13 results on '"Elsa Moreira"'
Search Results
2. Integration of HIV in the Human Genome: Which Sites Are Preferential? A Genetic and Statistical Assessment
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Juliana Gonçalves, Elsa Moreira, Inês J. Sequeira, António S. Rodrigues, José Rueff, and Aldina Brás
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Genetics ,QH426-470 - Abstract
Chromosomal fragile sites (FSs) are loci where gaps and breaks may occur and are preferential integration targets for some viruses, for example, Hepatitis B, Epstein-Barr virus, HPV16, HPV18, and MLV vectors. However, the integration of the human immunodeficiency virus (HIV) in Giemsa bands and in FSs is not yet completely clear. This study aimed to assess the integration preferences of HIV in FSs and in Giemsa bands using an in silico study. HIV integration positions from Jurkat cells were used and two nonparametric tests were applied to compare HIV integration in dark versus light bands and in FS versus non-FS (NFSs). The results show that light bands are preferential targets for integration of HIV-1 in Jurkat cells and also that it integrates with equal intensity in FSs and in NFSs. The data indicates that HIV displays different preferences for FSs compared to other viruses. The aim was to develop and apply an approach to predict the conditions and constraints of HIV insertion in the human genome which seems to adequately complement empirical data.
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- 2016
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3. Evaluation of drought using SPEI drought class transitions and log-linear models for different agro-ecological regions of India
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Debashis Mandal, N. K. Sharma, Elsa Moreira, N. M. Alam, C. Jana, P. K. Mishra, and G.C. Sharma
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010504 meteorology & atmospheric sciences ,Markov chain ,0208 environmental biotechnology ,Primary production ,02 engineering and technology ,Seasonality ,medicine.disease ,01 natural sciences ,Confidence interval ,020801 environmental engineering ,Odds ,Geophysics ,Geochemistry and Petrology ,Climatology ,Evapotranspiration ,medicine ,Log-linear model ,Precipitation ,0105 earth and related environmental sciences ,Mathematics - Abstract
Markov chain and 3-dimensional log-linear models were attempted to model drought class transitions derived from the newly developed drought index the Standardized Precipitation Evapotranspiration Index (SPEI) at a 12 month time scale for six major drought prone areas of India. Log-linear modelling approach has been used to investigate differences relative to drought class transitions using SPEI-12 time series derived form 48 yeas monthly rainfall and temperature data. In this study, the probabilities of drought class transition, the mean residence time, the 1, 2 or 3 months ahead prediction of average transition time between drought classes and the drought severity class have been derived. Seasonality of precipitation has been derived for non-homogeneous Markov chains which could be used to explain the effect of the potential retreat of drought. Quasi-association and Quasi-symmetry log-linear models have been fitted to the drought class transitions derived from SPEI-12 time series. The estimates of odds along with their confidence intervals were obtained to explain the progression of drought and estimation of drought class transition probabilities. For initial months as the drought severity increases the calculated odds shows lower value and the odds decreases for the succeeding months. This indicates that the ratio of expected frequencies of occurrence of transition from drought class to the non-drought class decreases as compared to transition to any drought class when the drought severity of the present class increases. From 3-dimensional log-linear model it is clear that during the last 24 years the drought probability has increased for almost all the six regions. The findings from the present study will immensely help to assess the impact of drought on the gross primary production and to develop future contingent planning in similar regions worldwide.
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- 2017
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4. SPI drought class prediction using log-linear models applied to wet and dry seasons
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Elsa Moreira
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Contingency table ,010504 meteorology & atmospheric sciences ,0208 environmental biotechnology ,Forecast skill ,02 engineering and technology ,01 natural sciences ,Confidence interval ,020801 environmental engineering ,Odds ,Geophysics ,Geochemistry and Petrology ,Statistics ,Dry season ,Log-linear model ,Precipitation ,Categorical variable ,0105 earth and related environmental sciences ,Mathematics - Abstract
A log-linear modelling for 3-dimensional contingency tables was used with categorical time series of SPI drought class transitions for prediction of monthly drought severity. Standardized Precipitation Index (SPI) time series in 12- and 6-month time scales were computed for 10 precipitation time series relative to GPCC datasets with 2.5° spatial resolution located over Portugal and with 112 years length (1902–2014). The aim was modelling two-month step class transitions for the wet and dry seasons of the year and then obtain probability ratios – Odds – as well as their respective confidence intervals to estimate how probable a transition is compared to another. The prediction results produced by the modelling applied to wet and dry season separately, for the 6- and the 12-month SPI time scale, were compared with the results produced by the same modelling without the split, using skill scores computed for the entire time series length. Results point to good prediction performances ranging from 70 to 80% in the percentage of corrects (PC) and 50–70% in the Heidke skill score (HSS), with the highest scores obtained when the modelling is applied to the SPI12. The adding up of the wet and dry seasons introduced in the modelling brought improvements in the predictions, of about 0.9–4% in the PC and 1.3–6.8% in the HSS, being the highest improvements obtained in the SPI6 application.
