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1. Tracking neuroinflammatory biomarkers in Alzheimer’s disease: a strategy for individualized therapeutic approaches?

2. Alzheimer’s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

4. Combinations in the first-line treatment of patients with advanced/metastatic renal cell cancer: regulatory aspects

5. European Medicines Agency review of ixazomib (Ninlaro) for the treatment of adult patients with multiple myeloma who have received at least one prior therapy

6. Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

7. Interaction between Ephrins and mGlu5 Metabotropic Glutamate Receptors in the Induction of Long-Term Synaptic Depression in the Hippocampus

8. Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

9. Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis

10. Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons

11. Metabotropic glutamate receptors in stem/progenitor cells

12. Nanomolar concentrations of anabolic–androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures

13. Anorexia in Hemodialysis Patients: The Possible Role of Des-Acyl Ghrelin

14. Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells

15. Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors

16. Interactions between Ephrin-B and Metabotropic Glutamate 1 Receptors in Brain Tissue and Cultured Neurons

17. Testosterone amplifies excitotoxic damage of cultured oligodendrocytes

18. Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats

19. Functional Characterization of WNT7A Signaling in PC12 Cells

20. Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways

21. The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways

22. Suppressive effect of melatonin administration on ethanol-induced gastroduodenal injury in rats in vivo

23. Contents Vol. 4, 1995

24. Regulatory evaluation of Glybera in Europe — two committees, one mission

25. Subject Index Vol. 4, 1995

26. An old threat in a new setting: High prevalence of silicosis among jewelry workersThe work was performed at Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia.

27. Honorary Doctorate Awarded to Thomas Karger

28. Therapeutic Options in Alzheimer's Disease: From Classic Acetylcholinesterase Inhibitors to Multi-Target Drugs with Pleiotropic Activity.

29. Tracking neuroinflammatory biomarkers in Alzheimer's disease: a strategy for individualized therapeutic approaches?

30. Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T‐Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.

31. Alzheimer's disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

33. The European Medicines Agency Review of Pertuzumab for the Treatment of Adult Patients With HER2-PositiveMetastatic or Locally Recurrent Unresectable Breast Cancer: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use

34. Risk of Guillain-Barré syndrome after 2010-2011 influenza vaccination.

36. Differential activation of the calcium/protein kinase C and the canonical β-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells.

37. Anorexia in Hemodialysis Patients: The Possible Role of Des-Acyl Ghrelin.

38. Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

39. Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells.

40. Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

41. Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.

50. Regulatory evaluation of Glybera in Europe - two committees, one mission.

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