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Objective: Frozen shoulder (FS) is a painful and debilitating condition affecting the shoulder joint. When patients fail to improve after conservative treatments, operative treatments including arthroscopic capsular release (ACR) and manipulation under anesthesia (MUA) are recommended. However, the comparison between these two interventions remains controversial. This study aimed to compare the efficacy and safety of ACR and MUA for refractory FS. Methods: A systematic review and meta‐analysis was conducted following the Preferred Reporting Items for Systematic Review and Meta‐analyses (PRISMA) guidelines. PubMed, EMBASE, Cochrane Library, and Web of Science were searched for eligible studies until December 10, 2023. Meta‐analyses were conducted using Manager V.5.3.3. Pooled effect sizes were expressed as the weighted mean difference (WMD) or odds ratio (OR) with 95% confidence intervals (CIs). Results: A total of eight comparative studies with 768 patients were included. Compared with MUA, ACR had statistically better Δ VAS (WMD, −0.44; 95% CI, −0.71 to −0.18; I2 = 6%; p = 0.001) at over 12‐month follow‐up, which did not reach the minimal clinically important difference (MCID). Other outcomes regarding pain relief, function, and range of motion (ROM) improvements were not statistically different between the two groups at different follow‐up timepoints. Compared with the MUA group, the ACR group had a significantly higher rate of severe complications (OR, 4.14; 95% CI, 1.01 to 16.94; I2 = 0%; p = 0.05), but comparable rates of mild complications and additional intervention. Conclusions: In treating refractory FS, ACR demonstrated comparable pain relief, functional and ROM improvements, rates of mild complications and additional intervention but a higher risk of severe complications to MUA during short‐term follow‐up periods. Notably, ACR exhibited statistically superior improvement in the long‐term pain relief compared to the MUA group, although it did not reach the MCID. [ABSTRACT FROM AUTHOR]

The direct relationship existing between the average rate constant 〈k〉 for pyrene excimer formation and the local concentration [Py]loc of ground-state pyrenyl labels covalently attached to a macromolecule was established for 55 pyrene-labeled macromolecules (PyLM). These PyLM belonged to three different families of macromolecules with the first representing short monodisperse linear chains end-labeled with pyrene (polystyrene, poly(ethylene oxide), and poly(N-isopropyl acrylamide)), the second representing long polydisperse linear chains randomly labeled with pyrene (poly(methyl acrylate), poly(methyl methacrylate), polystyrene, poly(butyl methacrylate), poly(methoxyethyl methacrylate), and poly(N-isopropyl acrylamide)), and the third being comprised of two series of pyrene end-labeled low generation dendrimers with a bis(hydroxymethyl)propionic acid or a polyamidoamine backbone. The assumption, that the polymeric segments probed by an excited pyrenyl label covalently attached to one of these macromolecules obeyed Gaussian statistics, enabled the calculation of their square root average squared end-to-end distance (LPy), which was applied to calculate [Py]loc. The log–log plots of 〈k〉 as a function of [Py]loc yielded straight lines with a slope of unity for all families of macromolecules studied in four different organic solvents demonstrating the validity and generality of the 〈k〉-vs.-[Py]loc relationship. Since an experimentalist knows how the the pyrenyl labels are covalently attached onto a macromolecule, [Py]loc offers a means to probe the local density of a macromolecule, which can be employed to characterize its conformation in solution. Consequently, the 〈k〉-vs.-[Py]loc relationship provides a novel experimental means to probe the conformation of macromolecules which should establish pyrene excimer formation as an appealing method for conformational studies of macromolecules in solution, which should nicely complement scattering techniques. [ABSTRACT FROM AUTHOR]

The purpose of the study was to evaluate the production of lignin-modifying enzyme extracts and delignified biomass from agro-industrial wastes using white rot fungi (Inonotus sp. Sp2, Stereum hirsutum Ru-104, Bjerkandera sp. BOS55, Pleurotus eryngii IJFM 169 and Phanerochaete chrysosporium BKM-F-1767). These were screened based on their adaptability and colonization ability on different substrates, as well as by the Laccase, Manganese peroxidase, and Lignin peroxidase enzymatic production. Native strains (Inonotus sp. Sp2 and S. hirsutum Ru-104) showed the highest growth kinetics under the solid-substrate fermentation conditions and the growth rate parameters of the kinetic logistic model for the different substrates were between 0.39–0.81 (1/d) and 0.42–0.83 (1/d), respectively; the determination coefficients were ≥0.99. Inonotus sp. Sp2 was subsequently cultured in static flasks to produce crude enzyme extracts, obtaining manganese peroxidase activity levels of 18.5 and 31.3 (U/g) when growing in corn cob husk and spent tea leaves, respectively. Besides, it was to establish that the best conditions for lignin-modifying enzymes production using corn cob husk are 70% of initial moisture and 2.12 mm of particle size; reaching after 30 incubation days a manganese peroxidase activity of 21 ± 6 (U/g) under these conditions; enzyme that showed a suitable thermostability. [ABSTRACT FROM AUTHOR]

Background: While Achilles tendon rupture is a common injury sustained especially in sporting events, distal Achilles tendon rupture is less common. Even rarer is a bilateral traumatic distal Achilles tendon sleeve rupture, with outcomes of such injury unknown. The following case report describes this rare injury, not reported to date elsewhere. Case: A 57-year-old Finnish man with no predisposing medical history had a traumatic bilateral distal Achilles tendon sleeve avulsion injury. Clinical and radiological evaluation confirmed the diagnosis. Treatment included suture anchors in a modified suture bridge style with customized rehabilitation protocol postoperatively. Symptoms continued to be relieved at 1 year postoperatively. Conclusion: A modified suture bridge style and meticulous rehabilitation protocol including motivated patient contributed to very satisfying results in this very rare bilateral injury. [ABSTRACT FROM AUTHOR]

