104 results on '"Dong‐Min Lee"'
Search Results
2. Retrospective analysis on prognosis of oral cancer patients according to surgical approaches for effective cancer ablation: swing approach versus visor approach
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Yun-Ho Kim, Jae-Young Yang, Dong-Min Lee, Jae-Yeol Lee, Dae-Seok Hwang, Mi-Heon Ryu, and Uk-Kyu Kim
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Swing approach ,Visor approach ,Oral cancer ,Prognosis ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
Abstract Background For the surgical treatment of oral cancer, it is sometimes necessary to expand intraoral access within the oral cavity. The “swing approach” that involves lip splitting of the mandible and temporary mandibular osteotomy and the “visor approach” that does not split the lower lip and mandible are mainly used. This study analyzed postoperative outcomes such as complications, recurrence rate, and survival rate by these two approaches. The goal of this study is to evaluate the surgical outcomes of patients using these two approaches, to propose effective perioperative management for oral cancer surgery, and to compare the prognosis of oral cancer patients. Materials and methods From 2005 to 2020, 29 patients who underwent surgery at the Department of Oral and Maxillofacial Surgery of Pusan National University Dental Hospital for oral cancer lesions occurred in the mandible, floor of mouth, and tongue were selected for the study. Based on the surgical approach used, a chart review was conducted on various prognostic clinical factors such as the patients’ sex and age, primary site, TNM stage, histopathologic grade, recurrence and metastasis, postoperative survival rate, adjuvant chemo-radiation therapy, satisfaction with aesthetics/function/swallowing, length of hospital stay, tracheostomy and its duration, and neck dissection and its type. Statistical analysis was conducted using SPSS 25.0 (SPSS Inc., Chicago, IL) through Fisher’s exact t-test. Result There was no statistically significant difference between two groups in terms of clinical and pathological findings, such as survival rate, the need for adjuvant therapies, and the local recurrence rate. Although better outcomes were observed in terms of function, aesthetics, and postoperative complications in the group with visor approach, there was still no statistically significant difference between two groups. However, the duration of hospital stay was shorter in the visor approach group. Conclusion There was no statistically significant difference in clinical prognostic factors between the swing approach and the visor approach. Therefore, when choosing between the two approaches for the ablation of oral cancer, it is considered to select the surgical priority approach that can be easy access based on the size and location of the lesion. The visor approach had advantages of aesthetics and healing period.
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- 2024
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3. Multi-Band NIR-Based Low-Light Image Enhancement via Dual-Teacher Cross Attention
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Jeong-Hyeok Park, Dong-Min Lee, Tae-Hyeon Kim, Tae-Sung Park, and Jong-Ok Kim
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Retinex-theory ,cross-attention ,multi-band NIR ,knowledge distillation ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Low-light images often lack visibility and information, and traditional methods of adjusting camera sensitivity and exposure time can result in visual quality degradation. In this paper, we propose a low-light enhancement method that utilizes two novel approaches to address these issues. The first approach involves using multi-band NIR (Near Infra-red) to preserve structural components, while a transformer-based cross-attention module efficiently calculates the correlation between NIR and RGB for effective fusion. The second approach involves implementing dual-teacher knowledge distillation, where normal- and mid-light teacher networks transfer low-light enhancement knowledge to the student. Our proposed method produces better color and detail restoration results than existing methods, particularly in ultra low-light environments. We also provide our own datasets for two different low-light conditions, enabling wide evaluations and ablation studies.
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- 2024
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4. An on-demand bioresorbable neurostimulator
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Dong-Min Lee, Minki Kang, Inah Hyun, Byung-Joon Park, Hye Jin Kim, Soo Hyun Nam, Hong-Joon Yoon, Hanjun Ryu, Hyun-moon Park, Byung-Ok Choi, and Sang-Woo Kim
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Science - Abstract
Abstract Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy.
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- 2023
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5. High-Q Transformer Neutralization Technique for W-Band Dual-Band LNA Using 0.1 μm GaAs pHEMT Technology
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Taejoo Sim, Dong-min Lee, Wansik Kim, Kichul Kim, Jeung Won Choi, Min-Su Kim, and Junghyun Kim
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lna ,dual-band ,gaas phemt ,transformer-based neutralization ,w-band ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Electricity and magnetism ,QC501-766 - Abstract
In this study, a dual-band low-noise amplifier (LNA) was implemented by applying a transformer-based neutralization technology to the W-band. Incorporating the neutralization technique was difficult owing to performance degradation in the W-band. However, circuit performance was enhanced thanks to the layout optimization of transformer-based neutralization networks, and the improved operation was confirmed in the W-band. The neutralization technique was implemented in four stages with a 0.1-μm gallium arsenide (GaAs) pseudomorphic high-electron-mobility-transistor monolithic microwave integrated circuit LNA. The LNA showed small signal gains of 20.3 dB and 21.7 dB and noise figures of 5.0 dB and 6.4 dB (at 84 GHz and 96 GHz, respectively) while consuming 46 mW from a 1-V supply.
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- 2023
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6. Radio frequency hyperthermia system for skin tightening effect by filled waveguide aperture antenna with compact metamaterials
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Ikhwan Kim, Dong-Min Lee, Jae-Woo Shin, Gyoun-Jung Lee, Eun-Seong Kim, and Nam-Young Kim
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RF hyperthermia ,metamaterial ,skin tightening ,beauty device ,waveguide aperture antenna ,Biotechnology ,TP248.13-248.65 - Abstract
Radio frequency (RF) hyperthermia focuses on raising the target area temperature to a value exceeding 45°C. Collagen is stimulated when the temperature rises to 45°C at the dermal layer, resulting in skin tightening. However, most studies on RF hyperthermia have focused on tumor ablation or using electrodes to radiate an electromagnetic field, which is highly inefficient. This study proposed a non-invasive RF hyperthermia skin-tightening system with a compact metamaterial-filled waveguide aperture antenna. The proposed RF system increased the temperature by 11.6°C and 35.3°C with 20 and 80 W of 2.45 GHz RF power, respectively, within 60 s and exhibited a very focused effective area. Furthermore, a metamaterial was proposed to reduce the size of the waveguide aperture antenna and focus the electromagnetic field in the near-field region. The proposed metamaterial-filled waveguide aperture antenna was compact, measuring 10 mm × 17.4 mm, with a peak gain of 2.2 dB at 2.45 GHz. The measured hyperthermia performance indicated that the proposed RF system exhibited better power- and time-efficient hyperthermia performance than other RF hyperthermia systems in the cosmetic skin lifting commercial market. The proposed RF hyperthermia systems will be applied into a new generation of beauty cosmetic devices.
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- 2024
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7. Compact Dual-Band On-Body Near Field Antenna With Reflector for Measuring Deep Core Temperature
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Ikhwan Kim, Dong-Min Lee, Min-Hyuk Cho, Yun-Joo Lee, Ji-Ho Han, Jae-Woo Shin, Hak-Yong Lee, Eun-Seong Kim, and Nam-Young Kim
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Deep core temperature measurement ,dual-band antenna ,on-body antenna ,sim4life ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Human deep core temperature is a vital health condition parameter. Human body temperature change begins from the deep core followed by change in skin temperature. Measuring deep core temperature is the first action for rapid detection of health condition. Infrared thermometer can measure temperature; however, the only measures the skin temperature. The use of microwave radiometer for measuring deep core temperature has garnered attention. The antenna, an important component of the microwave radiometer, has rarely been focused upon in studies on measurement of deep core temperature. This study proposed compact dual-band on-body near field antenna with a reflector for measuring deep core temperature using a microwave radiometer. The proposed antenna size is 13 mm $\boldsymbol {\times }\,\,13$ mm with a 20 mm $\boldsymbol {\times }\,\,20$ mm reflector 3 mm above the radiator. The proposed antenna was simulated and designed on a full 3D body model and simplified flat phantom and measured on real human wrist. It achieved sufficient bandwidth and volume loss density can be used in microwave radiometers for measuring deep core temperature.
