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The green synthesis of silver nanoparticles (SNPs) is the most economical, rapid, facile, and eco-friendly technique. In this study, pathogenic bacteria from human stool were identified, and the antibacterial potency of Nigella sativa L. seed extracts containing SNPs was assessed. The identification of the isolated pathogenic bacteria was achieved through the analysis of their 16 S rDNA sequences. The characterization of SNPs was done by ultraviolet–visible spectroscopy (UV–VIS spectroscopy), scanning electron microscope (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Six pathogenic bacteria were isolated from human stool and isolated bacteria were identified by 16 S rDNA sequencing analysis. SNPs were found in the size range of 30–60 nm and showed good antibacterial and antifungal activity. The maximum zone of inhibition was found against A. spanius at 32.0±0.8 nm. Achromobacter spanius, Pseudomonas geniculate, and Enterobacter asburiae WL115 were extremely sensitive to heated treated nanoparticles at 100 μg ml−1. In the current work, N. sativa L. was investigated because it produced SNPs effectively, may be used as a safe, affordable agent, and may have antibacterial and antifungal properties. The potential biological uses of SNPs will be encouraged by these discoveries, which will drive future research.

Infection with the hepatitis B virus (HBV) has serious public health concerns. HBV infection can lead to acute hepatitis B (AHB) or chronic hepatitis B (CHB). After recovery, the viral genome (DNA) may persist for an extended period within the liver tissue and sometimes in the peripheral mononuclear cells and serum, leading to occult hepatitis B virus infection (OBI), which is characterised by the absence of HBV surface antigen (HBsAg). Additionally, the existence of OBI DNA poses a threat to specific patient groups, such as those with patients undergoing hemodialysis. The available literature has shown ongoing efforts to improve understanding of the immune defence of hemodialysis patients. This review aims to support these efforts and elucidate the immune response's role in patients undergoing hemodialysis with OBI.

Laser welding was performed using different filler wires, ER70S steel, commercially pure iron, and pure nickel filler, in the context of welding X80 pipeline steel to assess the microstructure and mechanical properties of the weld metal. Introducing an ER70S wire promoted acicular ferrite formation in the fusion zone, compared to a bainitic microstructure in an autogenous laser weld. The use of pure iron wire was considered as a potential strategy for reducing hardenability, as it led to the dilution of alloying elements in the fusion zone, increasing ferrite content and reducing weld metal hardness to a level compliant with API pipeline standards. The addition of pure nickel wire was used to reveal the degree of weld metal mixing imposed by the laser (thus providing an unambiguous tracer element) when it is combined with filler material dilution in the fusion zone, revealing that the upper region contained 38% wire material and the lower region only 12%. This accounts for the differences observed between the upper versus lower portions of the weld metal when other wires are used, and the use of hardness mapping and micro-indentation demonstrates the correlation between the variations in mechanical properties and microstructural differences introduced by incomplete mixing of the filler wire elements.

“BAU-Insectv2” represents a novel agricultural dataset tailored for deep learning applications and biomedical image analysis focused on plant-insect interactions. This dataset encompasses a diverse collection of high-resolution images capturing intricate details of plant-insect interactions across various agricultural settings. Leveraging deep learning methodologies, this study aims to employ convolutional neural networks (CNN) and advanced image analysis techniques for precise insect detection, classification, and understanding of insect-related patterns within agricultural ecosystems. We mainly focus on addressing insect-related issues in South Asian crop cultivation. The dataset's extensive scope and high-quality imagery provide a robust foundation for developing and validating models capable of accurately identifying and analyzing diverse plant insects. The dataset's utility extends to biomedical image analysis, fostering interdisciplinary research avenues across agriculture and biomedical sciences. This dataset holds significant promise for advancing research in agricultural pest management, ecosystem dynamics, and biomedical image analysis techniques.

Ca2+ overload-induced mitochondrial dysfunction is considered a contributing factor alcohol-associated liver disease pathogenesis. Here the authors report that PDK4 promotes Ca2 + -channelling complex formation at the endoplasmic reticulum-mitochondria contact sites, which contributes to the pathogenesis of alcohol-associated liver disease in studies with male mouse and hepatocyte models.

Alcohol‐associated liver disease is the leading cause of chronic liver disease. We hypothesized that the expression of specific coding genes is critical for the progression of alcoholic cirrhosis (AC) from compensated to decompensated states. For the discovery phase, we performed RNA sequencing analysis of 16 peripheral blood RNA samples, 4 healthy controls (HCs) and 12 patients with AC. The DEGs from the discovery cohort were validated by quantitative polymerase chain reaction in a separate cohort of 17 HCs and 48 patients with AC (17 Child‐Pugh A, 16 Child‐Pugh B, and 15 Child‐Pugh C). We observed that the numbers of differentially expressed messenger RNAs (mRNAs) were more pronounced with worsening disease severity. Pathway analysis for differentially expressed genes for patients with Child‐Pugh A demonstrated genes involved innate immune responses; those in Child‐Pugh B belonged to genes related to oxidation and alternative splicing; those in Child‐Pugh C related to methylation, acetylation, and alternative splicing. We found significant differences in the expression of heme oxygenase 1 (HMOX1) and ribonucleoprotein, PTB binding 1 (RAVER1) in peripheral blood of those who died during the follow‐up when compared to those who survived. Conclusion: Unique mRNAs that may implicate disease progression in patients with AC were identified by using a transcriptomic approach. Future studies to confirm our results are needed, and comprehensive mechanistic studies on the implications of these genes in AC pathogenesis and progression should be further explored.

Spot joints between aluminum and steel sheets were produced by cold metal transfer arc welding using an AlSi3Mn alloy low melting point filler wire. The current study found that by using optimal welding conditions, the thickness of the joint interface was significantly reduced compared to previous studies. The interface thickness increased from a few nanometers at the center of weld to 1.7 micrometers (1.2 mm from center of weld) at periphery of weld. The reduction in joint thickness helped to achieve better joint properties. The tensile shear and fatigue properties of the spot joints were evaluated in conjunction with interrupted mechanical tests to determine the fracture mechanisms. This study investigates the fatigue properties and fracture mechanisms of cold metal transfer arc spot joints, which has not been done previously. The tensile shear fractures exhibit primarily interfacial fracture passing through an intermetallic compound layer at the joint interface. However, three different modes of fractures are observed during fatigue tests, including interfacial fracture, sheet fracture, and mixed-mode fracture. Interrupted fatigue tests reveal numerous crack initiation in pores/particles in the deposited weld metal and coagulation of those cracks leads to sheet fracture during the fatigue tests. Sheet fracture mode fractures are mainly observed during high cycle fatigue conditions.