The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spectrum anti-microbial activity. Compared to other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. Owing to their nano-scale, AgNPs penetrate deeper into the complexities of the root canal systems and dentinal tubules, as well as enhancing the antibacterial properties of endodontic irrigants and sealers. AgNPs gradually increase the dentin hardness in endodontically treated teeth and promote antibacterial properties when used as a carrier for intracanal medication. The unique properties of AgNPs make them an ideal additive for different endodontic biomaterials. However, the possible side effects of AgNPs, such as cytotoxicity and tooth discoloration potential, merits further research. [ABSTRACT FROM AUTHOR]

Dentinal hypersensitivity or cervical dentinal sensitivity is one of the commonest clinical problems. The aim of this randomized controlled trial was to evaluate the effectiveness of a single chair side application of 100% pure calcium sodium phosphosilicate (NovaMin®) in reducing dentin hypersensitivity following ultrasonic scaling as evaluated on a visual analogue scale (VAS). The study included 50 subjects who were selected based on an evaluation of dentinal hypersensitivity on a VAS carried out using a metered air blast from a three-way syringe and divided into two groups (n = 25/group); i.e., the test group (Group A) received the NovaMin® paste and the control group (Group B) received a placebo paste made from pumice. All the 50 subjects included in the study were had VAS scores of 3 or more. The NovaMin® powder mixed with distilled water was applied. Dentinal hypersensitivity was reassessed immediately and after 1, 2 and 4 weeks after the procedure. Results showed that the percentage reduction of dentinal hypersensitivity following a single application of NovaMin® in powder form was about 76.38% immediately, 67.72% one week postoperatively, 52.76% two weeks postoperatively and 26.78% four weeks postoperatively. It can be concluded from the results of the current clinical study demonstrated that a single chair side application of NovaMin® in powder form has a significant and immediate reduction in dentinal hypersensitivity, which lasted nearly for four weeks. [ABSTRACT FROM AUTHOR]

The objective was to compare the strain of three calcium silicate cements using an optical system based on the 3D digital image correlation method (3D-DIC). Dentine disks from 30 upper premolars were sectioned transversely to obtain 2 mm-thick sections and enlarged with a 4 mm diameter bur. An additional 30 samples were made in Teflon molds (4 × 2 mm). Dentine discs and Teflon molds were divided into three groups with ten samples each and then filled with MTA+ (Cerkamed), Biodentine (Septodont) and Well-Root PT (Vericom). The strain was determined using the 3D-DIC method in two zones: the peripheral and central zones. Data were analyzed using ANOVA with Scheffe's post hoc test, a paired t-test and Pearson correlation (α = 0.05). Analysis showed that there were significant differences in the values of deformation between all tested materials in both zones. Comparing the strain in both zones, there were significant differences between zones in the Biodentin and Well-Root PT group on dentine discs, and in the Biodentine and MTA group on Teflon discs. Comparing the strain measured on different disc types, the higher values were found on Teflon. All the examined calcium silicate-based cements showed deformation after initial setting. The highest strain was recorded for Biodentine and the lowest was for Well-Root PT. [ABSTRACT FROM AUTHOR]

In high school settings, the small learning community (SLC) concept often manifests in the form of career academies. Career academies function as SLCs organized around career and technical education (CTE) themes; although, CTE is often misunderstood. This study examined a community outreach campaign that used traditional and nontraditional advertising and marketing outlets to combat negative media attention toward career academies. All media outlets examined were effective at reaching the targeted community, yielding a positive response in calls to action. Continued research is needed to better understand how advertising and marketing can be utilized in public education, specifically with combating negative views toward CTE. [ABSTRACT FROM AUTHOR]

Traditional Chinese medicine is one of the ancient medicines which is popular in Asian countries, among which the residue produced by the use of anti-biodegradables is endless, and causes significant adverse impacts on the environment. However, the high acidity of anti-biodegradable residues and some special biological activities make it difficult for microorganisms to survive, resulting in a very low degradation rate of lignocellulose in naturally stacked residues, which directly impedes the degradation of residues. We aimed to identify the fungal strains that efficiently biodegrade anti-biodegradable residue and see the possibility to improve the biodegradation of it and other agricultural wastes by co-cultivating these fungi. We isolated 302 fungal strains from anti-biodegradable residue to test hydrolysis ability. Finally, we found Coniochaeta sp., Fomitopsis sp., Nemania sp., Talaromyces sp., Phaeophlebiopsis sp. which inhabit the anti-biodegradable residues are capable of producing higher concentrations of extracellular enzymes. Synergistic fungal combinations (viz., Fomitopsis sp. + Phaeophlebiopsis sp.; Talaromyces sp. + Coniochaeta sp. + Fomitopsis sp.; Talaromyces sp. + Fomitopsis sp. + Piloderma sp. and Talaromyces sp. + Nemania sp. + Piloderma sp.) have better overall degradation effect on lignocellulose. Therefore, these fungi and their combinations have strong potential to be further developed for bioremediation and biological enzyme industrial production. [ABSTRACT FROM AUTHOR]