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- 2023
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8. A Highly Integrated Radio Frequency Receiver RF CMOS Module for Core Body Temperature Thermometer
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Ikhwan Kim, Wonil Jang, Hyeon-Sik Hwang, Byeong-Jae Seo, Dong-Min Lee, Ji-Ho Han, Jae-Woo Shin, Young-Ro Yoon, Taehyoun Oh, Hyung-Chul Park, Eun-Seong Kim, Yun-Seong Eo, and Nam-Young Kim
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Dicke radiometer ,total power radiometer ,temperature sensor IC ,duty cycle modulator ,RF CMOS ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
This paper presents a highly integrated radio frequency (RF) CMOS receiver module for monitoring the core body temperature thermometer, which operates in the dual band 1.35 and 2.75 GHz ranges. The RF receiver IC, such as a Dicke radiometer, includes the full receiver circuits, RF switch and modulator, and duty calibrating circuit using a 65 nm CMOS process. With the proposed duty cycle modulation, accurate temperature sensing is achievable even with a receiver gain mismatch and fluctuation. The measured temperature ranges from 22 to 47.3°C, and the measured voltage slope is 2.97 mV/ms • °C, and the temperature error is less than 0.9°C in 1.35 GHz band. The radiometric RF CMOS IC has a size of $1.6\times2.3$ mm2 and the current consumption of 52 mW. Unlike the general skin temperature measurement of existing infrared (IR) sensors, the RF microwave core body thermometer equipped with an RF receiver IC that measures core body temperature inside a human body will be used in various fields as a digital healthcare and medical device.
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- 2023
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9. RNA-Seq of an LPS-Induced Inflammation Model Reveals Transcriptional Profile Patterns of Inflammatory Processes
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Kisung Sheen, Seokho Myung, Dong-Min Lee, Sanghyeon Yu, Yueun Choi, Taeyoon Kim, Jihan Kim, Sang-Gu Ji, Myung-Seo Kim, Wonnam Kim, Yoonsung Lee, Man S. Kim, and Yeon-Cheol Park
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LPS-induced inflammation model ,whole-blood bulk RNA-seq ,core gene list ,Science - Abstract
The LPS-induced inflammation model is widely used for studying inflammatory processes due to its cost-effectiveness, reproducibility, and faithful representation of key hallmarks. While researchers often validate this model using clinical cytokine markers, a comprehensive understanding of gene regulatory mechanisms requires extending investigation beyond these hallmarks. Our study leveraged multiple whole-blood bulk RNA-seq datasets to rigorously compare the transcriptional profiles of the well-established LPS-induced inflammation model with those of several human diseases characterized by systemic inflammation. Beyond conventional inflammation-associated systems, we explored additional systems indirectly associated with inflammatory responses (i.e., ISR, RAAS, and UPR) using a customized core inflammatory gene list. Our cross-condition-validation approach spanned four distinct conditions: systemic lupus erythematosus (SLE) patients, dengue infection, candidemia infection, and staphylococcus aureus exposure. This analysis approach, utilizing the core gene list aimed to assess the model’s suitability for understanding the gene regulatory mechanisms underlying inflammatory processes triggered by diverse factors. Our analysis resulted in elevated expressions of innate immune-associated genes, coinciding with suppressed expressions of adaptive immune-associated genes. Also, upregulation of genes associated with cellular stresses and mitochondrial innate immune responses underscored oxidative stress as a central driver of the corresponding inflammatory processes in both the LPS-induced and other inflammatory contexts.
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- 2024
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10. A graphene nanoplatelets-based high-performance, durable triboelectric nanogenerator for harvesting the energy of human motion
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Irfan Shabbir, Dong-Min Lee, Dong Chul Choo, Yong Hun Lee, Kwan Kyu Park, Keon Ho Yoo, Sang-Woo Kim, and Tae Whan Kim
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Graphene nanoplatelet ,Surface abrasion ,Triboelectric nanogenerators ,Sliding mode ,Gesture recognition ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Triboelectric nanogenerators (TENGs) have been widely investigated to harness mechanical energy that is driven by repetitive human motion. Conventional human motion-driven TENGs are mostly based on contact–separation (CS) mode, but their energy harvesting performance is limited due to the high crest factor (the ratio of the peak to the RMS value of output voltage). Here, we demonstrate a new rolling type triboelectric nanogenerator (RL-TENG), exhibiting the lower crest factor than CS mode TENGs, using a metal layer and graphene nanoplatelets-doped PDMS. These additions helped improve the dielectric constant and the charge storage capacity of the TENG, which led to a high electrical output while minimizing surface damage. As compared to a pristine TENG, our device, a RL-TENG, generated an open-circuit peak voltage of 75.2 V, which was almost 15 times higher than that of the pristine device, and a short-circuit peak current of 7.36μA, which was 12 times higher. With a dual-side double-belt TENG (DB-TENG), these values were improved to 164 V and 10μA. Lastly, our device was used in a real-life application, to harvest mechanical energy from the movement of the human elbow while walking, and was able to produce a high voltage output of up to 821 V. These results show that the DB-TENG can be used for high-efficiency harvesting of energy from human motion.
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- 2022
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11. Dual-Band On-Body Near Field Antenna for Measuring Deep Core Temperature With a Microwave Radiometer
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Ikhwan Kim, Dong-Min Lee, Yun-Joo Lee, Jae-Woo Shin, Eun-Seong Kim, Hakyoung Lee, and Nam-Young Kim
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Deep core temperature measurement ,dual-band antenna ,on-body antenna ,microwave radiometer ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Deep core temperature is the most basic and important information about health conditions. Non-contact infrared thermometers are widely used for human body temperature measurement. However, infrared thermometers are not suitable for deep core temperature measurement. To overcome this limitation, measuring deep core temperature with a microwave radiometer is gaining attention. In this study, we propose a dual-band on-body near-field antenna for measuring deep core temperature with a microwave radiometer application. The proposed antenna has a compact size of 20 mm $\times30$ mm $\times1.52$ mm. The negative (−) radiator is located at the top of the substrate and the positive (+) radiator is located at the bottom of the substrate. The dual-band is proposed for high temperature resolution and is achieved by a meander slot on the radiator. The antenna is fabricated on a high dielectric substrate and the stubs are proposed to reduce the size of the proposed antenna so that it can be used on various human body parts.
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- 2022
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12. Fatigue life evaluation of socket welded pipe with incomplete penetration defect: I-test and FE analysis
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Dong-Min Lee, Seung-Jae Kim, Hyun-Jae Lee, and Yun-Jae Kim
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Socket welded pipe ,Incomplete penetration defect ,Fatigue test ,Finite element analysis ,Stress analysis ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
This paper presents experimental and numerical analysis results regarding the effects of an incomplete penetration defect on the fatigue lives of socket welded pipes. For the experiment, four-point bending fatigue tests with various defect geometries (defect depth and circumferential length) were performed, and test results are presented in terms of stress-life data. The results showed that for circumferentially short defects, the fatigue life tends to increase with increasing crack depth, but for longer defects, the trend becomes the opposite. Finite element analysis showed that for short defects, the maximum principal stress decreases with increases in crack depth. For a longer defect, the opposite trend was found. Furthermore, the maximum principal stress tends to increase with an increase in defect length regardless of the defect depth.
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- 2021
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13. Triboelectrification induced self-powered microbial disinfection using nanowire-enhanced localized electric field
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Zheng-Yang Huo, Young-Jun Kim, In-Yong Suh, Dong-Min Lee, Jeong Hwan Lee, Ye Du, Si Wang, Hong-Joon Yoon, and Sang-Woo Kim
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Science - Abstract
Air-transmitted pathogens are a recognized threat to public health. Here, the authors develop a self-powered, rapid disinfection method toward air-transmitted microbes using the localized electric field to damage the outer structures of microbes driven by a triboelectric nanogenerator.
