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Abstract We propose a physics‐informed convolutional decoder (PICD) framework for inverse modeling of heterogenous groundwater flow. PICD stands out as a direct inversion method, eliminating the need for repeated forward model simulations. The framework combines data‐driven and physics‐driven approaches by integrating monitoring data and domain knowledge into the inversion process. PICD utilizes a convolutional decoder to effectively approximate the spatial distribution of hydraulic heads, while Karhunen–Loève expansion (KLE) is employed to parameterize hydraulic conductivities. During the training process, the stochastic vector in KLE and the parameters of the convolutional decoder are adjusted simultaneously to minimize the data‐mismatch and the physical violation. The final optimized stochastic vectors correspond to the estimation of hydraulic conductivities, and the trained convolutional decoder can predict the evolution and distribution of hydraulic heads. Various scenarios of groundwater flow are examined and results demonstrate the framework's capability to accurately estimate heterogeneous hydraulic conductivities and to deliver satisfactory predictions of hydraulic heads, even with sparse measurements.

Aim. This paper presents results of a study on the Polish adaptation of the Personality Inventory for ICD-11 (PiCD), which was developed to measure pathological traits under a new, dimensional model of personality disorders proposed in ICD-11. Method. The study involved a non-clinical sample of N = 597 adults (51.4% female; Mage = 30.24 years, SD = 12.07 years). For convergent and divergent validity, Personality Inventory for DSM-5 (PID-5) and Big Five Inventory-2 (BFI-2) were used. Results. The results showed the Polish adaptation of the PiCD to be reliable and valid. Cronbach's alpha coefficient for PiCD scale scores ranged from 0.77 to 0.87 (Ma = 0.82). The four-factor structure of PiCD items with the three unipolar factors, "Negative Affectivity", "Detachment", and "Dissociality", and one bipolar "Anankastia" vs. "Disinhibition" factor was conformed. All PiCD traits are related to PID-5 pathological traits and BFI-2 normal traits in an expected way both in correlational and factor analyses. Conclusions. Obtained data demonstrate satisfactory internal consistency, factorial validity, and convergent-discriminant validity of the Polish adaptation of PiCD in a non-clinical sample. [ABSTRACT FROM AUTHOR]

We propose a physics‐informed convolutional decoder (PICD) framework for inverse modeling of heterogenous groundwater flow. PICD stands out as a direct inversion method, eliminating the need for repeated forward model simulations. The framework combines data‐driven and physics‐driven approaches by integrating monitoring data and domain knowledge into the inversion process. PICD utilizes a convolutional decoder to effectively approximate the spatial distribution of hydraulic heads, while Karhunen–Loève expansion (KLE) is employed to parameterize hydraulic conductivities. During the training process, the stochastic vector in KLE and the parameters of the convolutional decoder are adjusted simultaneously to minimize the data‐mismatch and the physical violation. The final optimized stochastic vectors correspond to the estimation of hydraulic conductivities, and the trained convolutional decoder can predict the evolution and distribution of hydraulic heads. Various scenarios of groundwater flow are examined and results demonstrate the framework's capability to accurately estimate heterogeneous hydraulic conductivities and to deliver satisfactory predictions of hydraulic heads, even with sparse measurements. Plain Language Summary: Inverse modeling refers to estimate the unknown model parameters with measurements of model responses. In groundwater flow problems, the information about subsurface formation parameters is very limited, so inverse modeling is required to inference the uncertain formation parameters with sparse measurements. Many conventional inversion methods necessitate repeated forward calculations to compare the predictions with measurements and evaluate the likelihood of different estimations, resulting in a substantial computational burden. In this work, we propose a novel physics‐informed convolutional decoder (PICD) framework, which, as a direct inversion method, can circumvent the need for multiple forward calculations during the inversion process. In addition to measurements, physical laws are leveraged to provide extra information for inversion, alleviating the dependence on data, and enforcing the predictions align with measurements as well as domain‐specific knowledge. Several groundwater flow problems are considered to validate the effectiveness of the proposed PICD framework, and satisfactory performance can be obtained. The proposed PICD framework emerges as a promising tool for efficient and informed groundwater flow inverse modeling. Key Points: A physics‐informed deep learning framework is proposed for inversion of groundwater flowInversion can be performed directly without iterative forward modelingSatisfactory inversion performance can be achieved even with sparse measurements [ABSTRACT FROM AUTHOR]

The Personality Inventory for ICD-11 (PiCD) was recently developed to assess the ICD-11 model of personality disorders. The purpose of this study was to examine the construct validity of the PiCD using the Minnesota Multiphasic Personality Inventory (MMPI)-2-Restructured Form (MMPI-2-RF) and the Computerized Adaptive Test of Personality Disorders Static Form (CAT-PD-SF). We administered these tests to 328 college students (150 males, 178 females). We found that the PiCD had adequate internal consistency reliability. Correlations between scores from the PiCD scales and the criterion measures generally indicated adequate discriminant validity. Along the same lines, convergent validity was adequate for the PiCD Negative Affective, Disinhibition, and Dissocial scales. However, the evidence was more mixed for the PiCD Detachment and Anankastic domains, which may be due to limitations with the content domains for these scales. Consistent with other research and theoretical expectations, a conjoint exploratory factor analysis utilizing the PiCD and MMPI-2-RF PSY-5 scales also indicated that anankastic and disinhibition may be more appropriately conceptualized as measuring opposite poles of one construct. Implications of these findings for the PiCD and the ICD-11 model are discussed. [ABSTRACT FROM AUTHOR]

