267 results on '"Jacobson, Matthew P."'
Search Results
2. Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts
3. Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
4. Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
5. Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues
6. Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2
7. Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase
8. Gasdermin D pore structure reveals preferential release of mature interleukin-1
9. Synthetic group A streptogramin antibiotics that overcome Vat resistance
10. Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite
11. Clinical Translation of the LevelCheck Decision Support Algorithm for Target Localization in Spine Surgery
12. Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency
13. A potent and selective inhibitor targeting human and murine 12/15-LOX
14. GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors
15. Assignment of function to a domain of unknown function : DUF1537 is a new kinase family in catabolic pathways for acid sugars
16. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters
17. A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP
18. Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus
19. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells
20. Searching for molecular hypoxia sensors among oxygen-dependent enzymes.
21. Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells
22. SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
23. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily
24. Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily
25. Turning a protein kinase on or off from a single allosteric site via disulfide trapping
26. Cofilin Is a pH Sensor for Actin Free Barbed End Formation: Role of Phosphoinositide Binding
27. Legitimization and the discursive (re)production of social domination
28. SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production
29. Assessing the Activation of Tyrosine Kinase KIT through Free Energy Calculations.
30. Discovery of new enzymes and metabolic pathways by using structure and genome context
31. Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function
32. Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice
33. Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies
34. An atomistic model of passive membrane permeability: application to a series of FDA approved drugs
35. Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: Successful in silico prediction of the relative permeabilities of cyclic peptides
36. Surfaces affect ion pairing
37. Virtual ligand screening against Escherichia coli dihydrofolate reductase: improving docking enrichment using physics-based methods
38. Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1
39. Complete protein structure determination using backbone residual dipolar couplings and sidechain rotamer prediction
40. Force field validation using protein side chain prediction
41. Computer-aided antibody design
42. Scaling rules for resonance dynamics near a saddle point: The pendulum as a Zero-order model
43. Numerical pattern recognition analysis of CO atmospheric simulation experiments
44. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase‑2.
45. Protomer alignment modulates specificity of RNA substrate recognition by Ire1.
46. Baseline subtraction using robust local regression estimation
47. Synthesis and Screening of α‑Xylosides in Human Glioblastoma Cells.
48. The synthesis and structural requirements for measuring glucocorticoid receptor expression in vivo with (±)-11C-YJH08 PET.
49. Observation of Coriolis Coupling between ν2 + 4ν4 and 7ν4 in Acetylene X̃1Σ+g by Stimulated Emission Pumping Spectroscopy
50. Visualizing intramolecular vibrational redistribution: expectation values of resonance operators
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