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- 2016
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5. An exploratory study of spatial annual maximum of monthly precipitation in the northern region of Portugal
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D. Prata Gomes, Elsa Moreira, and M. Manuela Neves
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021110 strategic, defence & security studies ,Multivariate statistics ,0211 other engineering and technologies ,Magnitude (mathematics) ,02 engineering and technology ,Geostatistics ,01 natural sciences ,Field (geography) ,010104 statistics & probability ,Geophysics ,Geochemistry and Petrology ,Climatology ,Environmental science ,Precipitation ,0101 mathematics ,Spatial dependence ,Agricultural productivity ,Event (probability theory) - Abstract
Adequately analyzing and modeling the extreme rainfall events is of great importance because of the effects that their magnitude and frequency can have on human life, agricultural productivity and economic aspects, among others. A single extreme event may affect several locations, and their spatial dependence has to be appropriately taken into account. Classical geostatistics is a well-developed field for dealing with location referenced data, but it is largely based on Gaussian processes and distributions, that are not appropriate for extremes. In this paper, an exploratory study of the annual maximum of monthly precipitation recorded in the northern area of Portugal from 1941 to 2006 at 32 locations is performed. The aim of this paper is to apply max-stable processes, a natural extension of multivariate extremes to the spatial set-up, to briefly describe the models considered and to estimate the required parameters to simulate prediction maps.
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- 2016
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6. Rubella Seropositivity in Pregnant Women After Vaccination Campaign in Brazil's Federal District
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Lenora Gandolfi, Franco Batista Leite, Tamires Vital, Inês Sequeira, Elsa Moreira, Nadjar Nitz, Yanna Karla de Medeiros Nóbrega, Riccardo Pratesi, Mariana Hecht, Bruna de Carvalho, and Juliana K.B. de Andrade
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Adult ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,National Health Programs ,030106 microbiology ,Immunology ,Population ,Antibodies, Viral ,medicine.disease_cause ,Mass Vaccination ,Rubella ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Seroepidemiologic Studies ,Virology ,medicine ,Humans ,Seroprevalence ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,Seroconversion ,education ,Congenital rubella syndrome ,education.field_of_study ,business.industry ,Obstetrics ,Vaccination ,Rubella virus ,Middle Aged ,medicine.disease ,Immunoglobulin M ,Immunization ,Immunoglobulin G ,Molecular Medicine ,Female ,business ,Brazil ,Measles-Mumps-Rubella Vaccine - Abstract
Rubella is an acute viral disease that usually does not generate sequels; however, in pregnant women the infection can cause serious abnormalities to fetuses, which are collectively called congenital rubella syndrome. In Brazil, population immunization was started in 1992, but few epidemiological studies have been conducted to assess vaccination coverage and seroconversion since then. The aim of this work is to evaluate the seropositivity of pregnant women to rubella virus after vaccination campaign was carried out in 2008. Serological tests for rubella diagnosis were performed in 87 pregnant women who attended the University of Brasilia Hospital, Federal District, Brazil. Antirubella IgG antibodies were detected in 83 out of 87 pregnant women (95.4%), with an age-independent seroprevalence. Only one woman was positive in IgM serological tests. Our data suggest high levels of vaccination coverage and antirubella immunization in the Brazil Federal District population.
