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AIM: To investigate the diagnostic value of the axial length/corneal radius of curvature(AL/CR)for myopia in children and adolescents.METHODS: PubMed, Embase, The Cochrane Library, CNKI, CBM, WanFang Data and VIP databases were searched to collect clinical research on the value of AL/CR in diagnosing myopia in children and adolescents, and the retrieval time was from establishment to September 30, 2023. The QUADAS-2 tool was used to evaluate the quality of the extracted literature. A random-effects model was used to pool diagnostic test data, Meta-regression and subgroup analysis were performed to explore sources of heterogeneity.RESULTS: A total of 10 articles involving 19 872 study participants were included, and Meta-analysis showed that the pooled sensitivity of the AL/CR for the diagnosis of myopia in children and adolescents was 0.91[95%CI(0.90-0.91)], the pooled specificity was 0.84 [95%CI(0.84-0.85)], and area under the SROC curve of 0.95 [95%CI(0.93-0.96)].CONCLUSION: The AL/CR is a good indicator of myopia in children and adolescents.

AIM:To compare the differences, correlations and consistency of IOL Master 700 or Lenstar LS900 in preoperative ocular biometry and the accuracy of intraocular lens(IOL)degree calculation of cataract patients with high myopia.METHODS: Retrospective study. A total of 136 cases(136 eyes)of high myopia and cataract patients who underwent phacoemulsification at the ophthalmology department of Army Medical Center of PLA from March 2021 to March 2023 were collected, with a mean age of 57.38±8.08 years. Patients were divided into 3 groups based on axial length(AL): 41 eyes in group A(26 mm≤ AL ≤28 mm), 43 eyes in group B(28 mm< AL ≤30 mm)and 52 eyes in group C(AL >30 mm). AL, mean keratometry(Km), anterior chamber depth(ACD), lens thickness(LT)and white-to-white(WTW)were preoperatively measured by two instruments, respectively. Barrett Universal II formula was used to calculate the IOL degrees of all patients, the appropriate reserved diopter was decided individually, and the prediction error(PE)and absolute error(AE)of the two instruments were compared.RESULTS:The AL and ACD of patients in the three groups measured by Lenstar LS900 were higher than the AL measurd by IOL Master 700(all Pgroup B>group A. However, there was no statistical significance in LT, Km, and WTW measured by the two instruments(all P>0.05). All biometric parameters measured by the two devices were positively correlated(all r>0.9, P0.05), but the IOL Master 700 calculated a smaller PE than Lenstar LS900(P

This study delves into Ulcerative colitis (UC), a persistent gastrointestinal disorder marked by inflammation and ulcers, significantly elevating colorectal cancer risk. The emergence of single-cell RNA sequencing (scRNA-seq) technology has opened new avenues for dissecting the intricate cellular dynamics and molecular mechanisms at play in UC pathology. By analyzing scRNA-seq data from individuals with UC, our study has revealed a consistent enhancement of inflammatory response pathways throughout the course of the disease, alongside detailing the characteristics of endothelial cell damage within colitis environments. A noteworthy finding is the downregulation of Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase (LHPP), which exhibited a inversely correlate with STAT3 expression levels. The markedly reduced expression of LHPP in both the tissues and plasma of UC patients positions LHPP as a compelling target for therapeutic intervention. Our findings highlight the pivotal role LHPP could play in moderating inflammation, spotlighting its potential as a crucial molecular target in the quest to understand and treat UC.

Basic oxygen furnace (BOF) steelmaking is a widely used method for steelmaking production, and the bath stirring has a significant influence on dynamics of bath flow and mixing. Therefore, the effect of bottom gas flowrate, nozzle number and configuration, and bottom gas distribution mode on bath stirring are summarized in this study. Reasonable matching of bottom gas flowrate, nozzle number and configuration, as well as intensive study on the coupling effect of gas flowrate gradient and exchange frequency on non-uniform stirring would receive more and more attention in the coming years. With wide concern on the low-carbon and high-efficient production for BOF steelmaking, as a kind of recyclable iron-containing resource, the rapid melting and reasonable utilization of scrap in converter bath were emphasized in recent works, which could be promoted with high-efficient bottom stirring. The effect of bottom stirring on heat and mass transfer during scrap melting process was reviewed in this work, and the influence mechanism of bottom stirring on coupled heat and mass transfer should be further investigated. In addition, an overview of recently published physical and numerical simulation describing the bottom stirring and its effect on scrap melting would provide an outlook for future work.