Background: Anteromedial tibial plateau fracture with posterolateral corner (PLC) injury is a relatively rare combined injury in the clinic. In addition, there is no unified treatment scheme for this combined injury. The purpose of this study was to evaluate the clinical and imaging results of single-stage arthroscopic-assisted surgery for anteromedial tibial plateau fracture with PLC injury, and to explore the advantages of this surgical technique.Method: In this retrospective study, a total of 9 patients (7 males and 2 females) were included, aged 24-64 years (average 40.7 years), treated in our Department of Orthopedics from January 2016 to January 2021. In the preoperative evaluations, there were 9 cases of anteromedial tibial plateau fractures with PLC injuries, 6 cases of concomitant PCL injuries, 6 cases of concomitant medial or lateral meniscus injuries, and 2 cases of concomitant fibular head avulsion fractures. All patients underwent single-stage arthroscopic-assisted surgery.Results: All patients were followed up, and the average follow-up period was 15.2 months (range 12-18 months). The average operation time was 135.6 min (range 100-160 min), and the average surgical blood loss was 87.2 ml (range 60-110 ml). The anatomical reduction was achieved in 9 cases, and the anatomical reduction rate was 100%. The average fracture healing time was 13.1 weeks (range 12-16 weeks). At the last follow-up, the average VAS score was 1 (range 0-2); the average Lysholm function score was 90.7 (range 86-95), and the average IKDC score was 91.4 (range 88-95); the average knee extension angle of all patients was 0° and the average knee flexion angle was 128.3° (average 120-135°); The posterior drawer test, the Lachman test and the dial test were negative for all cases. None of the patients had operation-related complications.Conclusion: Single-stage arthroscopy-assisted surgery in the treatment of anteromedial tibial plateau fracture with PLC injury can achieve good clinical outcomes, restore the stability of the knee joint, and reduce the risk of severe lower extremity dysfunction. [ABSTRACT FROM AUTHOR]

Purpose: A major part of knowledge management for knowledge-intensive firms such as professional service firms is the increasing focus on thought leadership. Despite being a well-known term, it is poorly defined and analysed in the academic and practitioner literature. The aim of this article is to answer three questions. First, what is thought leadership? Second, what tensions exist when seeking to create thought leadership in knowledge-based organisations? Third, what further research is needed about thought leadership? The authors call for cross-disciplinary and academic–practitioner approaches to understanding the field of thought leadership. Design/methodology/approach: The authors review the academic and practitioner literature on thought leadership to provide a rich oversight of how it is defined and can be understood by separating inputs, creation processes and outcomes. The authors also draw on qualitative data from 12 in-depth interviews with senior leaders of professional service firms. Findings: Through analysing and building on previous understandings of the concept, the authors redefine thought leadership as follows: "Knowledge from a trusted, eminent and authoritative source that is actionable and provides valuable solutions for stakeholders". The authors find and explore nine tensions that developing thought leadership creates and propose a framework for understanding how to engage with thought leadership at the industry/macro, organisational/meso and individual/micro levels. The authors propose a research agenda based on testing propositions derived from new theories to explain thought leadership, including leadership, reducing risk, signalling quality and managing social networks, as well as examining the suggested ways to resolve different tensions. Originality/value: To the best of the authors' knowledge, they are the first to separate out thought leadership from its inputs, creation processes and outcomes. The authors show new organisational paradoxes within thought leadership and show how they can play out at different levels of analysis when implementing a thought leadership strategy. This work on thought leadership is set in a relatively under-explored context for knowledge management researchers, namely, knowledge-intensive professional service firms. [ABSTRACT FROM AUTHOR]

The paper aims to evaluate the performance of the Lagrange-based finite element method and the non-uniform rational B-splines isogeometric analysis of time-harmonic acoustic exterior scattering problems using high-order local absorbing boundary conditions, in particular based on the Karp's and Wilcox's far-field expansions. The analysis of accuracy and convergence of both methods is achieved by observing the effect of the order of the approximating polynomial, the number of degrees of freedom, the wave number, and the absorbing boundary conditions tuning parameters. It is concluded that, regardless of the polynomial order, IGA provides a higher accuracy per degree of freedom compared to the traditional Lagrange-based finite element method. [ABSTRACT FROM AUTHOR]

Production of an extracellular thermophilic and alkali stable laccase from Phoma herbarum isolate KU4 was reported for the first time, both in submerged fermentation (SmF, highest 1590 U/mL) and solid state fermentation (SSF, highest 2014.21 U/mL) using agro-industrial residues. The laccase was partially purified to 7.93 fold with the apparent molecular weight of 298 kDa. The enzyme had pH optimum at 5.0 and temperature optimum at 50 °C, with maximum stability at pH 8.0. It showed activity towards various phenolic and non-phenolic compounds. The kinetic parameters, Km, Vmax and Kcat of the laccase for DMP were 0.216 mM, 270.27 U/mg and 506.69 s−1, respectively. Laccase activity was inhibited by various metal ions and conventional inhibitors, however, it was slightly increased by Zn2+. The laccase showed good decolorization efficiency towards four industrial dyes, namely, methyl violet (75.66%), methyl green (65%), indigo carmine (58%) and neutral red (42%) within 24 h. FTIR analysis of the decolorized products confirmed the degradation of the dyes. The decolorization efficiency of the enzyme suggests that the partially purified laccase could be used to decolorize synthetic dyes present in industrial effluents and for waste water treatments. The thermophilic and alkali stable laccase may also have wider potential industrial applications. [ABSTRACT FROM AUTHOR]