The International Classification of Diseases–11th revision (ICD-11) classification of personality disorders is the official diagnostic system that is used all over the world, and it has recently been renewed. However, as yet very few data are available on its performance. This study examines the Personality Inventory for ICD-11 (PiCD), which assesses the personality domains of the system, and the Standardized Assessment of Severity of Personality Disorder (SASPD), which determines severity. The Spanish versions of the questionnaires were administered to a community (n = 2,522) and a clinical sample (n = 797). Internal consistency was adequate in the PiCD (α =.75 to.84) but less so in the SASPD (α =.64 and.73). Factor analyses suggested a unidimensional or bidimensional structure for severity, while revealing that the personality trait qualifiers are organized into four factors: negative affectivity, detachment, dissociality, and a bipolar domain of disinhibition–anankastia. The mutual relationships between traits and severity were analyzed, as well as the ability of the whole system to identify clinical subjects. Although further improvements are required, the results generally support the use of the PiCD and the SASPD and help substantiate the new ICD-11 taxonomy that underlies them. [ABSTRACT FROM AUTHOR]

Phagocytosis-induced cell death (PICD) is diminished in cord blood monocytes (CBMO) as compared to cells from adults (PBMO) due to differences in the CD95-pathway. This may support a prolonged pro-inflammatory response with sequels of sustained inflammation as seen in neonatal sepsis. Here we hypothesized that TNF-α mediated induction of apoptosis is impaired in CBMO due to differences in the TNFR1-dependent internalization. Monocytes were infected with Escherichia coli-GFP (E. coli-GFP). Monocyte phenotype, phagocytic activity, induction of apoptosis, and TNF-α/TNF-receptor (TNFR) -expression were analysed. In the course of infection TNF-α-secretion of CBMO was reduced to 40% as compared to PBMO (p

Invasive fungal infections with Candida albicans (C. albicans) occur frequently in extremely low birthweight (ELBW) infants and are associated with poor outcome. Phagocytosis of C.albicans initializes apoptosis in monocytes (phagocytosis induced cell death, PICD). PICD is reduced in neonatal cord blood monocytes (CBMO).Phagocytosis of C. albicans causes PICD which differs between neonatal monocytes (CBMO) and adult peripheral blood monocytes (PBMO) due to lower stimulation of TLR-mediated immune responses.The ability to phagocytose C. albicans, expression of TLRs, the induction of apoptosis (assessment of sub-G1 and nick-strand breaks) were analyzed by FACS. TLR signalling was induced by agonists such as lipopolysaccharide (LPS), Pam3Cys, FSL-1 and Zymosan and blocked (neutralizing TLR2 antibodies and MYD88 inhibitor).Phagocytic indices of PBMO and CBMO were similar. Following stimulation with agonists and C. albicans induced up-regulation of TLR2 and consecutive phosphorylation of MAP kinase P38 and expression of TNF-α, which were stronger on PBMO compared to CBMO (p < 0.005). Downstream, TLR2 signalling initiated caspase-3-dependent PICD which was found reduced in CBMO (p < 0.05 vs PBMO).Our data suggest direct involvement of TLR2-signalling in C. albicans-induced PICD in monocytes and an alteration of this pathway in CBMO.

Here, we report the coincident measurement of PICD and PECD effects in 1-phenylethylamine upon multiphoton ionization. Both photo-ion circular dichroism (PICD) and photo-electron circular dichroism (PECD) are methods to distinguish enantiomers. In PICD, a difference in total ion yields upon multiphoton ionization with circular polarized light is measured, whereas, in PECD, circular dichroism is observed in the angular distribution of the photoelectrons. Here, we report on our continuous effort to measure the PICD and PECD effects in coincidence, i.e. simultaneously under the same measurement conditions using a home-built photoion–photoelectron coincidence spectrometer. Pure samples of R-(+)-1-phenylethylamine and S-(−)-1-phenylethylamine have been photo-ionized using a femtosecond laser operated at 394 nm. [ABSTRACT FROM AUTHOR]

The American Association for the Study of Liver Diseases recognizes large volume paracentesis as draining greater than 5 liters of ascites and states there is no limit in the amount of ascites drained with appropriate replacement of albumin. For many practitioners performing safe large volume paracentesis between 5 and 10 liters or even 20 liters is not an uncommon practice. However, drainage of higher volumes outside common practice may raise concerns of patient intolerance and complication. The largest volume paracentesis reported in the literature to date is 41 liters. However, few other reports approach this volume. This case report demonstrates patient tolerance of a 39.5-liter paracentesis performed with close monitoring and hypertonic albumin replacement in a patient with chylous ascites due to high-grade follicular lymphoma.

Phagocytosis-induced cell death (PICD) is diminished in cord blood monocytes (CBMO) as compared to cells from adults (PBMO) due to differences in the CD95-pathway. This may support a prolonged pro-inflammatory response with sequels of sustained inflammation as seen in neonatal sepsis. Here we hypothesized that TNF-α mediated induction of apoptosis is impaired in CBMO due to differences in the TNFR1-dependent internalization. Monocytes were infected with Escherichia coli-GFP (E. coli-GFP). Monocyte phenotype, phagocytic activity, induction of apoptosis, and TNF-α/TNF-receptor (TNFR) -expression were analysed. In the course of infection TNF-α-secretion of CBMO was reduced to 40% as compared to PBMO (p<0.05). Neutralization of TNF-α by an αTNF-α antibody reduced apoptotic PICD in PBMO four-fold (p < 0.05 vs. infection with E. coli). PICD in CBMO was reduced 5-fold compared to PBMO and showed less responsiveness to αTNF-α antibody. CBMO expressed less pro-apoptotic TNFR1, which, after administration of TNF-α or infection with E. coli was internalized to a lesser extent. With similar phagocytic capacity, reduced TNFR1 internalization in CBMO was accompanied by lower activation of caspase-8 (p < 0.05 vs. PBMO). Stronger caspase-8 activation in PBMO caused more activation of effector caspase-3 and apoptosis (all p < 0.05 vs. PBMO). Our results demonstrate that TNFR1 internalization is critical in mediating PICD in monocytes after infection with E.coli and is reduced in CBMO. [ABSTRACT FROM AUTHOR]