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- 2021
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14. Automated Detection of Periodontal Bone Loss Using Deep Learning and Panoramic Radiographs: A Convolutional Neural Network Approach
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Jihye Ryu, Dong-Min Lee, Yun-Hoa Jung, OhJin Kwon, SunYoung Park, JaeJoon Hwang, and Jae-Yeol Lee
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artificial intelligence ,deep learning ,diagnostic imaging ,periodontitis ,periodontal bone loss ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
(1) Background: The accurate diagnosis of periodontal disease typically involves complex clinical and radiologic examination. However, recent studies have demonstrated the potential of deep learning in improving diagnostic accuracy and reliability through the development of computer-aided detection and diagnosis algorithms for dental problems using various radiographic sources. This study focuses on the use of panoramic radiographs, which are preferred due to their ability to assess the entire dentition with a single radiation dose. The objective is to evaluate whether panoramic radiographs are a reliable source for the detection of periodontal bone loss using deep learning, and to assess its potential for practical use on a large dataset. (2) Methods: A total of 4083 anonymized digital panoramic radiographs were collected using a Proline XC machine (Planmeca Co., Helsinki, Finland) in accordance with the research ethics protocol. These images were used to train the Faster R-CNN object detection method for detecting periodontally compromised teeth on panoramic radiographs. (3) Results: This study demonstrated a high level of consistency and reproducibility among examiners, with overall inter- and intra-examiner correlation coefficient (ICC) values of 0.94. The Area Under the Curve (AUC) for detecting periodontally compromised and healthy teeth was 0.88 each, and the overall AUC for the entire jaw, including edentulous regions, was 0.91. (4) Conclusions: The regional grouping of teeth exhibited reliable detection performance for periodontal bone loss using a large dataset, indicating the possibility of automating the diagnosis of periodontitis using panoramic radiographs.
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- 2023
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15. The Potential and Merits of Narrative-Based Virtual Fieldwork in Preservice Geography Teacher Education
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Dong-Min Lee
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virtual fieldwork ,preservice geography teacher education (PGTE) ,narrative-based virtual fieldwork (NVF) ,narrative-based geospatial technologies (NGSTs) ,Story Maps ,Education - Abstract
The purpose of this study is to analyze the potential and merits of narrative-based virtual fieldwork in preservice geography teacher education. Virtual fieldwork can effectively complement, implement, and foster fieldwork. In addition, narrative is closely related to fieldwork. To proceed with the research, this study developed a travel geography class for PGTs (primary geography teachers) that included narrative-based fieldwork assignments. This study deduced four themes to illuminate the potential of narrative-based virtual fieldwork (NVF) by using a phenomenographic analysis of the reflective journals written by the participating preservice geography teachers who completed their NVF assignments. The results of this study suggested that the NVF possibly involves the PGTs’ engagement in, procedural and contextual understanding of, and teaching knowledge of virtual fieldwork thanks to its specific characteristic of integrating narrative and virtual fieldwork. The results of this study provide concrete discussions on the potential and merits of NVF in PGTE.
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- 2023
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16. Mixed Triboelectric and Flexoelectric Charge Transfer at the Nanoscale
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Huimin Qiao, Pin Zhao, Owoong Kwon, Ahrum Sohn, Fangping Zhuo, Dong‐Min Lee, Changhyo Sun, Daehee Seol, Daesu Lee, Sang‐Woo Kim, and Yunseok Kim
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atomic force microscopy ,charge transfer ,flexoelectricity ,triboelectricity ,Science - Abstract
Abstract The triboelectric effect is a ubiquitous phenomenon in which the surfaces of two materials are easily charged during the contact‐separation process. Despite the widespread consequences and applications, the charging mechanisms are not sufficiently understood. Here, the authors report that, in the presence of a strain gradient, the charge transfer is a result of competition between flexoelectricity and triboelectricity, which could enhance charge transfer during triboelectric measurements when the charge transfers of both effects are in the same direction. When they are in the opposite directions, the direction and amount of charge transfer could be modulated by the competition between flexoelectric and triboelectric effects, which leads to a distinctive phenomenon, that is, the charge transfer is reversed with varying forces. The subsequent results on the electrical power output signals from the triboelectrification support the proposed mechanism. Therefore, the present study emphasizes the key role of the flexoelectric effect through experimental approaches, and suggests that both the amount and direction of charge transfer can be modulated by manipulating the mixed triboelectric and flexoelectric effects. This finding may provide important information on the triboelectric effect and can be further extended to serve as a guideline for material selection during a nanopatterned device design.
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- 2021
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17. Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty
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Dong-Min Lee and In-Hyuk Chung
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Precocious puberty ,Gonadotropin-releasing hormone stimulation test ,Gonadotropin-releasing hormone ,Luteinizing hormone ,Bone age ,Pediatrics ,RJ1-570 - Abstract
Purpose The standard method used to diagnose central precocious puberty (CPP) is the gonadotropin releasing hormone stimulation test (GnRHST). However, this test is inconvenient for children because it is time-consuming and requires multiple samples. This study aimed to determine the reliability of morning unstimulated luteinizing hormone (mLH) level when screening for CPP, with an emphasis on the influence of diurnal variation. Methods This study included 160 girls with signs of early puberty (SMR 2) under 8 years of age. They were classified as CPP or non-CPP based on their standard GnRHST. The auxological, biochemical, and hormonal characteristics of subjects were retrospectively evaluated. The prognostic value of single morning unstimulated gonadotropin level was examined for use in CPP screening. Results Of 160 patients, 121 (75.6%) presented with CPP, and 39 (24.4%) were determined to be prepubertal. The mLH/mFSH (morning unstimulated follicular stimulating hormone) ratio showed significant differences between the 2 groups (P
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- 2019
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18. Solar-induced hybrid energy harvesters for advanced oxidation water treatment
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Zheng-Yang Huo, Dong-Min Lee, Young-Jun Kim, and Sang-Woo Kim
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Energy Resources ,Energy sustainability ,Energy systems ,Science - Abstract
Summary: Water treatment based on advanced oxidation processes (AOPs) supplies clean water to rural areas lacking electric power supply and/or during natural disasters and pandemics. Considering the abundance of solar energy in the ambient environment, the solar-driven AOPs show an interesting potential to driving the water purification process. Involving the energy harvester (EH) that harvests mechanical or thermal energy into electricity to the solar-driven AOPs can achieve sustainable and self-powered water purification. Herein, we summarize the recent progress in the application of solar-induced hybrid EHs that harvest solar and mechanical/thermal energy simultaneously to drive AOP water treatment. A detailed discussion of the solar-induced hybrid EHs enabling AOP water treatment based on the mechanisms of piezo-, tribo-, pyro-, and thermo-assisted photocatalysis is provided. In addition, this paper explores future opportunities and strategies of the solar-induced hybrid EHs to drive the AOP water treatment in actual situations with unstable and fluctuating environmental conditions.
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- 2021
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19. Design and Micro-Nano Fabrication of a GaAs-Based On-Chip Miniaturized Bandpass Filter with Intertwined Inductors and Circinate Capacitor Using Integrated Passive Device Technology
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Jian Chen, Bao-Hua Zhu, Shan Yang, Wei Yue, Dong-Min Lee, Eun-Seong Kim, and Nam-Young Kim
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gallium arsenide ,air-bridge structure ,bandpass filter ,capacitor ,inductor ,integrated passive device ,Chemistry ,QD1-999 - Abstract
In this study, we propose a miniaturized bandpass filter (BPF) developed by combining an approximate circular (36-gon) winding inductor, a circinate capacitor, and five air-bridge structures fabricated on a gallium arsenide (GaAs) substrate using an integrated passive device (IPD) technology. We introduced air-bridge structures into the outer metal wire to improve the capacitance per unit volume while utilizing a miniaturized chip with dimensions 1538 μm × 800 μm (0.029 λ0 × 0.015 λ0) for the BPF. The pattern was designed and optimized by simulating different dimensional parameters, and the group delay and current density are presented. The equivalent circuit was modeled to analysis various parasitic effect. Additionally, we described the GaAs-based micro-nano scale fabrication process to elucidate the proposed IPD technology and the physical structure of the BPF. Measurements were conducted with a center frequency of 1.53 GHz (insertion loss of 0.53 dB) and a 3-dB fractional bandwidth (FBW) of 70.59%. The transmission zero was located at 4.16 GHz with restraint of 35.86 dB. Owing to the benefits from its miniaturized chip size and high performance, the proposed GaAs-based IPD BPF was verified as an excellent device for various S-band applications, such as satellite communication, keyless vehicle locks, wireless headphones, and radar.
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- 2022
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20. A very small amount (0.1 wt%) of Co(OH)2 nanoplates enhances triboelectric performance of polymers.