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- 2017
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7. Assessing drought cycles in SPI time series using a Fourier analysis
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Elsa Moreira, Diogo Martins, and Luis S. Pereira
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lcsh:GE1-350 ,Series (stratigraphy) ,010504 meteorology & atmospheric sciences ,lcsh:QE1-996.5 ,0207 environmental engineering ,lcsh:Geography. Anthropology. Recreation ,02 engineering and technology ,Biology ,01 natural sciences ,lcsh:TD1-1066 ,Monsoon rainfall ,lcsh:Geology ,lcsh:G ,North Atlantic oscillation ,13. Climate action ,Climatology ,General Earth and Planetary Sciences ,Precipitation ,lcsh:Environmental technology. Sanitary engineering ,Precipitation index ,020701 environmental engineering ,Short duration ,lcsh:Environmental sciences ,0105 earth and related environmental sciences - Abstract
In this study, drought in Portugal was assessed using 74 time series of Standardized Precipitation Index (SPI) with a 12-month timescale and 66 years length. A clustering analysis on the SPI Principal Components loadings was performed in order to find regions where SPI drought characteristics are similar. A Fourier analysis was then applied to the SPI time series considering one SPI value per year relative to every month. The analysis focused on the December SPI time series grouped in each of the three identified clusters to investigate the existence of cycles that could be related to the return periods of droughts. The most frequent significant cycles in each of the three clusters were identified and analysed for December and the other months. Results for December show that drought periodicities vary among the three clusters, pointing to a 6-year cycle across the country and a 9.4-year cycle in central and southern Portugal. Both these cycles likely show the influence of the North Atlantic Oscillation (NAO) on the occurrence and severity of droughts in Portugal. Relative to other months it was observed that cycles varied according to the common occurrence of precipitation: for the rainy months – November, December and January – cycles are similar to those for December; for the dry months – May to September – where the lack of precipitation masks the occurrence of drought, the dominant cycles are of short duration and cannot be related to the NAO or other large circulation indices to explain drought variability; for the transition months – February, March, April and October – 6-year and 3-year cycles were identified, the latter being more strongly apparent in central and southern Portugal. NAO influence is again identified relative to the 6-year cycles. The short cycles are apparently associated with positive SPI, thus with wetness, not drought. Overall, results confirm the importance of the NAO as a driving force for dry and wet periods.
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- 2015
8. Clustering of log-linear models using LRTp-values to assess homogeneous regions relative to drought class transitions
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Elsa Moreira, João T. Mexia, and Luis S. Pereira
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Statistics and Probability ,Contingency table ,Class (set theory) ,Series (mathematics) ,Applied Mathematics ,Similarity (network science) ,Modeling and Simulation ,Likelihood-ratio test ,Statistics ,Precipitation ,Log-linear model ,Statistics, Probability and Uncertainty ,Cluster analysis ,Mathematics - Abstract
In this study, a statistical method is used aiming at finding if Alentejo, southern Portugal, could be considered a homogeneous region for drought management purposes. Time series of the standardized precipitation index (SPI) were obtained for 40 locations in the region using precipitation data for the period 1932–1999 (67 years). Contingency tables for the transitions between SPI drought classes were obtained for these time series. Log-linear models were fitted to these contingency tables to estimate the probabilities for drought class transitions. An approach of model clustering, where log-linear models were clustered using the asymptotic p-value of a likelihood ratio test (LRT) for the equality of parameters between pairs of models, was applied. Two types of LRT were performed: one considering all the parameters of the log-linear model of interest; another considering just some parameters of interest. Two p-value similarity matrices were computed to find similar models that could form clusters, however...
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- 2012
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9. L models and multiple regressions designs
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João T. Mexia, Roman Zmyślony, Elsa Moreira, and Miguel Fonseca
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Statistics and Probability ,Combinatorics ,Discrete mathematics ,Matrix (mathematics) ,Column vector ,Statistics, Probability and Uncertainty ,Lambda ,Mathematics - Abstract
Given an orthogonal model $${{\bf \lambda}}=\sum_{i=1}^m{{{\bf X}}_i}{\boldsymbol{\alpha}}_i$$ an L model $${{\bf y}}={\bf L}\left(\sum_{i=1}^m{{{\bf X}}_i}{\boldsymbol{\alpha}}_i\right)+{\bf e}$$ is obtained, and the only restriction is the linear independency of the column vectors of matrix L. Special cases of the L models correspond to blockwise diagonal matrices L = D(L1, . . . , Lc). In multiple regression designs this matrix will be of the form $${\bf L}={\bf D}(\check{{\bf X}}_1,\ldots,\check{{\bf X}}_{c})$$ with \({\check{{\bf X}}_j, j=1,\ldots,c}\) the model matrices of the individual regressions, while the original model will have fixed effects. In this way, we overcome the usual restriction of requiring all regressions to have the same model matrix.