Objective: This experiment was undertaken to assess the scope and cost-effectiveness of the fer¬mented corn mixture (FCM)-based buffalo fattening approach compared to urea molasses straw (UMS) and silage-based approach. Materials and Methods: A completely comparative randomized design experiment was con¬ducted for 90 days with three treatments and five buffalo bulls in each. UMS, silage, and FCM roughage-based fattening diets were attributed as T1, T2, and T3, respectively. Two types of protein supplements, i.e., Type 1 (Bangladesh Livestock Research Institute-developed) for T1 and T2 and Type 2 (prescribed by farmers) for T3 treatments, were used. All the parameters were analyzed through Statistical Package for the Social Sciences, 20 software. Results: Dry matter intake (kg, %live weight) was significantly higher in T1 (2.65), followed by T2 (2.34) and T3 (2.00), respectively. The crude protein intake, digestible crude protein intake, and digestible dry matter intake (kg/d) significantly (p < 0.05) differed between T1 and T3, but not T2. The digest¬ibility of acid detergent fiber (65.97) was significantly higher for T3 than T1 and T2 (54.44 and 58.73, respectively). Neutral detergent fiber digestibility of T3 (70.35) also differed (p < 0.05) with T1 (60.97) but not T2 (64.78). No difference was observed in the case of growth, but feed conversion ration was found to be significantly (p < 0.05) better in T2 (7.10) than T1 (8.35), where T3 (7.24) was neutral. The significantly (p < 0.001) highest expense [216.37 Bangladesh taka (BDT)/kg gain] was required for T1, followed by T2 and T3 (174.47 and 126.33 BDT/kg gain, respectively). Net profit from T3 and T2 (15,877 and 15,175 BDT, respectively) gained significantly (p < 0.05) higher than T1 (11,265 BDT). Conclusion: The FCM-based diet was suitable and cost-effective as a buffalo fattening approach. [J Adv Vet Anim Res 2021; 8(2.000): 195-202]

Terminalia chebula Retz, commonly known as ‘Haritaki/Myrobalan,’ has been utilised as a traditional medicine for a long time. It has been extensively exercised in various indigenous medicine practices like Unani, Tibb, Ayurveda, and Siddha to remedy human ailments such as bleeding, carminative, dysentery, liver tonic, digestive, antidiarrheal, analgesic, anthelmintic, antibacterial and helpful in skin disorders. Studies on the pharmacological effects of T. chebula and its phytoconstituents documented between January, 1996 and December, 2021 were explored using various electronic databases. During the time mentioned above, several laboratory approaches revealed the biological properties of T. chebula, including antioxidative, antiproliferative, anti-microbial, proapoptotic, anti-diabetic, anti-ageing, hepatoprotective, anti-inflammatory, and antiepileptic. It is also beneficial in glucose and lipid metabolism and prevents atherogenesis and endothelial dysfunction. Different parts of T. chebula such as fruits, seeds, galls, barks extracted with various solvent systems (aqueous, ethanol, methanol, chloroform, ethyl-acetate) revealed major bioactive compounds like chebulic acid, chebulinic acid, and chebulaginic acid, which in turn proved to have valuable pharmacological properties through broad scientific investigations. There is a common link between chebulagic acid and chebulanin with its antioxidant property, antiaging activity, antiinflammatory, antidiabetic activity, and cardioprotective activity. The actions may be through neutralizing the free radicals responsible for producing tissue damage alongside interconnecting many other diseases. The current review summarises the scientifically documented literature on pharmacological potentials and chemical compositions of T. chebula, which is expected to investigate further studies on this subject.

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis. Immunohistochemistry analyses of explanted livers identified two SAH phenotypes despite a similar clinical presentation, one with high intrahepatic neutrophils (Neuhi), but low levels of CD8+ T cells, and vice versa. RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS production, was upregulated and correlated with hepatic inflammation and disease progression. To study specifically the mechanisms related to Neuhi in AH patients and liver injury, we used the mouse model of chronic-plus-binge ethanol feeding and found that myeloid-specific deletion of the Ncf1 gene abolished ethanol-induced hepatic inflammation and steatosis. RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA). In conclusion, two distinct histopathological phenotypes based on liver immune phenotyping are observed in SAH patients, suggesting a separate mechanism driving liver injury and/or failure in these patients.

A continuous cooling transformation (CCT) diagram was developed using thermal simulation techniques to replicate the coarse-grain heat-affected zone (CGHAZ) of an X80 line pipe steel. Specimens were heated to a peak temperature of 1350 °C with a 1 s hold time, followed by cooling at several rates between 7.6 and 356 °C/s. The thermo-mechanical specimen design was compatible with sub-size instrumented Charpy impact testing, which allowed the toughness to be evaluated. Following dilatometry measurements during continuous cooling, specimens were prepared and examined using optical and scanning-electron microscopy. In addition, the initial CGHAZ microstructure (upper bainite) was reheated to a peak temperature of 850 °C for 1 s (double cycled) and cooled at three different cooling rates (10, 5 and 2 °C/s). This allowed the influence of intercritical reheating, which occurs in multi-pass welds to be investigated in terms of microstructure, tensile strength and notch toughness. It was observed that the microstructure consisted of effective grain (matrix) and untempered MA when cooling at 10 or 5 °C/s. However, when reheating was followed by a cooling rate of 2 °C/s, the microstructure consisted of a combination of effective grain and a more benign distribution of tempered MA, which provided better low temperature impact toughness.

Breast cancer (BC) is the most common cancer type among women with a distinct clinical presentation, but the survival rate remains moderate despite advances in multimodal therapy. Consequently, a deeper understanding of the molecular etiology is required for the development of more effective treatments for BC. The relationship between inflammation and tumorigenesis is well established, and the activation of the pro-inflammatory transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is frequently identified in BC. Constitutive NF-κB activation is linked to cell survival, metastasis, proliferation, and hormonal, chemo-, and radiotherapy resistance. Moreover, the crosstalk between NF-κB and other transcription factors is well documented. It is reported that vitamin C plays a key role in preventing and treating a number of pathological conditions, including cancer, when administered at remarkably high doses. Indeed, vitamin C can regulate the activation of NF-κB by inhibiting specific NF-κB-dependent genes and multiple stimuli. In this review, we examine the various NF-κB impacts on BC development. We also provide some insight into how the NF-κB network may be targeted as a potential vulnerability by using natural pro-oxidant therapies such as vitamin C.