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Jina Park, Inah Hyun, Yoon Kee Kim, Hanbyeol Jung, Dong-Min Lee, Sang-Woo Kim, and Seung Uk Son
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Hexagonal Co(OH)
2 nanoplates with a diameter of 1.28 ± 0.08 mm and a thickness of 52 ± 14 nm were prepared, showing facile generation of static electricity in a plastic container. Based on this observation, Co(OH)2 nanoplates were incorporated into polymer matrixes such as polyvinylpyrrolidone (PVP) and polyurethane (PU). The resultant PVP– Co(OH)2 (PVP–Co) and PU–Co(OH)2 (PU–Co) films bearing an optimal amount (0.1 wt%) of Co(OH)2 nanoplates showed dramatically-enhanced triboelectric performance, compared with pristine polymer films. While PVP and PU films exhibited output peak-to-peak voltages (Vp–p ) of 249 and 423 V and output peak-to-peak currents (Ip–p ) of 23 and 60 mA, respectively, with a pushing force of 2 kg f, the PVP–Co0.1 and PU–Co0.1 films showed Vp–p of 407 and 612 V with Ip–p of 41 and 85 mA, respectively. Triboelectric devices fabricated with PVP–Co0.1 and PU–Co0.1 films showed the maximum power densities of 0.38 and 1.22 mW cm−2 , respectively, and worked as power sources to charge a capacitor and to operate LEDs and a calculator. We suggest that the enhanced triboelectric performance of PVP– Co0.1 and PU–Co0.1 is attributable to the facile oxidation of Co2+ to Co3+ in Co(OH)2 nanoplates. [ABSTRACT FROM AUTHOR]- Published
- 2024
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21. Combined Anterolateral Ligament and Anterior Cruciate Ligament Injury Is Associated With Increased Lateral Femoral Condyle Ratio
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Nam-Hong Choi, Dong-Min Lee, Hee-Jong Shin, and Brian N. Victoroff
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Orthopedics and Sports Medicine - Abstract
to investigate the association between the lateral femoral condylar ratio (LFCR), the posterior tibial slope (PTS), and injury of the anterolateral ligament (ALL).Inclusion criteria were patients with acute anterior cruciate ligament (ACL) tear after noncontact injury during sports from October 1997 to May 2021. The LFCR and PTS were measured, and injury of the ALL was evaluated. Patients were divided into 2 groups: isolated ACL tear (isolated group) and combined ACL with ALL tear (combined group). The LFCR and PTS were compared between the isolated and combined groups. For each risk factor, the receiver operating characteristic curve, the area under the curve (AUC), and its 95% confidence interval (CI) were calculated to determine the cutoff for detecting increased risk of ALL injury.There were 83 patients in the isolated group and 176 patients in the combined group. Demographics of the 2 groups did not differ significantly. The LFCR was significantly larger in the combined group than in the isolated group (P = .000). The PTS did not differ between the two groups (P = .405). The LFCR (odds ratio [OR] = 1.58; P = .000) was a significant factor. Age, body mass index, and PTS were not associated with an ALL injury. The AUC (0.79; 95% CI, 0.74-0.85) for the LFCR had a sensitivity of 73% and specificity of 76% to predict an ALL rupture. The calculated cutoff of 64.5 was associated with an increased risk for ALL rupture (OR = 8.65; 95% CI, 4.73-15.81) when compared with the isolated group.An increased LFCR was associated with the ALL injury. However, increased PTS was not associated with ALL injury. These findings need to be considered for clinicians in treating ACL tear patients at risk for an ALL injury.III, retrospective comparative prognostic trial.
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- 2023
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22. Micropipette tip intubation in rats as a replacement for conventional endotracheal tube intubation
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Myung-Good Kim, eong-Ho Ryu, Dong Min Lee, Tae-Seo Park, and Ji-An Choi
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Otorhinolaryngology ,Surgery - Abstract
Endotracheal intubation is often necessary in the course of animal experiments, especially in craniofacial surgery. However, endotracheal intubation can be a major burden in this context. The authors performed simple and cost-saving method using a 200 μL yellow micropipette tip, and the success of this method was demonstrated by X-ray and autopsy. We used a total of 30 rats. After the rats were fixed with a plaster, the trachea and vocal cords were visualized with the tongue pulled back. Under direct visualization of the vocal cords, a curving micropipette tip was advanced into the trachea. This method can be learned quickly and applied successfully by general experimenters. We successfully intubated all 30 rats without any complications. The success rate of micropipette tip intubation was 100%. This procedure was performed by one experimenter within 2 to 3 minutes after induction of anesthesia. We demonstrated its superiority by X-ray and autopsy. Herein, we describe endotracheal intubation of rats using micropipette tips. To the best of our knowledge, this method is novel and represents the simplest and most efficient means of intubation in rats, providing an alternative to conventional endotracheal intubation.
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- 2023
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23. Electric-field-driven interfacial trapping of drifting triboelectric charges via contact electrification
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Jin-Kyeom Kim, Gi Hyeon Han, Sun-Woo Kim, Hee Jun Kim, Rahul Purbia, Dong-Min Lee, Jong Kyu Kim, Hee Jae Hwang, Hyun-Cheol Song, Dukhyun Choi, Sang-Woo Kim, Zhong Lin Wang, and Jeong Min Baik
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Nuclear Energy and Engineering ,Renewable Energy, Sustainability and the Environment ,Environmental Chemistry ,Pollution - Abstract
A new facile strategy to maximize the charge density over 1000 μC m−2 for a high-output TENG is demonstrated by introducing new physics in contact electrification, i.e. ‘Electric-field-driven interfacial trapping of drifting triboelectric charges’.
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- 2023
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24. Effects of molecular ordering on circularly polarized emission from a twisted mesogenic conjugated polymer
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Dong-Min Lee, Gi-Eun Kim, Jae-Hoon Kim, and Chang-Jae Yu
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Materials Chemistry ,General Chemistry - Abstract
The measured EL g factors (symbols) were fitted with a quadratic equation of the order parameter in the twisted configuration of a mesogenic conjugate polymer (F8BT) doped with various concentrations of a chiral dopant (R5011).
- Published
- 2023
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25. ISRIB plus bortezomib triggers paraptosis in breast cancer cells via enhanced translation and subsequent proteotoxic stress
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Dong Min Lee, Min Ji Seo, Hong Jae Lee, Hyo Joon Jin, and Kyeong Sook Choi
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Cyclohexylamines ,Cell Death ,Cell Survival ,Biophysics ,Apoptosis ,Breast Neoplasms ,Drug Synergism ,Cell Biology ,Endoplasmic Reticulum Stress ,Biochemistry ,Cell Line ,Bortezomib ,Cell Line, Tumor ,Protein Biosynthesis ,Acetamides ,MCF-7 Cells ,Proteostasis ,Unfolded Protein Response ,Humans ,Female ,Multiple Myeloma ,Proteasome Inhibitors ,Molecular Biology - Abstract
Despite the success of proteasome inhibitors (PIs) in treating hematopoietic malignancies, including multiple myeloma (MM), their clinical efficacy is limited in solid tumors. In this study, we investigated the involvement of the integrated stress response (ISR), a central cellular adaptive program that responds to proteostatic defects by tuning protein synthesis rates, in determining the fates of cells treated with PI, bortezomib (Bz). We found that Bz induces ISR, and this can be reversed by ISRIB, a small molecule that restores eIF2B-mediated translation during ISR, in both Bz-sensitive MM cells and Bz-insensitive breast cancer cells. Interestingly, while ISRIB protected MM cells from Bz-induced apoptosis, it enhanced Bz sensitivity in breast cancer cells by inducing paraptosis, the cell death mode that is accompanied by dilation of the endoplasmic reticulum (ER) and mitochondria. Combined treatment with ISRIB and Bz may shift the fate of Bz-insensitive cancer cells toward paraptosis by inducing translational rescue, leading to irresolvable proteotoxic stress.
