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Food allergy is a hypersensitive response to food, generally protein, triggered by body immune system. These responses can be mild, however in very rare cases may cause severe reactions and life threatening known as called anaphylaxis. Food allergy has been one of the main factors for product recall. It can happen due to many reasons, such as product package labeling fault, raw material labeling fault and cross contamination. Validation of the effectiveness of cleaning and sanitation process become a critical point to minimize cross contamination. This study aimed to determine the optimum chemical concentration and contact time to eliminate egg residue in biscuit production cleaning process, obtain valid and verified cleaning procedures, and produce cleaning procedures that can be implemented in a production line. The result showed that physical cleaning/pre-cleaning for 30 minute and using 1% (v/v) concentration of caustic based polybrite chemical cleaning for 3-minute contact time can effectively eliminate the egg residue on stainless steel and polyurethane surface equipment. Food contact surface material and product characteristics (wet dough, dry biscuit) affected the number of egg residue on the equipment. Packing area with food contact surface equipment made from stainless steel is not considered critical area for allergen sanitation. It is shown that prior to sanitation process, analysis of egg allergen residue has already given negative result. Validation process can prove the effectiveness of allergen sanitation process to prevent potential egg allergen cross contamination in biscuit production.

Sensitisasi makanan dan aeroalergen memegang peran pada patogenesis penyakit atopik seperti dermatitis atopik (DA), rinitis alergik dan asma. Dermatitis atopik merupakan suatu penyakit kronik yang tidak dapat disembuhkan 100% dan sering mengalami eksaserbasi, serta menimbulkan masalah pada orang tua dan dokter. Banyak faktor yang berperan pada DA, baik faktor eksogen atau endogen maupun kombinasi keduanya. Faktor genetik merupakan salah satu faktor yang berperan pada DA. Faktor eksogen seperti makanan aeroalergen banyak dilaporkan sebagai pencetus timbulnya DA. Masih terdapat perbedaan pendapat mengenai makanan sebagai penyebab tetapi terdapat bukti bahwa bila makanan dihindarkan gejala dermatitis membaik. Susu sapi memprovokasi gejala DA pada usia bayi1 dan 30% DA disebabkan alergi susu sapi2. Alergen hirup seperti tungau debu rumah berperan pada patogenesis DA, terutama pada anak; hal ini berdasarkan beberapa pengamatan klinis, uji kulit dan IgE spesifik yang tinggi serta terdapat perbaikan gejala klinis DA setelah penghindaran tungau debu rumah.3 Alergen makanan lebih berpengaruh pada usia bayi kurang dari 1 tahun sedangkan aeroalergen pada usia di atas 2 tahun.4 H asil penelitian di Departemen IKA RSCM menunjukkan bahwa DA pada anak dengan onset kurang dari 1 tahun yang telah tersensitisasi telur dan aeroalergen akan meningkatkan risiko alergi saluran napas di kemudian hari sampai sepuluh kali lipat

Latar belakang. Dermatitis atopik (DA) merupakan manifestasi awal atopic marchyang berhubungan dengan alergi makanan. Alergen penyebab dan faktor risiko yang memengaruhi penting diketahui. Tujuan. Mengetahui sensitisasi dan faktor risiko alergi pada DA setelah usia 2 tahun. Metode. Penelitian deskriptif potong lintang terhadap 35 subjek DA sejak Januari-Maret 2011. Sensitisasi diketahui dengan uji tusuk kulit. Hasil. Sensitisasi terjadi pada 29 subjek dari 35 subjek, dengan faktor risiko pajanan asap rokok ditemukan pada 21 subjek, faktor risiko alergi sedang dan tinggi 19 subjek, tidak mendapat ASI eksklusif 9 subjek, dan makanan padat usia dini 21 subjek. Sensitisasi alergen makanan ditemukan pada 26 subjek. Kesimpulan. Sebagian besar subjek DA mengalami sensitisasi oleh alergen makanan. Faktor risiko pajanan asap rokok, faktor risiko alergi sedang dan tinggi, tidak mendapat ASI eksklusif, dan mendapat makanan padat usia dini ditemukan lebih sering pada anak DA