Vernal Keratoconjunctivitis (VKC) is a chronic conjunctival inflammatory condition that typically affects children. Extracellular microRNAs (miRNAs) are small noncoding RNA molecules, the expression of which is reported to regulate cellular processes implicated in several eye diseases. The aim of this preliminary study is to identify the miRNA expression profile in the tears of children with VKC vis-à-vis controls, and to statistically evaluate these miRNAs as potential diagnostic biomarkers of VKC. The study involved a VKC group and a control group. Tear specimens were collected using Schirmer’s strips. RNA was isolated using miRNeasy Micro kit and quantification was performed using an Agilent Bioanalyzer RNA 6000 Nano kit and Small RNA kit. miRNA profiling was performed using the Agilent microarray technique. A total of 51 miRNAs (48 upregulated and three downregulated) were differentially expressed in the tears of children with VKC and controls. The three most significantly upregulated miRNAs were hsa-miR-1229-5p, hsa-miR-6821-5p, and hsa-miR-6800-5p, and the three most significantly downregulated miRNAs were hsa-miR-7975, hsa-miR-7977, and hsa-miR-1260a. All the upregulated miRNAs are potential diagnostic biomarkers of VKC pending validation due to their larger discriminatory area under the curve (AUC) values. miRNA target prediction analysis revealed multiple overlapping genes that are known to play a role in conjunctival inflammation. We identified a set of differentially expressed miRNAs in the tears of children with VKC that may play a role in VKC pathogenesis. This study serves as the platform study for future miRNA studies that will provide a deeper understanding of the pathophysiology of VKC.

Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.

Environmental damage is without a doubt one of the most serious issues confronting society today. As dental professionals, we must recognize that some of the procedures and techniques we have been using may pose environmental risks. The usage and discharge of heavy metals from dental set-ups pollute the environment and pose a serious threat to the ecosystem. Due to the exclusive properties of nanosized particles, nanotechnology is a booming field that is being extensively studied for the remediation of pollutants. Given that the nanoparticles have a high surface area to volume ratio and significantly greater reactivity, they have been greatly considered for environmental remediation. This review aims at identifying the heavy metal sources and their environmental impact in dentistry and provides insights into the usage of nanoparticles in environmental remediation. Although the literature on various functions of inorganic nanoparticles in environmental remediation was reviewed, the research is still confined to laboratory set-ups and there is a need for more studies on the usage of nanoparticles in environmental remediation.

Alcohol-associated liver disease (ALD) represents a spectrum of histopathological changes, including alcoholic steatosis, steatohepatitis, and cirrhosis. One of the early responses to excessive alcohol consumption is lipid accumulation in the hepatocytes. Lipid ω-hydroxylation of medium- and long-chain fatty acid metabolized by the cytochrome P450 4A (CYP4A) family is an alternative pathway for fatty acid metabolism. The molecular mechanisms of CYP4A in ALD pathogenesis have not been elucidated. In this study, WT and Shp−/− mice were fed with a modified ethanol-binge, National Institute on Alcohol Abuse and Alcoholism model (10 days of ethanol feeding plus single binge). Liver tissues were collected every 6 hours for 24 hours and analyzed using RNA-Seq. The effects of REV-ERBα agonist (SR9009, 100 mg/kg/d) or CYP4A antagonist (HET0016, 5 mg/kg/d) in ethanol-fed mice were also evaluated. We found that hepatic Cyp4a10 and Cyp4a14 expression were significantly upregulated in WT mice, but not in Shp−/− mice, fed with ethanol. ChIP quantitative PCR and promoter assay revealed that REV-ERBα is the transcriptional repressor of Cyp4a10 and Cyp4a14. Rev-Erbα−/− hepatocytes had a marked induction of both Cyp4a genes and lipid accumulation. REV-ERBα agonist SR9009 or CYP4A antagonist HET0016 attenuated Cyp4a induction by ethanol and prevented alcohol-induced steatosis. Here, we have identified a role for the SHP/REV-ERBα/CYP4A axis in the pathogenesis of ALD. Our data also suggest REV-ERBα or CYP4A as the potential therapeutic targets for ALD.

Microgrids (MGs) are playing an important role in the maximum utilization of distributed energy resources. The optimal economic operation and low-carbon electricity generation can enhance MGs effectiveness. This paper presents the results of a solar-photovoltaic (PV)-driven islanded MG's techno-economic optimization analysis and environmental life-cycle assessment (LCA) to achieve economical and environmentally superior performance. A net present cost (NPC)-based simulation for optimal sizing of the MG is proposed. A novel life-cycle inventory (LCI) is developed to evaluate the impacts of the MG under 21 midpoint indicators and three endpoint indicators by the ReCiPe 2016 method, metal particle releases by the Ecopoints approach, and the greenhouse-gas emissions by the IPCC method. The sensitivity analysis is carried out to verify the effects for three different batteries and five different PV modules for all of the considered impact indicators. The results reveal that the proposed MG offers a revenue of 29,520 US$/yr by routing excess energy to neighbors after fulfilling the prosumers' demand at an optimal net present cost of 364,906 US$. Furthermore, the outcomes obtained from the LCA analysis show that, among the MG components, batteries have the highest impact on human health (74%) and the ecosystem (78%) due to greater greenhouse-gas emissions (CO2-48%, CH4-37%, and N20-48%).

The necessity to increase renewable energy consumption in the industrial, residential, and commercial use is crucial due to increasing use and decreasing reserve of fossil fuels. This paper is focused on the modelling and optimization of solar industrial process heating system using a flat plate collector and evacuated tube collector integrated into lead mining process for 7 different lead miner countries of the world: Australia, Canada, Indonesia, China, Peru, Russia, USA. Comparative analysis among seven miner countries is conducted by considering a few cases based on solar industrial process heating system design. The number of solar collectors installed is then optimized for three different designs of SHIP system in two different locations in Australia. To analyze the reduction potential of environmental burdens, life cycle assessment of lead mining process has been carried out based on the global average dataset. Environmental impact can be greatly reduced in global warming, human toxicity, and fossil fuel scarcity through the solar process heat integration. The evacuated-tube collector based solar process heating system with solar loop heat exchanger would have the highest efficiency and solar fraction over the other types of systems considered. Increasing the number of solar collector installation would result in higher solar fraction and capital cost.