Two methods of laser-induced mass-selective chiral analysis based on circular dichroism have been reported in the literature: photo-ion circular dichroism (PICD) and photo-electron circular dichroism (PECD). In PICD, a difference in total ion yields upon multiphoton ionization with circular polarized light is measured, whereas in PECD, the circular dichroism is observed in the angular distribution of the photoelectrons. Here, we report the first coincident measurement of the PICD and PECD effects. A home-built photoion–photoelectron coincidence spectrometer has been used to measure both the PICD and the PECD effects simultaneously under the same measurement conditions. Pure samples of R- and S-methyloxirane have been photo-ionized using a femtosecond laser operation at 396 nm. [ABSTRACT FROM AUTHOR]

This is the Editorial Introduction to the first issue of Theory and Practice in Child Development (T&PICD). The T&PICD is an international, open access, peer-reviewed journal devoted to child development related issues. This inaugural issue features five articles prepared by 14 authors. We would like to extend our appreciations to all who contributes by submitting or reviewing manuscripts or have been readers of T&PICD. [ABSTRACT FROM AUTHOR]

Intelligent or smart completion wells vary from conventional wells. They have downhole flow control devices like Inflow Control Devices (ICD) and Interval Control Valves (ICV) to enhance reservoir management and control, optimizing hydrocarbon output and recovery. However, to explain their adoption and increase their economic return, a high level of justification is necessary. Smart horizontal wells also necessitate optimizing the number of valves, nozzles, and compartment length. A three-dimensional geological model of the As reservoir in AG oil field was used to see the influence of these factors on cumulative oil production and NPV. After creating the dynamic model for the As reservoir using the program Petrel (2017.4), we improve the robustness of forecasting production from smart wells using reservoir simulation. High-level details in the rock and fluid flow properties are required in the horizontal well region to capture the flow dynamics accurately. Thus, the study offers an enhanced method for predicting the performance of intelligent or smart wells in reservoir modeling. This model was history matched for a period of 20 years for three horizontal wells by using program Petrel (2017.4) and ECLIPS (2011). After successful validation of model on a field scale and well level, performance prediction was carried out to see the effect of (number of valves, number of nozzle and compartment length) using PICD/AFCV completion. Optimizing well performance entails lowering water-cut. From an economic viewpoint, the goal is to maximize NPV or profit, depending on the situation, from PICD wells, which compared to other wells. [ABSTRACT FROM AUTHOR]

To assess the psychometric properties of the Personality Inventory for ICD-11 (PiCD, where ICD-11 is the International Classification of Diseases, 11th Revision), a sample of Italian community-dwelling adult participants (N = 1,122) was administered the PiCD, the Five-Factor Model Rating Form, the Big Five Inventory, the Personality Inventory for DSM-5 Short Form (where DSM-5 is the Diagnostic and Statistical Manual of Mental Disorders, fifth edition), and the Measure of Disordered Personality Functioning. Our findings supported the unidimensionality hypothesis for the PiCD Negative Affectivity, Detachment, and Dissocial scale items, whereas adequate fit indices were observed for the bifactor model of the PiCD Disinhibition and Anankastic item joint polychoric correlation matrix. The PiCD scales showed adequate internal consistency, test-retest reliability (n = 262), and meaningful relationships with five-factor model domains and their maladaptive variants. A four-factor model of the joint correlation matrix of the PiCD, Personality Inventory for DSM-5 Short Form, and the five-factor model composite score was provided with adequate fit. All PiCD scales were significantly associated with the impairment in personality functioning. (PsycINFO Database Record (c) 2019 APA, all rights reserved). [ABSTRACT FROM AUTHOR]

Background: Therapeutic abdominal paracentesis is associated with the occurrence of paracentesis induced circulatory dysfunction (PICD), manifested by a marked increase of plasma renin activity. Previous studies were performed either before model for end-stage liver disease (MELD) allocation or done in patients with low MELD scores. The aim of study was to characterize the change of plasma renin activity-aldosterone concentration and investigate the clinical importance of PICD after non-large volume paracentesis with differences in the MELD cirrhotic ascites. Materials and Methods: Cirrhotic patients with tense ascites were divided in two groups by MELD calculation: MELD ≤15 and MELD >15. Changes in plasma renin, aldosterone and other laboratory tests were assessed before and 6 days after modest volume paracentesis (less than 5 liters). PICD was defined as an increase in plasma renin activity on the sixth day after paracentesis of more than 50% of baseline value to a level >4 ng/mL/hr. After paracentesis, complications were also assessed within 90 days of followup periods. Factors associated with death were determined using Cox proportional hazards models. Results: Sixteen patients with MELD <15 and 14 patients with MELD greater than 15, the high meld group, were included in the present study. A significant increase in the median change of plasma renin but not plasma aldosterone between the groups of MELD >15 and MELD ≤15 were 54.7% (10.8 to 1,800) vs. 17.6% (0 to 536.4) (p = 0.01) and 15.2% (3.3 to 59.1) vs. 11.6% (0 to 200) (p = 0.55), respectively. Notably, 35.7% of patients, all of whom were in the high MELD group, had PICD events with the Kaplan-Meier survival analysis demonstrating a short median survival of 28 days. High MELD patients had more acute kidney injury consequence (28.6% vs. 0%; p = 0.04) and a significantly increased 90 days mortality as compared to low MELD patients (71.4% vs. 6.3%, p<0.01). Multivariate Cox regression analysis indicated that only high MELD but not PICD can predict mortality with 10.73 times higher risk of death after paracentesis than low MELD patients (adjusted hazard ratio 10.73, 95% CI 1.24 to 92.98, p = 0.03). Conclusion: Non-large volume paracentesis in high MELD cirrhotic patients causes a significant increase in plasma renin activity. PICD occurred only in high MELD patients and was associated with an increasing risk of acute kidney injury and mortality. An elevated MELD score in advanced cirrhotic patients should be considered as an increased risk for development of circulatory dysfunction, more complications and a short survival even after non-large volume paracentesis without albumin replacement. [ABSTRACT FROM AUTHOR]

We propose an approach to the analysis and interpretation of spectra of photoinduced circular dichroism (PICD) of semiconductor nanocrystals, in particular, quantum dots, based on comparison of these spectra with the spectra of magnetic circular dichroism (MCD). We show that MCD and PICD spectra have similar features. The values of parameters similar to the well-known parameters A and B of the MCD spectra, which characterize the splitting and mixing of states, are determined from the PICD spectra. [ABSTRACT FROM AUTHOR]