Latar belakang. Penyakit alergi pada anak diperkirakan meningkat seiring dengan pola kehidupan yang berhubungan dengan pengaruh lingkungan, yaitu paparan alergen. Kadang-kadang paparan alergen tidak diketahui tetapi anak datang dengan manifestasi penyakit alergi. Identifikasi alergen yang memicu munculnya penyakit alergi merupakan hal yang penting dan dapat dijadikan salah satu strategi untuk preventif. Tujuan. Membuktikan hubungan paparan alergen terhadap timbulnya penyakit alergi pada anak. Metode. Penelitian observasional dengan desain belah lintang. Subyek adalah semua pasien anak berumur 2 tahun hingga 14 tahun dengan manifestasi alergi berupa dermatitis atopi, rinitis alergi, konjungtivitis alergi, dan asma. Subjek berasal dari Poliklinik Umum Anak, Paru Anak, Telinga-Hidung-Tenggorok, Kulit- Kelamin, dan Mata RSUP Dr. Kariadi Semarang. Periode penelitian Agustus 2000 hingga Januari 2001. Orangtua subjek diminta mengisi kuesioner. Dilakukan uji tusuk kulit (skin prick test) untuk konfirmasi alergen berupa aeroalergen dan alergen makanan. Analisis statistik menggunakan chi-square. Hasil. Subyek 44 anak dengan alergi, terdiri dari 63,6% rinitis alergi, 25% asma, 34,1% dermatitis atopi, dan 2,3% konjungtivitis alergi. Rasio perempuan : laki-laki = 1,2:1. Uji tusuk kulit positif pada 45,5% kasus. Hasil aeroalergen berupa debu rumah (75,0%), mite culture (70,0%), human dander (70,0%), kecoa (65,0%), animal dander (25%), pollen (10%), fungi (5%). Alergen makanan berupa makanan laut (30,0%), telur (5%), dan 5% coklat. Terdapat hasil positif beberapa paparan alergen. Didapatkan paparan tanaman dalam rumah sebagai penyebab dermatitis atopi (p=0,008). Kasus asma 90,9% menunjukkan hasil uji tusuk kulit positif (p=0,001). Kesimpulan. Aeroalergen merupakan alergen yang paling banyak dijumpai pada anak dengan penyakit alergi.

Latar Belakang: Rendahnya efektivitas imunoterapi dan kepuasan orang tua perlu dieksplorasi untuk menurunkan angka dropout imunoterapi yang masih tinggi. Tujuan: mengevaluasi pengaruh keberadaan gejala alergi di luar saluran nafas pada efektivitas imunoterapi dalam meredakan gejala alergi dan kepuasan para orang tua. Metode: Penelitian dilaksanakan mulai 1 Januari 2008 sampai 31 Desember 2018 dengan disain kohort retropektif pada anak alergi debu rumah dengan gejala saluran nafas moderate-persistent yang diberikan imunoterapi alergen debu rumah subkutan. Setelah fase rumatan imunoterapi selesai, tingkat gangguan kualitas hidup dan frekuensi gejala, jumlah hari/minggu bebas gejala alergi, dan tingkat kepuasan orang tua dievaluasi dalam 30 hari. Hasil: Sejumlah 100 % dari total subjek penelitian (2,171 pasien) sensitif pada alergen debu rumah dengan gejala saluran nafas. Sebesar 79,7 % pasien membaik menjadi mild-intermittent. Rerata jumlah hari bebas gejala pada 30 hari paska fase rumatan imunoterapi adalah 25,1 + 8,31 hari. Tingkat kepuasan yang tinggi dinyatakan oleh 72,9 % orangtua pasien. Adanya komorbiditas dermatitis atopik, urtikaria, dan gejala alergi saluran cerna tidak berpengaruh terhadap skor perbaikan gejala alergi saluran nafas. Keberadaan dermatitis atopik, urtikaria, dan gangguan saluran cerna berkorelasi dengan penurunan jumlah hari bebas gejala. Simpulan: Keberadaan dermatitis atopik, urtikaria, dan gangguan saluran cerna sebagai komorbiditas tidak menurunkan efektivitas imunoterapi alergen debu rumah dalam meredakan gejala alergi saluran nafas, tetapi menurunkan jumlah hari/minggu bebas dari gejala alergi dan tingkat kepuasan orang tua pasien.