Introduction Prolonged obstructed labour often results from lack of access to timely obstetrical care and affects millions of women. Current burden of disease estimates do not include all the physical and psychosocial sequelae from prolonged obstructed labour. This study aimed to estimate the prevalence of the full spectrum of maternal and newborn comorbidities, and create a more comprehensive burden of disease model.Methods This is a cross-sectional survey of clinicians and epidemiological modelling of the burden of disease. A survey to estimate prevalence of prolonged obstructed labour comorbidities was developed for prevalence estimates of 27 comorbidities across seven categories associated with prolonged obstructed labour. The survey was electronically distributed to clinicians caring for women who have suffered from prolonged obstructed labour in Asia and Africa. Prevalence estimates of the sequelae were used to calculate years lost to disability for reproductive age women (15 to 49 years) in 54 low- and middle-income countries that report any prevalence of obstetric fistula.Results Prevalence estimates were obtained from 132 participants. The median prevalence of reported sequelae within each category were: fistula (6.67% to 23.98%), pelvic floor (6.53% to 8.60%), genitourinary (5.74% to 9.57%), musculoskeletal (6.04% to 11.28%), infectious/inflammatory (5.33% to 9.62%), psychological (7.25% to 24.10%), neonatal (13.63% to 66.41%) and social (38.54% to 59.88%). The expanded methodology calculated a burden of morbidity associated with prolonged obstructed labour among women of reproductive age (15 to 49 years old) in 2017 that is 38% more than the previous estimates.Conclusions This analysis provides estimates on the prevalence of physical and psychosocial consequences of prolonged obstructed labour. Our study suggests that the burden of disease resulting from prolonged obstructed labour is currently underestimated. Notably, women who suffer from prolonged obstructed labour have a high prevalence of psychosocial sequelae but these are often not included in burden of disease estimates. In addition to preventative and public health measures, high quality surgical and anaesthesia care are urgently needed to prevent prolonged obstructed labour and its sequelae.

Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases. Impaired autophagy prevents the clearance of excessive lipid droplets (LDs), damaged mitochondria, and toxic protein aggregates, which can be generated during the progression of various liver diseases, thus contributing to the development of steatosis, injury, steatohepatitis, fibrosis, and tumors. In this review, we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver diseases. We also examine the mechanisms of defects in autophagy, and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), focusing mainly on steatosis and liver injury. Finally, we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases. Keywords: Autophagy, Non-alcoholic fatty liver disease (NAFLD), Alcoholic liver disease (ALD), Liver injury, Steatosis

Purpose The aim of this study was to evaluate the clinical and radiographic outcomes after medial open wedge high tibial osteotomy (MOWHTO) using Ilizarov fixator. Materials and Methods MOWHTO was performed on 25 knees of 24 consecutive patients. Upon radiographic assessment, alignment was shown as the femoral tibial angle (FTA). The posterior tibial slope (PTS) and the Insall-Salvati Index (ISI) were also measured. Results A visual analogue scale (VAS) improved significantly upon follow up (P < 0,001 for all). The overall mean FTA was 4.60 ± 4.30º varus preoperatively; at the last postoperative follow up, the value was 8.40 ± 2.0º valgus. The mean correction angle was 08.1 ± 2.0º. A significant increase in PTS was evident (P

This article describes genesis and the advances of schooling, research and extension of animal nutrition science and practices in Bangladesh. It portrays sine qua non of the advancement of animal nutrition, fodder production and frontier knowledge of allied disciplines. Domestic growth of good practices and its global and regional competitive advantages are delineated for supporting the growing need of safe animal sourced food pillared with profit, people, planet and the ethics of sustainable production of farm animals. A vision of becoming world middle income country with a national population plateau of around 202.0 million and demographic shifts by 2050 may require the annual production of 130.0 and 27.0 thousand tons of manufactured dairy and beef feed furthering global trading competitions for feed ingredients. This competition may be minimized through the production and supply of domestic sourced unique quality feeds and value additions to roughages. Capacity enhancement in research, education and extension will boost socioeconomic and the production efficiency of farm animals and enhance sustainable growth of feed industry racing with regional and global competitions.

Energy sharing through a microgrid (MG) is essential for islanded communities to maximise the use of distributed energy resources (DERs) and battery energy storage systems (BESSs). Proper energy management and control strategies of such MGs can offer revenue to prosumers (active consumers with DERs) by routing excess energy to their neighbours and maintaining grid constraints at the same time. This paper proposes an advanced power-routing framework for a solar-photovoltaic (PV)-based islanded MG with a central storage system (CSS). An optimisation-based economic operation for the MG is developed that determines the power routing and energy sharing in the MG in the day-ahead stage. A modified droop controller-based real-time control strategy has been established that maintains the voltage constraints of the MG. The proposed power-routing framework is verified via a case study for a typical islanded MG. The outcome of the optimal economic operation and a controller verification of the proposed framework are presented to demonstrate the effectiveness of the proposed power-routing framework. Results reveal that the proposed framework performs a stable control operation and provides a profit of 57 AU$/day at optimal conditions.

Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases.

High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location. While intracellular HMGB1 is important for DNA structure maintenance, gene expression, and autophagy induction, extracellular HMGB1 acts as a damage-associated molecular pattern (DAMP) molecule to alert the host of damage by triggering immune responses. The biological function of HMGB1 is mediated by multiple receptors, including the receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs), which are expressed in different hepatic cells. Activation of HMGB1 and downstream signaling pathways are contributing factors in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and drug-induced liver injury (DILI), each of which involves sterile inflammation, liver fibrosis, ductular reaction, and hepatic tumorigenesis. In this review, we will discuss the critical role of HMGB1 in these pathogenic contexts and propose HMGB1 as a bona fide and targetable DAMP in the setting of common liver diseases.

Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic instability mechanism during progression of other solid cancers is not well understood. Herein, we explored telomere dynamics in patient-derived epithelial ovarian cancers (OC), a malignancy characterized by multiple distinct subtypes, extensive molecular heterogeneity, and widespread genomic instability. We discovered a high frequency of telomere fusions in ovarian tumor tissues; however, limited telomere fusions were detected in normal adjacent tissues or benign ovarian samples. In addition, we found relatively high levels of both telomerase activity and hTERT expression, along with anaphase bridges in tumor tissues, which were notably absent in adjacent normal ovarian tissues and benign lesions. These results suggest that telomere dysfunction may occur early in ovarian carcinogenesis and, importantly, that it may play a critical role in the initiation and progression of the disease. Recognizing telomere dysfunction as a pervasive feature of this heterogeneous malignancy may facilitate the future development of novel diagnostic tools and improved methods of disease monitoring and treatment.