ObjectiveTo analyze the disinfection quality of nursing institutions in Fengxian District， so as to provide evidence for improving disinfection work in nursing institutions.MethodsA total of 54 nursing institutions for the elderly in Fengxian District of Shanghai were selected as the monitoring sites during 2017‒2021. The samples from indoor air， surface of objects， tableware and hands of staff were collected for bacteriological testing， and then evaluated for the quality of sanitary disinfection.ResultsFrom 2017 to 2021， the annual qualified rate of disinfection quality in the nursing institutions was 84.85%‒100.00%， and there was a significant difference of the monitoring samples among different years （χ2=51.73，P

Objective To obtain the non-structure protein 14 (Nsp14) of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) with higher purity and enzymatic activity. Methods This study firstly analyzed the rare codons in the gene of nsp14 according to the codon usage bias of E. coli, followed by codon optimization. The optimized nucleotide fragment of nsp14 was cloned into four kinds of expressing vectors respectively. Comparative analysis of yield and solubility was performed among these expressed four fusion proteins. The best one was chosen for further optimization of expressing conditions. After the fusion protein was purified by glutathione affinity column, the fusion tag was removed by 3C protease, and then the protein was purified by glutathione affinity column and molecular sieve column for further analysis of enzymatic activity through urea polyacrylamide gel electrophoresis. Results Many rare codons were found in expression of SARS-CoV-2 nsp14 in E. coli, among which some rare codons were distributed in close range and tandem. The best recombinant plasmid for expressing the fusion protein was pGEX6P1-GST-OPTI-Nsp14, which gave an eptimal expression in 30 ℃ with high yield and solubility. After purification, a higher purity of Nsp14 with nuclease activity was obtained. Conclusions This study shows that the SARS-CoV-2 Nsp14 protein with nuclease activity is successfully prepared, which lays a foundation for the further research on the structure and function of SARS-CoV-2 Nsp14, and provides favorable conditions for screening antiviral drugs targeting at Nsp14 of SARS-CoV-2.

This article presents a study on the design of high-speed inter-satellite links for the global navigation satellite system, which consists of 24 middle earth orbit, 3 inclined geosynchronous orbit, 3 geostationary orbit satellites, and 4 typical ground stations based on the laser link of slowly varying continuous system and high-speed Ka link. Pre-allocation of node connections in inter-satellite link construction is conducted by employing the optimized Dijkstra algorithm using finite-state automata. In addition, topological design and routing planning principles are utilized for high-speed inter-satellite links. Based on full constellation orbit data of a regression period and locations of the ground station nodes, an hourly link construction program is obtained using the scheme described above. The calculation result of the position dilution of precision values of all satellites, the average inter-satellite transmission delay, and the inter-satellite link switching meet the requirements of measurement, data transmission, and management for navigation constellation.

With graphite oxide (GO) as the main raw material, combining with carboxymethyl cellulose (CMC), hydrothermal reduction combined ice template method was used to prepare graphene/carboxymethyl cellulose composite aerogel (HGA/CMC), through drying under the environmental pressure and hydrophobic modification. The HGA/CMC was characterized through SEM, FT-IR, XPS and microcomputer controlled electronic universal testing machine, which proves the successful combination between GO and CMC and the effective hydrophobic modification. HGA/CMC can absorb pure oil because of its abundant pore structure, the adsorption capacity of oil is 70.28-172.78 g·g-1, and the higher the oil density is, the greater the oil mass can be adsorbed by aerogel per unit mass. Furthermore, HGA/CMC shows good selective adsorption capacity for floating oil on water, heavy oil on water bottom and emulsified oil in water. HGA/CMC can be recycled by mechanical extrusion, and its adsorption capacity loss is only 15% after 10 times of extrusion regeneration. It is an oily wastewater treatment material with application potential.