Ikan tongkol merupakan salah satu produk laut penyebab alergi makanan. Gejala klinis reaksi alergi makanan adalah gatal, bentol, bengkak, sesak nafas, batuk, dan yang terparah adalah syok anafilaksis. Pengobatan dan pencegahan alergi makanan yang terbaik adalah menghindari konsumsi penyebab alergi. Menghindari konsumsi suatu makanan sebaiknya berdasarkan uji alergi seperti Skin Prick Test (SPT). SPT dilakukan menggunakan reagen SPT yang dicukitkan pada lapisan epidermis kulit lengan bagian volar. Reagen alergen pada penelitian ini merupakan protein ikan tongkol yang berasal dari laut Indonesia dan diekstrak dengan buffer fosfat, Profil ekstrak protein menggunakan elektroforesis dan immunoblotting untuk menentukan protein allergen. Sebanyak 15 pita protein terdeteksi pada ekstrak ikan tongkol yaitu protein dengan berat molekul antara 17 sampai 152 kDa. Potensi alergenik terdapat pada pita protein dengan berat molekul antara 12 sampai 50 kDa. Reagen SPT ikan tongkol mempunyai sensitivitas sebesar 81.8% dan spesifitas 100% sehingga disimpulkan bahwa reagen ekstrak ikan tongkol dapat digunakan sebagai reagen skin prick test Kata kunci: Alergi, protein, tongkol, gejala klinis, skin prick test Tuna fish is one of the marine products that can cause allergic. Clinical symptoms of allergic are a bump, swelling, shortness of breath, coughing and anaphylactic shock is the worst symptom. The best medication and treatment is avoiding the consumption of food that could cause allergy. Avoiding consumption of food should be based on an allergy test such as a Skin Prick Test (SPT). SPT using reagent which is applied on the skin of the forearm between the wrist and elbow. The reagent for SPT is a protein solution of tuna which was extracted by phosphate buffer then protein profile was detected using electrophoresis. Immunoblotting was done to determine the molecular weight of the allergen protein. Fifteen protein bands were detected on tuna fish extract; the molecular weight of the protein was obtained between 17 to 152 kDa. Protein allergenic are molecules that have protein bands with a molecular weight between 12 and 50 kDa. Tuna fish extract solution for SPT had a sensitivity is 81.8%, and specificity is 100%, it was concluded that tuna fish reagent could be used as SPT reagent. Keywords: Allergen, protein, tuna fish, skin prick test.

Feline atopic skin syndrome (FASS) describes allergic skin diseases in cats associated with sensitivity to environmental allergens. Allergen-specific immunotherapy (ASIT) aims to reduce or eliminate symptoms associated with subsequent exposure to the causative allergen. The primary outcome of this study was to determine if the quality of life (QoL) of cats and owners improved as a result of ASIT. The secondary outcome was to determine whether the QoL improved in cats treated with ASIT compared with cats treated symptomatically. Eight cats were included in the ASIT group (AG) and 6 cats in the control group (CG). Validated quality of life questionnaires were retrospectively completed by cat owners for the period before and after treatment. The QoL of cats improved significantly with ASIT. Cats were significantly less lazy, nervous, aggressive, restrained, preened less while sleeping and hid less, were less disturbed by consultations, were more playful and interactive with their environment, and had better appetites than before treatment. Owners felt significantly less physically exhausted and less emotionally distressed compared to before ASIT treatment and their expenses were significantly lower. On the contrary various symptomatic treatments did not significantly improve the quality of life of the cats or their owners in any of the terms. No serious side effects were observed with ASIT. The quality of life of animals suffering from chronic diseases is important as it determines the decisions of owners and veterinarians on the modalities of lifelong treatment. Validated questionnaires are still rarely used in veterinary practice and research. [ABSTRACT FROM AUTHOR]

