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Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy

Authors :
Huang, Yen-Chu
Lyu, Rong-Kuo
Tseng, Mu-Yun
Chang, Hong-Shiu
Hsu, Wen-Chuin
Kuo, Hung-Chou
Chu, Chun-Che
Wu, Yih-Ru
Ro, Long-Sun
Huang, Chin-Chang
Chen, Chiung-Mei
Source :
Journal of Neuroimmunology. Jan2009, Vol. 206 Issue 1/2, p100-105. 6p.
Publication Year :
2009

Abstract

Abstract: Prostaglandin D2 synthase (PGDS) is the most abundant brain protein in cerebrospinal fluid (CSF) and is tied closely with inflammatory processes. This study investigated whether CSF PGDS levels in patients with acute inflammatory demyelinating polyneuropathy (AIDP) are altered. The results suggest that PGDS concentration is significantly increased in the CSF of AIDP patients compared with the control patients (p <0.05) due to a blood-CSF barrier dysfunction, whereas the intrathecal synthesis of PGDS, reflected by the CSF PGDS/albumin ratio, is significantly decreased in AIDP compared with the control group (p <0.05). The changes of CSF PGDS/albumin ratio are only observed in AIDP patients, but not in Miller Fisher Syndrome (MFS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), or multiple sclerosis (MS) patients. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01655728
Volume :
206
Issue :
1/2
Database :
Academic Search Index
Journal :
Journal of Neuroimmunology
Publication Type :
Academic Journal
Accession number :
36102945
Full Text :
https://doi.org/10.1016/j.jneuroim.2008.10.011