The electronic and adsorption properties of the zigzag‐edged triangle graphene nanosheets with different size are investigated, including the calculation of the adsorption energy, sensitivity and recovery time after adsorbing CO2, NO2, CH4 and CO. The results show that the quantum size effect is satisfied in the triangle graphene nanosheets, and its conductivity type can be changed from p to n. In addition, the triangle graphene nanosheets with n = 5 has the highest sensitivity to NO2 (374.79%), which is more than 300 times as compared to the lowest one. The recovery time of triangle graphene nanosheets with n = 4 is the shortest, and its sensitivity and recovery time are the best at 144 K. These results reveal that the zigzag‐edged triangular graphene nanosheets can serve as the fundamental structural unit for the design of high sensitivity gas sensors. [ABSTRACT FROM AUTHOR]

Magneto‐caloric materials offer the possibility to design environmentally friendlier thermal management devices compared to the widely used gas‐based systems. The challenges to develop this solid‐state based technology lie in the difficulty of finding materials presenting a large magneto‐caloric effect over a broad temperature span together with suitable secondary application parameters such as low heat capacity and high thermal conductivity. A series of compounds derived from the PbFCl structure is investigated using a combination of computational and experimental methods focusing on the change of cell volume in magnetic and non‐magnetic ground states. Scaling analysis of the magnetic properties determines that they are second order phase transition ferromagnets and that the magnetic entropy change is driven by the coupling of magneto‐elastic strain in the square‐net through the magnetic transition determined from neutron and synchrotron X‐ray diffraction. The primary and secondary application related properties are measured experimentally, and the c/a parameter is identified as an accurate proxy to control the magnetic transition. Chemical substitution on the square‐net affords tuning of the Curie temperature over a broad temperature span between 252 and 322 K. A predictive machine learning model for the c/a parameter is developed to guide future exploratory synthesis. [ABSTRACT FROM AUTHOR]

In this work, seven indigenous macrofungal isolates were selected to screen for their laccase production capability. Among them, isolates viz., Pleurotus eryngii, Pleurotus florida, Pleurotus sajor caju and Gandoderma lucidum were found to exhibit high laccase activity in the preliminary studies and were thus selected for the optimization studies with an aim to enhance laccase production. The pH optimization studies were carried out between pH range of 4–6. The laccase activity and biomass were found to be optimum at pH 4, 4.5, 4.5 and 5 for P. eryngii, P. florida, P. sajor caju and G. lucidum, respectively. Optimization studies with chemical inducers namely, tannic acid, 2,6 dimethoxyphenol and copper sulphate at three different concentration levels were conducted and tannic acid at 2 mM concentration was found to increase the laccase activity to about 45% followed by 2,6 dimethoxyphenol (2 mM) with an increase of about 43% and copper sulphate (0.1 mM) showing 21% increase in the yield. Biodegradation studies utilizing laccase isolated from P. eryngii, P. florida and P. sajor caju was carried out for a commonly detected fluoroquinolone antibiotic, levofloxacin, in water and pharmaceutical wastewater. The results indicated that the degradation efficiency of levofloxacin using laccase isolated from P. eryngii (88.9%) was comparable to commercial laccase (89%). When the cost economics of using crude laccase was evaluated against commercial laccase it was evident that the total cost of the treatment could be reduced by 71.7% if commercial grade laccase was replaced by crude enzyme extracted from indigenous macrofungi such Pleurotus eryngii, Pleurotus florida, and Pleurotus sajor caju indicating a promising and cost-effective alternative for wastewater treatment. [ABSTRACT FROM AUTHOR]

Creative workers in media industries work under particular employment conditions and structures that can be described as "atypical employment". For most of the creative workforce, employment is not full-time, and the average annual income is low and unpredictable. It is important for the creative workforce to know that reputation plays a decisive role in overcoming barriers of entry to networks, and obstacles to employment in artistic-creative projects. Thus, it is crucial to learn how reputational capital can be built, developed, preserved and expanded. Therefore, this paper will present a theoretical framework for reputation management that demonstrates the complex cause-and-effect relationships among a creative worker's reputational capital as an intangible resource in a media network. It will be shown that a creative worker's personal branding has instrumental value for the development and maintenance of reputational capital. Moreover, this paper conceptualises reputation management based on a review of related literature for the purpose of conceptual development. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to examine the impact of microblogging word of mouth (MWOM) through twitter on value co-destruction for Athens, as a tourism destination facing a sustained crisis. The study demonstrates the sentiment and sharing evolution of tweets, illustrating the value co-destruction of a tourism destination. Overall, the study expands understanding on the online footprints of MWOM in the field of tourism. Design/methodology/approach: It uses social media focused data mining and sentiment analysis, to analyze more than 90,000 tweets posted by top twitter influencers between 2013 and 2015. The methodology that the authors have adopted follows seven steps: first, identification of the top-5 twitter influencers who use the hashtag #Athens, based on their klout score; second, collection of tweets from the top-5 twitter influencers, for the period from January 2013 until June 2015; third, collection of the retweets metadata of the above tweets and of the corresponding retweeter accounts (i.e. user id, name, screen name), together with the frequency of retweeting per tweet; fourth, collection of user metadata (i.e. location and number of followers) from the retweeter accounts; fifth, influence computation of retweetwers using their klout score; sixth, tweets classification based on the klout score of their retweeters; and seventh, sentiment analysis of the collected tweets. Findings: The findings show the high potential of value co-destruction in virtual environments, through negative MWOM related to tourism destinations in crisis, and shared among highly influencing users, that disseminate negative stories through microblogging. The findings also reveal the existence of negativity bias that can reduce the risks of visiting a new destination facing a crisis and, at the same time, significantly destroy the destination's value. Originality/value: This is the first study to examine the impact of MWOM through twitter on a tourism destination facing a sustained crisis, such as Athens. This study uses social media focused data mining and sentiment analysis, to analyze more than 90,000 tweets posted by top twitter influencers between 2013 and 2015. The findings reveal the existence of negativity bias that can reduce the risks of visiting a new destination facing a crisis and, at the same time, significantly destroy the destination's value. [ABSTRACT FROM AUTHOR]