Copyright of Indonesian Fisheries Processing Journal / Jurnal Pengolahan Hasil Perikanan Indonesia is the property of IPB University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Information about three-dimensional structure of protein is important to clearly understand its character and function in molecular level. Protein structure determination through laboratory testing needs highly cost of steps and instrument. Three dimensional structure of protein can be scientifically predicted using several in silico methods. The structure of allergen protein was predicted using SWISS-MODEL as homology method in this research. The result showed that structure prediction of allergen protein B7TWE7 (UniProt ID) from Fagus sylfatica (beechnut) have three-dimensional structure with identity value 72% and e-value = 3,4x10-58. This study used the 1e09A (PDB ID) of Prunus avinus (cherry) as a template.Keywords: allergen, homology method, protein structure, swiss-model ABSTRAKInformasi struktur tiga dimensi protein penting untuk memahami sifat dan fungsi protein ditingkat molekular secara detil. Penentuan struktur protein dengan cara pengujian di laboratorium memerlukan tahapan dan instrumentasi dengan biaya tinggi. Struktur tiga dimensi protein dapat diprediksi secara ilmiah dengan menggunakan beberapa metode secara in silico. Metode yang digunakan pada penelitian ini adalah metode homologi menggunakan program SWISS-MODEL. Protein yang akan diprediksi struktur tiga dimensinya adalah protein alergen pangan. Hasil penelitian menunjukkan bahwa prediksi struktur protein alergen B7TWE7 (UniProt ID) dari Fagus sylfatica (beechnut) dengan metode homologi menggunakan program SWISS-MODEL menghasilkan model struktur tiga dimensi protein dengan nilai identity 72% dan e-value = 3,4x10-58. Template protein yang digunakan adalah 1e09A (PDB ID) dari Prunus avinus (cherry).Kata kunci: alergen, metode homologi, struktur protein, swiss-model

Copyright of Sanamed is the property of Sanamed and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Allergen-Specific Immunotherapy (ASIT) is the only etiological therapy of allergic diseases that potentially modifies the course and progression of the disease. It has been shown to be effective in treating allergic rhinitis with/without conjunctivitis, allergic asthma and anaphylactic hypersensitivity to hymenoptera sting. Although, even if it has been used to treat allergic diseases for more than 100 years, and despite of its proven effectiveness, ASIT is often under-administered in treating of these diseases. It is performed by using a standardized allergen extract, most commonly applied under the skin, and in recent years increasingly as sublingual immunotherapy. Indications, application, implementation and follow up of ASIT are set by a physician, subspecialist in allergy and clinical immunology. Since the subcutaneous application of ASIT carries the risk of occurrence of anaphylaxis, it should be carried out in specialized facilities that are additionally equipped and the staff are further educated. Decisions on the introduction and continuation of ASIT should be made case-by-case, taking into account the specificities of each patient (personalized approach) such as allergen avoidance, efficacy of pharmacological treatment, quantity and type of medication needed to achieve disease control, side effects of pharmacological treatment, patient motivation, etc. This article will show mechanisms, indications and contraindications for the introduction of ASIT, patient selection criteria, application methods, safety and efficacy, as well as novel therapeutic approach of ASIT in the treatment of allergic diseases in children. [ABSTRACT FROM AUTHOR]