Batteries have been extensively used in many applications; however, very little is explored regarding the possible environmental impacts for their whole life cycle, even though a lot of studies have been carried out for augmenting performance in many ways. This research paper addresses the environmental effects of two different types of batteries, lithium-ion (LiIo) and nickel-metal hydride (NiMH) batteries, in terms of their chemical constituents. Life cycle impact analysis has been carried out by the CML, ReCiPe, EcoPoints 97, IPCC, and CED methods. The impacts are considered in categories such as global warming, eutrophication, freshwater aquatic ecotoxicity, human toxicity, marine aquatic ecotoxicity and terrestrial ecotoxicity. The results reveal that there is a significant environmental impact caused by nickel-metal hydride batteries in comparison with lithium-ion batteries. The reason behind these impacts is the relatively large amount of toxic chemical elements which are present as constituents of NiMH batteries. It can be anticipated that a better environmental performance can be achieved through optimization, especially by cautiously picking the constituents, taking into account the toxicity aspects, and by minimizing the impacts related to these chemicals.

This paper reviews around 41 articles providing the trends, characteristics, research gaps and challenges of these studies that may help e-waste management-related academics and practitioners with an overview of the need for such tool to be applied. The results and highlighted future research perspectives discussed in this study will definitely help to analyze e-waste management systems with more critical aspects, i.e., hidden and known flows of waste products and associated materials, economic assessment of material recovery and the role of responsible authorities.

The demand for clean energy is strong, and the shift from fossil-fuel-based energy to environmentally friendly sources is the next step to eradicating the world’s greenhouse gas (GHG) emissions. Solar energy technology has been touted as one of the most promising sources for low-carbon, non-fossil fuel energy production. However, the true potential of solar-based technologies is established by augmenting efficiency through satisfactory environmental performance in relation to other renewable energy systems. This paper presents an environmental life-cycle assessment (LCA) of a solar-photovoltaic (PV) system and a solar-thermal system. Single crystalline Si solar cells are considered for the solar PV system and an evacuated glass tube collector is considered for the solar thermal system in this analysis. A life-cycle inventory (LCI) is developed considering all inputs and outputs to assess and compare the environmental impacts of both systems for 16 impact indicators. LCA has been performed by the International Reference Life Cycle Data System (ILCD), Impact 2002+, Cumulative Energy Demand (CED), Eco-points 97, Eco-indicator 99 and Intergovernmental Panel on Climate Change (IPCC) methods, using SimaPro software. The outcomes reveal that a solar-thermal framework provides more than four times release to air ( 100 % ) than the solar-PV ( 23.26 % ), and the outputs by a solar-PV system to soil ( 27.48 % ) and solid waste ( 35.15 % ) are about one third that of solar-thermal. The findings also depict that the solar panels are responsible for the most impact in the considered systems. Moreover, uncertainty and sensitivity analysis has also been carried out for both frameworks, which reveal that Li-ion batteries and copper-indium-selenium (CIS)-solar collectors perform better than others for most of the considered impact categories. This study revealed that a superior environmental performance can be achieved by both systems through careful selection of the components, taking into account the toxicity aspects, and by minimizing the impacts related to the solar panel, battery and heat storage.

Oral premalignant disorders (OPMDs) are a group of potentially malignant conditions that pose a significant health burden globally. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as crucial regulators of gene expression and have been implicated in various biological processes, including carcinogenesis. This review synthesizes existing knowledge to provide a comprehensive understanding of the molecular mechanisms underlying OPMDs and to highlight the potential of miRNAs as promising biomarkers and therapeutic targets. Additionally, this review seeks to explore the potential of miRNA-based diagnostic biomarkers for early detection of OPMDs in the current literature on miRNAs in OPMDs, examining their involvement in disease pathogenesis, diagnostic potential, and therapeutic implications. Dysregulated miRNAs can target genes involved in critical cellular processes, such as cell cycle regulation, apoptosis, and DNA repair, leading to disease progression. Notably, miR-21, miR-31, miR-135b, and miR-486-5p have shown promise as potential biomarkers for early detection of oral premalignant lesions. Furthermore, the paper discusses the therapeutic implications of miRNAs in OPMDs. Preclinical studies have demonstrated the efficacy of miRNA-targeted therapies, such as miRNA mimics and inhibitors, in suppressing the growth of oral premalignant lesions. Early-phase clinical trials have shown promising results, indicating the potential for personalized treatment approaches. The findings underscore the importance of understanding the molecular mechanisms underlying these disorders and provide insights for the development of improved diagnostic and therapeutic strategies. However, they pose certain limitations given their intrinsic variability in expression profiles, the need for optimized isolation and detection methods, and potential hurdles in transitioning from preclinical success to clinical applications. Thus, future clinical studies are warranted to fully exploit the potential of miRNAs in the management of OPMDs. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Arsenic concentrations in 25% of tube wells in Bangladesh exceed 50mug/L, a level known to be hazardous. Levels in individual wells vary widely. We gathered data on arsenic exposure levels and skin lesion prevalence to address the lack of knowledge about risks where the average arsenic concentrations was lower. METHODS: The nongovernmental organization Gonoshasthaya Kendra did three related studies of keratotic skin lesions since 2004: (1) an ecological prevalence survey among 13 705 women aged > 18 in a random sample of 53 villages; (2) a case-control study of 176 cases and age- and village-matched referents; and (3) a prevalence survey of the entire population of 11 670 in two additional villages. We calculated prevalence as a function of average arsenic concentrations as reported in the National Hydrochemical Survey, and measured arsenic concentrations in wells used by subjects in the case-control study. FINDINGS: The prevalence of skin lesions was 0.37% in people exposed to arsenic concentrations below 5mug/L, 0.63% at 6-50mug/L, and 6.84% at 81mug/L. In the case-control analysis, relative risk of skin lesions increased threefold at concentrations above 50mug/L (P < 0.05). CONCLUSION: Little serious skin disease is likely to occur if the arsenic concentration in drinking water is kept below 50mug/L, but ensuring this water quality will require systematic surveillance and reliable testing of all wells, which may be impractical. More research is needed on feasible prevention of toxic effects from arsenic exposure in Bangladesh.

