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Proportional reasoning is a key topic both at school and in everyday life. However, students are often misled by their preconceptions regarding proportions. Our hypothesis is that these limitations can be mitigated by working on alternative ways of categorizing situations that enable more adequate inferences. Multiple categorization triggers flexibility, which enables reinterpreting a problem statement and adopting a more relevant point of view. The present study aims to show the improvements in proportional reasoning after an intervention focusing on such a multiple categorization. Twenty-eight 4th and 5th grade classes participated in the study during one school year. Schools were classified by the SES of their neighborhood. The experimental group received 12 math lessons focusing on flexibly envisioning a situation involving proportional reasoning from different points of view. At the end of the school year, compared to a control group, the experimental group had better results on the posttest when solving proportion word problems and proposed more diverse solving strategies. The analyses also show that the performance gap linked to the school's SES classification was reduced. This offers promising perspectives regarding multiple categorization as a path to overtake preconceptions and develop cognitive flexibility at school.

We propose to assess conceptual knowledge of mathematical notions by having recourse to isomorphic word problems. We assumed that failing to solve isomorphic problems is an indicator of lack of conceptual knowledge. To reach these conclusions, two experiments were conducted among 4th and 5th grade students. In experiment 1, each student had to solve one isomorphic word problem allowing two solving strategies. Results from experiment 1 showed that semantic context promoted a one-sided perspective, constraining the strategies used. The second experiment questioned if the strategy choices by students reflected a lack of procedural knowledge or difficulty in conceptual knowledge. Students solved several problems with the explicit task of proposing two strategies. Results showed that students struggled to identify the conceptual structure of the problems: they changed their strategy depending on semantic contexts, and did not succeed in adopting two encodings for the same problem. This lack of flexibility does not reflect weak procedural knowledge but difficulties in conceptual knowledge. Once conceptual knowledge is characterized as the ability to get over dependence on semantic context, using word problems as assessment tools for conceptual development opens up educational perspectives.

Introduction: Many studies in physical education (PE) have sought to identify and categorize the modes of student interaction in order to gain greater insight into the nature of cooperative activity. More others recent studies have examined how modes of interaction evolve on the basis of the modes of collective activity that they generate. These studies have shown to describe and explain the interactions among individuals and the processes they generate, which then lead to the construction, deconstruction or reconstruction of different interaction modes. Although some studies have sought to describe the dynamics of student interactions, very few have quantified these dynamics. By doing so, however, researchers might gain a new perspective on student interaction modes that inspires new designs for teaching in PE, thereby having professional impact. The present study extends this research by investigating the dynamics of student interaction, with a focus on the emergence of interaction modes during orienteering lessons. For this purpose, the study was conducted within the methodological framework of course of action theory, which is an effective approach for examining activity in natural situations to provide insight into the experience of activity from the actors perspective. Method: The study was conducted in two classes of seventh-grade students (about 12 years old) in which 16 students volunteered and were available for post-action interviews immediately after the lessons under study. These volunteers were placed in eight affinity-based dyads. The teachers planned orienteering lessons at similar levels of difficulty and duration but modified the lessons across a range of contextual features. Two categories of data were collected: (1) data from audiovisual recordings as the students searched for the checkpoints and (2) verbalization data during the post-action interviews with the students. The data were processed in two steps: one qualitative, the other quantitative. The qualitative step consisted of processing the data of the student experiences to characterize their interactions in the three different contexts. In the quantitative step, the data from the first step were graphically represented to depict the interaction dynamics within the student dyads. Results and discussion: The qualitative analysis showed the emergence of three modes of student interaction shared across each learning context: co-construction, confrontation and delegation. The quantitative analysis revealed the percentages of the different modes of interaction and therefore characterized the interaction dynamics. Our results showed that the interaction dynamics within the dyads were both unique and similar in the task contexts in terms of both ratios of change and distribution. Results are discussed across two major points of interest: (1) the observation of the same interaction modes whatever the context yet with quite different dynamics and (2) proposals for PE teacher interventions.