Penelitian bertujuan untuk mengetahui jumlah bakteri asam laktat (BAL) dan Eschericia coli (E. coli) dalam sekum serta kadar IgA cairan usus pada tikus normal dan tikus yang disensitisasi alergen dinitrochlorobenzene (DNCB). Penelitian ini menggunakan tikus Wistar betina umur 6-8 minggu yang disuplementasi susu fermentasi berupa susu Acidophilus dan kefir serta kontrol. Variabel yang diamati meliputi jumlah BAL, E. coli dalam sekum dan kadar IgA cairan usus tikus normal dan tikus yang disensitisasi alergen DNCB. Analisis data menggunakan Rancangan Acak Lengkap pola searah. Hasil penelitian menunjukkan bahwa suplementasi susu fermentasi berupa susu Acidophilus, kefir maupun kontrol terhadap jumlah BAL, E. coli sekum serta IgA usus tikus baik normal maupun yang disensitisasi alergen DNCB tidak menunjukkan perbedaan yang nyata (P>0,05). Rerata BAL isi sekum tikus normal dengan suplementasi kefir, susu Acidophilus dan kontrol berturut-turut: 8,59; 8,61 dan 8,44 log CFU/g, pada tikus yang disensitisasi alergen DNCB berturut-turut: 8,58; 9,14 dan 8,91 log CFU/g. Rerata E. coli isi sekum tikus normal dengan suplementasi kefir, susu Acidophilus dan kontrol berturut-turut: 7,14; 7,61 dan 7,05 log CFU/g, pada tikus yang disensitisasi alergen DNCB berturut-turut: 7,63; 7,31 dan 7,25 log CFU/g. Rerata IgA usus tikus normal dengan suplementasi kefir dan kontrol berturut-turut: 883,34 dan 874,84 ng/ml, pada tikus yang disensitisasi alergen DNCB berturut-turut: 907,84 dan 955,47 ng/ml. Berdasarkan hasil tersebut disimpulkan bahwa jumlah BAL dan E. coli pada tikus normal yang suplementasi susu fermentasi berbeda dengan jumlah BAL pada yang disensitisasi alergen DNCB. Pemberian kefir pada tikus normal maupun yang disensitisasi alergen DNCB dapat menstimulasi kadar IgA dalam usus. (Kata kunci: Susu fermentasi, Bakteri asam laktat, Eschericia coli, IgA, Dinitrochlorobenzene (DNCB))

The relationship between man and horse goes back to prehistoric times. Horses are among the most significant human domesticated animals. Currently, due to mechanization, the role of horses as an economic resource has decreased, but their recreational role is still important. Taking into account frequent contact with humans, they are of great importance as a potential source of allergens, constituting a significant cause of various allergic reactions. The article describes a case of an acute allergic reaction in a patient with bronchial asthma after contact with a horse allergen, which was brought along with the clothing of a person who had contact with the animal. The frequency of allergies, the prevalence and types of allergens as well as anaphylactic reactions to horses are discussed. The application of diagnostics based on allergen components was discussed, as well as component diagnostics performed in the patient in the context of allergy to panallergens from the lipocalin group was described. [ABSTRACT FROM AUTHOR]

The aim was to compare the values of allergy biomarkers, total IgE (uIgE), specific IgE (sIgE) and specific IgE index (IsIgE) against the cocksfoot (Dactilis glomerata, Dac g) grass allergen and eosinophilic granulocytes in and beyond the pollination season. Children with confirmed hypersensitivity to cocksfoot allergens (N=80) were selected and divided into two groups. Group 1 included children examined during the pollination season (n=64) and group 2 children examined out of the pollination season (n=16). The concentration of selected parameters was determined by standardized laboratory procedures. The values of all allergy biomarkers tested, especially sIgE and IsIgE, were statistically significantly higher in the group of children tested during the cocksfoot flowering season as compared with the group tested out of the season (p<0.05). Consequently, correlation of the biomarkers was higher during the season of exposure to the causative allergen. In conclusion, the results obtained indicate that biomarkers of allergies, sIgE and IsIgE in particular, should be determined at the time of exposure to the Dac g allergen. [ABSTRACT FROM AUTHOR]

