172 results on '"Inuzuka, Hiroyuki"'
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2. Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligase
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3. O-GlcNAcylation in tumorigenesis and its implications for cancer therapy
4. Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
5. Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells
6. PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
7. AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation
8. PRMT1 methylates METTL14 to modulate its oncogenic function
9. Pharmacological inhibition of the SKP2/p300 signaling axis restricts castration-resistant prostate cancer
10. Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy
11. Ring domains are essential for GATOR2-dependent mTORC1 activation
12. Protein neddylation in lung tumorigenesis: Target validation and targeted therapy
13. Delayed fluorescence from inverted singlet and triplet excited states
14. Targeting micro-environmental pathways by PROTACs as a therapeutic strategy
15. Targeted Degradation of Receptor-Interacting Protein Kinase 1 to Modulate the Necroptosis Pathway.
16. Functional analysis of the emerging roles for the KISS1/KISS1R signaling pathway in cancer metastasis
17. Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
18. G protein–coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts
19. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ
20. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle
21. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy
22. Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
23. USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK.
24. Physiological functions of FBW7 in cancer and metabolism
25. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis
26. Structurally Specific Z‑DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1.
27. SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation
28. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner
29. USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.
30. Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2.
31. SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
32. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
33. SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer
34. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
35. SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression
36. Acetylation-Dependent Regulation of Skp2 Function
37. Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase
38. Tumor suppressor functions of FBW7 in cancer development and progression
39. An Evolving Role for DEPTOR in Tumor Development and Progression
40. Skp2: A novel potential therapeutic target for prostate cancer
41. Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1
42. mTOR Drives Its Own Activation via SCF βTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR
43. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
44. Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction
45. Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase
46. regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
47. Chapter 12 Experimental Approaches to Investigate the Proteasomal Degradation Pathways Involved in Regulation of Apoptosis
48. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets
49. The PDZ Scaffold NHERF-2 Interacts with mGluR5 and Regulates Receptor Activity
50. Chirality-Induced Magnetoresistance Due to Thermally Driven Spin Polarization.
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