Background: Exosomes are the smallest extracellular vesicles (30–150 nm) secreted by all cell types, including synovial fluid. However, because biological fluids are complex, heterogeneous, and contain contaminants, their isolation is difficult and time-consuming. Furthermore, the pathophysiology of osteoarthritis (OA) involves exosomes carrying complex components that cause macrophages to release chemokines and proinflammatory cytokines. This narrative review aims to provide in-depth insights into exosome biology, isolation techniques, role in OA pathophysiology, and potential role in future OA therapeutics. Methods: A literature search was conducted using PubMed, Scopus, and Web of Science databases for studies involving exosomes in the osteoarthritis using keywords "Exosomes" and "Osteoarthritis". Relevant articles in the last 15 years involving both human and animal models were included. Studies involving exosomes in other inflammatory diseases were excluded. Results: Despite some progress, conventional techniques for isolating exosomes remain laborious and difficult, requiring intricate and time-consuming procedures across various body fluids and sample origins. Moreover, exosomes are involved in various physiological processes associated with OA, like cartilage calcification, degradation of osteoarthritic joints, and inflammation. Conclusion: The process of achieving standardization, integration, and high throughput of exosome isolation equipment is challenging and time-consuming. The integration of various methodologies can be employed to effectively address specific issues by leveraging their complementary benefits. Exosomes have the potential to effectively repair damaged cartilage OA, reduce inflammation, and maintain a balance between the formation and breakdown of cartilage matrix, therefore showing promise as a therapeutic option for OA. [ABSTRACT FROM AUTHOR]

Background: Meniscal injuries frequently require surgical intervention to restore knee joint function and stability. Intraoperative platelet-rich plasma (PRP) injection has emerged as a potential adjunctive therapy to enhance tissue healing post-meniscal repair. This systematic review and meta-analysis aimed to evaluate the efficacy of PRP in terms of pain relief, functional recovery, and overall success rates in patients undergoing meniscal repair procedures. Methods: A comprehensive search strategy was employed to identify relevant studies across Scopus, PubMed, Embase, and the Cochrane Library databases. The inclusion criteria encompassed human studies, including randomized controlled trials (RCTs), cohorts, and case–control studies, focusing on intraoperative platelet-rich plasma (PRP) use post-meniscal repair and reporting outcomes related to pain, functionality, and cure rates. Exclusion criteria comprised animal studies, non-English publications, studies lacking relevant outcome measures, and those with insufficient data. Two reviewers independently screened titles and abstracts, resolving disagreements through consensus or consultation with a third reviewer, followed by a full-text assessment for potentially eligible studies. Data extraction was conducted independently by two reviewers using a standardized form. The reliability of observational studies was evaluated using the Newcastle–Ottawa Scale. Subgroup analyses and pooled effect estimates for main outcomes were computed using RevMan 5.3, a meta-analysis tool. Results: The demographic analysis revealed that the PRP group had an average age of 41.39 years, while the control group had an average age of 42.1 years. In terms of gender distribution, the PRP group consisted of 61 men and 29 women, while the control group had 62 men and 34 women. Pain ratings showed a preference for PRP with a mean difference of 4.83 (p = 0.13). However, there was no significant difference in Lysholm scores (mean difference: − 0.44, p = 0.91) or IKDC scores (mean difference: 2.80, p = 0.14) between the PRP and control groups. Similarly, ROM measures did not show a statistically significant difference, with a mean difference of 2.80 (p = 0.18). Additionally, there was no significant distinction in failure rates between the PRP and control groups, as indicated by a weighted mean difference of 0.71 (p = 0.52). These findings suggest that while PRP may offer some benefits in pain relief, its impact on functional recovery, range of motion, and failure rates following meniscal repair procedures is inconclusive. Conclusion: The current evidence regarding the effect of intraoperative platelet-rich plasma (PRP) injection on patients undergoing meniscal repair remains inconclusive. While some studies suggest potential benefits in terms of pain relief and functional recovery, others show no significant differences compared to control groups. The impact of PRP therapy on overall success rates, including rates of re-tear and revision surgery, is also uncertain. Further well-designed randomized controlled trials with larger sample sizes are needed to provide more robust evidence and guide clinical practice in orthopedic surgery. [ABSTRACT FROM AUTHOR]

Inflammatory arthritis commonly initiates in the soft tissues lining the joint. This lining swells, as do the cells in it and inside the joint fluid, producing chemicals that induce inflammation signs such as heat, redness, and swelling. MicroRNA (miRNA), a subset of non-coding small RNA molecules, post-transcriptionally controls gene expression by targeting their messenger RNA. MiRNAs modulate approximately 1/3 of the human genome with their multiple targets. Recently, they have been extensively studied as key modulators of the innate and adaptive immune systems in diseases such as allergic disorders, types of cancer, and cardiovascular diseases. However, research on the different inflammatory joint diseases, such as rheumatoid arthritis, gout, Lyme disease, ankylosing spondylitis, and psoriatic arthritis, remains in its infancy. This review presents a deeper understanding of miRNA biogenesis and the functions of miRNAs in modulating the immune and inflammatory responses in the above-mentioned inflammatory joint diseases. According to the literature, it has been demonstrated that the development of inflammatory joint disorders is closely related to different miRNAs and their specific regulatory mechanisms. Furthermore, they may present as possible prognostic and diagnostic biomarkers for all diseases and may help in developing a therapeutic response. However, further studies are needed to determine whether manipulating miRNAs can influence the development and progression of inflammatory joint disorders. [ABSTRACT FROM AUTHOR]

The world is facing a tremendous problem in the form of food insecurity that is posing a great challenge to achieving sustainable development goal 2 of creating a hunger-free world. Refugees and displaced populations are particularly vulnerable to food insecurity and malnutrition, who lack any productive assets and depend on aid. Rohingya refugees, displaced from Myanmar and took refuge in Cox’s Bazar, Bangladesh, live in a crowded unhealthy environment and are severely vulnerable to food insecurity and malnutrition. In our recent study, we found that only 21.6% of the households in Rohingya refugee camps had acceptable food security status. Interestingly, this study further revealed that acceptable food security status was significantly higher among the households that had some additional income aside from aid, compared to those relying on aid alone. This shows the importance of promoting livelihood opportunities to improve food security status among the camp dwellers. In this paper, we presented our views on promoting livelihood opportunities to address the overwhelming food insecurity crisis among the Rohingya refugees in Bangladesh. [ABSTRACT FROM AUTHOR]