Introduction: One of the aims of physical education (PE) is to develop social skills such as cooperation, teamwork, and mutual helping among students. Cooperation is a broad research topic, implicating several disciplines in the human sciences (e.g. psychology, sociology, linguistics, philosophy). It is also an important topic in various domains of practice like organizational management, ergonomics, sports performance, and PE and sports pedagogy. Studies in sport have shown that cooperation between partners is not automatically produced by the cooperative structure of the learning tasks. In this exploratory study, we focused on the links between cooperation and trust judgments about one's partner. We characterized the processes by which students construct trust judgments in dyadic cooperative interactions during climbing lessons. This study was carried out within the theoretical and methodological frameworks of the 'course of action.' Method: Two middle-school students in 10th-grade participated in this study. They formed a fixed dyad based on personal affinity. During the four climbing lessons under study, the students alternated the roles of climber and belayer. Their behaviors and communications were recorded on video and after each session they participated in self-confrontation interviews. From these data, we then reconstructed their courses of experience and focused particularly on preoccupations, meaningful elements in the situation, and mobilized knowledge. The elements contributing to the construction of the climber's trust judgments about his belayer were identified. Changes in these judgments were characterized in relation to the modes of cooperation between the students. Twenty-seven climbs were analyzed. Results and discussion: The results showed that the climber's trust judgments focused on two dimensions of the belayer's activity: the reliability of both the belay and his advice for success in the task. To build these trust judgments, the climber combined knowledge about his belayer (the partner's climbing skills, his mastery of safety techniques, his familiarity with the climbing equipment, and his typical attitudes in class) and interpretations of the events during belayer--climber cooperation (the attention shown by the partner, his requests for advice from other students, and the teacher's interventions). Moreover, the results showed the relationship between the development of each student's trust judgments about his partner and the positive and negative dynamics of cooperation between the students. Three typical connections were identified between the climber's trust judgments about his partner and the climber's involvement in cooperation. The results are discussed on the basis of two points: (a) the dynamic and composite character of the construction of trust judgments and (b) the construction of trust judgments as a condition for genuine cooperation between students. The students in the situation of climber displayed typical processes to build a trust judgment about their partner, and this trust judgment appears to be an important element in promoting and regulating cooperative interactions between students. Conclusions: We propose pedagogical perspectives for teachers with regard to understanding trust judgments in climbing and student cooperation. We also suggest new research perspectives with the objective of fully elucidating the dimensions of trust involved in cooperation.

La téléconsultation est un acte médical pris en charge par la sécurité sociale pour le suivi des patients depuis 2018 mais qui a connu un essor phénoménal avec la crise COVID de 2020. Le Conseil National Professionnel d'Allergologie a souhaité enquêter auprès de ses membres à ce propos. 82,1 % n'utilisait pas cet outil avant la crise mais pendant celle-ci 86,4 % des médecins l'ont fait et 66,8 % le font encore en 2021. La téléconsultation leur sert principalement pour le renouvellement d'une immunothérapie allergénique, de traitements symptomatiques et pour annoncer un bilan biologique. Un allergologue sur deux trouve "intéressant" le fait de pouvoir recevoir ainsi des nouveaux patients, notamment pour des patients dans un désert médical, une histoire d'allergie médicamenteuse ou une urticaire chronique. 57,3 % pensent gagner du temps grâce à la téléconsultation. On note ainsi que cet exercice de la médecine à distance est rentré dans les habitudes des allergologues qui ont su se l'approprier et l'adapter à leur pratique. Teleconsultation has been a reimbursed tool for monitoring patients since 2018 but which experienced a phenomenal boom with the COVID crisis of 2020. The National Professional Council of Allergology wanted to survey its members in this regard. 82.1% did not use this tool before the crisis but during it 86.4% of the doctors did it and 66.8% still do it in 2021. The teleconsultation is used mainly for the renewal of an allergen immunotherapy, symptomatic treatments and to announce a biological assessment. One in two allergists find it "interesting" to be able to receive new patients in this way, especially for patients in a medical desert, with a history of drug allergy or chronic urticaria. 57.3% think they save time thanks to teleconsultation. We note that this tool has become a habit of allergists who have known how to appropriate and adapt it to their practice. [ABSTRACT FROM AUTHOR]

