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3. Deceleration capacity derived from a five-minute electrocardiogram predicts mortality in the general population

Author

Steger, Alexander, Barthel, Petra, Müller, Alexander, Rückert-Eheberg, Ina-Maria, Linkohr, Birgit, Allescher, Julia, Maier, Melanie, Hapfelmeier, Alexander, Martens, Eimo, Heidegger, Helene Hildegard, Müller, Arne Michael, Rizas, Konstantinos D., Kääb, Stefan, Sinner, Moritz F., Sinnecker, Daniel, Laugwitz, Karl-Ludwig, Peters, Annette, and Schmidt, Georg

Published
2024
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6. Incidence and pattern of urgent revascularization in acute coronary syndromes treated with ticagrelor or prasugrel

Author

Aytekin, Alp, Scalamogna, Maria, Coughlan, J. J., Lahu, Shqipdona, Ndrepepa, Gjin, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Angiolillo, Dominick J., Hemetsberger, Rayyan, Tölg, Ralph, Valina, Christian, Müller, Arne, Kufner, Sebastian, Liebetrau, Christoph, Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Cassese, Salvatore

Published
2024
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11. Ticagrelor or prasugrel in patients with acute coronary syndrome with off-hour versus on-hour presentation: a subgroup analysis of the ISAR-REACT 5 trial

Author

Behnes, Michael, Lahu, Shqipdona, Ndrepepa, Gjin, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Gewalt, Senta, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Hemetsberger, Rayyan, Valina, Christian, Müller, Arne, Kufner, Sebastian, Hamm, Christian W., Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Fusaro, Massimiliano, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz-Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Akin, Ibrahim

Published
2023
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17. Access Route and Clinical Outcomes After Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome Undergoing Invasive Treatment Strategy

Author

Hemetsberger, Rayyan, Richardt, Gert, Lahu, Shqipdona, Valina, Christian, Menichelli, Maurizio, Abdelghani, Mohammad, Wöhrle, Jochen, Toelg, Ralph, Witzenbichler, Bernhard, Mankerious, Nader, Liebetrau, Christoph, Bernlochner, Isabell, Hamm, Christian W., Allali, Abdelhakim, Joner, Michael, Fusaro, Massimiliano, Xhepa, Erion, Hapfelmeier, Alexander, Kufner, Sebastian, Sager, Hendrik B., Schüpke, Stefanie, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Neumann, Franz-Josef, Kastrati, Adnan, and Cassese, Salvatore

Published
2022
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19. Vaccination as a risk factor for pediatric multiple sclerosis: Insights from a retrospective case–control study.

Author

Darvishi, Sonia, Donnachie, Ewan, Gasperi, Christiane, Hapfelmeier, Alexander, and Hemmer, Bernhard

Subjects
JUVENILE diseases, CROHN'S disease, POISSON regression, MULTIPLE sclerosis, AUTOIMMUNE diseases
Abstract

This study evaluated the association between pediatric multiple sclerosis and vaccinations within 5 years before diagnosis using German ambulatory claims data. Children with multiple sclerosis (n = 346) aged 9–17 were analyzed with logistic and Poisson regression. Control groups included children with Crohn's disease, psoriasis, and no autoimmune diseases. The results indicated a negative association between vaccinations and pediatric multiple sclerosis, with no significant risk identified. This negative relationship was consistent in sensitivity and clinically isolated syndrome analyses. Overall, the study's findings do not support the hypothesis that vaccination is a risk factor for pediatric multiple sclerosis. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Optimierung der Versorgung durch digitale Anwendungen am Beispiel des Mammakarzinoms.