Understanding children's mobility behaviour and parents escorting practices are important to developing a children-friendly society. But only a few studies concerning children's mobility behaviour have focused on developing countries. In this study, we attempted to develop an econometric model to understand escorting practices in a developing country. A multinomial logit (MNL) model is developed using travel diary data of 398 elementary school-going children, inhabiting in Chattogram City Corporation (CCC) area of Bangladesh. We have considered different combinations of environmental (both school and neighbourhood environment), socio-cultural, household, and personal factors to explain children's independent mobility behaviour for both school and discretionary trip purposes. The findings suggested that children's individual (e.g. education level) and parents' sociodemographic (e.g. income, access to cars, mother's education level) facilities available at school, and built-environmental factors (e.g. commercial density, road density, land use mix and proximity to open spaces) are significantly associated with parent's choice for chauffeuring their children in CCC area. Results will be useful to planners and policy makers for formulating effective measures to promote children's independent mobility and will be a guideline for urban planners to include children's mobility demand for the neighbourhood as well as city design. [ABSTRACT FROM AUTHOR]

MicroRNAs (miRNAs) are short, 19–23 nucleotide non-coding RNA molecules that regulate gene expression by silencing or degrading the target mRNA gene. Since their discovery in the nineties of the last century, they have emerged as key inflammatory regulators. Inflammation induces the synthesis of various miRNAs that modulate the expression of multiple molecules involved in orchestrating the inflammatory response. This review aims to provide an insight into the role of miRNAs as potential biomarkers, mediators, and potential therapeutic targets of dental pulp inflammation. A literature search was conducted using the keywords; biogenesis of microRNA, human dental pulp cells, pulpitis, and inflammation in PubMed and Scopus index databases for all the published articles dealing with the role of miRNAs in pulp inflammation in the last 10 years. According to the literature, there is a clear correlation between miRNAs and several physiological events, as well as their role as mediators of innate immune response and inflammation in dental pulp cells. Our narrative review stipulates that numerous miRNAs play a key role in modulating inflammation, delaying or enhancing cell repair, cell differentiation, and survival in dental pulp diseases. However, further studies are required for the validation of miRNAs as reliable biomarkers in dental pulp pathology and their targeted therapy. [ABSTRACT FROM AUTHOR]

Breast cancer (BC) is the most common cancer type among women with a distinct clinical presentation, but the survival rate remains moderate despite advances in multimodal therapy. Consequently, a deeper understanding of the molecular etiology is required for the development of more effective treatments for BC. The relationship between inflammation and tumorigenesis is well established, and the activation of the pro-inflammatory transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is frequently identified in BC. Constitutive NF-κB activation is linked to cell survival, metastasis, proliferation, and hormonal, chemo-, and radiotherapy resistance. Moreover, the crosstalk between NF-κB and other transcription factors is well documented. It is reported that vitamin C plays a key role in preventing and treating a number of pathological conditions, including cancer, when administered at remarkably high doses. Indeed, vitamin C can regulate the activation of NF-κB by inhibiting specific NF-κB-dependent genes and multiple stimuli. In this review, we examine the various NF-κB impacts on BC development. We also provide some insight into how the NF-κB network may be targeted as a potential vulnerability by using natural pro-oxidant therapies such as vitamin C. [ABSTRACT FROM AUTHOR]

Performance management of employees is a significant function of modern human resource management practices. This paper tried to measure the effectiveness of the performance management system (PMS) of some selected Readymade Garment (RMG) factories with the aim to develop a tailored PMS for the management employees. Opinions of 266 employees were considered in this study and one-sample "t-test" was used to test twenty-four hypotheses developed through an extensive literature review. The study found efficiency of the RMGs in attaining the projected outcome of PMS. This paper is one of the pioneers in regards to RMG sector of Bangladesh and the research outcome of which will contribute to enriching the existing body of knowledge of employee performance management in this sector. [ABSTRACT FROM AUTHOR]

Vernal Keratoconjunctivitis (VKC) is a chronic conjunctival inflammatory condition that typically affects children. Extracellular microRNAs (miRNAs) are small noncoding RNA molecules, the expression of which is reported to regulate cellular processes implicated in several eye diseases. The aim of this preliminary study is to identify the miRNA expression profile in the tears of children with VKC vis-à-vis controls, and to statistically evaluate these miRNAs as potential diagnostic biomarkers of VKC. The study involved a VKC group and a control group. Tear specimens were collected using Schirmer's strips. RNA was isolated using miRNeasy Micro kit and quantification was performed using an Agilent Bioanalyzer RNA 6000 Nano kit and Small RNA kit. miRNA profiling was performed using the Agilent microarray technique. A total of 51 miRNAs (48 upregulated and three downregulated) were differentially expressed in the tears of children with VKC and controls. The three most significantly upregulated miRNAs were hsa-miR-1229-5p, hsa-miR-6821-5p, and hsa-miR-6800-5p, and the three most significantly downregulated miRNAs were hsa-miR-7975, hsa-miR-7977, and hsa-miR-1260a. All the upregulated miRNAs are potential diagnostic biomarkers of VKC pending validation due to their larger discriminatory area under the curve (AUC) values. miRNA target prediction analysis revealed multiple overlapping genes that are known to play a role in conjunctival inflammation. We identified a set of differentially expressed miRNAs in the tears of children with VKC that may play a role in VKC pathogenesis. This study serves as the platform study for future miRNA studies that will provide a deeper understanding of the pathophysiology of VKC. [ABSTRACT FROM AUTHOR]

Environmental damage is without a doubt one of the most serious issues confronting society today. As dental professionals, we must recognize that some of the procedures and techniques we have been using may pose environmental risks. The usage and discharge of heavy metals from dental set-ups pollute the environment and pose a serious threat to the ecosystem. Due to the exclusive properties of nanosized particles, nanotechnology is a booming field that is being extensively studied for the remediation of pollutants. Given that the nanoparticles have a high surface area to volume ratio and significantly greater reactivity, they have been greatly considered for environmental remediation. This review aims at identifying the heavy metal sources and their environmental impact in dentistry and provides insights into the usage of nanoparticles in environmental remediation. Although the literature on various functions of inorganic nanoparticles in environmental remediation was reviewed, the research is still confined to laboratory set-ups and there is a need for more studies on the usage of nanoparticles in environmental remediation. [ABSTRACT FROM AUTHOR]