La biologie est un outil incontournable dans le diagnostic et la prise en charge des patients allergiques. L'apprentissage à l'interprétation d'un bilan biologique est essentiel pour le praticien. En raison de la diversité des cursus, les jeunes allergologues n'ont pas tous la même formation. À la demande du Conseil Scientifique de la Société française d'allergologie (SFA), le Groupe de Travail Biologie de l'Allergie a réalisé une enquête auprès des jeunes allergologues afin d'évaluer leur niveau de formation en biologie de l'allergie et de connaître leurs attentes en termes de formation continue. Au total, 162 allergologues ont été contactés et 36 ont répondu. Les répondants étaient majoritairement des femmes (78 %), allergologues exclusifs (83 %) et 69 % étaient issus du DES d'Allergologie. La moitié estimait avoir eu une formation suffisante en biologie de l'allergie et 50 % ont effectué un stage dans un laboratoire de biologie médicale. Soixante-trois pour cent se considéraient comme compétents pour l'interprétation des bilans. Pour leur formation continue, ils utilisaient les sites internet des sociétés savantes, les revues scientifiques et des webinaires qu'ils jugeaient satisfaisants. Aucune personne n'avait recours à un système d'évaluation des compétences. Plus de 95 % des répondants sont en faveur d'une mise à disposition de documents synthétiques de référence et tous les consulteraient s'ils étaient accessibles en ligne sur le site de la SFA. En conclusion, la formation des jeunes allergologues sur la biologie de l'allergie a besoin d'être complétée et harmonisée, sur le plan théorique et pratique. Plusieurs outils pédagogiques sont plébiscités pour le maintien des compétences. Blood tests are an essential tool for the diagnosis and management of allergy. Learning how to interpret test results is therefore essential for the physician. Due to the diversity of their education, young allergists do not all have the same training. At the request of the French Society of Allergology (SFA) Scientific Committee, the In vitro Diagnosis Working Group carried out a survey for young allergists in order to evaluate their level of initial training in allergy in vitro diagnosis and to know their expectations in terms of continuing medical education. A total of 162 allergists were consulted and 36 responded. Half of them considered that they had sufficient training in allergy in vitro diagnosis and 50% considered themselves competent in the interpretation of tests. For their continuing medical education, they use the websites of learned societies (SFA, EEACI), scientific journals and webinars and consider them satisfactory or very satisfactory. More than 95% of them are in favour of the online availability of summary sheets or reference documents in in vitro diagnosis, and all of them would consult these tools if they were accessible on the SFA website. In conclusion, the training of young allergists in allergy blood tests needs to be completed and standardised, both theoretically and practically. Several educational tools are available and popular to achieve this and help them to keep valuable skills up to date. [ABSTRACT FROM AUTHOR]

Maize tortilla is the best-recognized food product of Mexican gastronomy. Artisanal maize tortillas (AMT) are prepared with native maize varieties and a traditional process. The aims of this study were to identify sensory attributes, texture, and color in AMT that allow them to be differentiated from commercial tortillas, and to determine the chemical and mineral composition of both types of tortillas. Six landraces related to four Mexican maize races were used. Two commercial tortillas were included as references (tortillería and supermarket). Tortillas were subjected to sensory analysis by the modified Flash technique, texture and color were measured objectively and chemical and mineral analysis of all tortillas were evaluated. Lime taste and lime smell attributes were relevant to differentiate AMT from commercial tortillas; aftertaste and fracturability attributes were highly associated to supermarket tortillas. The fracturability attribute of tortillas is consider undesirable for taco preparation. Five of the six AMT were characterized by the presence of a layer, a characteristic that is associated with traditional tortilla made by Mexican consumer. Regarding chemical composition, supermarket tortillas exhibited the highest dietary fiber content (17.09%), but showed 30% more Na than AMT, with the exception of tortillas from Purepecha native variety. Besides, supermarket tortilla had 48.9% less Ca than AMT. The sensory attributes relevant to differentiate native maize tortillas from the commercial maize tortilla references were appearance, smell, and taste, while textural and color attributes played a lesser role.