Background: Invasive fungal infections with Candida albicans (C. albicans) occur frequently in extremely low birthweight (ELBW) infants and are associated with poor outcome. Phagocytosis of C.albicans initializes apoptosis in monocytes (phagocytosis induced cell death, PICD). PICD is reduced in neonatal cord blood monocytes (CBMO). Hypothesis: Phagocytosis of C. albicans causes PICD which differs between neonatal monocytes (CBMO) and adult peripheral blood monocytes (PBMO) due to lower stimulation of TLR-mediated immune responses. Methods: The ability to phagocytose C. albicans, expression of TLRs, the induction of apoptosis (assessment of sub-G1 and nick-strand breaks) were analyzed by FACS. TLR signalling was induced by agonists such as lipopolysaccharide (LPS), Pam3Cys, FSL-1 and Zymosan and blocked (neutralizing TLR2 antibodies and MYD88 inhibitor). Results: Phagocytic indices of PBMO and CBMO were similar. Following stimulation with agonists and C. albicans induced up-regulation of TLR2 and consecutive phosphorylation of MAP kinase P38 and expression of TNF-α, which were stronger on PBMO compared to CBMO (p < 0.005). Downstream, TLR2 signalling initiated caspase-3-dependent PICD which was found reduced in CBMO (p < 0.05 vs PBMO). Conclusion: Our data suggest direct involvement of TLR2-signalling in C. albicans-induced PICD in monocytes and an alteration of this pathway in CBMO. [ABSTRACT FROM AUTHOR]

Background: Large-volume total paracentesis may result in paracentesis-induced circulatory dysfunction, which is associated with poor outcomes.Aims: To explore the short- and long-term effects of paracentesis-induced circulatory dysfunction on systemic hemodynamics, renal function and other cirrhosis-related complications in patients with refractory ascites, following subtotal large-volume paracentesis.Methods: Patients with cirrhosis and refractory ascites without renal dysfunction had systemic hemodynamics, renal function, and neurohormones (plasma active renin, aldosterone, norepinephrine and angiotensin II) measured pre- and 6 days post-paracentesis. Paracentesis was limited to ≤8 L with 6-8 g of albumin per liter ascites drained. Patients were followed up until transjugular intrahepatic portosystemic shunt insertion, liver transplantation, or death. Paracentesis-induced circulatory dysfunction was defined as >50 % increase in plasma active renin 6 days post-paracentesis.Results: Fifty-seven patients (mean age 59.0 ± 9.4 years) had mean 6.8 ± 1.8 L of ascites removed with 9 ± 3 g of albumin given/L of ascites drained. Patients were followed up for 715 ± 104 days. Twenty-three patients (40.4 %) developed paracentesis-induced circulatory dysfunction with unchanged serum creatinine on day six, despite worsening of hemodynamics (mean arterial pressure 90 ± 10 mmHg at baseline vs. 84 ± 8 mmHg on day six, p < 0.05). Similar hemodynamic changes were observed among patients without paracentesis-induced circulatory dysfunction. There was no significant difference in the long-term renal function or cirrhosis-related complications between the groups.Conclusion: The occurrence of paracentesis-induced circulatory dysfunction, as defined by plasma active renin, may not have a significant short- and long-term impact on renal function or cirrhosis-related complications in patients with refractory ascites who undergo subtotal paracentesis with albumin infusion. [ABSTRACT FROM AUTHOR]

Previous studies suggested that right ventricular pacing was associated with pacing-induced cardiac dysfunction (PICD). The purpose of this study was to investigate the clinical characteristics including the incidence of undiagnosed cardiac sarcoidosis (CS) in patients with atrioventricular block (AVB) who manifest PICD. We retrospectively investigated consecutive patients with permanent pacemaker (PPM) undergoing a first-generator replacement surgery with a new PPM or an upgrade procedure to a cardiac resynchronization therapy (CRT) device between December 1, 2011 and June 30, 2017. Patients with AVB showing normal echocardiographic findings before PPM implantation were included and divided into 2 groups: patients with post-PPM left ventricular ejection fraction (LVEF) < 40% and/or undergoing an upgrade procedure to CRT (PICD group) and patients with post-PPM LVEF ≥ 40% who underwent replacement surgery with a new PPM (no-PICD group). There were 15 and 41 patients in the PICD and no-PICD groups, respectively. A wider-paced QRS duration just after the PPM implantation and/or lower pre-PPM LVEF was observed in the PICD group. Furthermore, 46.7% of the PICD patients (7/15) satisfied the diagnostic criteria for CS according to the guideline of the Japanese Circulation Society, although no patients fulfilled these criteria before PPM implantation. In conclusion, a high incidence of CS was observed in patients with AVB who had PICD. However, none of these patients was diagnosed with CS before PPM implantation. [ABSTRACT FROM AUTHOR]

In recent years, there has been growing interest in remote speech assessment through automated speech acoustic analysis. While the reliability of widely used features has been validated in professional recording settings, it remains unclear how the heterogeneity of consumer-grade recording devices, commonly used in nonclinical settings, impacts the reliability of these measurements. To address this issue, we systematically investigated the cross-device and test–retest reliability of classical speech acoustic measurements in a sample of healthy Chinese adults using consumer-grade equipment across three popular speech tasks: sustained phonation (SP), diadochokinesis (DDK), and picture description (PicD). A total of 51 participants completed two recording sessions spaced at least 24 hours apart. Speech outputs were recorded simultaneously using four devices: a voice recorder, laptop, tablet, and smartphone. Our results demonstrated good reliability for fundamental frequency and cepstral peak prominence in the SP task across testing sessions and devices. Other features from the SP and PicD tasks exhibited acceptable test–retest reliability, except for the period perturbation quotient from the tablet and formant frequency from the smartphone. However, measures from the DDK task showed a significant decrease in reliability on consumer-grade recording devices compared to professional devices. These findings indicate that the lower recording quality of consumer-grade equipment may compromise the reproducibility of syllable rate estimation, which is critical for DDK analysis. This study underscores the need for standardization of remote speech monitoring methodologies to ensure that remote home assessment provides accurate and reliable results for early screening. [ABSTRACT FROM AUTHOR]

