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2. Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Author

Estcourt, Lise J, McQuilten, Zoe K, Bardy, Peter, Cole-Sinclair, Merrole, Collins, Graham P., Crispin, Philip J., Curnow, Elinor, Curnow, Jennifer, Degelia, Amber, Dyer, Claire, Friebe, Adam, Floro, Lajos, Grand, Effie, Hudson, Cara, Jones, Gail, Joseph, Joanne, Kallmeyer, Charlotte, Karakantza, Marina, Kerr, Paul, Last, Sara, Lobo-Clarke, Maria, Lumley, Matthew, McMullin, Mary F, Medd, Patrick G., Morton, Suzy M., Mumford, Andrew D., Mushkbar, Maria, Parsons, Joseph, Powter, Gillian, Sekhar, Mallika, Smith, Laura, Soutar, Richard, Stevenson, William S., Subramoniapillai, Elango, Szer, Jeff, Thomas, Helen, Waters, Neil A., Wei, Andrew H., Westerman, David A., Wexler, Sarah A., Wood, Erica M., Stanworth, Simon J., Abioye, Adrienne, Afghan, Rabia, Ai, Sylvia Ai, Akanni, Magbor, Alajangi, Rajesh, Alam, Usmaan, Al-Bubseeree, Bahaa, Alderson, Sophie, Alderson, Craig, Ali, Sayed, Ali, Kabir, Alighan, Rookmeen, Allam, Rebecca Allam, Allen, Tania, Al-Sakkaf, Wesam, Ames, Kate, Anderson, Jacqueline, Andrews, Colin, Angel, Ann-Marie, Anlya, Manuela Anlya, Ansari, Farah, Appleby, Rowan, Arnold, Claire, Asbjornsdottir, Hulda, Asfaw, Biruk, Atkins, Elissa, Atkinson, Leela, Aubrey, Clare, Ayesha, Noor, Babbola, Lola, Badcock, David, Badcock, Samuel, Baggio, Diva, Bailiff, Ben, Baines, Kizzy, Baker, Holly, Baker, Victoria, Ball, Lindsay, Ball, Martin, Balquin, Irwin, Banks, Emma, Banos, George, Barnett, Jaytee, Barrie, Claire, Barron, Claire, Barton, Rebecca, Bason, Nina, Batta, Bindu, Bautista, Dianne, Bayley, Angela, Bayly, Emma, Baynes, Fionnuala, Bazargan, Ali, Bazeley, Rachel, Beadle, Yvonne, Beardsmore, Claire, Beattie, Kate, Bedford, Caroline, Behal, Rachna, Behan, Daniel, Bejan, Lilihna, Bell, Sarah, Bell, Karen, Bell, Louise, Bell, Kaitlyn, Benjamin, Reuben, Bennett, Sam, Benson, Gary, Benson, Warwick, Bent, Cameron, Bergin, Krystal, Berry, Alex, Besenyei, Stephanie, Besley, Caroline, Betteridge, Scott, Beveridge, Leigh, Bhattacharyya, Abir, Billen, Annelies, Bilmon, Ian, Binns, Emma, Birt, Mark, Bishop, David, Blanco, Andrea, Bleby, Lisa, Blemnerhet, Richard, Blombery, Piers, Blyth, Emily, Blythe, Nicola, Boal, Lauren, Boden, Ali, Bokhari, Syed W.I., Bongetti, Elisa, Booth, Stephen, Borley, Jayne, Bowen, David, Bowers, Dawn, Boyd, Stephen, Bradley, Sarah, Bradman, Helen, Bretag, Peta, Brillante, Maria, Brockbank, Rachel, Brough, Yasmin, Brown, Ellen, Brown, Jo, Brown, Eleanor, Brown, Claire, Brown, Jenny, Brown, Susan, Browning, Joe, Brownsdon, Alex, Bruce, David, Brydon-Hill, Ruth, Buckwell, Andrea, Burgess, Dannielle, Burke, Glenda, Burley, Kate, Burney, Claire, Burns, David, Burrows, Samuel, burton, Kieran, Butler, Jason, Cambalova, Lenka, Camozzi, Maria C., Campbell, Philip, Campfield, Karen, Campion, Victoria, Cargo, Catherine, Carmona, Julia, Carney, Dennis, Casan, Joshua, Cashman, Helen, Catt, Lorraine, Cattell, Michael, Cavill, Megan, Chadbone, Rachel, Chaganti, Sridhar, Chai, Yee, Chai, Khai Li, Chang, Joshua, Chapman, Judith, Chapman, Oliver G., Chapter, Tamika, Charlton, Andrew, Chau, Celina, Chauhan, Saleena, Chavda, Nikesh, Chen, Frederick, Chen, Melody, Chen, Meng Xi, Chen, Melanie, Chen, Melissa, Cheok, Kathleen, Cheung, Mai, Chidgey, Luke, Chmielokliec, Karolina, Choi, Philip, Choi, Jae, Chok, Anne, Chopra, Ruchika, Christopherson, Louise, Chu, Vicky, Chua, Chong Chyn, Chudakou, Pavel, Chugh, Vidushi, Chung, Chi, Clark, Erin, Clarke, Peter, Clarke, Kathleen, Clay, Jennifer, Clayton, Laura, Clements, Mitch, Clemmens, Jonathan, Clifford, Ruth, Collett, Dave, Collins, Maia, Collyer, Emily, Connolly, Maureen, Cook, Mark, Coombs, Sarah, Coppell, Jason, Cornwell, Sophie, Corrigan, Claire, Coughlin, Elizabeth, Couling, Jennifer, Cousins, Tony, Cowan, Catriona, Cox, Christine, Cox, Catherine, Coyle, Luke, Craig, Emily, Creasey, Thomas, Croan, Laura, Croft, Jane, Crosbie, Nicola, Crowe, Josephine, Crowther, Helen, Crozier, Jane, Culleton, Naomi, Cullis, Jonathan, Cumming, Anita, Cummins, Michelle, Cunningham, Adam, Curley, Cameron, Curtis, Samantha, Cuthbert, Robert, Cuthill, Kirsty, Dahahayake, Dinusha A, Dang, Amy, Davies, Marc, Davies, Ceri, Dawson, Emily, Day, Tom, De Abrew, Kanchana, De Lavallade, Hugues, De Silva, Neelaskshi, Dean, Georgina, Deane, Christopher, Demosthenous, Lisa, Desai, Amisha, Desborough, Michael, Devanny, Ian, Dhanapal, Jay, Dhani, Sundip, Di Martino, Vicky, Dickens, Emmy, DiCorleto, Carmen, Dinnett, Louise, Dirisan, Divya, Dixon, Karen, Dixon, Kiri, Doal, Inderjit, Dobivh, J, Docanto, Maria, Doecke, Helve, Donaldson, David, Donaldson, Kylee, Donohoe, Carrie, Douglas, Ashley, Doung, Stephen, Downer, Susan, D'Rozario, James, Drummond, Malcolm, Drummond, Mark, Drummond, Samantha, Drysdale, Elizabeth, D'Souza, Ross, D'Souza, Eugene, Dunn, Alex, Dutton, David, Dyson, Martin, Ediriwicurena, Kushani, Edleston, Sharon, Edwards, Dawn, Edwards, Morgan, Edwards, Anita, Eise, Nicole, Ellis, Steven, Ellis, Hayley, Elmonley, Shareef, Enstone, Rosemarie, Eordogh, Agnes, Erb, Sharon, Evans, Shannon, Evans, Megan, Ewing, Joanne, Eyre, Toby, Facey, Adam, Fammy, Mina, Farman, Jon, Farnell, Rachel, Favero, Laura, Fay, Keith, Ferguson, Karen, Fernon, Laura, Filshie, Robin, Finnegan, Damian, Fisher, Lisa, Flanagan, Asia, Fleck, Emma, Fletcher, Simon, Flora, Harpreet, Flower, Catherine, Fodor, Ioana, Foley, Heather, Folland, Emma, Folorunso, Comfort, Forbes, Molly, Fordwor, Katrina, Foster, Polly, Fox, Vanessa, Fox, Thomas, Francis, Olesya, Fryearson, Louise, Fuery, Madonna, Fung, Jiin, Furtado, Michelle, Galloway-Browne, Leanne, Gamble, Louise, Gamgee, Jeanette, Ganapathy, Arundathi, Gardner, Hayley, Gardner, Clare, Gasmelsheed, Noha, Gately, Amy, Gaynor, Lynda, Gebreid, Alex, Geffens, Ruth, George, Rachel, Gertner, Aniko, Ghebeh, Manar, Ghirardini, Emanuela, Giddings, Melainie, Gillett, Sandra, Gillett, Karen, Giri, Pratyush, Glass, Chris, Glewis, Sarah, Gooding, Sarah, Gordon, Olivia, Gordon, Joanne, Gottlieb, David, Gowda, Koushik, Gower, Elysie, Gray, Nicola, Grayer, Jo, Greaves, Elaine, Greenaway, Sally