Common ragweed (Ambrosia atremisiifolia) is one of the most frequent causes of pollen-induced allergic reactions both in humans and dogs. It has not been defined yet, what is the major allergen(s) to which most dogs allergic to ragweed show a positive result on intradermal skin test (IDST). In the present study sensitization to Ambrosia artemisiifolia pollen allergens in dogs with atopic dermatitis was examined with both in vivo and in vitro tests, including IDST and serum allergen specific IgE test. Detection of specific-IgE antibodies against ragweed allergens by immunoblotting in the sera of allergic dogs was optimized, as well. Dogs that were positive, as judged by IDST reactions to ragweed pollen allergens, also had alergen specific IgE antibodies in their sera. Results indicate that major allergens of A. artemisifolia pollen in dogs are Amb a 1 and Amb a 2. Further characterization of ragweed allergens is needed before they could potentially be used in intradermal testing or allergen immunotherapy in affected dogs. Also, we evaluated new Favrots diagnostic criteria for canine atopic dermatitis in dogs allergic to Ambrosia atremisiifolia pollen. It might be concluded that proposed criteria are of great assistance for seting up suspected diagnosis of canine atopic dermatitis, after ruling out other pruritic dermatoses. [ABSTRACT FROM AUTHOR]

Introduction. The analysis of allergen-specific IgE responses in birth cohorts with micro-arrayed allergens has provided detailed information regarding the evolution of specific IgE responses in children. Data regarding early development of allergen-specific IgG are needed. Materials and method. We analyzed the results obtained by searching for keywords "maternal allergens", "specific IgG", and "sensibilization" in PubMed and Elsevier databases. There were identified a number of 1984 publications, of which we kept exclusively those in extenso describing results of randomized studies. The studies were analyzed in order to identify the following variables: specific IgG dosage of maternal allergen in the third trimester, the identification of IgG in cord blood, and allergic reactions of children at two months, six months, one year and at five years. Results and discussion. A number of two studies have identified the fact that all children from mothers with elevated (>30 ISU) specific plasma IgG against an allergen did not have IgE sensitization against that allergen at the age of 5 years old. Conclusions. The latest studies in the field have shown that high levels of IgG specific to allergen in mothers during the third trimester and in cord blood seem to protect against allergic sensitization in children. This finding has clinical implications for the prevention of allergies, as well as in their treatment. Studies on human subjects are limited, but the experimental ones are promising, more studies being needed on this topic. [ABSTRACT FROM AUTHOR]

The article presents a study on the effect of allergen-specific immunotherapy (ASIT) in dogs with atopic dermatitis (AD). It states that serologic allergy testing, and microscopic examination of skin swabs and skin scrabs of dogs were conducted to eliminate secondary infections, skin diseases, and Flea allergy dermatitis. Results show that common allergens including local erythema, itching, and conjunctivitis were identified during ASIT.

Copyright of Journal of Food Technology & Industry / Jurnal Teknologi & Industri Pangan is the property of Bogor Agricultural University, Department of Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The diversity of products in a company makes the process of cleaning production areas important to prevent cross contamination. Cleaning in Place (CIP) is a method to clean product residues from production equipment automatically without the need to disassemble the machine. This study aims to determine the required minimum time for the CIP drying process to dry the production equipment. The experiment was done by testing the treatment based on changes in compressed air, drying, and cooling process time. Cleaning verification was done by examining visual inspection and test for detection of microbial contamination, allergens and ATP. The results showed that reducing the CIP processing time can be done by minimizing the drying time. The best treatment resulted in the treatment with compressed air 300 s, drying 900 s and cooling 900 s. This can be seen from the 3 repetitions, the results obtained by examining the overall appearance of the surface in the tote bin are clean and dry. In addition, changes in the time parameter did not affect the cleaning process of residues on the surface of the tote bin, which was shown in the results of testing for detection of microbial contamination, allergens and ATP.

Copyright of Journal of Syntax Literate is the property of Ridwan Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Asserts that the expression of the engrailed gene reveals nine putative segment-anlagen in the embryonic pleon of the fishwater crayfish. Analysis of the segment formation in its embryonic pleon; Vestiges of ancestral segments; Phylogeny of crustaceans or mandibulates.

Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background. The aim of this work was to find out which of the aeroallergens most often cause positive skin prick tests in the population with allergic diseases. Depending on the type of allergens, exposure to them can aggravate asthma symptoms and cause allergic conjunctivitis and allergic rhinitis. Material and methods. A group of 100 people between 18 and 78 years of age were included in the study. The average age was 45.8 years. There were 34 men and 66 women in the group. All patients were allergy clinic patients. The results of point skin tests for the basic aeroallergen panel were analyzed in this study and summarized using descriptive statistics. Results. Sixty subjects had positive tests for dust mites. Most subjects were allergic to two allergens. Monovalent allergy was found in 10 subjects. Multivalent allergy was predominant, but tended to involve relatively few allergens. Conclusions. The results obtained may be due to year-round exposure to the house dust mite allergen. Prolonged allergen exposure translates into more frequent immune responses and greater clinical response of patients, which is manifested by allergic rhinitis and/or bronchial asthma or allergic conjunctivitis. Due to the small patient population studied, this subject requires further analysis. [ABSTRACT FROM AUTHOR]

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Copyright of Lijecnicki Vjesnik is the property of Croatian Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lijecnicki Vjesnik is the property of Croatian Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lijecnicki Vjesnik is the property of Croatian Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

There are over 8 million dogs in Poland. Allergy to pets accounts for 2.5% of total allergy cases, while allergy to dogs constitutes 8% of the total pet allergies. About 6% of children with allergic rhinitis and 35% of the asthmatic children have positive SPTs to dog allergens. Avoiding of dog allergens is not feasible, since dog antigen is found at concentrations capable of producing allergic symptoms in all public places. There are 29 allergic proteins in dog hair, dander, urine, serum and saliva. Five major dog allergens have been identified: Can f1, Can f2, Can f3, Can f4. Can f5. Allergens Can f1 and Can f2 are found in dander, saliva and in skin. Can f3 is found in serum, Can f4 in hair, dander and skin. Can f5 is found in urine. Can f 1 and Can f5 are capable of binding 50-70% of IgE, while Can f2 and Can f3 bind 20-40% of IgE. Considerable differences have been observed in the quantity of dog allergens between various breeds, but it does not seem reasonable to regard any of the breed as hypoallergenic. Effect of influence of dog allergens and of being an owner of a dog on the development of allergy and asthma has not been yet clarified. Some authors stress the significance of constant contact with the animal and of breeding more than one dog at home. Up to now, it has not been possible to determine the effect of having a dog at home on development of allergy in children. [ABSTRACT FROM AUTHOR]

Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. The pathogenesis of atopic dermatitis includes genetic predisposition, epidermal barrier dysfunction, immunologic abnormalities and increased immunoglobulin E levels in some of the patients. Objective. Determination the allergen-specific immunoglobulin E level and serum interleukin-33 concentration in patients with atopic dermatitis. Material and methods. The study included 62 patients with atopic dermatitis at the mean age of 30.4 ±11.6 years. Clinical eveluation of the SCORAD index and the objective SCORAD (oSCORAD) was performed. Serum samples were analyzed for immunoglobulin E specific allergy using immunoblot kits for 21 allergens of atopy. Serum concentration of interleukin-33 was examined by ELISA. Results. The SCORAD index was higher (p < 0.05) in atopic dermatitis patients with immunoglobulin E specific to birch, dog fur, horse fur, Cladosporium herbarum, egg white, hazelnut, carrot, and potato than in those without such allergen-specific immunoglobulin E. Objective SCORAD was increased (p < 0.05) in atopic dermatitis patients with immunoglobulin E specific to birch, dog fur, Cladosporium herbarum, egg white, hazelnut, carrot, and potato in comparison to those without such allergen-specific immunoglobulin E. Mean serum concentration of interleukin- 33 in patients with atopic dermatitis was 4.9 ±8.12 pg/ml. Serum interleukin-33 level did not correlate with such clinical parameters as the extent of skin lesions, pruritus, sleep disorders, SCORAD index and objective SCORAD. Interleukin-33 level was not higher in atopic dermatitis patients with immunoglobulin E specific to any examined antigen in comparison to those without such immunoglobulin E. Conclusions. Our study suggests that interleukin-33 is not a reliable marker of activity in atopic dermatitis. Further studies are necessary to confirm this hypothesis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Technology & Industry / Jurnal Teknologi & Industri Pangan is the property of Bogor Agricultural University, Department of Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Indonesian Fisheries Processing Journal / Jurnal Pengolahan Hasil Perikanan Indonesia is the property of IPB University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Anaphylaxis is a sudden, life-threatening hypersensitivity reaction with multiorgan manifestations that requires urgent intervention. Globally, there is an observed increase in hospitalizations due to anaphylactic shock, particularly in children. Despite this increase, mortality rates remain stable or even show a tendency to decrease, estimated within the range of 0.5 to 1.0 deaths per million populations. Hypersensitivity reactions occur in response to an allergen, with the most common causes being nutritional allergens, insect bites, and medications. Anaphylactic shock, as the most severe form of anaphylaxis, is characterized by a significant decrease in blood pressure that can lead to circulatory failure. The key to successful treatment is timely recognition of symptoms, cessation of contact with the allergen and rapid application of appropriate medical therapy. Adrenaline (epinephrine) is considered the first and most important drug in the treatment of anaphylactic shock; therefore, its administration must not be delayed. The aim of these clinical guidelines is to present a recommended algorithm for the diagnosis and treatment of anaphylaxis and anaphylactic shock. [ABSTRACT FROM AUTHOR]