Optimal innate immune response to infection includes eradication of potential pathogens, resolution of associated inflammation, and restitution of homeostasis. Phagocytosing human polymorphonuclear leukocytes (hPMN) undergo accelerated apoptosis, a process referred to as phagocytosis‐induced cell death (PICD) and an early step in their clearance from inflammatory sites. Among human pathogens that modulate hPMN apoptosis, Neisseria gonorrhoeae delays PICD, which may contribute to the exuberant neutrophilic inflammation that characterizes gonorrhea. To elucidate the mechanisms underlying delayed PICD, we compared features of hPMN cell death that followed phagocytosis of N. gonorrhoeae FA1090 wild‐type (GC) or serum‐opsonized zymosan (OPZ), a prototypical stimulus of PICD. Phosphatidylserine externalization required NADPH oxidase activity after ingestion of GC or OPZ, and annexin V staining and DNA fragmentation were less after phagocytosis of GC compared to OPZ. Caspase 3/7 and caspase 9 activities after phagocytosis of GC were less than that seen after ingestion of OPZ, but caspase 8 activity was the same after ingestion of GC or OPZ. When hPMN sequentially ingested GC followed by OPZ, both caspase 3/7 and 9 activities were less than that seen after OPZ alone, and the inhibition was dose dependent for GC, suggesting that ingestion of GC actively inhibited PICD. Sequential phagocytosis did not block caspase 8 activity, mitochondrial depolarization, or annexin V/propidium iodide staining compared to responses of hPMN fed OPZ alone, despite inhibition of caspases 3/7 and 9. Taken together, these data suggest that active inhibition of the intrinsic pathway of apoptosis contributes to the delay in PICD after hPMN ingestion of N. gonorrhoeae. [ABSTRACT FROM AUTHOR]

In the current diagnostic systems, the International Classification of Diseases-11th rev. (ICD-11) and the Diagnostic and Statistical Manual of Mental Disorders-5th ed. (DSM-5), the evaluation and diagnosis of personality disorder (PD) aim at dimensional examination of the severity of its dysfunction and the stylistic features that accompany it. Since their implementation, or even before, several measures have been developed to assess PD severity and traits in both models. Thus, convergent validity metrics have been reported with various PD measures; however, the convergence of the same constructs included in the measures of these two models remains undefined. The objective of the present review was to examine whether there is a sufficient relationship between PD measures of the ICD-11 and DSM-5 AMPD in the general population. For this meta-analytic review, systematic searches were conducted in Web of Science, PubMed, Scopus, and Google Scholar. We included studies that reported Pearson's r correlations without restrictions on language, age, sex, setting, type of sample, or informant of the measures. We excluded associations with anankastia, psychoticism or the borderline pattern because they were not comparable between one dimensional model and the other. We examined the quality of the evidence with the JBI Critical Appraisal Checklist for Analytical Cross Sectional Studies, and performed the random effects meta-analysis with the 'meta' package of the RStudio software. Of the 5,629 results returned by the search, 16 studies were eligible; and showed moderate quality. The risk of bias was manifested by not specifying the details of the sample, the recruitment environment, and the identification and control of confounding factors. Thirteen studies provided two or more correlations resulting in a total of 54 studies for meta-analysis. The overall effect size estimate (correlation) was moderate for the overall model (r = 0.62, 95% CI [0.57, 0.67], p < 0.0001, I2 = 97.6%). For the subgroup of associations, ICD-11 severity model and DSM-5 AMPD severity model, the correlation was also moderate (k = 10, r = 0.57, 95% CI [0.48; 0.66]; I2 = 92.9%); as for the subgroup of associations, ICD-11 traits model and DSM-5 AMPD traits model (k = 44, r = 0.63, 95% CI [0.57; 0.69], I2 = 97.9%). The convergent validity between measures of PD severity and traits between one diagnostic system and another has been demonstrated in this review and they can probably be used interchangeably because they also measure the same constructs. Future research can address the limitations of this study and review the evidence for the discriminant validity of these measures. [ABSTRACT FROM AUTHOR]

Objectives: The contested categorical personality disorder (PD) criteria are not well suited to inform PD diagnoses in older adults. Yet, the classification of PDs is undergoing a critical transition phase with a paradigm shift to a dimensional approach for diagnosing PDs. No special attention was given to the expression of PDs in older age when the dimensional ICD‐11 model was developed. Given that PDs are highly prevalent in older adults, there is an urgent need to examine if ICD‐11 related instruments are able to adequately assess for PDs in older adults. Methods: The age‐neutrality of ICD‐11 measures was examined in a sample of 208 Dutch community‐dwelling adults (N = 208, M age = 54.96, SD = 21.65), matched on sex into 104 younger (age range 18–64) and 104 older (age range 65–93) adults. An instrument is considered not to be age‐neutral if a collective large level of differential item functioning (DIF) exists in a group of items of an instrument (i.e., 25% or more with DIF). We therefore set out to detect possible DIF in the following ICD‐11 self‐report measures: the Standardized Assessment of Severity of Personality Disorder (SASPD), the Personality Inventory for ICD‐11 (PiCD), and the Borderline Pattern Scale (BPS). Results: DIF analyses using a non‐parametric odds ratio approach demonstrated that SASPD, PiCD, and BPS were age‐neutral with less than 25% of items showing DIF. Yet, impact of DIF at scale level, examined by way of differential test functioning (DTF), indicated a DTF effect on the SASPD total score. Conclusions: These results of age‐neutrality of the PiCD and BPS are promising for measuring ICD‐11 traits and the borderline pattern. Yet, the age‐neutral measurement of PD severity requires further research. With a rapidly aging population, its accurate assessment across the entire adult life span, including older age, is a prerequisite for an adequate detection of PDs. Key points: Personality disorders (PDs) in older adults are prevalent, therefore accurate assessment instruments are needed.The classification and assessment of PDs is shifting toward a dimensional approach, given the critiques on categorical approaches.The current study demonstrates that the dimensional ICD‐11 model of PDs and related assessment instruments allow for accurate assessment of maladaptive traits and the borderline pattern in older adults by corroborating the age‐neutrality of the PiCD and borderline pattern scale instruments.Accurate assessment of PD severity across the adult life span requires further research. [ABSTRACT FROM AUTHOR]