Anne, Greenfield, Graeme, Greenwood, Matthew, Gregory, Gareth, Griffin, James, Griffith, Julia, Griffith, James, Griffiths, Lindsey, Grzegrzolka, Paulina, Gu, Yisu, Guest, Jo, Guinai, Rosanna, Gullapalli, Veena, Gunolr, A., Guo, Lina, H, Wayne, Hagua, Sophia, Haile, Senait, Hall, Richard, Hamdollah-Zadeh, Maryam, Hanif, Zahra, Hanlon, Kathleen, Hann, Nicholas, Hanna, Ramez, Hannah, Guy, Hapuarachchi, Sameera, Hardman, Jacinta, Hardy, Alison, Harris, Anthony, Harris, Kylie, Harrison, Beth, Harrison, Simon, Harrison, Lea-Anne, Harrop, Sean, Harvey, Caroline, Hatcliffe, Faye, Hawking, Jo, Hawkins, Matthew, Hayden, Janet, Hayman, Michelle, Haynes, Elizabeth, Heaney, Nicholas, Hebbard, Andrew, Hempton, Jenny, Hendunneti, Sasanka, Henry, Maeve, Heywood, Jonathan, Hildyard, Catherine, Hill, Lydia, Hilldrith, Annette, Hitev, Petar, Hiwase, Smita, Hiwase, Devendra, Hoare, Chris, Hodge, Renate, Holloway, Amy, Holt, Chloe, Holton, Kelly, Homer, Lauren, Horne, Gillian, Horvath, Noemi, Hotong, Linda, Houdyk, Kristen, Houseman, Katy, Hoxhallari, Ilda, Hsu, Hannah, Hsu, Nina, Huang, Gillian, Hudson, Kerryn, Hufton, Melanie, Hughes, Timothy, Hughes, Siobhan, Hurley, Kate, Huxley, Rosie, Ibitoye, Temitope, Ibrouf, Abubaken, Inam, Farha, Indran, Tishya, Ingham, Karen, Innes, Calum, Irvine, David, Jaafar, Sarah, Jain, Manish, Jameson, Laura, Janjua, Pardeep, Jarvis, Rebecca, Jatheendran, Abirami, Javed, Abbie, Jen, Sheila, Jobanpura, Shailesh, Jobson, Irene, John, Deborah, Johns, Sophie, Johnston, Amanda, Jones, Hollie, Jones, Francesca, Joniak, Karolina, Jovanovic, Michael, Jovic, Anita, Joyce, Lauren, Judd, Andrew, Kakarlamudi, Sudhakar, Kakaroubas, Nick, Kalita, Maggie, Kam, Shirly, Kan, Julie, Kandle, P, Kanellopoulos, Alex, Kao, Chien, Kaparou, Maria, Kartsios, Charamlampos, Katsioulas, Vicki, Kaye, Russell, Keen, Katie, Kelly, Richard, Kelly, Pauline, Kelly, Donna, Kelly, Melanie, Kennedy, Glen, Kennedy, Nola, Kenny, Angela, Kenworthy, Zoe, Kerridge, Ian, Kesavan, Murali, Khafizi, Angelika, Khakwani, Muhammad, Khalid, Amna, Khamly, Kate, Khan, Anjum, Khan, Dalia, Khan, Mojid, Khan, Lubna, Khoo, Mona, Khwaja, Asim, Kim, Grace, King, Andrew, King, Vicky, King, Donna, Kinsella, Francesca, Kipp, David, Kirandeep, Pachoo, Kirui, Laura C., Kishore, Bhuvan, Knectlhi, Christopher, Knot, Amy, Knot, Armit, Ko, Cathy, Kolaric, Caitlin, Koo, Ray, Kotadia, Mary, Kothari, Jaimal, Kottaridis, Panagiotis D., Kuiluinathan, Gajan, Kulasekararaj, Austin, Kwan, John, Kwok, Marwan, Kwok, Phillip, Kwok, Fiona, Laane, Kristiina, Lad, Deena, Laird, Jennifer, Lam, Ada, Lane, Mary, Lanenco, Monica, Lang, Susan, Langridge, Alex, Langton, Catherine, Lannon, Michelle, Latif, Annie, Latimer, Maya, Latter, Ruth, Lau, I-Jun, Lawless, Sarah, Lawless, Theresa, Leach, Mike, Leaney, Sarah, Leary, Heather, Leavy, James, LeBlanc, Abbey, Lee, Vivienne, Lee, Edwin, Lee, Jenny, Lee, Tamara, Leischkie, Marian, Leitinger, Emma, Leon, Christopher, Leonard, Jayne, Lewis, David, Lewis, Ian, Lewis, Tania, Lim, Daniel, Littlewood, Kelly, Liu, Dara, Loh, Joanna, Lokare, Anand, Lomas, Oliver, Lovell, Richard, Lowe, Theresa, Lowry, Lisa, Lubowiecki, Marcin, Lumb, Rebecca, Lynch, Gail, Macaulay, Amanda, MacDonald, Lyndsey, MacDonald-Burn, Jill, Macmillan, Margaret, Maddock, Karen, Mahaliyana, Tomas, Mahon, Cassandra, Maidment, Alison, Maier, Susie, Mairos, Michelle, Majid, Mahseeman, Mak, Ka L, Mak, Anne, Malendrayogau, Arunthrthy, Malham, Hana, Malyon, Felicity, Mandadapu, Vineela, Mandel, Laura, Mant, Sarah, Manton, Ruth, Maouche, Nadjoua, Maqbool, Muhammad G., Marchant, Gregory, Marinho, Mariana, Marks, David, Marner, Mike, Marr, Helen, Marshall, Gillian, Martin, Siobhan, Martin, Abigail, Marzolini, Maria, Mason, Kiara, Massie, Jonathan, Masson, Rebecca, Mathavan, Vidya, Mathew, Siju, Mathie, Judith, Mattocks, Lehenta, Maybury, Bernard, Mayer, Georgina, McAlister, Chyrelle, McAllister, Jo, McConnell, Stewart, McCracken, James, McCullagh, Liz, McCulloch, Rory, Mcdermott, Christopher, Mcdonald, Kerian, McGinniss, Laura, McGurk, Fiona, McIlwain, Jessica, McIver, Kirsten, Mckay, Pam, McKenna, Lorraine, Mclornan, Donal, McMahon, Coalon, McNeice, Linda, McNeill, Susan, McNickle, Molly, McQueen, Fiona, McRae, Simon, McTaggart, Bobby, Mehew, Jenny, Mehra, Varnn, Melly, Michelle, Menichelli, Tara, Micklethwatte, Ken, Mihailescue, Loredana, Mijovic, Aleksander, Millband, Hannah, Miller, Lucy, Millien, Samuel T., Milnthorpe, James, Minson, Adrian, Molnar, Eva, Monsour, Marc, Moody, Mary, Moon, Rebecca, Moore, Sally, Moore, Katy, Morgan, Kelly, Morralley, Rebecca, Morris, Denise, Morris, Kirk, Morrison, Nicole, Moss, Merinda, Mughal, Muhammad, Muir, Paul, Mukkath, David, Mulla, Aasiyu, Mulligan, Stephen, Mullings, Joanne, Mulqueen, Angela, Muluey, Caitlin, Murdoch, Sarah, Murrani, Sura, Murthy, Vidhya, Musngi, Jimmy, Mustafa, Nadreen, Mynes, Tracey, Nalpantidis, Anastasios, Nandurkar, Harshal, Nardone, Linda, Nasari, Latifa, Nash, Monica, Naylor, Georgina, Ngu, Loretta, Nguethina, Melissa, Nguyen, John, Nguyen, Joseph, Nichol, Wendy, Nicholls, Emma, Nicole, Catherine