In this paper, we introduce a methodology for improving the targeting of marketing campaigns using bridge prediction in communities based on the information of multilayer online social networks. The campaign strategy involves the identification of nodes with high brand loyalty and top-ranking nodes in terms of participation in bridges that will be involved in the evolution of the graph. Our approach is based on an efficient classification model combining topological characteristics of crawled social graphs with sentiment and linguistic traits of user-nodes, popularity in social media as well as meta path-based features of multilayer networks. To validate our approach we present a set of experimental results using a well-defined dataset from Twitter and Foursquare. Our methodology is useful to recommendation systems as well as to marketers who are interested to use social influence and run effective marketing campaigns. [ABSTRACT FROM AUTHOR]

High influential users are playing an important role in promoting information propagation in social media. Thus, it has been a very interesting problem to identify influential users in social media, and attracted numerous researchers. A great deal of research work has been devoted to solving this problem. However, the existing methods mainly focus on the network topology, ignoring users' behaviors. In this paper, we propose an High Influential Users Detection (HIUD) algorithm by analyzing users' behaviors. To evaluate the performance of our algorithm, we carry out extensive experiments on Sina and Tencent microblogging data sets, and compare it with other methods. The experimental results have shown that the HIUD achieves the best performance. Furthermore, we also make a spatial analysis on those high influential users with thermodynamic map. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to analyze the moderating effects of the social influence of the blogger and the extent to which the reader has experience of that blogger, on loyalty toward the blogger, via two variables: blogger interactive practices (BIPs) and blogger credibility. Design/methodology/approach: A quantitative empirical study was undertaken to estimate the research model. Structural equations were employed. Findings: The results show that blogger social influence moderates the relationships between BIPs and intention to recommend the blogger and blogger credibility; and between credibility and intention (to recommend the blogger and to follow their suggestions). Meanwhile, the extent of the reader's experience of the blogger moderates the relationships between BIPs and intention. Practical implications: The present work offers criteria that may be of value to bloggers and firms in assessing the extent to which the blogger's activities are effective in terms of achieving reader loyalty. The proposed variables are measured objectively online, using the Klout Index of social influence and the extent of the reader's experience of the blogger (inferred from the number of bloggers followed by the reader). Originality/value: Blogs are considered a mechanism to manage information overload in social media, and they are recognized for their influence on the reader's decision-making process. The study contributes to the knowledge-base by proposing two moderating variables of loyalty-formation: blogger social influence and the extent of the reader's experience of the blogger. [ABSTRACT FROM AUTHOR]

This study investigates the impact created upon firm value when social media, in an emerging market context. Social media enables communication with stakeholders in terms of financial and non-financial achievements, as well as issues of organization at low cost, in a direct and timely manner; thus, the study draws attention to the new phenomenon of enhanced value to firms through the use of social media. The sample consists of Turkish corporations listed on the BIST 100 Index of Borsa Istanbul for the year 2014, utilizing three metrics regarding social media usage: establishment of a social media account, the breadth of social media engagement, and the depth of social media engagement. The results demonstrate that depth of social media engagement has a significant positive association with firm value; whereas social media account ownership per se, and breadth of social media engagement do not show a viable statistical relationship. These findings imply that if social media accounts are opened and icons for several social media are placed on corporate websites, which is presently a fad and fashion, a benefit may not necessarily accrue. However, strong engagement for corporate purposes will generate the desired results and benefits. Thus, the study provides implications and guidance for firms which are using social media currently or thinking of using it in the future. [ABSTRACT FROM AUTHOR]

In this article the design and characterization of a set of novel red‐light‐emitting laser aza‐BODIPY dyes is reported. The applied synthetic method allows an exhaustive and versatile functionalization of both the dipyrrin core and the boron bridge. From the analysis of the photophysical and laser signatures, we determine the suitable modifications of the chromophoric backbone necessary to modulate the emission spectral region, efficiency and photostability under a strong irradiation regime. These dyes are endowed with efficient fluorescence and laser emission, and are particularly outstanding in terms of their high photostability, a key parameter to guarantee long‐lasting emission in any (bio)technological application. The herein‐reported results support, for the first time, the viability of aza‐BODIPYs as tunable red laser dyes. In fact, the laser performances of some of the tested aza‐BODIPYs surpass those of commercially available laser dyes in the same spectral region. Live long and glow: From the conducted computationally aided photophysical properties and the recording of the laser signatures, the structural guidelines which rule the emission properties of aza‐BODIPYs are determined. Some of the reported dyes display tunable, efficient and photostable laser emission at the red edge, surpassing the performance of commercially available laser dyes in this spectral window. [ABSTRACT FROM AUTHOR]

Abstract: We study pricing strategies of competing firms selling heterogeneous products to consumers. Goods are substitutes and there are network externalities between neighboring consumers. In equilibrium, firms price discriminate based on the network positions and charge lower prices to more central consumers. We also show that, under some conditions, firms' equilibrium profits decrease when either the network becomes denser or network effects increase. In contrast, consumers always benefit from being more connected to each other. We determine the optimal network structure and compare uniform pricing and discriminatory pricing from the perspectives of firms and consumers. [ABSTRACT FROM AUTHOR]

