Levels of bone turnover markers (N-terminal propeptide of type I procollagen and carboxy-terminal telopeptide of type I collagen) in Ukrainian population of different age and gender

Background. The purpose was to determine the level of N-terminal of type I procollagen (PINP) and carboxy-terminal telopeptide of type I collagen (β-CTX) and their relationship in the serum of a healthy Ukrainian population of varying age and gender. Materials and methods. The study included 3,850 people aged 20–89 years (3,351 women (mean age 59.05 ± 13.89 years) and 499 men (49.17 ± 15.8 years). All participants were divided by age based on the gerontological age classification: young age 20–44 yrs, middle age 45–59 yrs, elderly 60–74 yrs, and old 75–89 yrs, and between 7 groups by decades: from 20 to 89. β-CTX and serum PINP concentrations were determined by electrochemiluminescence immunoassay ECLIA on a Cobas E411 analyzer. Results. We have detected a significant effect of age on serum β-CTX and PINP variability in men (F = 6.64, p