S., Nicolson, Phillip, Nielson, David, Nikolousis, Emmanouil, Nix, Georgina, Njoku, Rita, Norman, Jane, Norman, Amy, Norris, Phoebe, North, Daniel, Norwood, Megan, Notcheva, Gaynor, Novitzky-Basso, Igor, Nyaboko, Joseph, Nygren, Maria, Obu, Ingrid, O'Connell, Siobhan, O'Connor, Jody, O'Kelly, Deanna, O'Niell, Aideen, Ony, Jeremy, Oo, Kathy, Oo, April, Oppermann, Anne, Orr, Ruth, O'Sullivan, Mary, Page, Jennifer, Palfreyman, Emma, Paneesha, Shankaranarayana, Panicker, Shyam, Parbutt, Catherine, Parigi, Elesha, Paris, Gemma, Parker, Tracey, Parnell, Caroline, Parrish, Christopher, Parsons, Alex, Pasat, Mioara, Patel, Natasha, Patel, Vijay, Patel, Pooja, Patel, Chaya, Pati, Nalini, Patterson, Andrea, Paul, Lauren, Payet, Danielle, Payne, Elspeth, Peachey, Victoria, Pearson, Amanda, Peniket, Andy, Percy, Laura, Pereyra, Millicent, Pervaiz, Omer, Phalod, Gunjan D, Pham, Anh, Pho, Jason, Pickard, Keir, Pidcock, Michael, Piggin, Anna, Pishyar, Yalda, Pocock, Abigail, Pol, Ranjendres, Polzella, Paolo, Poolan, Sonia, Portingale, Vicki, Posnett, Claire, Potluri, Sandeep, Potter, Victoria, Pratt, Guy, Prodger, Catherine, Pueblo, Andres, Puliyayil, Anish, Puvanakumar, Pratheepan, Qadri, Abdul, Quach, Hang, Quinn, Michael, Rafferty, Mark, Rahman, Marzia, Raj, Kavita, Raj, Sonia, Rajendran, Ramina, Ramanan, Radha, Ramasamy, Karthik, Rampotas, Alexandros, Ranchhod, Natasha, Rashid, Sabia, Ratanjee, Sunita, Rathore, Gurpreet, Ratnasingam, Sumita, Rayat, Manjit, Rayner, Michael, Reddell-Denton, Rebecca, Redding, Nicola, Reddy, Udaya, Rehman, Atique, Rice, Carol, Riches, Iwona, Rider, Thomas, Riley, John, Rinaldi, Ciro, Roberts, Kayleigh, Roberts, Andrew, Robertson, Bryony, Robertson, Peter, Robinson, Dan, Robinson, Rebecca, Robjohns, Emma, Robledo, Laura, Rodrigues, Ana, Rofe, Chris, Roff, Bridie, Rogers, Rachel, Rolt, Jill, Rooney, Carmela, Rose, Kathy, Rose, Hannah, Ross, David, Rouf, Shahara, Rourke, Claire, Routledge, David, Ruggiero, Janet, Rule, Simon, Rumsey, Richard, Sagge, Cherry, Saldhana, Helen, Salisbury, Richard, Salisbury, Sarah, Salvaris, Ross, Sanders, Kay, Sangombe, Mirriam, Sanigorska, Anna, Santos, Kristine, Sarkis, Taylah, Sarma, Anita, Saunders, Natalie, Schmidt, Kara, Schmidtmann, Anja, Schumacher, Ann, Scorer, Tom Scorer, Scott, Asleigh, Seath, Ingrid, Sejman, Frances, Selim, Adrian, Shamim, Nadia, Shan, Jocelyn, Shanmuganathan, Naranie, Shanmugaranjan, Shaminie, Sharpe, Michelle, Sharpley, Faye, Shaw, Emma, Sheath, Cara, Sheehy, Oonagh, Shen, Vivian, Sherbide, Solomon, Sheridan, Mathew, Sheridan, Jane, Sheridon, Matthew, Shields, Tracy, Sim, Hau V, Sim, Shirlene, Sims, Matt, Singaraveloo, Lydia, Singh, Gurcharan, Singh, Jasmine, Sladesal, Shree, Sloan, Andrew, Slobodian, Peter, Smith, Sophie, Smith, Sarit, Smith, Claire, Smith, Alastair, Smith, Neil, Snowden, Katherine, Solis, Joel, Somios, Denise, Soo, Jade, Spanevello, Michelle, Spaulding, Madeleie, Spence, Laura, Spillane, Liz, Spiteri, Alisha, Sprigg, Naomi, Springett, Sally, Stafford, Lynn, Stainthorp, Katherine, Stark, Kate, Steeden, Louise, Stephen, Ella, Stephenson, Aisling, Stewart, Andrew, Stewart, Orla, Stobie, Emma, Stokes, Chelsea, Streater, Jacqui, Suddens, Charlie-Marie, Suntharalingam, Surenthini, Surana, Narinder, Sutherland, Robyn, Sutherland, Antony, Sutton, David, Sweeney, Connor, Sweet, Reilly, Szucs, Aniko P, Taheri, Leila E., Tailor, Hinesh, Tam, Constantine, Tambakis, George, Tamplin, Mary, Tan, Chee, Tan, Sui, Tan, Joanne, Tan, Zhi, Taran, Tatiana, Tarpey, Fiona, Taseka, Angela, Tasker, Suzy, Tatarczuch, Maciej, Tayabali, Sarrah, Taylor, Hannah, Taylor, Robert, Taylor, Melaine, Taylor-Moore, Ella, Teasdale, Lesley, Tebbet, Elizabeth, Tedjasepstra, Aditya, Tedjaseputra, Aditya, Tepkumkun, Oummy, Terpstra, Andrew, Thomas, Wayne, Thomas, Shanice, Thompson, Rachel, Thornton, Thomas, Thorp, Bronwyn, Thrift, Moi Yap, Thwaites, Phillipa, Timbres, Jasmine, Tindall, Lauren, Tiong, Ing Soo, Tippler, Nicole, Todd, Tony, Todd, Shirley, Toghill, Neil, Tomlinson, Eve, Tooth, Jacinta, Topp, M., Trail, Nicola, Tran, Nguyen, Tran, Elizabeth, Tran, Vi, Treder, Bona, Tribbeck, Michelle, Trochowski, Siobhan, Truslove, Maria, Tse, Tsun, Tseu, Bing, Tucker, David, Turner, Kelly, Turner, Dianne, Turner, Herleen, Turner, Gillian, Twohig, Julie, Tylee, Thomas, Uhe, Micheleine, Underhill, Lauren, V, Joanne, Van der Vliet, Georgina, Van Tonder, Tina, VanderWeyden, Carrie, Varghese, Jerry, Vaughan, Lachlan, Veale, David, Vickaryyous, Nicky, Vince, Kathryn, Von Welligh, Jacoba, Vora, Sona, Wadehra, Karan, Walker, Rebecca, Walker, Stephen, Wallace, Roslyn, Wallniosve, Stephanie, Wallwork, S., Walmsley, Zoe, Walters, Fiona, Wang, Joyce, Wang, Angela, Wang, Chen, Wanyika, Mercy, Warcel, Dana, Wardrobe, Katrina, Warnes, Kristian, Waterhouse, Christopher, Waterworth, Adam, Watson, Caroline, Watson, Edmund, Watts, Emily, Weaver, Emma, Weber, Nicholas, Webley, Kaytie, Welford, Anna, Wells, Matt, Westbury, Sarah, Westcott, Jackie, Western, Robyn, Weston, Julia, White, Jessica, White, Phillipa, Whitehead, Anna, Whitehouse, James, Wieringa, Samantha, Willan, John, Williams, Sandra, Williams, Bethany, Williamson, Stephanie, Willoughby, Brett, Wilmot, Gail, Wilmott, Rosalind, Wilson, Joanna, Wilson, Emma, Wilson, Suzy, Wilson, Heather, Wilson, Caroline, Wilson, Tanya, Wilton, Margaret, Wiltshire, Paula, Wincup, Joanne, Wolf, Julia, Wong, Henna, Wong, Cyndi, Wong, Daniel, Wong, Jonathan, Wong, Shi Qin, Wood, Sarah, Wood, Henry, Wooding, Jackie, Woolley, Kelly, Wright, Myles, Wynn-Williams, Roland, Yannakou, Costas, Yeoh, Zhi Han, Yeung, David, Young, Agnes, Yuen, Flora, Yuen, Agnes, Zaja, Oliver, Zhang, Xiao-Yin, and Zhang, Mei