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- 2022
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26. Improving Long‐Term Stability of Kesterite Thin‐Film Solar Cells with Oxide/Metal/Oxide Multilayered Transparent Conducting Electrodes
- Author
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Jun Sung Jang, Vijay C. Karade, Mahesh P. Suryawanshi, Dong Min Lee, Jihun Kim, Suyoung Jang, Myeong Cheol Baek, Mingrui He, Jin Hyeok Kim, and Seung Wook Shin
- Subjects
Energy Engineering and Power Technology ,Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2023
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27. Cell activity manipulation through optimizing piezoelectricity and polarization of diphenylalanine peptide nanotube-based nanocomposite
- Author
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Huiling Guo, Dong-Min Lee, Pin Zhao, So-Hee Kim, Inah Hyun, Byung-Joon Park, Ju-Hyuck Lee, Huajun Sun, and Sang-Woo Kim
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
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28. A Phenomenological Approach to Understanding the Meaning and Characteristics of Primary Geography Teacher-Researcher Identities
- Author
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Dong-min Lee
- Subjects
Geography, Planning and Development ,Meaning (existential) ,Phenomenology (psychology) ,Earth-Surface Processes ,Epistemology - Abstract
This study aimed to interpret the meaning of primary geography teacher-researcher identities (PGTRIs) using phenomenology according to van Manen. Four emerging themes explained the meaning and char...
- Published
- 2021
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29. Free vibration analysis of axially moving beams using the transfer matrix method
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Jung Woo Lee, Jung Youn Lee, and Dong Min Lee
- Subjects
Physics ,Timoshenko beam theory ,0209 industrial biotechnology ,Differential equation ,Mechanical Engineering ,Transfer-matrix method (optics) ,02 engineering and technology ,Mechanics ,Fundamental frequency ,Vibration ,020303 mechanical engineering & transports ,020901 industrial engineering & automation ,Critical speed ,0203 mechanical engineering ,Mechanics of Materials ,Axial symmetry ,Beam (structure) - Abstract
A tractable transfer matrix method based on the classical beam theory is developed and is subsequently used to investigate the effects of the axial tensile load and moving speed on the natural frequencies of axially moving beams under three different end conditions. The differential equation for the proposed method is solved in a closed analytical form. The transfer matrix method is derived from the relationship between displacements and forces specified at both ends of the axially moving beam. The accuracy of the method is validated through a comparison between the predicted results and those of previous studies. The critical speed for the fundamental frequency of an axially moving beam is analyzed by investigating the moving speed value in the vicinity of divergence instability. The numerical results for the end conditions considered provide useful information for capturing the divergence instability.
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- 2021
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30. Removal of an intraosseous hemangioma of the frontal bone through an anterior hairline incision: a case report.
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Myung-Good Kim, Jeong-Ho Ryu, Dong Min Lee, Tae-Seo Park, Ji-An Choi, Keun-Cheol Lee, and Song-Hee Han
- Subjects
FRONTAL bone ,HEMANGIOMAS ,COMPUTED tomography - Abstract
An intraosseous hemangioma of the frontal bone is typically removed via a coronal incision. This procedure, while effective, can be lengthy and may result in complications such as a prominent scar and hair loss. An alternative approach involves a direct incision in the forehead, which leaves a less noticeable scar and allows a quicker recovery. However, in this specific case, the patient declined both coronal surgery and surgery through a direct forehead incision due to cosmetic concerns. Therefore, we proposed an anterior hairline incision. A 35-year-old woman presented with a firm, non-mobile, palpable mass on her right forehead. Preoperative non-contrast computed tomography revealed a heterogeneous osteolytic lesion. We performed an excisional biopsy through the anterior hairline. Postoperative non-contrast computed tomography was conducted 2 and 6 months after surgery. The wound was clean and free of complications, and there was no local recurrence. Partial resection can reduce scarring for patients who are concerned about cosmetic outcomes. However, the potential for recurrence remains a significant concern. We present this case of an anterior hairline incision for a hemangioma located in the forehead, evaluated using serial computed tomography for both preoperative and postoperative imaging. Abbreviation: CT, computed tomography. [ABSTRACT FROM AUTHOR]
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- 2023
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31. Triboelectric energy harvesting using conjugated microporous polymer nanoparticles in polyurethane films
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Yoon-Joo Ko, Hae Jin Kim, Dong-Min Lee, Sang Moon Lee, Sang-Woo Kim, Seung Uk Son, Seong In Park, and Chang Wan Kang
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Electrolytic capacitor ,Materials science ,Renewable Energy, Sustainability and the Environment ,Nanoparticle ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,Conjugated microporous polymer ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,Nano ,General Materials Science ,0210 nano-technology ,Energy harvesting ,Triboelectric effect ,Light-emitting diode ,Polyurethane - Abstract
This work introduces, for the first time, the energy harvesting performance of conjugated microporous polymers (CMPs) as tribo-positive materials for triboelectric nanogenerators (TENGs). Various nano or submicron CMP particles (CMP-X) were prepared by the Sonogashira coupling of 1,3,5-triethynylbenzene with 1,4-diiodoarenes. Optimized CMP-X nanoparticles in a polyurethane (PU) matrix showed excellent triboelectrification performance, displaying peak-to-peak voltages of up to 411 V and a maximum power density of 0.80 mW cm−2. Moreover, an optimized 5.0% CMP-H@PU-based TENG could be utilized as a power source for the charging of an electrolytic capacitor and for the operation of 100 LEDs.
- Published
- 2021
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32. Ultrasound‐Driven Injectable and Fully Biodegradable Triboelectric Nanogenerators
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Xiao Xiao, Xiangchun Meng, Dabin Kim, Sera Jeon, Byung‐Joon Park, Daniel Sanghyun Cho, Dong‐Min Lee, and Sang‐Woo Kim
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General Materials Science ,General Chemistry - Published
- 2023
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33. PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca2+ Imbalance
- Author
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Hong-Jae Lee, Dong-Min Lee, Min-Ji Seo, Ho-Chul Kang, Seok-Kyu Kwon, and Kyeong-Sook Choi
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Inorganic Chemistry ,PSMD14 ,paraptosis ,proteasome ,proteostasis ,Ca2+ imbalance ,Organic Chemistry ,General Medicine ,Physical and Theoretical Chemistry ,Molecular Biology ,Spectroscopy ,Catalysis ,Computer Science Applications - Abstract
PSMD14, a subunit of the 19S regulatory particles of the 26S proteasome, was recently identified as a potential prognostic marker and therapeutic target in diverse human cancers. Here, we show that the silencing and pharmacological blockade of PSMD14 in MDA-MB 435S breast cancer cells induce paraptosis, a non-apoptotic cell death mode characterized by extensive vacuolation derived from the endoplasmic reticulum (ER) and mitochondria. The PSMD14 inhibitor, capzimin (CZM), inhibits proteasome activity but differs from the 20S proteasome subunit-inhibiting bortezomib (Bz) in that it does not induce aggresome formation or Nrf1 upregulation, which underlie Bz resistance in cancer cells. In addition to proteasome inhibition, the release of Ca2+ from the ER into the cytosol critically contributes to CZM-induced paraptosis. Induction of paraptosis by targeting PSMD14 may provide an attractive therapeutic strategy against cancer cells resistant to proteasome inhibitors or pro-apoptotic drugs.
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- 2022
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34. High performance direct current-generating triboelectric nanogenerators based on tribovoltaic p-n junction with ChCl-passivated CsFAMA perovskite
- Author
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You-Sun Lee, Sera Jeon, Dabin Kim, Dong-Min Lee, Dohyung Kim, and Sang-Woo Kim
- Subjects
Renewable Energy, Sustainability and the Environment ,General Materials Science ,Electrical and Electronic Engineering - Published
- 2023
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35. Bifunctional catalytic activity of Ni–Co layered double hydroxide for the electro-oxidation of water and methanol
- Author
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Komal Patil, Vijay Karade, Eunae Jo, Pravin Babar, Sumit Korade, Jin Hyeok Kim, and Dong Min Lee
- Subjects
Materials science ,Electrolysis of water ,Renewable Energy, Sustainability and the Environment ,Oxygen evolution ,Energy Engineering and Power Technology ,Overpotential ,Electrocatalyst ,Catalysis ,chemistry.chemical_compound ,Fuel Technology ,chemistry ,Chemical engineering ,Saturated calomel electrode ,Hydroxide ,Bifunctional - Abstract
The development of nanostructured architectures using low-cost first–row transition metals with high electrocatalytic activity to replace noble-metal-based electrocatalysts has recently gained considerable attention in the field of clean and sustainable energy generation technology. In this study, highly efficient, binder-free, Ni–Co layered double hydroxide (NiCo-LDH) nanowires on a nickel foam (NF) substrate were fabricated via a simple, one-step hydrothermal synthesis procedure, and their use as electrocatalysts for the oxygen evolution reaction (OER) and methanol oxidation reaction (MOR) was studied. When NiCo-LDH was used as the OER electrocatalyst, the overpotential required to deliver a current density of 20 and 100 mA cm−2, was only 270 and 410 mV (without iR correction), and it exhibited a long-term stability of 50 h in 1 M KOH. Moreover, the as-prepared NiCo-LDH nanowire electrocatalyst presented remarkable electrochemical performance for the MOR with a higher current density of 761 mA cm−2 at 0.7 V vs. the saturated calomel electrode (SCE) and excellent stability in 1 M KOH with 0.5 M methanol. The vertically aligned NiCo-LDH nanowires presented numerous active sites and open structures and their synergism with the highly conductive NF substrate was responsible for the excellent electrochemical performance of the electrocatalyst.