Abstract: Because of the crucial role of ligninolytic enzymes in a variety of industrial processes, the demand for a new effective producer has been constantly increasing. Furthermore, information on enzyme synthesis by autochthonous fungal strains is very seldom found. Two fungal strains producing ligninolytic enzymes were isolated from Bulgarian forest soil. They were identified as being Trametes trogii and T. hirsuta. These two strains were assessed for their enzyme activities, laccase (Lac), lignin peroxidase (LiP) and Mn‐dependent peroxidase (MnP) in culture filtrate depending on the temperature and the type of nutrient medium. T. trogii was selected as the better producer of ligninolytic enzymes. The production process was further improved by optimizing a number of parameters such as incubation time, type of cultivation, volume ratio of medium/air, inoculum size and the addition of inducers. The maximum activities of enzymes synthesized by T. trogii was detected as 11100 U/L for Lac, 2.5 U/L for LiP and 4.5 U/L for MnP after 14 days of incubation at 25°C under static conditions, volume ratio of medium/air 1:6, and 3 plugs as inoculum. Among the supplements tested, 5% glycerol increased Lac activity to a significant extent. The addition of 1% veratryl alcohol had a positive effect on MnP. [ABSTRACT FROM AUTHOR]

In the present investigation, we study catalytic activity of copper nanoparticles stabilized onto a nitro functionalized polystyrene resin (Cu NPs@ Nitro-Resin). The size of stabilized copper nanoparticles was found between 3 and 9 nm. This work reports a cost-effective and sustainable protocol for the synthesis of propargylamines. Herein, we have developed microwave-assisted synthesis of propargylamine from 3 components coupling of aldehyde, alkynes, and amines (A3 coupling) in truly heterogeneous catalytic system. Reaction parameters, such as solvent, catalyst concentration reaction time, and recyclability, were investigated, and reaction conditions were optimized. The present method has advantages such as environmentally benign, ease to handle, short reaction time (≈25 min), excellent yields (98%), low E-factor (0.15), and high atom economy (94%). [ABSTRACT FROM AUTHOR]

Purpose: Misinformation can have lasting impacts in the management and control of a public emergency. The purpose of this paper is to demonstrate how misinformation flows and how user characteristics can shape such flows in the context of a violent riot in Singapore. Design/methodology/approach: The authors apply the two-step flow theory and discuss the mixed methods approach involving wrangling Twitter data and descriptive analysis to develop and analyse two corpuses of misinformation related to the riot. Findings: The findings are mostly consistent with the two-step flow theory, in that misinformation flows to the masses from opinion leaders (as indicated by higher measures such as online social influence and followers/following ratio). In the presence of misinformation, tweets opposing such misinformation may not always come from opinion leaders. Practical implications: The authors work furthers knowledge about how misinformation goes viral, which provides practical implications to help policymakers and scholars in understanding and managing the dynamics and pitfalls of misinformation during an emergency. Originality/value: This paper tackles the problem of misinformation in public emergencies using a mixed methods approach and contributes to ongoing theoretical work on managing online misinformation especially in public emergencies and crises. [ABSTRACT FROM AUTHOR]

Onion storage is widely practised worldwide in accordance to their cultural and economical practice. In India, method of storage adopted mostly depends on the traditional knowledge and commonly practised methods are bag, pucca/room, tat storage, bamboo, chawl structure and the losses associated are quite higher. Sprouting, desiccation and microbial spoilage are often observed in storage and it compels to choose advanced techniques like modified ventilated structures, modified atmospheric (MA) and controlled atmospheric (CA) storage. The CA and MA storage reduces the application of chemicals for sprout inhibition by manipulating the gas composition to extend the storage period of the onions. [ABSTRACT FROM AUTHOR]

The symbiotic fungus Amylostereum areolatum is essential for growth and development of larvae of the invasive woodwasp, Sirex noctilio. In the nutrient poor xylem of pine trees, upon which Sirex feeds, it is unknown whether Amylostereum facilitates survival directly through consumption (mycetophagy) and/or indirectly through digestion of recalcitrant plant polymers (external rumen hypothesis). We tested these alternative hypotheses for Amylostereum involvement in Sirex foraging using the innate dependency of all insects on dietary sources of sterol and the unique sterols indicative of fungi and plants. We tested alternative hypotheses by using GC-MS to quantify concentrations of free and bound sterol pools from multiple life-stages of Sirex, food sources, and waste products in red pine ( Pinus resinosa). Cholesterol was the primary sterol found in all life-stages of Sirex. However, cholesterol was not found in significant quantities in either plant or fungal resources. Ergosterol was the most prevalent sterol in Amylostereum but was not detectable in either wood or insect tissue (<0.001 μg/g). Phytosterols were ubiquitous in both pine xylem and Sirex. Therefore, dealkylation of phytosterols (sitosterol and campesterol) is the most likely pathway to meet dietary demand for cholesterol in Sirex. Ergosterol concentrations from fungal-infested wood demonstrated low fungal biomass, which suggests mycetophagy is not the primary source of sterol or bulk nutrition for Sirex. Our findings suggest there is a potentially greater importance for fungal enzymes, including the external digestion of recalcitrant plant polymers (e.g., lignin and cellulose), shaping this insect-fungal symbiosis. [ABSTRACT FROM AUTHOR]