Le rhumatologue et l'interniste peuvent être sollicités tant pour le diagnostic étiologique que pour la prise en charge thérapeutique d'une uvéite. L'étude prospective ULISSE (Uvéites: évaluation clinique et médico-économique d'une stratégie standardisée pour le diagnostic étiologique) a montré l'intérêt d'une stratégie diagnostique orientée selon le type anatomo-clinique de l'uvéite. Une analyse secondaire a montré qu'une faible proportion d'examens était utile au diagnostic. Ces examens sont peu coûteux, simples et guidés par les données cliniques. Les uvéites des spondyloarthrites suivent une « règle des 90 » : 90 % d'entre elles sont unilatérales, aiguës et antérieures. Environ 2/3 des spondyloarthrites sont diagnostiquées au moment de l'uvéite. L'existence de douleurs rachidiennes d'allure inflammatoire ou non doit faire rechercher une spondyloarthrite qui représente la première cause d'uvéite dans les pays occidentaux. Le risque de cécité est exceptionnel; la problématique est celle des récurrences (50 à 60 %). La sulfasalazine diminue la fréquence, la durée et l'intensité des uvéites et peut être proposée à titre préventif. La sarcoïdose est une cause sous-estimée d'uvéites (jusqu'à 15 %), notamment chez les femmes d'âge mûr. Le traitement des uvéites sarcoïdosiques s'apparente à celui des uvéites idiopathiques. Les uvéites de la maladie de Behçet affectent des individus jeunes, des deux sexes, de toute origine et se présentent habituellement comme une panuvéite et une vascularite rétinienne. Le traitement des uvéites associées à la maladie de Behçet a pour objectif l'obtention d'un calme oculaire total. Le pronostic des formes sévères et réfractaires a été transformé par les anticorps monoclonaux anti-TNF-α. Rheumatologists and internists may need to establish the etiological diagnosis and handle the therapeutic management of adults with uveitis. A prospective study named ULISSE (Uveitis: clinical and medicoeconomic evaluation of a standardized strategy for etiological diagnosis) has shown that a standardized strategy for the etiological diagnosis of uveitis was neither inferior nor superior to an open strategy. Subsequent analysis showed that only a few diagnostic tests were useful for the etiological assessment of uveitis. These tests were often inexpensive, simple, usually guided by clinical findings, and allowed an etiological diagnosis to be made for many patients. Three systemic diseases are particularly prevalent in patients referred to internists or rheumatologists: HLA-B27- and spondyloarthritis-associated uveitis, Behçet's disease, and sarcoidosis. Uveitis associated with spondyloarthritis follows a « rule of 90 »: around 90 of cases are unilateral, anterior, and acute. Among patients with uveitis and spondyloarthritis, about two thirds are diagnosed with joint disease during a uveitis assessment. Patients with inflammatory or noninflammatory low back pain should be routinely evaluated for spondyloarthritis, which is the leading cause of uveitis in western countries. The risk of blindness is extremely low, and the main complication is recurrent uveitis, seen in 50 to 60 % of cases. Sulfasalazine decreases the frequency, duration, and severity of uveitis and can be used prophylactically. Sarcoidosis is an underestimated cause of uveitis, which occurs in 15 % of cases, with a predilection for middle-aged women. The treatment of sarcoid uveitis largely follows the general principles of idiopathic uveitis. Behçet's disease uveitis affects young people of both sexes and of all origins and usually presents as panuveitis and retinal vasculitis. The treatment of Behçet's uveitis aims at a complete disappearance of the ocular inflammation. The prognosis of the severe and refractory forms has been dramatically changed by the introduction of TNF-α antagonists. [ABSTRACT FROM AUTHOR]

