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6. Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy

Author

Huang, Yen-Chu, Lyu, Rong-Kuo, Tseng, Mu-Yun, Chang, Hong-Shiu, Hsu, Wen-Chuin, Kuo, Hung-Chou, Chu, Chun-Che, Wu, Yih-Ru, Ro, Long-Sun, Huang, Chin-Chang, and Chen, Chiung-Mei

Subjects
*DEMYELINATION, *MYELIN sheath diseases, *CEREBROSPINAL fluid, *PROSTAGLANDINS, *MULTIPLE sclerosis, *GUILLAIN-Barre syndrome, *PATIENTS
Abstract

Abstract: Prostaglandin D2 synthase (PGDS) is the most abundant brain protein in cerebrospinal fluid (CSF) and is tied closely with inflammatory processes. This study investigated whether CSF PGDS levels in patients with acute inflammatory demyelinating polyneuropathy (AIDP) are altered. The results suggest that PGDS concentration is significantly increased in the CSF of AIDP patients compared with the control patients (p <0.05) due to a blood-CSF barrier dysfunction, whereas the intrathecal synthesis of PGDS, reflected by the CSF PGDS/albumin ratio, is significantly decreased in AIDP compared with the control group (p <0.05). The changes of CSF PGDS/albumin ratio are only observed in AIDP patients, but not in Miller Fisher Syndrome (MFS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), or multiple sclerosis (MS) patients. [Copyright &y& Elsevier]

Published
2009
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