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Experimental fission studies for reaction physics or nuclear spectroscopy can profit from fast, efficient, and radiation-resistant fission fragment (FF) detectors. When such experiments are performed in-beam in intense thermal neutron beams, additional constraints arise in terms of target-detector interface, beam-induced background, etc. Therefore, wide gap semi-conductor detectors were tested with the aim of developing innovative instrumentation for such applications. The detector characterization was performed with mass- and energy-separated fission fragment beams at the ILL (Institut Laue Langevin) LOHENGRIN spectrometer. Two single crystal diamonds, three polycrystalline and one diamond-on-iridium as well as a silicon carbide detector were characterized as solid state ionization chamber for FF detection. Timing measurements were performed with a 500-µm thick single crystal diamond detector read out by a broadband amplifier. A timing resolution of ∼10.2 ps RMS was obtained for FF with mass A = 98 at 90 MeV kinetic energy. Using a spectroscopic preamplifier developed at INFN-Milano, the energy resolution measured for the same FF was found to be slightly better for a ∼50-µm thin single crystal diamond detector (∼1.4% RMS) than for the 500-µm thick one (∼1.6% RMS), while a value of 3.4% RMS was obtained with the 400-µm silicon carbide detector. The Pulse Height Defect (PHD), which is significant in silicon detectors, was also investigated with the two single crystal diamond detectors. The comparison with results from α and triton measurements enabled us to conclude that PHD leads to ∼50% loss of the initial generated charge carriers for FF. In view of these results, a possible detector configuration and integration for in-beam experiments has been discussed.

Measurement of specific loss power (SLP) of magnetic nanoparticles is crucial to assert the heating potential in magnetic hyperthermia. There has been a significant improvement in characterizing magnetic nanoparticles’ heat-triggered functions by many research groups. However, optimal experimental conditions along with notable determination methods of the SLP in magnetic hyperthermia have not been widely proposed until now. Despite the remarkable progress in this field, the evaluation process of SLP suffers from uncertainties and errors imposed not only by experimental parameters (depending on the particles, the conditions and the measurement) but by the estimation methodology, as well. In this work, we propose a step by step standardization protocol, starting from definition and recording of potential uncertainty and error sources, present during a typical magnetic hyperthermia experimental protocol. The error of each specific parameter is estimated and translated to ultimate heating efficiency evaluation. According to our analysis, magnetic hyperthermia experiment and its corresponding estimation, under non-adiabatic conditions, may lead to a propagated uncertainty up to 14% on the SLP value. Meanwhile, different heating evaluation methods were assessed under a wide range of experimental conditions, with the ‘modified law of cooling’ proving to be the most accurate one—limiting the SLP uncertainty to values under 5%—compared to the ‘initial slope’ and ‘Box–Lucas’ methods, which show a remarkable uncertainty of over 15%. All parameters involved in the heating efficiency evaluation and their associated uncertainties analysis presented in this work, are included in a standardisation protocol, a handy guideline for determining accurate, reliable and reproducible SLP values, thus adequately evaluating its impact in potential bioapplications. [ABSTRACT FROM AUTHOR]

Abstract The overall estimated risk of recurrence after an apparently complete thyroid cancer resection ranges from 5% CTCs (p = 0.09) and with >30% S‐phase cells at baseline (p = 0.0015), predicting ≤1 year relapsing lesion event. These results suggest a new intriguing frontier of precision oncology forefront cytology‐based liquid biopsy.