Published
2025
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4. Direct oral anticoagulants or vitamin K antagonists in emergencies: comparison of management in an observational study

Author

Chen, V., Young, L., Merriman, E., Curnow, J., Gallus, A., Boey, J., Tan, Chee Wee, McRae, S., Hugman, A., Joseph, J., Harper, P., Brighton, T., Royle, G., Crowther, H., Tran, H., Campbell, P., Baker, R., Baker, Ross I., Gilmore, Grace, Chen, Vivien, Young, Laura, Merriman, Eileen, Curnow, Jennifer, Joseph, Joanne, Tiao, Jim Y., Chih, Jun, McRae, Simon, Harper, Paul, Tan, Chee W., Brighton, Timothy, Royle, Gordon, Hugman, Amanda, Hankey, Graeme J., Crowther, Helen, Boey, Jirping, Gallus, Alexander, Campbell, Philip, and Tran, Huyen

Published
2023
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5. Association Between the Access Site for Coronary Angiography and Catheter-induced Coronary Artery Dissection

Author

Di Santo, Pietro, Boland, Paul W., Abdel-Razek, Omar, Simard, Trevor, Jung, Richard G., Parlow, Simon, Motazedian, Pouya, Joseph, Joanne, Theriault-Lauzier, Pascal, Alomar, Ali, Hillani, Ali, Alhassani, Saad, Ali, Mohamed Bayoumi, Kyeremanteng, Kwadwo, Coyle, Doug, Fergusson, Dean, Wells, George A., Froeschl, Michael, Labinaz, Marino, Russo, Juan J., and Hibbert, Benjamin

Published
2023
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8. Evaluation of plasminogen activator inhibitor-1 as a biomarker of unplanned revascularization and major adverse cardiac events in coronary angiography and percutaneous coronary intervention

Author

Jung, Richard G., Simard, Trevor, Di Santo, Pietro, Dhaliwal, Shan, Sypkes, Caleb, Duchez, Anne-Claire, Moreland, Robert, Taylor, Katlyn, Parlow, Simon, Visintini, Sarah, Labinaz, Alisha, Marbach, Jeffrey, Sarathy, Kiran, Bernick, Jordan, Joseph, Joanne, Boland, Paul, Abdel-Razek, Omar, Harnett, David T., Ramirez, F. Daniel, and Hibbert, Benjamin

Published
2020
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12. Percutaneous repair of a sinotubular junction aortic pseudoaneurysm with an atrial septal defect occluder: a case report.

