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Background. Data from numerous studies indicate a significant prevalence of vitamin D deficiency in Ukraine and the world. In recent years, the Ukrainian medical community has faced two important challenges — the COVID-19 pandemic and the russian aggression, which significantly affected the organization and availability of medical care. Despite the previous epidemiological studies in Ukraine devoted to the vitamin D status, there are no data during the past 5 years that became the background for this research. The purpose was to analyze the vitamin D status in the adult population of Ukraine during the COVID-19 pandemic and russian aggression. Materials and methods. Data of the serum level of 25-hydroxyvitamin D (25(OH)D) in 5029 adults aged 20–99 years, who for various reasons applied for its measurement, were retrospectively analyzed. The analysis was performed depending on the year and month of observation, the age and gender of the subjects, and the 25(OH)D level. Results. The mean serum level of 25(OH)D in the total group was 33.2 [24.1–43.8] ng/ml. The assessment of the number of 25(OH)D tests for 2018–2022 did not reveal any signi­ficant differences in 2018 and 2019 but established a significant decrease during the russian aggression in Ukraine in 2022 (by 55.7 %) compared to 2018, as well as indices during the COVID-19 pandemic (by 21.6 % compared to 2020, by 23.5 % in 2021). During the observation period, it was established a decrease in the vitamin D deficiency proportion from 20.6 % in 2018 to 9.3 % in 2022, and an increase in the proportion of subjects with suboptimal (from 6.6 to 11.4 %, respectively) and high serum concentrations of 25(OH)D (from 2.2 to 12.7 %). Conclusions. Our results indicate a grown serum 25(OH)D level during 2020–2022 in the adult population of Ukraine compared to the indices of previous years and a decreased share of vitamin D deficiency in the Ukrainian population. In addition, a decrease in the number of 25(OH)D level tests was established, especially during the period of the russian aggression, which should be taken into account during the planning measures to optimize the vitamin D status in the adult population of Ukraine.

Background. The purpose was to determine the level of N-terminal of type I procollagen (PINP) and carboxy-terminal telopeptide of type I collagen (β-CTX) and their relationship in the serum of a healthy Ukrainian population of varying age and gender. Materials and methods. The study included 3,850 people aged 20–89 years (3,351 women (mean age 59.05 ± 13.89 years) and 499 men (49.17 ± 15.8 years). All participants were divided by age based on the gerontological age classification: young age 20–44 yrs, middle age 45–59 yrs, elderly 60–74 yrs, and old 75–89 yrs, and between 7 groups by decades: from 20 to 89. β-CTX and serum PINP concentrations were determined by electrochemiluminescence immunoassay ECLIA on a Cobas E411 analyzer. Results. We have detected a significant effect of age on serum β-CTX and PINP variability in men (F = 6.64, p

Background. Today, vitamin D deficiency and insufficiency is a global problem of public health affecting an estimated 1 billion people worldwide. Numerous studies show that the biological effects of vitamin D are not limited to the regulation of calcium-phosphorus metabolism; it also affects other physiological processes in the body. The purpose of the study was to evaluate the efficacy and safety of dietary supplement Olidetrim in the correction of vitamin D deficiency in postmenopausal women, and to study the effects of vitamin D levels on pain severity and quality of life. Materials and me­thods. The study included 26 postmenopausal women aged 50 to 83 years who had a deficiency or insufficiency of vitamin D. All patients took Olidetrim 1000 IU, 1 capsule 3 times a day for 3 months. At each visit, we examined the level of 25(OH)D using electrochemiluminescent method, severity of low back pain by means of a visual analogue scale, the algo-functional state of large joints was determined using the WOMAC scale (subscales of pain, stiffness, physical functioning), the patient’s quality of life was evaluated on the ECOS-16 scale. Assessment of the condition was carried out after 1 and 3 months. Results. Level of 25(OH)D significantly increased in the examined women after 1 (p = 0.000004) and 3 months (p = 0.000002) of Olidetrim intake. After 3 months of taking Olidetrim, vitamin D deficiency in postmenopausal women was not registered, 69.6 % of patients had vitamin D insufficiency, and the level of vitamin D was optimal in 30.4 % of patients. The maximum level of pain significantly decreased after 1 (p = 0.01) and 3 months (p = 0.01). According to the results of the WOMAC questionnaire, we found a significant increase of daily activity after 1 and 3 months in patients who received Olidetrim. During the observation period, women had no side effects associated with taking a dietary supplement. Conclusions. Olidetrim is an effective and safe dietary supplement for the correction of vitamin D deficiency in postmenopausal women.

Background. Vitamin D deficiency is prevalent in all the world countries. Recent studies show the correlation between vitamin D deficiency and musculoskeletal disorders. The purpose of this study is to examine vitamin D deficiency and insufficiency prevalence in patients of various ages, who have musculoskeletal disorders, and to reveal the influence of seasonal factors on these conditions. Materials and methods. 3460 patients of the Ukrainian Scientific Medical Center of Osteoporosis Problems, aged 1 to 92 years, who were referred by other specialists to the center for bone state evaluation, were examined. A majority of the patients presented with osteoporosis and its complications, spinal osteochondrosis, knee and hip osteoarthritis (mean age — 52.90 ± 21.10 years). Most of the patients were women (83.5 %). 25(ОН)D and parathyroid hormone analyses were performed by means of electrochemiluminescent method (Elecsys 2010 analyzer, Roche Diagnostics, Germany) and cobas test-systems. Statistica 6.0 software package (Copyright StatSoft, Inc., 1984–2001) was also used. Results. Among the patients with musculoskeletal pathology, the highest 25(ОН)D level was noted in the age group of 1–9 years and the lowest — in the age group of 80 and over. Age negatively influenced 25(ОН)D values. Prevalence of vitamin D deficiency among the patients with musculoskeletal pathology was 37.3 %, vitamin D insufficiency — 30.6 %; 32.1 % of patients had normal vitamin D status. Normal 25(OH)D level was found in 38.0 % of children, 33.2 % of adults and in 29.6 % of elderly patients. Month of blood sampling had a significant influence on 25(ОН)D content (F = 7.49; p

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