Discovery of new enzymes and metabolic pathways by using structure and genome context

Authors :: Zhao, Suwen
Kumar, Ritesh
Sakai, Ayano
Vetting, Matthew W.
Wood, B. McKay
Brown, Shoshana
Bonanno, Jeffery B.
Hillerich, Brandan S.
Seidel, Ronald D.
Babbitt, Patricia C.
Almo, Steven C.
Sweedler, Jonathan V.
Gerlt, John A.
Cronan, John E.
Jacobson, Matthew P.
Source :: Nature. October 31, 2013, Vol. 502 Issue 7473, p698, 8 p.
Publication Year :: 2013
Abstract: Assigning valid functions to proteins identified in genome projects is challenging: overprediction and database annotation errors are the principal concerns (1). We and others (2) are developing computation-guided strategies for [...]

Subjects :: Enzyme activation -- Research
Cell metabolism -- Research
Enzyme kinetics -- Research
Metabolomics -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation

Tools