Food-dependent exercise-induced anaphylaxis (FDEIA) is a special type of anaphylaxis. Allergic reactions develop only when food is consumed with a cofactor. Cofactor of the reaction are exercise, nonsteroidal anti-inflammatory drugs, alcohol and infection. The frequency of FDEIA is different in the geographical area of the word. The pathogenesis of food- dependent anaphylaxis induced by exercise or other cofactors is not fully understood. In this case, the cause may be increased permeability of the gastrointestinal epithelium and greater bioavailability of allergens, or an increase in plasma osmolality during physical activity. In practice, every allergic reaction can be amplified by cofactors. There are allergens, such as ω-5-gliadin, lipid transport proteins, and tropomyosin, for which their role seems to be particularly important. In many cases of FDEIA, the allergen causing the reaction is not identified. The gold standard for diagnosing food allergy is the oral challenge test. In the case of FDEIA, conducting them is a challenge due to the need to introduce a cofactor into the test. It is necessary to explain to the patient the nature of FDEIA and the allergens that sensitize him. The most important thing is to completely avoid eating foods that trigger reactions 4 hours before and 2 hours after exercise. Biological drugs may become a new treatment method. [ABSTRACT FROM AUTHOR]

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Czecho-Slovak Pediatrics / Česko-Slovenská Pediatrie is the property of Czech Medical Association of JE Purkyne and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hypersensitivity to Hymenoptera venom, occurring in approximately 3-5% of the population in Europe and the United States, is an important and difficult medical problem due to the fact that reactions after stings may pose a direct threat to life. In most cases, allergic reactions after stings are IgE-dependent, which is confirmed by the presence of specific IgE antibodies in the skin and/or serum against venom allergens. Diagnosing of hypersensitivity to Hymenoptera venom is often very difficult. This article presents the case of a patient who, as a result of her first bee sting, suffered a toxic-inflammatory reaction despite the presence of specific IgE antibodies to icarapine (rApi m10) detected in in vitro diagnostics. After a few years, the second sting, this time by a wasp, led to an anaphylactic reaction with abdominal symptoms predominating. Despite the lack of sIgE to wasp venom allergens in in vitro tests, hypersensitivity was confirmed in intradermal tests using wasp venom extract. After the final diagnosis was made, the patient was qualified for „ultra-rush” specific alergen immunotherapy using wasp venom extract. In each case, it is necessary to perform extensive diagnostics to confirm the immunological background of the reaction, which is also necessary to determine indications for the implementation of specific allergen venom immunotherapy. [ABSTRACT FROM AUTHOR]

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Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Contact dermatitis (eczema), recognized as an entity even in ancient times of mankind's history reflects an inflammatory process which occurs in tegument by direct contact with noxious agents from the environment. Action subject to a variety of multiple pathogen factors, skin exercises different the role of barrier in the context of growing predisposing conditions. Contact dermatitis represents 4 to 7 per cent of the dermatological disorders, while skin diseases are responsibles for over half of the occupational conditions (1). [ABSTRACT FROM AUTHOR]