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The effect of recalcitrant soil and water pollutant 2,4,6-trinitrotoluen (TNT) on gene expression in Arabidopsis thaliana rosettes and roots was studied separately for the first time using microarrays. Seven-day exposure to TNT resulted in 170 up- and 122 down-regulated genes in the rosettes and 61 up- and 51 down-regulated genes in the roots (expression difference > 1.5-fold; p[ t test] < 0.05). TNT concentration, 5 µg/ml, was selected according to the dose response analysis and study of TNT uptake from liquid media. Although many TNT induced genes fell into ontology groups annotated as response to biotic and abiotic stresses in rosettes and roots, only a small overlap of TNT effects on transcriptome was observed between rosettes and roots. The rosettes exhibited induction of several genes associated with toxin metabolism, such as UDP-glycosyltransferases and ATP-binding cassette (ABC) family transporters. On the other side, no genes known to be involved in TNT transformation were found to be up-regulated in the roots. The genes coding for enzymes involved in the cell wall modifications were abundantly up-regulated in roots. Microarray data indicated that after a relatively long incubation with TNT (7 days), metabolism of this xenobiotic proceeded mainly in aerial parts, while its translocation into cell walls still took place in the roots. Results obtained by microarray hybridization were validated by quantitative real-time reverse-transcription PCR. Nitrate reductase 1, several glycosyltransferases and ABC transporters, sucrose-proton symporter 2, thioredoxin-dependent peroxidase 2, and gamma-glutamyltransferase are discussed for their potential to enhance detoxification and toleration capability of plants to TNT. [ABSTRACT FROM AUTHOR]

Chlorinated phenolic compounds are among the most abundant recalcitrant wastes produced by the paper and pulp industry, being accumulated in the effluents after secondary treatments. Due to their high toxicity to a wide range of organisms, chlorinated phenolic compounds pose a big concern to human and environmental health. These compounds are produced upon the partial degradation of lignin during bleaching process, and as such they are degradable by white rot fungi, the only organisms capable of degrading lignin to CO2 and H2O. White rot fungi are a group of organisms very suitable for the removal of chlorinated phenolic compounds from the environment. Indeed, they are robust, ubiquitous organisms and may survive also in the presence of high concentrations of various pollutants, even with a low bioavailability. The activity of white rot fungi is mainly due to the action of oxidoreductive enzymes, i.e., laccase, manganese peroxidase and lignin peroxidase, which are deliberately released by fungal cells into their nearby environment. In cases of secondary metabolism and oxidative stress, the fungi produce other intra- and extracellular enzymes to provide substrates for the key enzymes just mentioned. Phanerochaete chrysosporium is one of the most widely studied fungi, for which intermediary products and reactions involved in the degradation of chlorophenols have been identified. Extracellular laccases and peroxidases carry out the first productive step in the oxidation of chlorophenols, forming para-quinones and consequently releasing a chlorine atom. Further degradative steps involving several enzymes and highly reactive, nonspecific redox mediators produced by the fungus render it capable of efficiently degrading several toxic compounds. In soil environment, chlorophenols may be involved in physical-chemical processes such as polymerization and/or adsorption of/on humic substances that may hinder their degradation by microbial cells, even though both processes can result in dehalogenation of the chlorinated compounds. This review analyzes the presence of chlorophenols in the environment, their main chemical and physical properties, and the main processes in their degradation by white rot fungi with particular attention to soil environment. The reactions involved in the process, the intermediary products, the factors that may affect the fungal transformation of chlorophenols, and the possible applications for environmental purposes of both the whole fungal cells and/or their enzymes as isolated catalytic agents are also addressed. [ABSTRACT FROM AUTHOR]

The involvement of ligninolytic and cellulolytic enzymes, such as laccase, lignin peroxidase, manganese peroxidase, carboxymethylcellulase (CMCase), and filter paper activity (FPA), in the decomposition process of leaf litter driven by 6 soil-inhabiting fungi imperfecti was studied under solid-state fermentations. All the tested fungi exhibited varied production profiles of lignocellulolytic enzymes and each caused different losses in total organic matter (TOM) during decomposition. Based on the results, the 6 fungi could be divided into 2 functional groups: Group 1 includes Alternaria sp., Penicillium sp., Acremonium sp., and Trichoderma sp., and Group 2 includes Pestalotiopsis sp. and Aspergillus fumigatus. Group 1, with higher CMCase and FPA activities, showed a higher decomposition rate than the fungi of Group 2 over the first 16 d, and thereafter the cellulolytic activities and decomposition rate slowed down. Group 2 showed the maximum and significantly higher CMCase and FPA activities than those of the Group 1 fungi during the later days. This, combined with the much higher laccase activity, produced a synergistic reaction that led to a much faster average mass loss rate. These results suggest that the fungi of Group 1 are efficient decomposers of cellulose and that the fungi of Group 2 are efficient decomposers of lignocellulose. During cultivation, Pestalotiopsis sp. produced an appreciable amount of laccase activity (0.56±0.09 U/ml) without the addition of inducers and caused a loss in TOM of 38.2%±3.0%, suggesting that it has high potential to be a new efficient laccase-producing fungus. [ABSTRACT FROM AUTHOR]

To select a thermotolerant fungal strain for decolorization of wastewaters, ligninolytic enzyme production (lignin peroxidase, manganese peroxidase [MnP], and laccase), decolorization, and removal of total phenol and chemical oxygen demand (COD) were detected. Thirty-eight fungal strains were studied for enzyme production at 35 and 43°C on modified Kirk agar medium including 2,2\'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and MnCl2. Thirteen strains grew on manganese-containing agar and provided green color on ABTS-containing agar plates under culture at 43°C. Decolorization of wastewater from alcohol distillery (WAD) by these strains was compared under static culture at 43°C, and Pycnoporus coccineus FPF 97091303 showed the highest potential. Thereafter, immobilized mycelia were compared with free mycelia for WAD decolorization under culture conditions of 43°C and 100 rpm. The immobilized mycelia on polyurethane foam enhanced the ligninolytic enzyme production as well as total phenol and color removal. At about the same COD removal, MnP and laccase produced by immobilized mycelia were 2 and 19 times higher than by free mycelia; the simultaneous total phenol and color removal were 3.1 and 1.5 times higher than the latter. Moreover, decolorization of synthesis dye wastewater was carried out at 43°C and 100 rpm. More than 80% of 300 mg/L of reactive blue-5 was decolorized by the immobilized mycelia within 1 to 2 d for four cycles. [ABSTRACT FROM AUTHOR]