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- 2020
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36. Trifunctional layered electrodeposited nickel iron hydroxide electrocatalyst with enhanced performance towards the oxidation of water, urea and hydrazine
- Author
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In Jae Lee, Pravin Babar, Dong Min Lee, Jin Hyeok Kim, Vijay Karade, Abhishek C. Lokhande, and Sambhaji M. Pawar
- Subjects
Electrolysis of water ,Hydrazine ,Inorganic chemistry ,Oxygen evolution ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrocatalyst ,01 natural sciences ,Redox ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Catalysis ,Anode ,Biomaterials ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,Hydroxide ,0210 nano-technology - Abstract
In recent years, low-cost, non-noble metal-based and stable catalysts have gained attention for the development of clean energy devices. Additionally, the synthesis of materials that can exhibit more than one electrocatalytic reaction is notable. In this work, stepwise electrodeposited nickel-iron hydroxide nanoarrays are investigated as anode electrocatalysts with enhanced performance towards the oxidation of water, urea, and hydrazine. The stepwise electrodeposited nickel-iron hydroxide (NiFe(OH)2-SD/NF) electrodes show excellent electrocatalytic activity and stability for the oxygen evolution reaction (OER) with a low potential of 1.45 V (vs RHE) at a current density of 10 mA cm−2. These electrodes further display excellent catalytic activity towards the urea oxidation reaction (UOR) and hydrazine oxidation reaction (HzOR) with potentials lower than 1.32 V (vs RHE) and 0.06 V (vs RHE), respectively. Owing to synergistic effects, a porous structure for mass transport leads to excellent electrocatalytic performance. This non-precious-metal nickel-iron hydroxide, prepared by a simple synthesis approach, is promising for hybrid water electrolysis applications and the development of environmentally friendly clean energy reactions.
- Published
- 2019
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37. A phenomenological study of the meaning of geography teacher-researcher identities
- Author
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Dong-min Lee
- Subjects
Phenomenology (philosophy) ,05 social sciences ,Geography, Planning and Development ,0507 social and economic geography ,050301 education ,Practitioner research ,Management, Monitoring, Policy and Law ,Raw data ,050703 geography ,0503 education ,Teacher education ,Education ,Epistemology - Abstract
The purpose of this study was to interpret the meaning of geography teacher-researcher identities (GTRIs) using van Manen phenomenology. The raw data were obtained through in-depth interviews with ...
- Published
- 2019
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38. Loperamide overcomes the resistance of colon cancer cells to bortezomib by inducing CHOP-mediated paraptosis-like cell death
- Author
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Mi Ae Kim, Yong Won Choi, Kyeong Sook Choi, Mi Jin Yoon, A Reum Lee, Min Ji Seo, In Young Kim, Hae In Lee, Dong Min Lee, Mi Ri Kwon, and Min June Shim
- Subjects
0301 basic medicine ,Programmed cell death ,Colorectal cancer ,Antineoplastic Agents ,Apoptosis ,CHOP ,Loperamide ,Biochemistry ,Paraptosis ,Bortezomib ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Antidiarrheals ,Cyclophosphamide ,Pharmacology ,Cell Death ,Dose-Response Relationship, Drug ,business.industry ,HCT116 Cells ,medicine.disease ,030104 developmental biology ,Doxorubicin ,Drug Resistance, Neoplasm ,Vincristine ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Unfolded protein response ,Cancer research ,Proteasome inhibitor ,Prednisone ,business ,Proteasome Inhibitors ,HeLa Cells ,medicine.drug - Abstract
Although the proteasome inhibitor (PI) bortezomib (Btz) is in current clinical use as a front-line treatment for multiple myeloma, its clinical efficacy in solid tumors has not been satisfactory. Here, we show that loperamide (Lop), an antidiarrheal drug, effectively sensitizes various colon cancer cells, but not normal epithelial cells, to PI-mediated cell death. We report that combined treatment with Btz and Lop induces paraptosis-like cell death accompanied by severe endoplasmic reticulum (ER)-derived vacuolation. Furthermore, Lop potentiates Btz-mediated ER stress and ER dilation due to misfolded protein accumulation and Ca2+ imbalance, leading to CHOP upregulation and subsequent paraptosis-like cell death. Taken together, our results show for the first time that a combined regimen of PI and Lop may provide an effective and safe therapeutic strategy against solid tumors, including colon cancer, by enhancing the sensitivity to PIs and reducing the side effects of such treatment.
- Published
- 2019
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39. RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis
- Author
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Yong-Jun Kwon, Dong Min Lee, Hyun Goo Woo, Kyeong Sook Choi, Jin Yeop Kim, Ki Deok Kim, and Hong Jae Lee
- Subjects
0301 basic medicine ,Programmed cell death ,Small interfering RNA ,Benzylamines ,Curcumin ,Cell ,lcsh:Medicine ,Antineoplastic Agents ,Breast Neoplasms ,Biology ,Endoplasmic Reticulum ,Article ,Paraptosis ,03 medical and health sciences ,0302 clinical medicine ,RNA interference ,Cell Line, Tumor ,medicine ,Humans ,RNA, Small Interfering ,lcsh:Science ,Gene Library ,Membrane Potential, Mitochondrial ,Gene knockdown ,Multidisciplinary ,Cell Death ,lcsh:R ,High-Throughput Screening Assays ,Mitochondria ,030104 developmental biology ,medicine.anatomical_structure ,Apoptosis ,Cancer cell ,Cancer research ,Quinazolines ,Female ,RNA Interference ,lcsh:Q ,Ubiquitin Thiolesterase ,030217 neurology & neurosurgery - Abstract
Accumulating reports demonstrate that apoptosis does not explain all the effects of cancer therapy due to the innate and acquired apoptotic resistance of malignant cancer cells. Recently, paraptosis, a type of programmed cell death accompanied by dilation of mitochondria and/or the endoplasmic reticulum (ER), has garnered interest in cancer research as an alternative way to kill apoptosis-resistant cancers. We describe here the adaptation and validation of a high-content cell-based assay to screen and identify novel paraptotic regulators employing the malignant breast cancer cells undergoing curcumin-induced paraptosis. We used YFP-Mito cells, which express fluorescence selectively in mitochondria, to select paraptosis-related genes whose corresponding siRNAs appeared to modulate mitochondrial dilation, a morphological feature of paraptosis. From the selected 38 candidate genes, we chose ubiquitin specific peptidase 10 (USP10), a ubiquitin specific protease, as a strongly active candidate that warranted further evaluation of its involvement in paraptosis. We found that both siRNA-mediated knockdown of USP10 and treatment with the USP10 inhibitor, spautin-1, effectively attenuated curcumin-induced paraptosis. This systematic assay, in which a siRNA library is screened for the ability to ameliorate paraptotic changes in mitochondria, may enable researchers to identify potent regulators of paraptosis and new candidate genes/drugs to combat malignant breast cancer.