L'immunothérapie allergénique est le seul traitement étiologique des allergies. La forme sublinguale est un traitement à prendre quotidiennement au minimum pendant 3 ans. L'observance des patients est un problème majeur car seulement 15 % des patients terminent les 3 ans. Afin d'améliorer cette problématique, il faut en identifier les causes (financières, effets secondaires, absence d'amélioration clinique, mauvaise compréhension du traitement ou lassitude) pour proposer au patient une solution adaptée (suivi personnalisé, encouragements, informations régulières). Les moyens technologiques modernes comme la télémédecine, les applications mobiles, les réseaux sociaux sont également des outils au service de l'allergologue pour accompagner le patient dans sa prise en charge. Allergen immunotherapy is the only etiological treatment for allergies. The sublingual form is a long treatment, to be taken daily for at least 3 years. Patient adherence is a major problem as only 15% of patients maintain it for 3 years. To improve this, it is necessary to find the causes (financial, side effects, lack of clinical improvement, poor understanding of the treatment or forgetfulness) to give to the patient a suitable solution (personalized follow-up, support, available information). Modern technological means such as telemedicine, mobile applications, social networks are also tools for the allergist to help the patient to continue his allergen immunotherapy. [ABSTRACT FROM AUTHOR]

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En 2018, une enquête déclarative a été menée auprès de patients allergiques sous immunothérapie depuis au moins 5 mois. Cinq milles sept cent soixante réponses ont été reçues entre janvier et fin décembre 2018. Les trois quarts des patients utilisaient la forme sublinguale en gouttes. La majorité des patients s'estimait améliorée par l'immunothérapie et n'avait plus besoin de prendre de traitement symptomatique. Quatre-vingt pour cent des patients avaient moins voire n'avaient plus d'absentéisme. Ainsi, 89 % jugeaient l'immunothérapie efficace à très efficace. In 2018, a declarative survey was conducted among allergic patients receiving immunotherapy for at least 5 months. Five thousand seven hundred and sixty responses were received between January and the end of December 2018. Three-quarters of patients were using a sublingual drop formulation. Most patients felt better following desensitization and no longer required symptomatic treatment. 89% considered desensitization effective to very effective. [ABSTRACT FROM AUTHOR]

Abstract Engineered nanomaterials are used in various applications due to their particular properties. Among them, Iron Oxide Nanoparticles (Fe 2 O 3 -NPs) are used in Biomedicine as theranostic agents i.e. contrast agents in Magnetic Resonance Imaging and cancer treatment. With the increasing production and use of these Fe 2 O 3 -NPs, there is an evident raise of Fe 2 O 3 -NPs exposure and subsequently a higher risk of adverse outcomes for the environment and Human. In the present paper, we investigated the effects of an intravenous daily Fe 2 O 3 -NPs exposure on Wistar rat for one week. As results, we showed that several hematological parameters and transaminase (ALT and AST) levels as well as organ histology remained unchanged in treated rats. Neither the catecholamine levels nor the emotional behavior and learning / memory capacities of rats were impacted by the sub-acute intravenous exposure to Fe 2 O 3 -NPs. However, iron level in plasma and iron content homeostasis in brain were disrupted after this exposure. Thus, our results demonstrated that Fe 2 O 3 -NPs could have transient effects on rat but the intravenous route is still safer that others which is encouraging for their use in medical and/or biological applications. [ABSTRACT FROM AUTHOR]