The ICD‐11 has a new diagnostic system for personality disorder, which includes five optional trait specifiers to characterize the diagnosed pathology. The current study evaluated the internal structure and construct validity of the Personality Assessment Questionnaire for ICD‐11 (PAQ‐11) personality trait domains in a US population‐representative community sample. An exploratory factor analysis revealed the support for a four‐factor model underlying the 17 PAQ‐11 items, reflecting four of the five ICD‐11 trait domains (Negative Affectivity, Detachment, Disinhibition and Anankastia). Moreover, correlation analyses revealed that the PAQ‐11 domain scale scores were associated, as expected, with their counterparts from two other ICD‐11 trait domain measures, as well as with traditional personality disorder scores. More broadly, the results raised questions about the structural integrity of the Dissociality domain scale, and the discriminant validity of the Disinhibition and Anankastia scales. The overall conclusion was nevertheless promising with respect to the PAQ‐11 serving as a brief screening measure for the ICD‐11 trait domains. [ABSTRACT FROM AUTHOR]

The promise of replacing the diagnostic categories of personality disorder with a better-grounded system has been only partially met. We still need to understand whether our main dimensional taxonomies, those of the International Classification of Diseases , 11th Revision (ICD-11) and the Diagnostic and Statistical Manual of Mental Disorders , Fifth Edition (DSM-5), are the same or different, and elucidate whether a unified structure is possible. We also need truly independent pathological domains, as they have shown unacceptable overlap so far. To inquire into these points, the Personality Inventory for DSM-5 (PID-5) and the Personality Inventory for ICD-11 (PiCD) were administered to 677 outpatients. Disattenuated correlation coefficients between 0.84 and 0.93 revealed that both systems share four analogous traits: negative affectivity, detachment, dissociality/antagonism, and disinhibition. These traits proved scalar equivalence too, such that scores in the two questionnaires are roughly interchangeable. These four domains plus psychoticism formed a theoretically consistent and well-fitted five-factor structure, but they overlapped considerably, thereby reducing discriminant validity. Only after the extraction of a general personality disorder factor (g-PD) through bifactor analysis, we could attain a comprehensive model bearing mutually independent traits. [ABSTRACT FROM AUTHOR]

In the current diagnostic systems, the International Classification of Diseases11th rev. (ICD-11) and the Diagnostic and Statistical Manual of Mental Disorders5th ed. (DSM-5), the evaluation and diagnosis of personality disorder (PD) aim at dimensional examination of the severity of its dysfunction and the stylistic features that accompany it. Since their implementation, or even before, several measures have been developed to assess PD severity and traits in both models. Thus, convergent validity metrics have been reported with various PD measures; however, the convergence of the same constructs included in the measures of these two models remains undefined. The objective of the present review was to examine whether there is a sufficient relationship between PD measures of the ICD-11 and DSM-5 AMPD in the general population. For this meta-analytic review, systematic searches were conducted in Web of Science, PubMed, Scopus, and Google Scholar. We included studies that reported Pearson’s r correlations without restrictions on language, age, sex, setting, type of sample, or informant of the measures. We excluded associations with anankastia, psychoticism or the borderline pattern because they were not comparable between one dimensional model and the other. We examined the quality of the evidence with the JBI Critical Appraisal Checklist for Analytical Cross Sectional Studies, and performed the random effects meta-analysis with the ‘meta’ package of the RStudio software. Of the 5,629 results returned by the search, 16 studies were eligible; and showed moderate quality. The risk of bias was manifested by not specifying the details of the sample, the recruitment environment, and the identification and control of confounding factors. Thirteen studies provided two or more correlations resulting in a total of 54 studies for meta-analysis. The overall effect size estimate (correlation) was moderate for the overall model (r  =  0.62, 95% CI [0.57, 0.67], p  <  0.0001, I² =  97.6%). For the subgroup of associations, ICD-11 severity model and DSM-5 AMPD severity model, the correlation was also moderate (k  =  10, r  =  0.57, 95% CI [0.48; 0.66]; I² =  92.9%); as for the subgroup of associations, ICD11 traits model and DSM-5 AMPD traits model (k  =  44, r  =  0.63, 95% CI [0.57; 0.69], I² =  97.9%). The convergent validity between measures of PD severity and traits between one diagnostic system and another has been demonstrated in this review and they can probably be used interchangeably because they also measure the same constructs. Future research can address the limitations of this study and review the evidence for the discriminant validity of these measures. [ABSTRACT FROM AUTHOR]

Ascites is the most common presentation of decompensated liver cirrhosis. It is treated with therapeutic paracentesis which is associated with several complications. The role of human albumin in patients with cirrhotic ascites remains elusive and has been extensively studied with conflicting results. Thus, in order to fully appraise the available data we sought to perform this systematic review and meta-analysis. Herein we included studies comparing the efficacy and safety of human albumin comparing with other volume expanders and vasoactive agents in patients undergoing paracentesis in cirrhotic ascites. Odds ratio (OR) and mean difference (MD) were used to estimate the outcome with a 95% confidence interval (CI). Albumin use reduced the odds of paracentesis induced circulatory dysfunction (PICD) by 60% (OR 0.40, 95% CI 0.27-0.58). While performing subgroup analysis, albumin use lowered the odds of PICD significantly (OR 0.34, 95% CI 0.22 -0.52) in comparison to other colloid volume expanders, but did not lower the odds of PICD in comparison to vasoconstrictor therapy (OR 0.93, 95% CI 0.35-2.45). Albumin was associated with a statistically significant lower incidence of hyponatremia (OR 0.59, 95% CI 0.39-0.88). Albumin did not reduce the overall mortality, readmission rate, recurrence of ascites, mean arterial pressure, incidence of renal impairment, hepatic encephalopathy, and gastrointestinal (GI) bleeding. Thus, treatment with albumin in cirrhotic ascites reduced PICD and hyponatremia although there was no benefit in terms of mortality, readmission rate, recurrence of ascites, hepatic encephalopathy, and GI bleeding. [ABSTRACT FROM AUTHOR]