- Published
- 2019
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40. Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty
- Author
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In Hyuk Chung and Dong-Min Lee
- Subjects
Luteinizing hormone ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Gonadotropin-releasing hormone ,03 medical and health sciences ,0302 clinical medicine ,Precocious puberty ,030225 pediatrics ,Internal medicine ,medicine ,Gonadotropin-releasing hormone stimulation test ,Morning ,business.industry ,lcsh:RJ1-570 ,Bone age ,lcsh:Pediatrics ,Odds ratio ,medicine.disease ,Confidence interval ,Endocrinology ,Pediatrics, Perinatology and Child Health ,Original Article ,business ,Body mass index - Abstract
Purpose The standard method used to diagnose central precocious puberty (CPP) is the gonadotropin releasing hormone stimulation test (GnRHST). However, this test is inconvenient for children because it is time-consuming and requires multiple samples. This study aimed to determine the reliability of morning unstimulated luteinizing hormone (mLH) level when screening for CPP, with an emphasis on the influence of diurnal variation. Methods This study included 160 girls with signs of early puberty (SMR 2) under 8 years of age. They were classified as CPP or non-CPP based on their standard GnRHST. The auxological, biochemical, and hormonal characteristics of subjects were retrospectively evaluated. The prognostic value of single morning unstimulated gonadotropin level was examined for use in CPP screening. Results Of 160 patients, 121 (75.6%) presented with CPP, and 39 (24.4%) were determined to be prepubertal. The mLH/mFSH (morning unstimulated follicular stimulating hormone) ratio showed significant differences between the 2 groups (Pl0.001). The mLH was correlated with GnRHST variables (r=0.532, Pl0.001). The mLH cutoff point when screening for CPP was 0.22 IU/L, which had sensitivity and specificity of 69.4% and 82.1%, respectively. In regression analysis, bone age (BA) (odds ratio [OR], 1.018; 95% confidence interval [CI], 0.967-1.071; P=0.506) and body mass index (BMI) (OR, 0.874; 95% CI, 0.583-1.310; P=0.515) were not significant predictors. The mLH≥0.22 IU/L group (OR, 9.596; 95% CI, 3.853-23.900; Pl0.001) was highly suggestive of CPP. Conclusion In this study, single morning unstimulated luteinizing hormone had clinical efficacy for CPP screening, but BA advanced over chronological age and BMI was not useful for CPP screening.
- Published
- 2019
41. Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis
- Author
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Gyeong-Hyeon Kim, Gyesoon Yoon, Eun-beom Lee, Young-Kyoung Lee, Dong Min Lee, Tae Jun Park, Kyeong Sook Choi, Hee-Jung Wang, So Mee Kwon, Seongki Min, and Sun-Mi Hong
- Subjects
0301 basic medicine ,retrograde signaling ,Cancer Research ,lcsh:RC254-282 ,Article ,NDUFA9 ,Metastasis ,Gene product ,STAT3 ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,medicine ,NFE2L1 ,biology ,Effector ,Microarray analysis techniques ,Chemistry ,STX12 ,hepatocellular carcinoma ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,mitochondrial defect ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Liver cancer - Abstract
Mitochondrial respiratory defects have been implicated in cancer progression and metastasis, but how they control tumor cell aggressiveness remains unclear. Here, we demonstrate that a mitochondrial respiratory defect induces nuclear factor-erythroid 2 like 1 (NFE2L1) expression at the transcriptional level via reactive oxygen species (ROS)-mediated STAT3 activation. We identified syntaxin 12 (STX12) as an effective downstream target of NFE2L1 by performing cDNA microarray analysis after the overexpression and depletion of NFE2L1 in hepatoma cells. Bioinformatics analysis of The Cancer Genome Atlas Liver Hepatocellular carcinoma (TCGA-LIHC) open database (n = 371) also revealed a significant positive association (r = 0.3, p = 2.49 ×, 10&minus, 9) between NFE2L1 and STX12 expression. We further demonstrated that STX12 is upregulated through the ROS/STAT3/NFE2L1 axis and is a key downstream effector of NFE2L1 in modulating hepatoma cell invasiveness. In addition, gene enrichment analysis of TCGA-LIHC also showed that epithelial&ndash, mesenchymal transition (EMT)-related core genes are significantly upregulated in tumors co-expressing NFE2L1 and STX12. The positive association between NFE2L1 and STX12 expression was validated by immunohistochemistry of the hepatocellular carcinoma tissue array. Finally, higher EMT gene enrichment and worse overall survival (p = 0.043) were observed in the NFE2L1 and STX12 co-expression group with mitochondrial defect, as indicated by low NDUFA9 expression. Collectively, our results indicate that NFE2L1 is a key mitochondrial retrograde signaling-mediated primary gene product enhancing hepatoma cell invasiveness via STX12 expression and promoting liver cancer progression.
- Published
- 2020
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42. A clinical review of reconstructive techniques for patients with multiple skin cancers on the face
- Author
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Dong Min Lee, Sung Hwan Bae, Yong Chan Bae, Su Bong Nam, and Geon Woo Kim
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Mohs surgery ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Basal cell carcinoma ,Melanoma ,Nose ,business.industry ,Cancer ,medicine.disease ,Skin neoplasms ,Plastic surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Skin grafting ,Surgery ,Original Article ,Radiology ,Skin cancer ,business - Abstract
BACKGROUND Cases of simultaneous multiple skin cancers in a single patient have become more common. Due to the multiplicity of lesions, reconstruction in such cases is more difficult than after a single lesion is removed. This study presents a series of patients with multiple facial skin cancers, with an analysis of the surgical removal, reconstruction process, and the results observed during follow-up. METHODS We reviewed 12 patients diagnosed with multiple skin cancers on the face between November 2004 and March 2016. The patients' medical records were retrospectively reviewed to identify the type of skin cancer, the site of onset, methods of surgical removal and reconstruction, complications, and recurrence during follow-up. RESULTS Nine patients had a single type of cancer occurring as multiple lesions, while three patients had different skin cancer types that occurred together. A total of 30 cancer sites were observed in the 12 patients. The most common cancer site was the nose. Thirteen defects were reconstructed with a flap, while 18 were reconstructed with skin grafting. The only complication was one case of recurrence of basal cell carcinoma. CONCLUSION Multiple skin cancers are removed by performing Mohs micrographic surgery or wide excision, resulting in multiple defect sites. The authors emphasize the importance of thoroughly evaluating local lesions surrounding the initially-identified lesions or on other sites when reconstructing a large defect which can not be covered by primary closure. Furthermore, satisfactory results can be obtained by using various methods simultaneously regarding the condition of individual patients, the defect site and size, and the surgeon's preference.
- Published
- 2018
43. Toward a Typology of Changes in Primary Teachers' Awareness of Geography Based on Receiving Graduate Education
- Author
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Dong-min Lee
- Subjects
Typology ,Graduate education ,05 social sciences ,Geography, Planning and Development ,0507 social and economic geography ,050301 education ,Grounded theory ,Teacher education ,Graduate students ,Mathematics education ,050703 geography ,0503 education ,Earth-Surface Processes ,Qualitative research - Abstract
This study illuminates the effects of graduate education on primary teachers' awareness of geography. Data were collected through interviews with twenty-one teachers who held M.A. or Ph.D. degrees in geography and analyzed using Straussian-grounded theory. The participants were categorized into four types. Many teachers (type A) showed meaningful refinement in their awareness of geography, and some of them (type B and C) identified themselves as experts in primary geography. However, a few participants (type D) showed only marginal development of their geographic knowledge. These results suggest the potential for improvements to graduate education in primary geography and for primary teachers.
- Published
- 2018
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44. Microbial Disinfection with Supercoiling Capacitive Triboelectric Nanogenerator
- Author
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Zheng‐Yang Huo, Dong‐Min Lee, Jang‐Mook Jeong, Young‐Jun Kim, Jihye Kim, In‐Yong Suh, Peixun Xiong, and Sang‐Woo Kim
- Subjects
Renewable Energy, Sustainability and the Environment ,General Materials Science - Published
- 2022
- Full Text
- View/download PDF
45. The role of skin antisepsis in upper extremity surgery to reduce surgical site infection: a comparison between single and triple regimens.