La biologie est un outil incontournable dans le diagnostic et la prise en charge des patients allergiques. Pour compléter l'enquête auprès des jeunes allergologues publiée en 2022, le Groupe de travail biologie de l'Allergie (GTBA) en partenariat avec l'ANAFORCAL a réalisé une nouvelle enquête auprès des allergologues seniors afin d'évaluer leur formation en biologie de l'allergie et de connaître leurs attentes en termes d'information et formation continue. Au total, 1092 allergologues ont été contactés (avec des doublons entre les deux listes) et 219 ont répondu. Les allergologues s'estiment être bien formés. Plus de 70 % estiment avoir de bonnes connaissances sur le sujet et 94 % se forment régulièrement sur le sujet, en congrès tout d'abord, par la lecture d'articles scientifiques puis en réunions de formation locales. Sur cet échantillon, 69,4 % ont lu les recommandations sur la biologie de l'allergie publiées en 2021. Parmi ceux qui l'ont lu, 90 % en sont satisfaits. Cependant sur cet échantillon, 89 % n'ont jamais fait de stage dans un laboratoire d'immunoallergologie pendant leurs études. Cette enquête rapporte que 95 % des répondants veulent plus de formation et information, à propos des nouveaux allergènes moléculaires, puis de l'exploration des angiœdèmes bradykiniques, des puces à allergènes, à propos de la tryptase et enfin pour le suivi de l'immunothérapie allergénique (ITA). Ces thématiques sont souhaitées en formation DPC en ligne, au congrès francophone d'allergologie (CFA), ou sous forme de fiches sur le site de la Société française d'allergologie (SFA). Biology is an essential tool in the diagnosis and management of allergic patients. To complete the survey of young allergists published in 2022, the Allergy Biology Working Group (GTBA) in partnership with ANAFORCAL has carried out a new survey of senior allergists to assess their training in allergy biology and to know their expectations in terms of information and continuing education. A total of 1095 allergists were contacted (with duplicates between the two lists) and 219 responded. Allergists consider themselves to be well trained. More than 70% believe they have a good knowledge of the subject and 94% receive regular training on the subject, first at congresses, by reading scientific articles and then at local training meetings. Of this sample, 69.4% have read the recommendations on the biology of allergy published in 2021. Of those who have read it, 90% are satisfied with it. However, of this sample, 89% had never done an internship in an immuno-allergology laboratory during their studies. This survey reports that 95% of respondents want more training and information, about new Activé par Editorial Manager® and ProduXion Manager® about Aries Systems Corporation molecular allergens, then the exploration of bradykine angioedema, allergen chips, about tryptase and finally for the follow-up of immunotherapy allergen (ITA). These themes are desired in online CPD training, at the French-speaking congress of allergology (CFA), or in the form of sheets on the site of the French Society of Allergology (SFA). [ABSTRACT FROM AUTHOR]

Abstract Background East and South East Asian subjects as well as Amerindians and Hispanic subjects are predominantly affected by Vogt-Koyanagi-Harada disease. In Europe, only few studies have described the clinical features and treatment of this disease, especially in France. Methods This retrospective case series was based on data collected from patients with a VKH disease diagnosed from January 2000 to March 2017, provided by three French Tertiary Centers. Results Forty-one patients (16 men and 25 women) were diagnosed: average age at diagnosis was 38.7 years. Patients were mainly from Maghreb (58%), but ethnic origins were multiple. Pleiocytosis was observed in 19 cases (63%) and 17 out of 41 patients showed audio vestibular signs (41%), and 11 showed skin signs (27%). Thirty-four were treated with corticosteroids (83%), 11 with an immunosuppressant treatment (27%) and 5 with biological therapy drugs (13%). Relapse was observed in 41% patients, even though final average visual acuity had improved. We did not find any significant clinical difference in the population from Maghreb compared to other populations, but for age and sex trends, since there was a majority of younger women. Conclusion We report here the second largest French cohort reported to date to our knowledge. The multiethnicity in our study suggests that VKH disease should be evoked whatever patients’ ethnicity.

The analysis of the vertical movements of the soil in the Po River plane of the Emilia-Romagna Region (Italy) was updated through an interferometric analysis referred to the 2011–2016 time-span. This activity is a continuation of previous studies on the state of knowledge of vertical soil movements in the same area, analyzed firstly by levelling and GNSS and more recently by SAR interferometry for the periods 1992–2000, 2002–2006, 2006–2011, on behalf of the Emilia-Romagna Region. The survey area analysed was approximately 13 300 km2, which corresponds to the territory of the regional plain. The interferometric dataset was calibrated through the use of velocity time series of several permanent GNSS stations. Among the 36 stations analysed, 22 were included in the study area: 16 were used for the calibration and 6 as check points). The velocities required for the calibration of the SAR analysis were calculated in the period following the important seismic events that struck the territory of the Emilia Romagna Region in May 2012. The interferometric analysis was carried out by TRE ALTAMIRA using the SqueeSAR™ technology. In particular, in order to update the interferometric dataset to 2016, it was necessary to perform a joint processing of the available RADARSAT-1 data and of the data acquired by the RADARSAT-2 satellite using a specific operating mode of the SqueeSAR™ algorithm known as stitching; this approach allowed the joint processing of images acquired in the same geometry by these two satellites. The study of the time series of the GNSS permanent stations used to provide the velocity datum to the interferometric analysis, is described, and the results of the SqueeSAR™ interferometric processing are reported. Statistical analyses on the spatial distribution and the type of scatterers have been performed during the screening and validation procedures of the dataset, and for the identification and removal of the outliers. Finally, the resulting map is described in order to analyse the measured soil movements with respect to the results obtained in past analyses, and the possible geological and human-induced causes, which could have produced them.