Neonates are highly susceptible to microbial infections which is partially attributable to fundamental phenotypic and functional differences between effector cells of the adult and neonatal immune system. The resolution of the inflammation is essential to return to tissue homeostasis, but given that various neonatal diseases, such as periventricular leukomalacia, necrotizing enterocolitis, or bronchopulmonary dysplasia, are characterized by sustained inflammation, newborns seem predisposed to a dysregulation of the inflammatory response. Targeted apoptosis of effector cells is generally known to control the length and extent of the inflammation, and previous studies have demonstrated that phagocytosis-induced cell death (PICD), a special type of apoptosis in phagocytic immune cells, is less frequently triggered in neonatal monocytes than in adult monocytes. We concluded that a rescue of monocyte PICD could be a potential therapeutic approach to target sustained inflammation in neonates. The EGFR ligand amphiregulin (AREG) is shed in response to bacterial infection and was shown to mediate cellular apoptosis resistance. We hypothesized that AREG might contribute to the reduced PICD of neonatal monocytes by affecting apoptosis signaling. In this study, we have examined a cascade of signaling events involved in extrinsic apoptosis by using a well-established in vitro E. coli infection model in monocytes from human peripheral blood (PBMO) and cord blood (CBMO). We found that CBMO shows remarkably higher pro-AREG surface expression as well as soluble AREG levels in response to infection as compared to PBMO. AREG increases intracellular MMP-2 and MMP-9 levels and induces cleavage of membrane-bound FasL through engagement with the EGF receptor. Our results demonstrate that loss of AREG rescues PICD in CBMO to the level comparable to adult monocytes. These findings identify AREG as a potential target for the prevention of prolonged inflammation in neonates. [ABSTRACT FROM AUTHOR]

The classification of personality disorder (PD) is undergoing a paradigm shift in which categorically defined specific PDs are being replaced by dimensionally defined maladaptive trait domains. To bridge the classificatory approaches, this study attempts to use items from the categorical PD model in DSM‐IV to measure the maladaptive trait domains described in DSM‐5 Section III/ICD‐11. A general population sample comprising 1228 participants completed the Screening Questionnaire of the Structured Clinical Interview for DSM‐IV Axis II (SCID‐II‐SQ), the Personality Inventory for DSM‐5 (PID‐5), and the anankastia scale of the Personality Inventory for ICD‐11 (PiCD). Using item response theory models and a psychometric linking technique, SCID‐II‐SQ items were evaluated for their contribution to measuring maladaptive trait domains. The best discriminating items were then selected to derive proxy scales. We found that convergent validity of these proxy scales was in a similar range to that of other self‐report measures for PD, except for the proxy scale for PiCD anankastia. However, only the proxy scale for negative affectivity showed acceptable reliability that would allow its application in research settings. Future studies should seek to establish a common metric between specific PDs and maladaptive trait domains using self‐report measures with higher specificity or semi‐structured interviews. [ABSTRACT FROM AUTHOR]

The International Classification of Diseases, 11th edition (ICD-11) adopted a fully dimensional model of personality disorder. The Personality Inventory for ICD-11 (PiCD) and Informant-Personality Inventory for ICD-11 (IPiC) were developed to assess the ICD-11 trait model, and the PiCD has since received significant validation support. However, there has only been one prior study of longitudinal predictive validity of the PiCD, two relatively short test–retest reliability studies of the PiCD, and no prior longitudinal tests of the IPiC. Longitudinal psychometric support for psychological assessment measures is essential. The present study provides a longer, larger, 2-year psychometric validation test of the PiCD and IPiC. Participants (N = 711) and their informants (N = 569) were recruited in the St. Louis Personality and Aging Network. The results demonstrated strong 2-year retest reliability for the PiCD and IPiC, as well as mean-level stability. Additionally, we explored the relationships between the PiCD and IPiC and important life outcome measures (depressive symptoms, satisfaction with life, and health status). The analysis revealed several significant associations between PiCD and IPiC scales and the outcome variables across time. Further, the PiCD Negative Affectivity and IPiC Detachment scales demonstrated incremental validity over each other and the outcome variables at Wave 1 in the prediction of depressive symptoms and satisfaction with life, respectively. The findings provide essential longitudinal test–retest reliability and predictive validity support for the PiCD and IPiC. Public Significance Statement: This 2-year study on the Personality Inventory for ICD-11 (PiCD) and Informant-Personality Inventory for ICD-11 (IPiC) highlights robust retest reliability for both scales in a sample of older community adults. Evidence is also found for mean-level stability and associations between the scales and depressive symptoms, satisfaction with life, and health status. This research provides essential, foundational longitudinal psychometric support for both the PiCD and IPiC scales. [ABSTRACT FROM AUTHOR]

Understanding central mechanisms underlying drug-induced toxicity plays a crucial role in drug development and drug safety. However, a translation of cellular in vitro findings to an actual in vivo context remains challenging. Here, physiologically based pharmacokinetic (PBPK) modeling was used for in vivo contextualization of in vitro toxicity data (PICD) to quantitatively predict in vivo drug response over time by integrating multiple levels of biological organization. Explicitly, in vitro toxicity data at the cellular level were integrated into whole-body PBPK models at the organism level by coupling in vitro drug exposure with in vivo drug concentration-time profiles simulated in the extracellular environment within the organ. PICD was exemplarily applied on the hepatotoxicant azathioprine to quantitatively predict in vivo drug response of perturbed biological pathways and cellular processes in rats and humans. The predictive accuracy of PICD was assessed by comparing in vivo drug response predicted for rats with observed in vivo measurements. To demonstrate clinical applicability of PICD, in vivo drug responses of a critical toxicity-related pathway were predicted for eight patients following acute azathioprine overdoses. Moreover, acute liver failure after multiple dosing of azathioprine was investigated in a patient case study by use of own clinical data. Simulated pharmacokinetic profiles were therefore related to in vivo drug response predicted for genes associated with observed clinical symptoms and to clinical biomarkers measured in vivo. PICD provides a generic platform to investigate drug-induced toxicity at a patient level and thus may facilitate individualized risk assessment during drug development. [ABSTRACT FROM AUTHOR]

