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Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease

Authors :
Sen Han
Ting Zhang
Praveen Kusumanchi
Nazmul Huda
Yanchao Jiang
Zhihong Yang
Suthat Liangpunsakul
Source :
Clinical and Molecular Hepatology, Vol 26, Iss 4, Pp 705-714 (2020)
Publication Year :
2020
Publisher :
Korean Association for the Study of the Liver, 2020.

Abstract

Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.

Details

Language :
English
ISSN :
22872728 and 2287285X
Volume :
26
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Clinical and Molecular Hepatology
Publication Type :
Academic Journal
Accession number :
edsdoj.71212707b675468e92305ad4ddfe61f3
Document Type :
article
Full Text :
https://doi.org/10.3350/cmh.2020.0166