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- 2009
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10. SPI Drought Class Predictions Driven by the North Atlantic Oscillation Index Using Log-Linear Modeling
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Elsa Moreira, Carlos L. Pires, and Luis S. Pereira
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Index (economics) ,lcsh:Hydraulic engineering ,010504 meteorology & atmospheric sciences ,0208 environmental biotechnology ,Geography, Planning and Development ,Forecast skill ,02 engineering and technology ,Forcing (mathematics) ,Aquatic Science ,01 natural sciences ,Biochemistry ,Odds ,3-dimensional log-linear models ,lcsh:Water supply for domestic and industrial purposes ,lcsh:TC1-978 ,Statistics ,Precipitation ,confidence intervals ,0105 earth and related environmental sciences ,Water Science and Technology ,Mathematics ,lcsh:TD201-500 ,drought class transitions ,odds ,Confidence interval ,020801 environmental engineering ,13. Climate action ,North Atlantic oscillation ,Climatology ,Log-linear model - Abstract
This study aims at predicting the Standard Precipitation Index (SPI) drought class transitions in Portugal, considering the influence of the North Atlantic Oscillation (NAO) as one of the main large-scale atmospheric drivers of precipitation and drought fields across the Western European and Mediterranean areas. Log-linear modeling of the drought class transition probabilities on three temporal steps (dimensions) was used in an SPI time series of six- and 12-month time scales (SPI6 and SPI12) obtained from Global Precipitation Climatology Centre (GPCC) precipitation datasets with 1.0 degree of spatial resolution for 10 grid points over Portugal and a length of 112 years (1902–2014). The aim was to model two monthly transitions of SPI drought classes under the influence of the NAO index in its negative and positive phase in order to obtain improvements in the predictions relative to the modeling not including the NAO index. The ratios (odds ratio) between transitional probabilities and their confidence intervals were computed in order to estimate the probability of one drought class transition over another. The prediction results produced by the model with the forcing of NAO were compared with the results produced by the same model without that forcing, using skill scores computed for the entire time series length. Overall results have shown good prediction performance, ranging from 73% to 76% in the percentage of corrects (PC) and 56%–62% in the Heidke skill score (HSS) regarding the SPI6 application and ranging from 82% to 85% in the PC and 72%–76% in the HSS for the SPI12 application. The model with the NAO forcing led to improvements in predictions of about 1%–6% (PC) and 1%–8% (HSS), when applied to SPI6, but regarding SPI12 only seven of the locations presented slight improvements of about 0.4%–1.8% (PC) and 0.7%–3% (HSS).
- Published
- 2016
11. Analysis of SPI drought class transitions using loglinear models
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Ana A. Paulo, Luis S. Pereira, Elsa Moreira, and João T. Mexia
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Contingency table ,Climatology ,Climate change ,Class (philosophy) ,Precipitation ,Log-linear model ,Precipitation index ,Water Science and Technology ,Odds ,Mathematics - Abstract
A total period of 67 years of standardized precipitation index (SPI) data sets were divided into three periods of 22/23 years and a loglinear modeling approach has been used to investigate differences relative to drought class transitions among these three periods. The study was applied to several locations in Alentejo region, southern Portugal, and four drought severity classes were considered. The drought class transitions were computed for the three periods to form a 3-dimensional contingency table. The application of loglinear modeling to these data allowed the comparison of the three periods in terms of probabilities of transition between drought classes in order to detect a possible trend in time evolution of droughts which could be related to climate change. Results show that the drought behavior for the first and last periods is similar, both showing worse drought events than the second. If just the second and third periods were compared one could conclude that droughts were aggravating and easily this behavior could be attributed to climate change, supporting the common assumption that a trend for progressive aggravation of drought occurrence exists. Therefore, results are more consistent with the existence of a long-term natural periodicity; however, this hypothesis should be tested using longer time series.
