is a B cell malignancy that can be aggressive and with a poor prognosis; the clinical course is heterogeneous. The epidemiology of MCL in Asia is not well documented but appears to comprise 2-6% of all lymphoma cases based on available data, with variation observed between countries. Although international guidelines are available for the treatment of MCL, there is a lack of published data or guidance on the clinical characteristics and management of MCL in patient populations from Asia. This paper aims to review the available treatment and, where clinical gaps exist, provide expert consensus from the Asian Lymphoma Study Group (ALSG) on appropriate MCL management in Asia. BODY: Management strategies for MCL are patient- and disease stage-specific and aim to achieve balance between efficacy outcomes and toxicity. For asymptomatic patients with clearly indolent disease, observation may be an appropriate strategy. For stage I/II disease, following international guidelines is appropriate, which include either a short course of conventional chemotherapy followed by consolidated radiotherapy, less aggressive chemotherapy regimens, or a combination of these approaches. For advanced disease, the approach is based on the age and fitness of the patient. For young, fit patients, the current practice for induction therapy differs across Asia, with cytarabine having an important role in this setting. Hematopoietic stem cell transplantation (HSCT) may be justified in selected patients because of the high relapse risk. In elderly patients, specific chemoimmunotherapy regimens available in each country/region are a treatment option. For maintenance therapy after first-line treatment, the choice of approach should be individualized, with cost being an important consideration within Asia. For relapsed/refractory disease, ibrutinib should be considered as well as other follow-on compounds, if available., Conclusion: Asian patient-specific data for the treatment of MCL are lacking, and the availability of treatment options differs between country/region within Asia. Therefore, there is no clear one-size-fits-all approach and further investigation on the most appropriate sequence of treatment that should be considered for this heterogeneous disease.

Rabies is a lethal zoonotic encephalomyelitis that causes an estimated 59,000 human deaths yearly worldwide. Although developing countries of Asia and Africa bear the heaviest burden, surveillance and disease detection in these countries is often hampered by the absence of local laboratories able to diagnose rabies and/or the difficulties of sample shipment from low-access areas to national reference laboratories. Filter papers offer a convenient cost-effective alternative for the sampling, shipment, and storage of biological materials for the diagnosis of many pathogens including rabies virus, yet the properties of diagnostic tests using this support have not been evaluated thoroughly. Sensitivity and specificity of molecular diagnosis of rabies infection using a reverse transcription followed by a hemi-nested polymerase chain reaction (RT-hn-PCR) either directly on brain tissue or using brain tissue dried on filter paper were assessed on 113 suspected field animal samples in comparison to the direct fluorescent antibody test (FAT) recommended by the World Health Organization as one of the reference tests for rabies diagnosis. Impact of the duration of the storage was also evaluated. The sensitivity and the specificity of RT-hn-PCR i) on brain tissue were 96.6% (95% CI: [88.1-99.6]) and 92.7% (95% CI: [82.4-98.0]) respectively and ii) on brain tissue dried on filter paper 100% (95% CI: [93.8-100.0]) and 90.9% (95% CI: [80.0-97.0]) respectively. No loss of sensitivity of RT-hn-PCR on samples of brain tissue dried on filter paper left 7 days at ambient temperature was detected indicating that this method would enable analyzing impregnated filter papers sent to the national reference laboratory at ambient temperature within a 1-week shipment time. It could therefore be an effective alternative to facilitate storage and shipment of samples from low-access areas to enhance and expand rabies surveillance., Competing Interests: The authors have declared that no competing interests exist.

In past decades, we have seen several epidemics of respiratory infections from newly emerging viruses, most of which originated in animals. These emerging infections, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and the pandemic influenza A(H1N1) and avian influenza (AI) viruses, have seriously threatened global health and the economy. In particular, MERS-CoV and AI A(H7N9) are still causing infections in several areas, and some clustering of cases of A(H5N1) and A(H7N9) may imply future possible pandemics. Additionally, given the inappropriate use of antibiotics and international travel, the spread of carbapenem-resistant Gram-negative bacteria is also a significant concern. These infections with epidemic or pandemic potential present a persistent threat to public health and a huge burden on healthcare services in the Asia-Pacific region. Therefore, to enable efficient infection prevention and control, more effective international surveillance and collaboration systems, in the context of the 'One Health' approach, are necessary., (© 2019 Asian Pacific Society of Respirology.)