Multiple processes contributing to natural land subsidence in a shallow coastal aquifer near Ravenna (Italy) were identified by analysing the relationships among different data set time series (water table level, rainfall, land reclamation drainage, sea level, etc.) and establishing the correlations with vertical ground motion observed at a high-resolution settlement gauge. Our study highlights the presence of three deformation components related to different processes controlling land subsidence: elastic, delayed-elastic, and irreversible (plastic) components. The elastic and delayed-elastic components are closely related to water table fluctuations that change the effective stress in two portions of the coastal aquifer at a daily (in the sandy unconfined portion) and seasonal time scales (in the layered clay-rich semi-confined prodelta portion), respectively. The irreversible component represents the trend in the land subsidence time series and is due to primary consolidation (pore pressure dissipation) of the fine-grained prodelta levels above where the settlement gauge is located. The amplitudes of the elastic component can be up to 0.2–0.3 mm whereas the amplitude of the delayed-elastic component reaches 0.89 mm. The primary consolidation rate of deformation is 0.9 mm yr−1 and constrains the likely age of prodelta sediments deposition to 1300–2800 years before present. The delayed-elastic subsidence rate has similar magnitude to that due to primary consolidation and is connected to poroelastic effects in the prodelta sequence following seasonal variations in water table. Our findings are important for planning land subsidence management and monitoring strategies especially where the surface aquifer structure is heterogeneous due to different depositional settings. The natural land subsidence rate in the Holocene sediments of the shallow coastal aquifer of Ravenna (North eastern Italy) that we measured in this study accounts for 10 %–20 % of the total current land subsidence rate observed in this portion of Ravenna coastal area (10–20 mm yr−1).

Guidelines recommend to explore mild delayed hypersensitivity reactions to beta-lactams (BL) in children with direct drug provocation tests (DPTs). The optimal duration of these DPTs remains unknown and DPTs lasting 1 to 10 days are proposed. No study has directly compared the frequency of positivity of directs DPTs according to their duration. To compare the frequency of positivity of DPTs of different duration performed to explore mild delayed hypersensitivity reactions to beta-lactams (BL) in children in different centers. Data from children explored between January 2019 and December 2021 for delayed mild reactions (isolated urticaria, maculopapular exanthema or non-specific skin rashes) to oral BL in six different pediatric centers performing DPTs of varying duration (1 day or 3 days or 2 days more than the index reaction) were analysed. In total, 673 children were included. The duration of the DPTs were 1 day in 60 cases (8.9%), 3 days in 69 cases (10.3%), and 2 days more than the index reaction in 544 cases (80.8%). The median age at the index reaction was 1.7 years [0.8–3.7] in the "group 1 day", 1.9 [1–3.6] years in the group "3 days" and 1.5 [1–3.3] in the group "2 days more". Amoxicillin was the main BL involved (72.8%). The median age at workup was 4.6 years [2.7–8.7] in the "group 1 day", 3.8 years [1.8–8.3] in the "group 3 days" and 3 years [1.7–7] in the group "2 days more". General characteristics of patients in the 3 groups were similar. Fifty-eight DPTs were positive (8.6%); reactions occurring during DPTs were all mild and delayed isolated skin rashes resolving spontaneously or with H1-antihistamines. One DPT was positive in the "group 1 day" (1.5%), 4 (5.8%) in the "group 3 days", and 53 (9,7%) in the "group 2 days more than the index reaction" (P = 0.08). The frequency of positive DPTs was higher for long DPT ("2 days more") than short DPT (1 or 3 days) (3.9% vs. 9.7%, P < 0.05). Our results support that increasing the duration of DPTs to explore mild delayed reactions to BL in children may improve their diagnosis performance. [ABSTRACT FROM AUTHOR]