The accurate evaluation of public transport (PT) services in developing countries is a challenging task due to a lack of reliable data and formal guidelines. The aim of this study was to develop a framework addressing these data limitations and quantify PT performance using output‐oriented Data Envelopment Analysis (DEA). The local bus service operation of Chattogram City Corporation area of Bangladesh was used as a case study. A performance assessment inventory was developed identifying the major stakeholders related to local bus service operations. The relative efficiencies of different bus routes (from users' and operators' perspectives) were estimated using the DEA model, which incorporated data from a semi‐structured questionnaire survey linked with the inventory. The PT authority also ranked all bus routes according to their degree of efficiency. Results indicated that relative efficiency scores in various routes varied according to the stakeholders' perspectives. A range of different parameters were considered when evaluating the performance of the service. The proposed inventory and framework would be useful for policymakers and urban planners in sequencing and prioritising different routes. This optimisation process would provide improved transport services to the general public. [ABSTRACT FROM AUTHOR]

Introduction: The expanding spectrum of therapeutic options for patients with Obstructive /surgical jaundice makes it necessary for the surgeon to precisely assess the etiology, location, level and extent of disease before operation. Aims were to compare the diagnostic accuracy, sensitivity and specificity of different imaging techniques like ultrasonography (USG), Computed tomography (CT) and Magnetic Resonance Cholangiopancreatography (MRCP) and Endoscopic Retrograde Cholangiopancreatography (ERCP) in evaluation of patients with malignant obstructive jaundice and correlation of histopathological findings after surgical/ therapeutic intervention. Methods: It was a prospective observational study conducted in the Department of General Surgery and Hepatobilliary unit, Dhaka Medical College Hospital and Bangabandhu Sheikh Mujib Medical University, Dhaka during January 2015 to December 2015 for duration of one year to find out the role of different imaging techniques in diagnosis of malignant lesions causing obstructive jaundice in 50 cases who fulfilled the inclusion criteria. Initial USG evaluation was followed by CT scan, MRCP and ERCP. The results were read by radiologists blinded to other imaging findings. Surgically fit patients with a stage of resectability should be offered the option of surgical resection for cure. For unresectable malignancies, the choice is between surgical palliation/bypass and ERCP with drainage. The characteristic surgical findings or ERCP features and histopathological diagnosis were recorded methodically as final. Results: Malignant obstructive jaundice is the commonest amongst the males and mean age was 47.56 ± 13.191 and the commonest etiology was Ca head of pancreas (30%). Diagnostic accuracy of MRCP (98%) in the diagnosis of malignant obstructive jaundice was relatively high (98%) as compared to ERCP (89.5%), CT (91.43%), USG (89.97%) in malignant obstructive jaundice respectively. In the diagnosis of malignant diseases, MRCP was more sensitive (95.83%) as compared to ERCP (89%), CT scan (91.67%) and ultrasonography (78.17%). Regarding specificity MRCP (100%) was the high in comparison among ERCP (94%), CT (90.91%) and USG (96.15%).Conclusion: It is concluded that malignant obstructive jaundice is the commonest amongst the males. Ca head of pancreas was the commonest malignant etiology in malignant obstructive jaundice. MRCP was superior to among USG, CT scan or ERCP in studying the malignant lesions. [ABSTRACT FROM AUTHOR]

The co-creation of knowledge through a process of mutual learning between scientists and societal actors is an important avenue to advance science and resolve complex problems in society. While the value and principles for such transdisciplinary water research have been well established, the power and empowerment dimensions continue to pose a challenge, even more so in international processes that bring together participants from the global north and south. We build on earlier research to combine known phases, activities and principles for transdisciplinary water research with a negotiated approach to stakeholder empowerment. Combining these elements, we unpack the power and empowerment dimension in transdisciplinary research for peri-urban groundwater management in the Ganges Delta. Our case experiences show that a negotiated approach offers a useful and needed complement to existing transdisciplinary guidelines. Based on the results, we identify responses to the power and empowerment challenges, which add to existing strategies for transdisciplinary research. A resulting overarching recommendation is to engage with power and politics more explicitly from the inception of transdisciplinary activities, as a key input for problem framing. [ABSTRACT FROM AUTHOR]

The gut microbiota is a critical mediator of nutrition and disease risk. Like most complex traits, the microbiome is under genetic regulation and differs between inbred strains of mice. We tested the effect of fecal microbiota transplantation (FMT) on obesity, and plasma glucose. For this study, we collected microbiota from 2 inbred strains of mice which differ in adiposity and glucose tolerance, C57BL/6J and WSB/EiJ. C57BL/6J female mice (n = 18) were first treated with antibiotics for 4 weeks to ablate the microbiota. Following ablation, the mice were transplanted with microbiota from a C57BL/6J or a WSB/EiJ mouse and clinical traits and plasma metabolomic profiles were interrogated at 2- and 4-weeks post-transplantation. Unexpectedly, the mice receiving WSB/EiJ microbiota increased adiposity but decreased plasma glucose. Metabolomic and 16S microbiota profiling indicated broad metabolic changes occurred during and after FMT. Detailed analysis of these interactions demonstrated specific microbiota-host metabolite interactions which may alter disease susceptibility. [ABSTRACT FROM AUTHOR]

Heavy metal chromium (Cr) is considered to be a serious environmental contaminant due to its toxic effect on living organisms. To mitigate and reduce the negative impacts of Cr in rice plant, the effect of exogenous supplementary calcium was evaluated as it functions as a signaling molecule at cellular level. In this study, growth parameters, protein content, and membrane stability were found to be restored due to calcium under Cr stress. Further, Atomic absorption spectrophotometric analysis revealed that calcium inhibits Cr translocation from root to shoot in rice seedlings. This event was addressed by the enhanced accumulation of phytochelatin that leads to vacuolar sequestration of Cr in roots. Furthermore, increased activity of Catalase, Peroxidase, and Glutathione reductase along with elevated glutathione also assures that calcium enhances antioxidant defense mechanism to cope with Cr toxicity. Abbreviations: Chromium: Cr; Iron: Fe; Calcium: Ca2+; PC: Phytochelatin; ROS: Reactive oxygen species; CAT: Catalase; POD: Peroxidase; SOD: Superoxide dismutase; GR: Glutathion reductase [ABSTRACT FROM AUTHOR]