Author

Jansen, Heike, Dinkel, Andreas, Benning, Katharina, Hapfelmeier, Alexander, Balteanu, Adrian, Schüttig, Wiebke, Himmler, Sebastian, Fall, Barbara, and Kiechle, Marion

Abstract

Copyright of Die Gynäkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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27. Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome in Relation to Estimated Glomerular Filtration Rate

Author

Wöhrle, Jochen, Seeger, Julia, Lahu, Shqipdona, Mayer, Katharina, Bernlochner, Isabell, Gewalt, Senta, Menichelli, Maurizio, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Hemetsberger, Rayyan, Valina, Christian, Kufner, Sebastian, Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Ndrepepa, Gjin

Published
2021
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29. LINAS‐Score: prognostic model for mortality assessment in patients with cirrhotic liver and infected ascites.

Author

Würstle, Silvia, Schneider, Tillman, Karapetyan, Siranush, Hapfelmeier, Alexander, Isaakidou, Andriana, Studen, Fabian, Schmid, Roland M., von Delius, Stephan, Rothe, Kathrin, Burgkart, Rainer, Obermeier, Andreas, Triebelhorn, Julian, Erber, Johanna, Voit, Florian, Geisler, Fabian, Spinner, Christoph D., Schneider, Jochen, and Wagner, Laura

Subjects
RECEIVER operating characteristic curves, CIRRHOSIS of the liver, PROGNOSTIC models, RANDOM forest algorithms, REGRESSION analysis
Abstract

Background and Aim: Patients with liver cirrhosis often face a grave threat from infected ascites (IA). However, a well‐established prognostic model for this complication has not been established in routine clinical practice. Therefore, we aimed to assess mortality risk in patients with liver cirrhosis and IA. Methods: We conducted a retrospective study across three tertiary hospitals, enrolling 534 adult patients with cirrhotic liver and IA, comprising 465 with spontaneous bacterial peritonitis (SBP), 34 with bacterascites (BA), and 35 with secondary peritonitis (SP). To determine the attributable mortality risk linked to IA, these patients were matched with 122 patients with hydropic decompensated liver cirrhosis but without IA. Clinical, laboratory, and microbiological parameters were assessed for their relation to mortality using univariable analyses and a multivariable random forest model (RFM). Least absolute shrinkage and selection operator (Lasso) regression model was used to establish an easy‐to‐use mortality prediction score. Results: The in‐hospital mortality risk was highest for SP (39.0%), followed by SBP (26.0%) and BA (25.0%). Besides illness severity markers, microbiological parameters, such as Candida spp., were identified as the most significant indicators for mortality. The Lasso model determined 15 parameters with corresponding scores, yielding good discriminatory power (area under the receiver operating characteristics curve = 0.89). Counting from 0 to 83, scores of 20, 40, 60, and 80 corresponded to in‐hospital mortalities of 3.3%, 30.8%, 85.2%, and 98.7%, respectively. Conclusion: We developed a promising mortality prediction score for IA, highlighting the importance of microbiological parameters in conjunction with illness severity for assessing patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Frequency, persistence and relation of disease symptoms, psychosomatic comorbidity and daily life impairment after COVID-19: a cohort study in general practice.

Author

Hapfelmeier, Alexander, Donhauser, Jan, Teusen, Clara, Eck, Stefanie, and Schneider, Antonius

Subjects
*SOMATOFORM disorders, *RISK assessment, *FAMILY medicine, *T-test (Statistics), *STATISTICAL significance, *MULTIPLE regression analysis, *PRIMARY health care, *MEDICALLY unexplained symptoms, *MULTIVARIATE analysis, *CHI-squared test, *DESCRIPTIVE statistics, *LONGITUDINAL method, *ODDS ratio, *PSYCHOSOMATIC disorders, *QUALITY of life, *STATISTICS, *ANALYSIS of variance, *COMPARATIVE studies, *SOCIODEMOGRAPHIC factors, *DATA analysis software, *COVID-19, *COMORBIDITY, *ACTIVITIES of daily living, *DISEASE risk factors
Abstract