Author

Joseph, Joanne, Scerbo, Jessica, Santo, Pietro Di, and Hibbert, Benjamin

Subjects
PERICARDITIS, ATRIAL septal defects, FALSE aneurysms, CORONARY artery bypass, AORTA, CARDIAC surgery
Abstract

Background Aortic pseudoaneurysms are complications that arise following cardiac surgery, thoracic trauma, infections, or inflammatory conditions. The mainstay treatment for aortic pseudoaneurysm is surgical management. Given significant morbidity and mortality related to thoracotomy, high-risk patients are not considered for cardiac surgery. Novel percutaneous repair using a variety of devices are being explored, especially in those with prohibitive risk for cardiac surgery. Case summary This case describes the use of an Amplatzer atrial septal defect (ASD) occluder device to manage an aortic pseudoaneurysm in a 69-year-old male who had previously undergone coronary artery bypass graft surgery and pericardial drainage for purulent pericarditis. Following successful implant, there were no complications seen after 2 years of follow-up. Discussion Percutaneous closure of a mycotic pseudoaneurysm with an Amplatzer ASD occluder device can be a safe and efficacious treatment option, especially in patients with prohibitive surgical risk. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Post-transplant lymphoproliferative disease in heart and lung transplantation: Defining risk and prognostic factors

Author

Kumarasinghe, Gayathri, Lavee, Orly, Parker, Andrew, Nivison-Smith, Ian, Milliken, Samuel, Dodds, Anthony, Joseph, Joanne, Fay, Keith, Ma, David D., Malouf, Monique, Plit, Marshall, Havryk, Adrian, Keogh, Ann M., Hayward, Christopher S., Kotlyar, Eugene, Jabbour, Andrew, Glanville, Allan R., Macdonald, Peter S., and Moore, John J.

Published
2015
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20. The utility of flow cytometric platelet forward scatter as an alternative to mean platelet volume.

Author

Connor, David, Rabbolini, David, Morel-Kopp, Marie-Christine, Fixter, Kate, Donikian, Dea, Kondo, Mayuku, Chan, Onki, Jarvis, Susan, Chen, Walter, Brighton, Timothy, Chen, Vivien, Ward, Christopher, and Joseph, Joanne

Subjects
MEAN platelet volume, BLOOD platelets, PLATELET count, INVERSE relationships (Mathematics), FLOW cytometry
Abstract

The use of mean platelet diameter (MPD) to classify inherited thrombocytopenia (IT) has been demonstrated in several studies. Alternatively, the mean platelet volume (MPV) may be used, but in macrothrombocytopenia this may not be available. We hypothesized that platelet forward scatter (FSC) measurements using flow cytometry may be used for the size-based classification of IT. The study aimed to assess the ability of platelet FSC to measure platelet size and whether it could be used as an alternative to the MPD or MPV. Blood samples were obtained from individuals undergoing investigation for inherited platelet function disorders (IPFD, n = 40) or platelet number disorders (IPND, n = 46). A hematology analyzer was used to obtain MPV and platelet counts, flow cytometry to measure platelet FSC and ImageJ software to measure MPD from stained blood smears. The International Society of Thrombosis and Hemostasis (ISTH) Bleeding Assessment Tool (BAT) was used to calculate bleeding scores. Twenty-nine(63%) of IPND patients had an MPV that could not be reported. A significant correlation to platelet FSC was found to the MPD (p <.0001) and MPV (p <.0001) and an inverse correlation with platelet count (p <.0001). No significant correlation was found between FSC and bleeding history. In conclusion, platelet FSC is an alternative to MPV and may be used in macrothrombocytopenia where the MPV is not recorded [ABSTRACT FROM AUTHOR]

Published
2022
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22. Comparison of flow cytometry with other modalities in the diagnosis of myelodysplastic syndrome.

Author

Pembroke, John S., Joseph, Joanne E., Smith, Sandy A. B. C., Parker, Andrew J. C., Jiang, Wei, and Sewell, William A.

Subjects
*FLOW cytometry, *MYELODYSPLASTIC syndromes, *BIOPSY, *ACQUISITION of data methodology, *MICROSCOPY, *IMMUNOHISTOCHEMISTRY, *COMPARATIVE studies, *IMMUNOPHENOTYPING, *MEDICAL records, *SENSITIVITY & specificity (Statistics), *CYTOGENETICS, BONE marrow examination
Abstract

Introduction: The myelodysplastic syndromes (MDSs) are heterogeneous myeloid malignancies, conventionally diagnosed by cytomorphology and cytogenetics, with an emerging role for flow cytometry. This study compared the performance of a 4‐parameter flow cytometry scoring system, the Ogata Score, with other modalities in the diagnosis of MDS. Methods: Bone marrow aspirate and trephine biopsies from 238 patients performed to assess for possible MDS were analysed, and the flow cytometry score was retrospectively applied. The sensitivity and specificity of the flow cytometry score, the aspirate microscopy, the trephine microscopy with immunohistochemistry, and cytogenetic and molecular results were determined relative to the final diagnosis. Results: The medical records of the 238 patients were reviewed to determine the final clinical diagnosis made at the time of the bone marrow examination. This final diagnosis of MDS, possible MDS or not MDS, was based on clinical features and laboratory tests, including all parameters of the bone marrow investigation, except for the flow cytometry score, which was only determined for this study. The flow cytometry score was 67.4% sensitive and 93.8% specific. Aspirate microscopy had higher sensitivity (83.7%) and similar specificity (92.0%), whereas trephine microscopy had similar sensitivity (66.3%) and specificity (89.4%) to flow cytometry. Although the flow cytometry score had a lower sensitivity than aspirate microscopy, in 18 patients (7.6% of the total) the flow cytometry score was positive for MDS, whereas aspirate microscopy was negative or inconclusive. Conclusion: The flow cytometry score and trephine microscopy exhibited reasonable sensitivity and high specificity, and complement aspirate microscopy in the assessment of MDS. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Building platelet phenotypes: Diaphanous-related formin 1 (DIAPH1)-related disorder.

Author

Rabbolini, David, Liang, Hai Po Helena, Morel-Kopp, Marie-Christine, Connor, David, Whittaker, Shane, Dunkley, Scott, Donikian, Dea, Kondo, Mayuko, Chen, Walter, Stevenson, William S, Campbell, Heather, Joseph, Joanne, Ward, Christopher, Brighton, Timothy, and Chen, Vivien M.