- Author
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Ji Sup Hwang, Dong Min Lee, and Yo Han Lee
- Subjects
- *
ANTISEPTICS , *MEDICAL records - Abstract
Purpose: No consensus exits regarding preoperative skin antisepsis for upper extremity surgery. We aimed to determine whether the use of povidone-iodine only (single regimen) instead of povidone-iodine and alcohol-chlorhexidine (triple regimen) resulted in an increased rate of surgical site infection (SSI), and to detect any associated factors that increased the infection risk. Methods: A cross-sectional, retrospective review of medical records was conducted for patients who underwent upper extremity surgery from March 2020 to February 2021. Either the single or triple regimen was used for preoperative skin antisepsis. The rate of SSI was compared based on a marked elevation of C-reactive protein (CRP) at 2 weeks after surgery, superficial SSI, and deep SSI. Logistic regression analysis was performed to identify factors associated with SSI among the evaluated parameters. Results: Among 175 patients (male, 81 and female, 94), the single regimen was used in 78 patients (44.6%) and the triple regimen in 97 patients (55.4%). The single regimen (odds ratio [OR], 2.425; 95% confidence interval [CI], 1.040--5.655) and a surgical procedure using a metal implant (OR, 3.602; 95% CI, 1.184--10.953) were significantly associated with a marked CRP elevation at 2 weeks. However, there was no difference in SSI rates between the single and triple regimens. Diabetes mellitus (OR, 6.636; 95% CI, 1.259-34.969) was the only factor significantly associated with superficial SSI through logistic regression analysis. Conclusion: Our study suggests that the single regimen resulted in a longer CRP elevation than the triple regimen, but was similarly effective in preventing SSI for upper extremity surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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46. Reconstruction of Large Facial Defects via Excision of Skin Cancer Using Two or More Regional Flaps
- Author
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Dong Min Lee, Yong Chan Bae, Su Bong Nam, Seong Hwan Bae, and June Seok Choi
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Mohs surgery ,lcsh:Surgery ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Hematoma ,medicine ,Basal cell carcinoma ,business.industry ,Large defects ,lcsh:RD1-811 ,medicine.disease ,Surgery ,Plastic surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Forehead ,Skin grafting ,Original Article ,Skin cancer ,business ,Multiple flaps - Abstract
Background Free-flap surgery and skin grafting can be used to reconstruct large facial defects that may result after skin cancer removal by Mohs micrographic surgery (MMS). However, these two methods may produce low postsurgical patient satisfaction with aesthetics, and free-flap surgery may produce an undue burden for the majority of skin cancer patients, who are of advanced age. Hence, the authors examined outcomes of large facial defect reconstruction using multiple flaps. Methods Among patients undergoing MMS for skin cancer at Pusan National University Hospital between January 2013 and December 2015, we evaluated 7 patients (2 males, 5 females; average age, 73.14 years) treated for large facial defects from basal cell carcinoma. Based on operative and follow-up records, we investigated the number and type of flaps used, postsurgical complications, and patients’ post-surgical satisfaction. Results Two and 3 types of flaps were used for 5 and 2 patients, respectively. Most frequently used were nasolabial flaps (7 times in 6 patients) and forehead flaps (once in each of 4 patients). The average follow-up period was 14 months, with no complications—including necrosis, hematoma, or wound dehiscence—observed. Post-surgical satisfaction averaged 4.4 out of a maximum of 5 points. Conclusions Reconstruction using two or more flaps for large facial defects after skin cancer removal using MMS produced satisfactory outcomes while preventing aesthetic problems. Practitioners should consider using multiple flaps when choosing a reconstruction method for large facial defects following skin cancer removal.
- Published
- 2017
47. A Typological Analysis of South Korean Primary Teachers' Awareness of Primary Geography Education
- Author
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Dong-min Lee
- Subjects
Value (ethics) ,05 social sciences ,Geography, Planning and Development ,0507 social and economic geography ,050301 education ,Thinking skills ,Grounded theory ,Five themes of geography ,Geography ,Geography education ,Pedagogy ,050703 geography ,0503 education ,Earth-Surface Processes ,Qualitative research - Abstract
This study illuminates primary teachers' awareness of geography education. Data were collected through interviews with twenty-one teachers and analyzed using Straussian-grounded theory. A total of 210 concepts were categorized into twenty-two categories. The participants were categorized into three types. Many participating teachers (type 1 and 2) were clearly aware of the core characteristics of geography, and some of them recognized themselves as primary geography specialists (type 1). However, a few teachers (type 3) seemed unaware of the value of geography. These results suggest the necessity of primary-teacher training to improve primary teachers' awareness of geography education.
- Published
- 2017
- Full Text
- View/download PDF
48. Computed Tomography Staging of Osteonecrosis of the Femoral Head
- Author
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Beomseok, Lee, Jae-Young, Lim, Dong Min, Lee, Jung Wee, Park, Young-Kyun, Lee, Yong-Chan, Ha, and Kyung-Hoi, Koo
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Femur Head Necrosis ,Arthroplasty, Replacement, Hip ,Humans ,Femur Head ,Tomography, X-Ray Computed ,Retrospective Studies - Abstract
Osteonecrosis of the femoral head (ONFH) usually affects patients younger than 50 years and frequently leads to collapse of the femoral head and subsequent osteoarthritis of the hip. Joint-preserving procedures are attempted in the early stages without collapse, while total hip arthroplasty (THA) is done during more advanced stages with femoral head collapse or a fracture in the necrotic portion. Thus, accurate staging of the disease is mandatory to decide therapeutic strategy. The purpose of this study is to determine the prevalence of occult fracture in the necrotic portion among osteonecrotic femoral heads, which were classified as Association Research Circulation Osseous (ARCO) stage 1 or 2 on radiographs.A preoperative computer tomography (CT) scan was routinely performed to obtain an adequate cup position in patients undergoing THA at our institution. Radiographs and CT scans of 308 patients, who underwent unilateral THA due to ONFH from January 2011 to December 2014, were assessed by two orthopedic surgeons to compare the stage based on simple radiography and that based on CT scans.Among the 308 hips, which were classified as stage I or II lesions on simple radiography, fracture inside the necrotic portion was seen in 63 hips (20.5%) on CT scans. Fifty-nine of the 63 patients were followed for two to five years. Further collapse of the femoral head occurred in 41 patients, and 36 of them underwent THA during the follow up.In this study, 20.5% of hips classified as ARCO stage I or II on simple radiography were found to be ARCO stage III on CT imaging. When a joint-preserving treatment is considered for early stage ONFH, CT examination is necessary for more precise staging of the disease.
- Published
- 2019
49. Emerging Energy Harvesting Materials and Devices for Self‐Powered Water Disinfection
- Author
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Dong-Min Lee, Zheng-Yang Huo, Young Jun Kim, Sang-Woo Kim, and Si Wang
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Disinfection ,Physical Phenomena ,Motion ,Materials science ,Electricity ,Waste management ,Drinking Water ,General Materials Science ,General Chemistry ,Water disinfection ,Energy harvesting ,Microbial inactivation - Abstract
Contaminated drinking water is one of the main pathogen transmission pathways making waterborne illnesses such as diarrheal diseases and gastroenteritis a huge threat to public health, especially in the areas where sanitation facilities and gird power are inadequate such as rural and disaster hit areas. Self-powered water disinfection systems are a promising solution in these cases. In this review paper, the authors provide an overview of the new and emerging methods of applying energy harvesting materials and devices as a source of power for water disinfection systems microbial disinfection in water by harnessing ambient forms of energy such as mechanical motion, light, and heat into electricity. The authors begin with a brief introduction of the different energy harvesting technologies commonly applied in water disinfection; triboelectric, piezoelectric, pyroelectric, and photovoltaic effects. Various microbial disinfection mechanisms and types of device construction are summarized. Then, a detailed discussion of the energy harvester-driven water disinfection process is provided. Finally, challenges and perspectives regarding the future development of self-powered water disinfection are described.
- Published
- 2021
- Full Text
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50. Mechanoreceptor‐Inspired Dynamic Mechanical Stimuli Perception based on Switchable Ionic Polarization
- Author
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Sung Soo Kwak, Hong-Joon Yoon, Dong-Min Lee, Young-Jun Kim, Sang-Woo Kim, Jihye Kim, Jae-Hwan Jung, SeongMin Kim, Yunseok Kim, and Sera Jeon
- Subjects
Materials science ,business.industry ,media_common.quotation_subject ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Mechanoreceptor ,medicine.anatomical_structure ,Perception ,Electrochemistry ,medicine ,Optoelectronics ,business ,Ionic polarization ,Triboelectric effect ,media_common - Published
- 2021
- Full Text
- View/download PDF
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