The formation of biodegradable hydrogels is reported based on enzymatic crosslinking reactions of modified polyaspartic acid. Poly(aspartic acid) polymers functionalized with aromatic groups were crosslinked in aqueous solution via peroxidase with hydrogen peroxide to form hydrogels. The reaction products were characterized based on time to gel, swelling ratio, sol fraction, storage and loss modulus, and entrapped enzyme. Optimum reaction conditions for gel synthesis were determined. Poly(aspartic acid) hydrogels have significant potential for use in biomedical applications such as in drug delivery due to the aqueous, non-toxic synthesis conditions as well as their inherent biodegradability by proteases. [ABSTRACT FROM AUTHOR]

There is evidence that ATM plays a wider role in intracellular signalling in addition to DNA damage recognition and cell cycle control. In this report we show that activation of the EGF receptor is defective in ataxia-telangiectasia (A-T) cells and that sustained stimulation of cells with EGF downregulates ATM protein in control cells but not in A-T cells expressing mutant protein. Concomitant with the downregulation of ATM, DNA-binding activity of the transcription factor Sp1 decreased in controls after EGF treatment but increased from a lower basal level in A-T cells to that in untreated control cells. Mutation in two Sp1 consensus sequences in the ATM promoter reduced markedly the capacity of the promoter to support luciferase activity in a reporter assay. Overexpression of anti-sense ATM cDNA in control cells decreased the basal level of Sp1, which in turn was increased by subsequent treatment of cells with EGF, similar to that observed in A-T cells. On the other hand full-length ATM cDNA increased the basal level of Sp1 binding in A-T cells, and in response to EGF Sp1 binding decreased, confirming that this is an ATM-dependent process. Contrary to that observed in control cells there was no radiation-induced change in ATM protein in EGF-treated A-T cells and likewise no alteration in Sp1 binding activity. The results demonstrate that EGF-induced downregulation of ATM (mutant) protein in A-T cells is defective and this appears to be due to less efficient EGFR activation and abnormal Sp1 regulation. Oncogene (2001) 20, 4281–4290. [ABSTRACT FROM AUTHOR]

This work explores simulations of polarized discussions from a general and theoretical premise. Specifically the question of whether a plausible avenue exists for a subgroup in an online social network to find a disagreement beneficial and what that benefit could be. A methodological framework is proposed which represents key factors that drives social media engagement including the iterative accumulation of influence and the dynamics for the asymmetric treatment of messages during a disagreement. It is shown that prior to a polarization event a trend towards a more uniform distribution of relative influence is achieved which is then reversed by the polarization event. The reasons for this reversal are discussed and how it has a plausible analogue in real world systems. A pair of inoculation strategies are proposed which aim at returning the trend towards uniform influence across users while refraining from violating user privacy (by remaining topic agnostic) and from user removal operations. [ABSTRACT FROM AUTHOR]

Laccases are copper-containing oxidase enzymes found in many fungi. They have received increasing research attention because of their broad substrate specificity and applicability in industrial processes, such as pulp delignification, textile bleaching, phenolic removal, and biosensors. In comparison with traditional submerged fermentation (SF), solid-state fermentation (SSF) is a simpler technique for laccase production and has many advantages, including higher productivity, efficiency, and enzyme stability as well as reduced production costs and environmental pollution. Here, we review recent advances in laccase production technology, with focus on the following areas: (i) Characteristics and advantages of lignocellulosic agricultural wastes used as SSF substrates of laccase production, including detailed suggestions for the selection of lignocellulosic agricultural wastes; (ii) Comparison of fungal laccase production from lignocellulosic substrates by either SSF or SF; (iii) Fungal performance and strain screening in laccase production from lignocellulosic agricultural wastes by SSF; (iv) Applications of laccase production under SSF; and (v) Suggestions and avenues for future studies of laccase production by fungal SSF with lignocellulosic materials and its applications. [ABSTRACT FROM AUTHOR]

Influence maximization in the social network becomes increasingly important due to its various benefit and application in diverse areas. In this paper, we propose DERND D-hops that adapt the radius-neighborhood degree to a directed graph which is an improvement of our previous algorithm RND d-hops. Then, we propose UERND D-hops algorithm for the undirected graph which is based on radius-neighborhood degree metric for selection of top-K influential users by improving the selection process of our previous algorithm RND d-hops. We set up in the two algorithms a selection threshold value that depends on structural properties of each graph data and thus improves significantly the selection process of seed set, and use a multi-hops distance to select most influential users with a distinct range of influence. We then, determine a multi-hops distance in which each consecutive seed set should be chosen. Thus, we measure the influence spread of selected seed set performed by our algorithms and existing approaches on two diffusion models. We, therefore, propose an analysis of time complexity of the proposed algorithms and show its worst time complexity. Experimental results on large scale data of our proposed algorithms demonstrate its performance against existing algorithms in term of influence spread within a less time compared with our previous algorithm RND d-hops thanks to a selection threshold value. [ABSTRACT FROM AUTHOR]