Campaigns by non-governmental organizations (NGOs) pressuring companies to adopt sustainability standards have caught academic interest in recent years. Critics of this approach toward increasing biodiversity protection and social justice argue that campaign successes are often short-lived while proponents emphasize the potential of NGO campaigns to achieve positive environmental and social change in the absence of governmental legislation. Focusing on the recent forest conservation policy of Asia Pulp and Paper (APP), a leading pulp and paper company operating in Southeast Asia, we analyze the challenges companies face in implementing sustainability commitments made as a result of NGO and market pressure. Drawing from research on policy implementation and corporate greening we identify key activities to help entrench APP's commitments in the company's operations. Furthermore, we suggest that a range of actions by different stakeholder groups can achieve broader effects of APP's commitments toward better environmental and social stewardship in the region's pulp and paper sector. [ABSTRACT FROM AUTHOR]

This paper compares 'high-impact' papers from China, Japan, India and Korea in 2012, together with papers from these countries in Cell, Nature, and Science (CNS) from 2010 to 2012. China leads on 'highly cited' and 'hot' papers in 2012, while Japan has the highest number in CNS (653), followed by China (471), Korea (131) and India (83). Although China published more high-impact papers in 2012, papers published in CNS were at a relatively low level, which appears to show that while some of the research in China is at a relatively high level, this is not entirely reflected in the number of papers in these 'elite' journals. [ABSTRACT FROM AUTHOR]

This paper reviews the determinants of formal microsaving (FMS), while also X-raying literature-documented conceptual sub-elements/sub-constructs of formal microsaving development (FMSD). This is with the intention to sensitize stakeholders as to what works for FMS and what doesn't. The paper also offers an overview of the state of research in this academic sub-domain, with suggestions/guides for related future research agenda. Analysis of 301 articles was undertaken using PRISMA. The paper's analysis affirms that the identified determinants were varied, using only a limited set of empirical methodologies. The geographical focus of most of the relevant studies were on Asia/Africa, with other regions largely ignored. The paper presents a novel review of the determinants of FMS. Also, the identified deconstructed sub-elements of FMSD could further sensitize researchers of its hitherto unknown multidimensional nature. Consequently, this could enhance the expansion of relevant empirical/theoretical knowledge with the additional possibility of initiating/influencing relevant global policy regeneration towards microsaving development. [ABSTRACT FROM AUTHOR]

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Over the last 25 years, Asia's economic rise has been extraordinary. Its share of global gross domestic product (GDP) has risen from 5.8% to 22.9%. The first phase of high economic growth — up to 1995 — saw Asia enter the global supply chain primarily with labor-intensive/low-cost manufacturing. Domestic consumption was a fairly low share of GDP; Asia was manufacturing mainly for consumption in the US and Europe. As such, it was primarily a rule-taker. In the second phase — from 1995 to 2020 — it gradually turned into an economic force joining the US and Europe in shaping the global economy, exercising significant influence upon the value chain, the cycles of the global economy, transport and logistics, the global capital markets and consumption patterns (consumer preferences and tastes). While not yet among the leading rule-makers, it had become difficult for policymakers (public and private) to make decisions without Asia's consent. To form an opinion of today's emerging third phase — post 2020 — the intriguing question is whether the Asian countries have adopted what may be termed Anglo-American economic thinking (basically, the primacy of the market). Or whether behind the curtain, the Asian economy works in its own way diverging from the American and British economic schools. Since demographics and sheer economic scale mean that Asia will dominate the global economy in the years to come, the nature of the Asian economy will be of crucial importance for the future global economy. The conclusion of this paper is that "Asia" in many respects differs — and fundamentally so — from market economy principles. How this prospect should be interpreted is also evolving, as circumstances change. Certainly, the repercussions of COVID-19 have not been the same in the US, Europe, East Asia and South Asia — and this may suggest that socio-political structures have a stronger impact on economic outcomes than economic theory teaches, thus calling into question the global validity of market economy principles. [ABSTRACT FROM AUTHOR]

"Go to temples of science and ideas of Europe. Imitate the Tugendbund, 'the Union of Virtue', of which thousands of German youth are the members. Always keep the rule of 'Fit soul is in fit body' in mind" (Petrov, 2013, p. 72). This study aimed to show the similarities, in terms of expression, emphasis, and implication, in the about/mission/vision/goals/objectives of various science centers from around the world and in the basic themes derived from Snellman's statement above, namely, Science for all, Science Centers for all, and Human welfare that he made as a challenge to not only his people but to everyone. Document and content analyses were applied in the study. Within the scope of these analyses, this study investigated the about/mission/vision/goals/objectives sections of websites of science centers from around the world (Asia, Europe, Global, Latin America/The Caribbean, North America, Africa). From this investigation, similar basic themes, derived from Snellman's statement challenging his people/everyone to adopt this devotion to science, were found in the areas of i) expression in ASTC, CIMUSET/CSTM, CASC and SAASTEC; ii) emphasis in ECSITE, ASDC, ASCN and NSCF; and iii) implication in ASPAC, ASTEN, NCSM, ABCMC and Red-POP. These basic themes, as found in the about/mission/vision/goals/objectives of science centers, can, in effect, be narrowed down to the one theme of "cultural institutions will be a big part of human life" (Madsen 2017, p. 68) science centers in the global village (Touraine, 2016, p. 121) of the future.