Subjects
BLOOD platelets, SENSORINEURAL hearing loss, PHENOTYPES, PHENOTYPIC plasticity, THROMBOCYTOPENIA
Abstract

Variants of the Diaphanous-Related Formin 1 (DIAPH-1) gene have recently been reported causing inherited macrothrombocytopenia. The essential/"diagnostic" characteristics associated with the disorder are emerging; however, robust and complete criteria are not established. Here, we report the first cases of DIAPH1-related disorder in Australia caused by the autosomal dominant gain-of-function DIAPH1 R1213X variant formed by truncation of the protein within the diaphanous auto-regulatory domain (DAD) with loss of regulatory motifs responsible for autoinhibitory interactions within the DIAPH1 protein. We affirm phenotypic changes induced by the DIAPH1 R1213X variant to include macrothrombocytopenia, early-onset progressive sensorineural hearing loss, and mild asymptomatic neutropenia. High-resolution microscopy confirms perturbations of cytoskeletal dynamics caused by the DIAPH1 variant and we extend the repertoire of changes generated by this variant to include alteration of procoagulant platelet formation and possible dental anomalies. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Ex Vivo Assessment of Different Oral Anticoagulant Regimens on Pump Thrombosis in a HeartWare Ventricular Assist Device.

Author

Rao, Sriram D., Connor, David E., Shehab, Sajad, Kerr, Nicholas P., Joseph, Joanne, Muthiah, Kavitha, Jain, Pankaj, Robson, Desiree, Jansz, Paul, and Hayward, Christopher S.

Abstract

BACKGROUND: In light of decreased intracranial hemorrhage with direct oral anticoagulants and concerns about their safety in continuous flow left ventricular assist devices, we conducted an ex vivo study of thrombus formation using multiple anticoagulation agents. METHODS: A continuous flow left ventricular assist device (HeartWare ventricular assist device) hemocompatibility loop was run using human blood under 7 conditions: control (no anticoagulation or antiplatelet); in vitro addition of aspirin; in vitro addition of apixaban at low dose (equivalent 2.5 mg twice daily); addition of apixaban at high dose (equivalent 5 mg twice daily); patients on warfarin; patients on apixaban (5 mg twice daily); and patients on dabigatran (150 mg twice daily). The primary outcome was time to formation of intrapump thrombosis. Secondary outcomes were reduction in clotting times over 1 hour, hemolysis, reduced platelet aggregation, and von Willebrand activity. RESULTS: Twenty-one runs were completed. Times to thrombosis in median (interquartile range) were control, 131 (127-- 134.5); in vitro aspirin, 124 (114.5--137); and patients on dabigatran, 131 (130.5--135.5) minutes, respectively. Times in patients on warfarin were, 137 (136.5--143.5); in vitro low-dose apixaban, 141 (138.5--142); and patients on apixaban, 140 (138--142.5) minutes, respectively. No thrombus formed in the in vitro high-dose apixaban group. There were no significant differences between the individual groups. When all apixaban groups were compared with nonapixaban groups, the time to thrombosis formation was significantly longer, 143 (137--150) versus 133.5 (128.5--140) minutes, P=0.02. There were similar changes in lactate dehydrogenase levels and other secondary end points. CONCLUSIONS: In an in vitro study of anticoagulation using human blood in a mock loop with a HeartWare HVAD, we demonstrated similar thrombosis times for apixaban and warfarin. Time to clotting was longer in the combined apixaban groups compared with combined other groups, but thrombosis times between individual groups were not significantly different. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Performance of Plasma Adenosine as a Biomarker for Predicting Cardiovascular Risk.

Author

Simard, Trevor, Jung, Richard G., Di Santo, Pietro, Ramirez, F. Daniel, Labinaz, Alisha, Gaudet, Chantal, Motazedian, Pouya, Parlow, Simon, Joseph, Joanne, Moreland, Robert, Marbach, Jeffrey, Boland, Paul, Promislow, Steven, Russo, Juan J., Chong, Aun‐Yeong, So, Derek, Froeschl, Michael, Le May, Michel, and Hibbert, Benjamin

Subjects
ADENOSINES, ACUTE coronary syndrome, CARDIOVASCULAR system physiology, STROKE, COLLATERAL circulation, MYOCARDIAL infarction
Abstract

Adenosine boasts promising preclinical and clinical data supporting a vital role in modulating vascular homeostasis. Its widespread use as a diagnostic and therapeutic agent have been limited by its short half‐life and complex biology, though adenosine‐modulators have shown promise in improving vascular healing. Moreover, circulating adenosine has shown promise in predicting cardiovascular (CV) events. We sought to delineate whether circulating plasma adenosine levels predict CV events in patients undergoing invasive assessment for coronary artery disease. Patients undergoing invasive angiography had clinical data prospectively recorded in the Cardiovascular and Percutaneous ClInical TriALs (CAPITAL) revascularization registry and blood samples collected in the CAPITAL Biobank from which adenosine levels were quantified. Tertile‐based analysis was used to assess prediction of major adverse cardiovascular events (MACE; composite of death, myocardial infarction, unplanned revascularization, and cerebrovascular accident). Secondary analyses included MACE subgroups, clinical subgroups and adenosine levels. There were 1,815 patients undergoing angiography who had blood collected with adenosine quantified in 1,323. Of those quantified, 51.0% were revascularized and 7.3% experienced MACE in 12 months of follow‐up. Tertile‐based analysis failed to demonstrate any stratification of MACE rates (log rank, P = 0.83), when comparing low‐to‐middle (hazard ratio (HR) 1.10, 95% confidence interval (CI) 0.68–1.78, P = 0.70) or low‐to‐high adenosine tertiles (HR 0.95, 95% CI 0.56–1.57, P = 0.84). In adjusted analysis, adenosine similarly failed to predict MACE. Finally, adenosine did not predict outcomes in patients with acute coronary syndrome nor in those revascularized or treated medically. Plasma adenosine levels do not predict subsequent CV outcomes or aid in patient risk stratification. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Diagnosis and management of heparin-induced thrombocytopenia: a consensus statement from the Thrombosis and Haemostasis Society of Australia and New Zealand HIT Writing Group.