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Copyright of Revue Francaise d'Allergologie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revue Francaise d'Allergologie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

L'objectif est la comparaison des performances diagnostiques de deux puces IgE multi-allergéniques de composition et de principe différents. Vingt et un patients polysensibilisés ou ayant présenté une anaphylaxie inexpliquée ont été testés par deux puces : la puce ISAC® et la puce ALEX2®. La concordance globale des résultats entre les deux puces est très bonne (97,8 %) pour les allergènes communs. L'analyse par famille moléculaire montre une plus grande fréquence de positivité d'ALEX® pour les LTP (7,4 % versus 5,8 %), alors que c'est l'inverse pour les PR-10 (14,9 % en ISAC® versus 11,9 % en ALEX®). Cependant, les concentrations observées ne sont pas comparables et sont plus élevées en ALEX® pour les PR-10. Comme attendu, le prétraitement par un inhibiteur spécifique bloque l'interférence des IgE anti-CCD dans la puce ALEX®. L'analyse par patient a permis de mettre en évidence des sensibilisations à certains allergènes moléculaires spécifiques de chaque puce : viandes, poissons et pistache présents uniquement sur ALEX2® ou alpha-Gal sur ISAC®. Les résultats obtenus avec les deux puces sont globalement concordants pour les allergènes communs. Une puce plus complète associant des extraits comme des allergènes moléculaires non disponibles pour certains en unitaires devrait trouver sa place dans l'exploration d'anaphylaxie inexpliquée, mais le choix et le nombre d'allergènes testés devrait évoluer pour répondre au mieux aux besoins cliniques. The aim is to compare the diagnostic performances of two multi-allergenic IgE microarrays of different composition and principle. Twenty-one patients with polysensitivity or unexplained anaphylaxis were tested by two microarrays: the ISAC® biochip and the ALEX2® biochip. The overall agreement of results between the two biochips was very good (97.8%), Analysis by molecular protein family shows a higher frequency of ALEX® positivity for LTP (7.4% versus 5.8 %), while the opposite is true for PR-10 (14.9% for ISAC® versus 11.9% for ALEX®). However, the concentrations observed in ALEX® for PR-10 are higher. As expected, a pretreatment by a specific inhibitor blocked the interference of anti-CCD IgE in ALEX® biochip. The analysis by patient allowed to highlight sensitizations to some specific components of each biochip: meat, fish, and pistachio present only on ALEX2® or alpha-Gal on ISAC®. The results obtained with the 2 biochips are generally consistent for common allergens. A more complete chip combining extracts as molecular allergens not available in individual tests should find its place in the exploration of unexplained anaphylaxis but the choice and number of allergens tested should evolve to best meet clinical needs. [ABSTRACT FROM AUTHOR]

La graine de tournesol est un aliment avec un fort potentiel sensibilisant mais finalement peu d'allergies confirmées. Les modes de sensibilisation sont multiples, respiratoires, digestifs et cutanés. De nombreuses manifestations cliniques ont été décrites, les profils des patients sont également très variés. Des réactions à l'huile de tournesol sont possibles mais exceptionnelles. Des prick-tests avec l'aliment natif et la recherche d'IgE spécifiques confirmeront le diagnostic. La recherche d'allergènes moléculaires a permis d'identifier notamment une LTP et des albumines 2S. Nous rapportons une série de cas déclarés au Réseau d'Allergo-Vigilance® et faisons une revue de la littérature sur le sujet. Sunflower seed is a food with a high sensitising potential but few allergies have been confirmed. Sensitization modes are multiple, respiratory, digestive and cutaneous. Numerous clinical manifestations have been described, and patient profiles are also very various. Reactions to sunflower oil are possible but very rare. Prick tests with the native food and the search for specific IgE antibodies will confirm the diagnosis. The search for molecular allergens has allowed the identification of LTP and 2S albumin. We report a series of cases declared to the Allergy-Vigilance Network®, and review the literature on the subject. [ABSTRACT FROM AUTHOR]