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- 2006
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12. Regressional modeling of electrodialytic removal of Cu, Cr and As from CCA treated timber waste: application to sawdust
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Lisbeth M. Ottosen, Alexandra B. Ribeiro, Eduardo P. Mateus, Elsa Moreira, and João T. Mexia
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Cleaning agent ,Softwood ,Waste management ,Forestry ,Plant Science ,Electrodialysis ,Industrial and Manufacturing Engineering ,Matrix (chemical analysis) ,chemistry.chemical_compound ,chemistry ,visual_art ,Polynomial method ,visual_art.visual_art_medium ,Environmental science ,General Materials Science ,Statistical analysis ,Sawdust ,Chromated copper arsenate - Abstract
Waste of wood treated with chromated copper arsenate (CCA) is expected to increase in volume over the next decades. Alternative disposal options to landfilling are becoming more attractive to study, especially those that promote re-use. The authors have studied and modeled the electrodialytic (ED) removal of Cu, Cr and As from CCA treated timber waste. The method uses a low-level direct current as the “cleaning agent”, combining the electrokinetic movement of ions in the matrix with the principle of electrodialysis. The technique was tested in eight experiments using a laboratory cell on sawdust of out-of-service CCA treated Pinus pinaster Ait. poles. The experiments differ because the sawdust was saturated with different assisting agents and different percentages of them. In order to select the best assisting agent in jointly removing the three metals and subsequently the best percentage of the selected assistant agent, a statistical analysis was made. First, three experiments were selected as being the best. Second, for the selected experiments, a polynomial model was found to describe the time evolution of the total concentrations of each metal in the electrolytes. Based on this modeling, a multi-treatment regression approach was further used to select the final range of experiments.
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- 2005
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13. Monthly Prediction of Drought Classes Using Log-Linear Models under the Influence of NAO for Early-Warning of Drought and Water Management
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Ricardo M. Trigo, Elsa Moreira, Ana Russo, and CMA - Centro de Matemática e Aplicações
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Log-linear modeling ,lcsh:Hydraulic engineering ,Index (economics) ,010504 meteorology & atmospheric sciences ,0208 environmental biotechnology ,Geography, Planning and Development ,Standardized Precipitation and Evapotranspiration Index (SPEI) ,Forecast skill ,02 engineering and technology ,Aquatic Science ,01 natural sciences ,Biochemistry ,Odds ,drought classes ,Persistence ,lcsh:Water supply for domestic and industrial purposes ,lcsh:TC1-978 ,Evapotranspiration ,SDG 13 - Climate Action ,Temporal scales ,0105 earth and related environmental sciences ,Water Science and Technology ,Mathematics ,lcsh:TD201-500 ,North Atlantic Oscillation (NAO) ,Drought classes ,persistence ,Standardized Precipitation Index (SPI) ,log-linear modeling ,Confidence interval ,020801 environmental engineering ,13. Climate action ,North Atlantic oscillation ,Climatology ,Log-linear model - Abstract
SFRH/BPD/99757/2014 This work was partially supported by the projects IMDROFLOOD-Improving Drought and Flood Early Warning, Forecasting and Mitigation using real-time hydroclimatic indicators (WaterJPI/0004/2014) and project UID/MAT/00297/2013 (Centro de Matematica e Aplicacoes), both funded by funded by Fundacao para a Ciencia e a Tecnologia, Portugal (FCT). Ana Russo thanks also FCT by the Post-Doc research grant SFRH/BPD/99757/2014. Drought class transitions over a sector of Eastern Europe were modeled using log-linear models. These drought class transitions were computed from time series of two widely used multiscale drought indices, the Standardized Preipitation Evapotranspiration Index (SPEI) and the Standardized Precipitation Index (SPI), with temporal scales of 6 and 12 months for 15 points selected from a grid over the Prut basin in Romania over a period of 112 years (1902-2014). The modeling also took into account the impact of North Atlantic Oscillation (NAO), exploring the potential influence of this large-scale atmospheric driver on the climate of the Prut region. To assess the probability of transition among different drought classes we computed their odds and the corresponding confidence intervals. To evaluate the predictive capabilities of the modeling, skill scores were computed and used for comparison against benchmark models, namely using persistence forecasts or modeling without the influence of the NAO index. The main results indicate that the log-linear modeling performs consistently better than the persistence forecast, and the highest improvements obtained in the skill scores with the introduction of the NAO predictor in the modeling are obtained when modeling the extended winter months of the SPEI6 and SPI12. The improvements are however not impressive, ranging between 4.7 and 6.8 for the SPEI6 and between 4.1 and 10.1 for the SPI12, in terms of the Heidke skill score. publishersversion published
- Published
- 2018
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