Background: Long-lasting symptoms with a possible relation to psychosomatic comorbidity have been described following COVID-19. However, data is sparse in general practice. The trial's objective was to investigate the time-dependent frequency of disease symptoms and relation to psychosomatic comorbidity and daily life impairment (DLI). Methods: Comparative cohort study of patients reporting a previous SARS-CoV-2 infection and uninfected controls in general practice. Participants were recruited in 14 general practices in the greater Munich area. Data collection was questionnaire based with a 12 months follow-up. Descriptive statistics, multivariable regression and bivariate correlations were used for analysis. Results: A total of n = 204 cases infected up to 42 months ago (n = 141 Omicron, n = 63 earlier variants), and n = 119 controls were included. Disease symptoms were substantially more prevalent in cases (55–79% vs. 43% within one year of infection). This difference also appeared in the multivariable analysis adjusting for socio-demographics and psychosomatic comorbidity with odds ratios (OR) of 4.15 (p < 0.001) and 3.51 (p = 0.054) for the cohorts with Omicron or earlier variants infection (vs. controls), respectively. It was persistent with earlier variants (OR 1.00 per month, p = 0.903), while a decreasing trend was observed for Omicron (OR 0.89 per month, p < 0.001). DLI was especially correlated with fatigue (r = 0.628). Conclusion: DLI, psychosomatic comorbidity and independently increased disease symptoms require holistic treatment of the patient in general practice according to the bio-psycho-social model. A key role in restoring the daily life capability may be attributed to the symptom fatigue. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Structure and quality of bedside teaching: A videographic analysis.

Author

Blaschke, Anna-Lena, Hapfelmeier, Alexander, Rubisch, Hannah P. K., Berberat, Pascal O., and Gartmeier, Martin

Subjects
*STATISTICAL correlation, *PEARSON correlation (Statistics), *MEDICAL education, *RESEARCH funding, *CRONBACH'S alpha, *EDUCATIONAL outcomes, *QUESTIONNAIRES, *UNDERGRADUATES, *TEACHING methods, *HOSPITAL patients, *DESCRIPTIVE statistics, *TEACHERS, *MOTIVATION (Psychology), *ROOMS, *CLINICAL competence, *CLINICAL education, *QUALITY assurance, *LEARNING strategies, *DATA analysis software, *TIME, *VIDEO recording
Abstract

Bedside teaching (BST) is a core element of medical education. In light of a reported decrease in BST, evidence on how to use BST time most efficiently should be developed. Given that little research into the tangible quality characteristics of good BST has been reported, we investigated the influence of various teacher and structural characteristics on the perceived quality of BST. We filmed and coded 36 BSTs involving 24 lecturers and 259 students. Structural characteristics of interest were: number of students and patients, overall duration, and the proportion of clinical examination. Lecturer questionnaires provided insight into teaching experience and intrinsic motivation, and student evaluations assessed the quality of BSTs in three dimensions. Correlations are reported using the Pearson r and a linear mixed model (LMM). The intrinsic motivation of lecturers was significantly positively correlated with perceived quality, but their experience was only weakly so correlated. In the LMM, a significant association was observed for the quality dimension of clinical teaching with the number of patients and the proportion of time spent on clinical examination. Based on our findings, we recommend including multiple patients in BSTs, and providing substantial opportunities for clinical examination. Regarding lecturers, motivation matters more than experience. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome and High Bleeding Risk

Author

Lahu, Shqipdona, Presch, Antonia, Ndrepepa, Gjin, Menichelli, Maurizio, Valina, Christian, Hemetsberger, Rayyan, Witzenbichler, Bernhard, Bernlochner, Isabell, Joner, Michael, Xhepa, Erion, Hapfelmeier, Alexander, Kufner, Sebastian, Rifatov, Nonglag, Sager, Hendrik B., Mayer, Katharina, Kessler, Thorsten, Laugwitz, Karl-Ludwig, Richardt, Gert, Schunkert, Heribert, Neumann, Franz-Josef, Sibbing, Dirk, Angiolillo, Dominick J., Kastrati, Adnan, and Cassese, Salvatore

Published
2022
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