Author

Joseph, Joanne, Rabbolini, David, Enjeti, Anoop K, Favaloro, Emmanuel, Kopp, Marie‐Christine, McRae, Simon, Pasalic, Leonardo, Tan, Chee Wee, Ward, Christopher M, Chong, Beng H, and Kopp, Marie-Christine

Abstract

Introduction: Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder that occurs following the administration of heparin and is caused by antibodies to platelet factor 4 and heparin. Diagnosis of HIT is essential to guide treatment strategies using non-heparin anticoagulants and to avoid unwanted and potential fatal thromboembolic complications. This consensus statement, formulated by members of the Thrombosis and Haemostasis Society of Australia and New Zealand, provides an update on HIT pathogenesis and guidance on the diagnosis and management of patients with suspected or confirmed HIT.Main Recommendations: A 4Ts score is recommended for all patients with suspected HIT prior to laboratory testing. Further laboratory testing with a screening immunoassay or confirmatory functional assay is not recommended in individuals with a low 4Ts score. However, if there are missing or unreliable clinical data, then laboratory testing should be performed. A positive functional assay result confirms the diagnosis of HIT and should be performed to confirm a positive immunoassay result. Heparin exposure must be ceased in patients with suspected or confirmed HIT and initial treatment with a non-heparin alternative instituted. Non-heparin anticoagulants (danaparoid, argatroban, fondaparinux and bivalirudin) used to treat HIT should be given in therapeutic rather than prophylactic doses. Direct oral anticoagulants may be used in place of warfarin after patients with HIT have responded to alternative parenteral anticoagulants with platelet count recovery.Changes in Management AsA Result Of This Statement: These are the first Australasian recommendations for diagnosis and management of HIT, with a focus on locally available diagnostic assays and therapeutic options. The importance of examining both clinical and laboratory data in considering a diagnosis of HIT cannot be overstated. [ABSTRACT FROM AUTHOR]

Published
2019
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34. Effects of antiplatelet therapy on platelet extracellular vesicle release and procoagulant activity in health and in cardiovascular disease.

Author

Connor, David E., Ly, Ken, Aslam, Anoosha, Boland, John, Low, Joyce, Jarvis, Susan, Muller, David W., and Joseph, Joanne E

Subjects
PLATELET aggregation inhibitors, ISCHEMIA, CARDIOVASCULAR diseases risk factors, CORONARY angiography, BLOOD sampling, FLOW cytometry, DISEASE risk factors
Abstract

Dual antiplatelet therapy with aspirin and clopidogrel is commonly used to prevent recurrent ischemic events in patients with cardiovascular disease. Whilst their effects on platelet reactivity are well documented, it is unclear, however, whether antiplatelet therapy inhibits platelet extracellular vesicle (EV) release. The aim of this study was to investigate the effects of antiplatelet therapy on platelet EV formation and procoagulant activity. Blood samples from 10 healthy controls not receiving antiplatelet therapy were incubated in vitro with aspirin or a P2Y12 inhibitor (MeSAMP). Blood samples from 50 patients receiving long-term dual antiplatelet therapy and undergoing coronary angiography were also studied. Platelet reactivity was assessed by Multiplate™ impedance aggregometry. Platelet EV formation and procoagulant activity of pretreated and untreated blood samples in response to arachidonic acid (AA), adenosine diphosphate (ADP), ADP+PGE1, and thrombin receptor-activating peptide (TRAP) stimulation were assessed by flow cytometry and Procoag-PL assays, respectively. Incubation of normal platelets with aspirin significantly inhibited AA-induced platelet reactivity, EV formation, and procoagulant activity, whilst MeSAMP significantly inhibited platelet reactivity and EV formation in response to AA, ADP, and TRAP, but had minimal effect on procoagulant activity. Most patients receiving dual antiplatelet therapy showed an appropriate reduction in platelet reactivity in response to their treatment; however there was not complete inhibition of increased platelet and EV procoagulant activity in response to ADP, AA, or TRAP. In addition, we could not find any correlation between platelet reactivity and procoagulant activity in patients receiving dual antiplatelet therapy. [ABSTRACT FROM AUTHOR]

Published
2016
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37. THE UPROOTING OF THE AMERICAN DREAM: THE DIMINISHED AND DEFERRED RIGHTS OF THE U.S. CITIZEN CHILD IN THE IMMIGRATION CONTEXT.

Author

Joseph, Joanne

Subjects
AMERICAN Dream, LEGAL status of children of undocumented immigrants, LEGAL status of citizens, IMMIGRATION law, DEPORTATION, DUE process of law, MATHEWS v. Eldridge (Supreme Court case), ACTIONS & defenses (Law)
Abstract

The article discusses the American dream in relation to the diminished and deferred rights of U.S. citizen children in the immigration context, focusing on a debate over how the U.S. Board of Immigration Appeals should respect the rights of the American citizen children of undocumented immigrants in deportation proceedings. An "extreme hardship standard" is mentioned, along with the U.S. Supreme Court case Mathews v. Eldridge which deals with due process rights under the nation's Constitution.

Published
2014

38. A case of a markedly elevated dabigatran concentration resistant to the approved dose of idarucizumab.

Author

Cashman, Helen, Roberts, Darren M., Welch, Susan, and Joseph, Joanne

Subjects
PYRIDINE, BENZIMIDAZOLES, MONOCLONAL antibodies, DRUG resistance, DRUG interactions
Abstract

The article presents the case of dabigatran resistance to idarucizumab in a 64-year-old atrial fibrillation patient. Topics discussed include the use of dabigatran for the treatment of venous thromboembolism and stroke prevention in non-valvular atrial fibrillation, use of the Hemoclot direct thrombin inhibitor assay in measuring dabigatran concentration, and the necessity for coagulation monitoring and additional idarucizumab doses in such cases.

Published
2021
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39. A Cottage Model for Eldercare.

Author

Thistleton, William, Warmuth, Jacqueline, and Joseph, Joanne M.

Subjects
GERIATRIC care units, SERVICES for older people, HEALTH surveys, JOB satisfaction, MEDICAL personnel
Abstract

Objective: An overview of medical, cognitive, and affective changes experienced by geriatric long-term care residents during a migration from traditional healthcare delivery to a cottage-based model. Background: New architectural models hold great promise for improving health and social outcomes for residents. New studies must explore the resident, family, and staff outcomes across transformations, as well as the business case for change. Methods: A longitudinal, quasi-experimental design was employed, with an emphasis on regularly acquired institutional data, including the Minimum Data Set, as well as commonly available survey instruments including the MOSES, the 2005 NSWHN, and Castle's Job Satisfaction Questionnaire. Descriptive statistics, McNemar's Exact Test, repeated measures ANOVA, and t-tests were used as well as narratives from families, staff, and management. Results: Staff perceived enhanced institutional respect (t(72) = 2.38, p = 0.02) and work environment, and families perceived more staff cooperation and a better bond between staff and residents. No changes were discerned in a resident's prevalence of pain (odds ratio 0.43, p = .34, 95% CI [0.07, 1.88]), mobility (odds ratio 0.50, p =.19, 95% CI [0.17, 1.32]), range of motion(odds ratio 0.57, p = .55, 95% CI [0.12, 2.25]), or depression and anxiety (odds ratio 2.33, p =.11, 95% CI [0.84, 7.41]). A modest decline in residents' systolic (t (101) = 3.74, p < .001) and diastolic (t (101) = 2.870, p < .01) blood pressures was demonstrated. The rate at which a resident's Activities of Daily Living score declined was attenuated (t (57) = 3.37, p <. 001). Operational costs remained constant across the move. Conclusions: Cottage settings were aesthetically appealing to residents, family, and staff. Modest improvements in health outcomes were observed, and operational costs remained stable. [ABSTRACT FROM AUTHOR]

Published
2012
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41. IMPRESSION MANAGEMENT EFFECTS IN THE FORCED COMPLIANCE SITUATION.