Introduction A percutaneously placed implantable intravascular defibrillator (PICD) has been developed with a right ventricular (RV) single-coil lead and titanium electrodes in the superior vena cava (SVC) and the inferior vena cava (IVC). This study evaluated implant techniques, device stability, and anchor histology of the PICD over 9 months in a canine model. Methods Twenty-four hounds (wt = 30-55 kg) were anesthetized and a custom sheath introduced into the right femoral vein. The PICD was advanced over a wire and positioned with the titanium electrodes (cathodes) in the SVC and the IVC. A nitinol anchor secured the device in the jugular. The RV lead was positioned in the RV apex and screwed into place. The catheters, wires, and sheath were removed with an average implant time of 14 minutes. In one group of animals (n = 13), serial venograms were performed at 7 days, 14 days, and 28 days. In a second group (n = 6) and third group (n = 5), venograms were also performed at 90 days and 270 days, respectively. Six canines were sacrificed and anchor histologic examination done at 90 days. Results All implants were successful with no surgical complications observed. Devices (N = 24) remained appropriately positioned with no anchor migration. Histology at 90 days showed 98% endothelialization of the anchor. Venograms revealed patent IVC and jugular veins in all animals at every time point examined. Conclusions The PICD can be rapidly and chronically implanted in animals. Long-term intravascular defibrillator placement is feasible in a canine model. [ABSTRACT FROM AUTHOR]

Summary Background Although physical irritant contact dermatitis (PICD) is a common occupational dermatosis, it is one of the least well understood because of its multiple types, lack of diagnostic test, and the many mechanisms involved in its production. Objectives To characterize the materials and mechanisms of physical irritation of the skin. Methods We did a retrospective analysis over the past 20 years of all patients with a diagnosis of PICD at St John's Institute of Dermatology Contact Dermatitis Clinic. Results Of the 29 000 patients who attended the clinic over the study period, 392 patients were diagnosed with PICD and of these, 335 files were analysed. Conclusions Our findings show that PICD accounted for 1·15% of all patients attending the contact clinic over the study period. Diverse occupations and materials were implicated. The most common cause of PICD was low humidity due to air-conditioning, which caused dermatitis of the face and neck in office workers due to drying out of the skin. [ABSTRACT FROM AUTHOR]

Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal monocytes with ongoing proinflammatory cytokine release, could be associated with the progression of various inflammatory diseases in neonates. Our previous data indicate that amphiregulin (AREG) is increasingly expressed on the cell surface of neonatal monocytes, resulting in remarkably higher soluble AREG levels after proteolytic shedding. In this study, we found that E. coli-infected neonatal monocytes show an increased phosphorylation of ERK, increased expression of Bcl-2 and Bcl-XL, and reduced levels of cleaved caspase-3 and caspase-9 compared to adult monocytes. In both cell types, additional stimulation with soluble AREG further increased ERK activation and expression of Bcl-2 and Bcl-XL and reduced levels of cleaved caspase-3 and caspase-9 in an EGFR-dependent manner. These data suggest that reduced PICD of neonatal monocytes could be due to reduced intrinsic apoptosis and that AREG can promote protection against PICD. This reduction of the intrinsic apoptosis pathway in neonatal monocytes could be relevant for severely prolonged inflammatory responses of neonates. [ABSTRACT FROM AUTHOR]

We study the dimension of loci of special line bundles on stable curves and for a fixed semistable multidegree. In case of total degree d = g - 1 , we characterize when the effective locus gives a Theta divisor. In case of degree g - 2 and g, we show that the locus is either empty or has the expected dimension. This leads to a new characterization of semistability in these degrees. In the remaining cases, we show that the special locus has codimension at least 2. If the multidegree in addition is non-negative on each irreducible component of the curve, we show that the special locus contains an irrreducible component of expected dimension. [ABSTRACT FROM AUTHOR]

Background: Albumin after large volume paracentesis (LVP) reduces paracentesis-induced circulatory dysfunction (PICD). The most efficacious dose of albumin for LVP is unclear. Objective: To evaluate the impact of implementing a standardized LVP order set on albumin utilization and patient outcomes. Methods: This is a retrospective review of patients with ascites due to cirrhosis who received a therapeutic paracentesis at a large, academic institution. Primary outcome was amount of albumin used prior to and after order set implementation. Albumin doses were standardized in the order set to 25 g (5-6 L removed), 50 g (7-10 L), and 75 g (>10 L). Patient outcomes were rates of hyponatremia, renal impairment, and hypotension. Results: There were 100 patients included in each arm of the final analysis. Patients prior to order set implementation received a higher amount of albumin per liter removed compared to those post-implementation (8.3 g/L vs 6.5 g/L, respectively; P <.01). There were no significant differences between groups in absolute changes in serum sodium (0 mEq/L vs −1 mEq/L, P =.64), serum creatinine (0.06 mg/dL vs 0.05 mg/dL, P =.94), or systolic blood pressure (−4 mm Hg vs −3 mm Hg, P =.96). There were no differences between groups in rates of hyponatremia (1.6% vs 6.6%, P =.21), renal impairment (11.3% vs 11.5%, P =.97), or hypotension (17.4% vs 17.6%, P =.97). Conclusions: Use of an order set to guide albumin dosing based on amount of ascitic fluid removed during LVP resulted in a significant reduction in the amount of albumin given with no difference in adverse effects. [ABSTRACT FROM AUTHOR]