Municipal wastewater treatment plants (MWWTPs) are considered essential to protect human health and aquatic systems. However, several studies in the scientific field have identified adverse environmental effects in these treatment units that involve challenges in the water industry. Therefore, this work has the following objectives: (1) to understand the global context in which MWWTPs operate and (2) to determine the thematic and geographic trend in scientific research. Through the "Publish or Perish" software, scientific articles indexed in the Scopus and Google Scholar databases during the period 2000 to 2020 were obtained. Specific terms were used: "Municipal Wastewater Treatment Plants"; "Municipal Wastewater Treatment Plants," so that all terms must be contained in the title of the document. Categorization was defined according to key concepts considered as adverse effects indicated in the literature and that involve common problems in the water industry at the municipal level. As a result, 1844 documents (papers, reviews, books, book chapters, citations, letters, theses, and conference papers) were retrieved and subjected to a process of refinement (discrimination) where only articles, chapters, conference papers, and reviews were considered. Finally, 800 articles were selected for further content analysis, identifying seven categories and 30 subcategories. The category of "Emerging contaminants" was the most relevant within the research topics, and the category with the least available research was "Air quality." The articles were also analyzed by economic region, identifying Asia with the largest number of studies on various topics. In conclusion, future research should be oriented towards management, energy, and air quality issues, because they are subjects of little research involving process efficiency, energy savings, and impacts on the quality of life. [ABSTRACT FROM AUTHOR]

A longer life brings opportunities for older adults and their families as well as for their communities. Commercial businesses can be successful in innovating on these opportunities and achieving business expansion when they better understand the market dynamics and spectrum of older adults as consumers and view them more as assets rather than as burdens to society. While there is no "typical" older adult consumer, some traits, characteristics, and physical realities may be more common, including those related to family and community, the shopping experience, brand marketing and packaging, food and nutrition, and health. The opportunities of longer life are impacted by health and underscore the importance of positive, healthy aging-related behaviors like good nutrition and active lifestyles. Healthy aging also requires a sustained commitment and action from country leaders to formulate evidence-based polices--like systematic nutrition screening and intervention-and healthcare workforce training and education that can strengthen and support an active aging population. In addition, governments should consider engaging commercial businesses to help set sustainable policies that can advance products for older adults. Finally, governments should set national and local goals to incentivize commercial business development and investment in public-private partnerships to improve quality of care, promote healthy aging, and impact outcomes for noncommunicable diseases, ultimately benefitting population health for Asia-Pacific Economic Cooperation (APEC) countries.

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Recently, the prevalence of myopia has increased significantly in Asia. One of the possible etiologies for the same may be partly related to the amount of work requiring the use of screens. Therefore, I will present possible causes and countermeasures with regard to the display and its effect on the progression of myopia. [ABSTRACT FROM AUTHOR]

Simple Summary: The quality of muscle plays an important role in improving the economic benefit of aquatic products. The paper mulberry (Broussonetia papyrifera, BP) grows wildly in the south of Asia. In this experiment, grass carps (initial weight: 50.0 ± 0.5 g) were fed diets with the addition of 0%, 5%, 10%, 15% and 20% BP in a control diet (crude protein: 31%, crude fat: 3.8%) for 8 weeks. In conclusion, adding 5% BP did not affect the growth of grass carp. However, the supplementation of 10% BP could improve muscle quality through improving muscle hardness, reducing fat accumulation and muscle fiber diameter, at the cost of reducing growth performance. The present study investigated the effects of dietary paper mulberry (Broussonetia Papyrifera, BP) on growth performance, muscle quality and muscle growth-related mRNA expressions of grass carp. Fish (initial weight: 50.0 ± 0.5 g) were fed diets supplemented with 0% (control diet), 5%, 10%, 15% and 20% BP for 8 weeks. The results showed that increasing levels of paper mulberry linearly and quadratically decreased the special gain rate (SGR) and increased the feed conversion rate (FCR) of grass carp (p < 0.05). Significantly positive quadratic trends were found between paper mulberry levels and muscle crude fat or crude protein of grass carp (p < 0.05). In comparison to the control diet, the 10%BP and 15%BP groups had significantly decreased muscle crude fat and increased crude protein (p < 0.05). The levels of paper mulberry resulted in a linear and quadratic increase in water loss of grass carp muscle (p < 0.05), and all groups with paper mulberry supplementation were significantly higher than the control group (p < 0.05). Significant positive linear and quadratic trends were found between the paper mulberry levels and muscle fiber diameter or density of grass carp (p < 0.05). In comparison to the control diet, the significant differences were found in the 15%BP and 20%BP groups (p < 0.05). The muscle adhesiveness and hardness linearly and quadratically increased with the increasing levels of paper mulberry (p < 0.05), and both of which increased significantly when the level of paper mulberry reached 10% (p < 0.05). In addition, the increase in paper mulberry linearly and quadratically improved the expressions of myoblast determination protein (MyoD), myogenin (MyoG), paired box protein 7 (Pax7) and myostatin 1 (MSTN1) (p < 0.05). When the supplementation of paper mulberry reached 15%, the expressions of all these mRNAs were significantly higher than those of the control group (p < 0.05). In summary, adding 5% paper mulberry did not affect the growth of grass carp. However, the supplementation of 10% paper mulberry could improve muscle quality through improving muscle hardness, reducing fat accumulation and muscle fiber diameter, at the cost of reducing growth performance. [ABSTRACT FROM AUTHOR]