Author

Joseph, Joanne M., Gals, Gerald G., Tedeschi, James T., and Cunningftam, Michael R.

Subjects
SOCIAL science research, IMPRESSION management, INTERPERSONAL relations, PERSONALITY & situation, SOCIAL influence, ATTITUDE (Psychology)
Abstract

Two forced compliance studies were conducted in which the S's expectations regarding the situational appropriateness of his behavior were manipulated. In the first study (N = 36 female undergraduates) E indicated agreement or disagreement with the S's counterattitudinal essay or else did not give an opinion. Although attitude change occurred in the Agree and No Feedback groups, there was none in the Disagree condition. Three conditions were created in the second study (N = 142 male and female undergraduates): Standard Dissonance, Control, and a Model condition in which a confederate told the E his essay did not reflect his real attitude. Attitude change occurred in both experimental groups, but more occurred in the Dissonance than the Model condition. These results are interpreted in terms of impression management theory. [ABSTRACT FROM AUTHOR]

Published
1979
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42. PERSON PERCEPTION AND THE STUDY OF AGGRESSION.

Author

Stapleton, Richard E., Joseph, Joanne M., and Tedeschi, James T.

Subjects
AGGRESSION (Psychology), ATTITUDE (Psychology), COLLEGE students, REACTION time, PSYCHOPHYSIOLOGY, ELECTRIC shock
Abstract

A critical analysis of the concept of aggression provided a basis for empirically demonstrating the relativity involved in the use of the label "aggressive." Male and female undergraduates (N = 60) were employed as naive observers and were given descriptions of a frequently used paradigm in the study of aggression. They read one of three scenarios depicting the interaction of two persons in a competitive reaction-time game involving the exchange of electric shocks of various intensities. Results showed that observers were highly consistent in their labeling of behavior. In the depicted scenarios, a player was labeled as nonaggressive, defensive, good, and impotent as long as his shock intensity settings were lower than the other player's, and were labeled as aggressive, offensive, bad, and potent when he set higher intensities than his opponent. [ABSTRACT FROM AUTHOR]

Published
1978
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43. PERCEIVED AGGRESSION: A RE-EVALUATION OF THE BANDURA MODELING PARADIGM.

Author

Joseph, Joanne M., Kane, Thomas R., Nacci, Peter L., and Tedeschi, James T.

Subjects
AGGRESSION (Psychology), BEHAVIORAL assessment of children, PSYCHOLOGICAL techniques, CHILD psychology, ATTRIBUTION (Social psychology), SOCIAL science research
Abstract

Two experiments were performed to examine whether naive observers would label as aggressive the destructive behavior of a child following the latter's observation of an adult model. Experiment I provided descriptions of a standard modeling paradigm to female introductory psychology students. One of four sequences was presented in written form: the model and child were both constructive or destructive, the model was destructive and the child was constructive, or vice versa. The results showed that imitative destructive behavior by a child was not perceived as aggressive or bad, whereas the same pattern of play was considered aggressive and bad in the absence of similar behavior by a model (p < .03). Experiment II replicated the design and results of the first study and accrued information regarding the legitimizing function of the model. Observers attributed responsibility for imitative destructive behavior to the model and believed the child considered the behavior as appropriate and likely to produce rewards. The present results question the generalizability of prior findings and the adequacy of the modeling paradigm for the study of aggression. [ABSTRACT FROM AUTHOR]

Published
1977
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44. PERCEIVED FREEDOM, AGGRESSION, AND RESPONSIBILITY AND THE ASSIGNMENT OF PUNISHMENT.

Author

Kane, Thomas R., Joseph, Joanne M., and Tedeschi, James T.

Subjects
AGGRESSION (Psychology), DECISION making, CHOICE (Psychology), COLLEGE students, ATTITUDE (Psychology), SOCIAL science research
Abstract

The present experiment investigated the effects of the decision freedom of a transgressor on attributions of aggression and responsibility, and the assignment of punishment by naive observers. In a mass testing session Ss (N = 48 female college students) read one of four descriptions of Mr. X, a corporate vice president, who embezzled $50,000 under varying degrees of coercion. The degree of constraint operating on Mr. X prior to his decision to embezzle was manipulated by providing (or not providing) justifications for his behavior involving threats made upon the safety of Mr. X or his family. After reading a scenario Ss were asked to rate the aggressiveness of Mr. X on a semantic differential instrument and to indicate whether they perceived him as deserving of legal responsibility or punishment. Results revealed that constraints which reduced the transgressor's decision freedom also lessened the dispositional aggressiveness attributed, the blame assigned, and the retribution meted out to him. Additionally, it was found that observers considered the decision freedom of an actor even when the latter's action had been instigated by a coercive agent. [ABSTRACT FROM AUTHOR]

Published
1977
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45. Immune thrombocytopenia in the setting of ovarian dermoid cysts: implications for diagnosis and management.

Author

Ai, Sylvia S. Y. and Joseph, Joanne E.

Subjects
*ANTICOAGULANTS, *THROMBOCYTOPENIA treatment, *COMPUTED tomography, *OVARIAN cysts, *PREDNISONE, *THROMBOCYTOPENIA, *TUMOR markers, *DERMOID cysts, *DIAGNOSIS, *THERAPEUTICS
Abstract

The article presents a case study of a 41-year-old Vietnamese woman presented with a platelet count of 23 × 109/L and gum bleeding due to Immune thrombocytopenia. On presentation, the remainder of the full blood count was normal with a haemoglobin level of 128 g/L and a white cell count of 6.9 × 109/L; she developed bilateral deep vein thrombosis while thrombocytopenic and the use of intravenous immunoglobulin (IVIG).

Published
2018
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49. TCT-363 Incidence and Timing of Device-Related Thrombus in Percutaneous Implantable Cardiac Devices: A Systematic Review and Meta-Analysis.

Author

Jung, Richard, Simard, Trevor, Gillmore, Taylor, Rizk, Mina, Di Santo, Pietro, Joseph, Joanne, Stotts, Cameron, Motazedian, Pouya, Prosperi-Porta, Graeme, Abdel-Razek, Omar, Parlow, Simon, Lepage-Ratte, Melissa, Shorr, Risa, Ramirez, Francisco, Alkhouli, Mohamad, Rodes-Cabau, Josep, Holmes, David, and Hibbert, Benjamin

Subjects
*THROMBOSIS, *ARTIFICIAL implants
Published
2022
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