A liquid chromatography-tandem mass spectrometry (LC-MS) method for screening 53 stimulants in animal foods was developed. The method uses 2% formic acid-acetonitrile/water (80/20) as the extraction solvent and carries out one-step purification by FaVEx-AP solid phase extraction column. Endeavorsil C18 column was used for separation, and multiple reaction monitoring (MRM) mode was used for data acquisition and analysis. The results showed that the correlation coefficient (R2) was more than 0.99. The detection limit and quantification limit were 0.25–10μg/kg and 1–10μg/kg. The recoveries were 62.25%–123.32% and the relative standard deviation (RSD) was 1.17%–22.03%. The method is rapid, simple and accurate, and is suitable for the determination of 53 kinds of stimulants in animal-derived foods.

The effect of the substrate surface roughness on tribological properties of MoS2/Ti films, and the friction and wear mechanism was studied. MoS2/Ti films were deposited on bearing steel with different surface roughness by magnetron sputtering. The adhesion strength between the film and substrate, phase composition, surface morphology and surface roughness of MoS2/Ti films were obtained respectively by scratch tester, X-ray diffractometer(XRD), scanning electron microscope (SEM) and roughness profiler. And the tribological properties of MoS2/Ti films under dry friction, solid-oil composite lubrication and solid-grease composite lubrication were studied by a ball-on-disk tribometer. The results show that with the increase of the substrate surface roughness, the surface roughness of MoS2/Ti films increases, the intensity of (002)MoS2 and (100)MoS2 diffraction peaks first decreases and then increases, and the adhesion strength between the film and substrate decreases. When the surface roughness of the substrate is 0.01 μm, the MoS2/Ti films have good lubrication characteristics under dry friction condition. The average friction coefficient is 0.101, and the wear scar is shallow and small. With the increase of substrate roughness, the average friction coefficient and the wear rate of the samples increase first and then decrease. Meanwhile, the main wear mechanism of the film changes from abrasive wear to chip formation and fragmentation. And the effect of intermolecular interaction is greater than that of mechanical engagement, when the substrate roughness of the samples is large (Ra=0.26 μm). Under the condition of solid-oil composite lubrication, there is no fragmentation phenomenon on the worn surface with large substrate roughness. The wear scar is shallow, and the average friction coefficient is reduced by about 19%. Under the condition of solid-grease composite lubrication, the tribological properties of the samples are poor, and the effect of the substrate surface roughness on the friction coefficient is not significant.

Reliability and safety of an electro-hydraulic position servo system (EHPSS) can be greatly reduced for potential sensor and actuator faults. This paper proposes a novel reconfiguration control (RC) scheme that combines multi-model and adaptive control to compensate for the adverse effects. Such a design includes several fixed models, one adaptive model, and one reinitialized adaptive model. Each of the models has its own independent controller that is based on a complete parametrization of the corresponding fault. A proper switching mechanism is set up to select the most appropriate controller to control the current plant. The system output can track the reference model asymptotically using the proposed method. Simulation results validate robustness and effectiveness of the proposed scheme. The main contribution is a reconfiguration control method that can handle component faults and maintain the acceptable performance of the EHPSS.

IntroductionUrban ecological instruction is an important method of sustainable development that couples the needs of the population and the environment, thus facilitating high-quality development. This study aimed to transform existing large-scale considerations of ecological urban construction to provide a more grounded evaluation framework. We constructed an integrated framework that considers economic, environmental, social, cultural, and ecological factors and their contribution to urban ecological construction.MethodsWe used methods of subjective and objective empowerment, exploratory spatial data analysis, and the obstacle degree model to explore spatiotemporal variations in urban ecological construction.ResultsOur results showed that: (1) From 2006 to 2018, urban ecological construction in the Yellow River basin (YRB) exhibited a “polycentric” spatial differentiation pattern and a significant, gradually decreasing “center-periphery” spatial distribution trend. (2) High–high areas (with high agglomeration and high urban ecological construction) in the YRB are mainly distributed in Shandong Province and the adjacent regions, whereas low–low areas are mainly distributed in south–central Ningxia Province and southern Gansu Province. (3) Analysis of urban ecological construction characteristics across different city scales, functional types, spatial carriers, and basin locations shows that the urban ecological construction level is directly proportional to the scale of the city. The level of urban ecological construction is relatively higher in the Shandong Peninsula urban agglomeration, in the priority development area of the North China Plain, and in the downstream and right bank of the YRB. Spatial differences are mainly controlled by the net difference between regions from the upstream and midstream scales, as well as intra-regional differences between the left and right banks. (4) Marked differences can be observed in the obstacles to ecological construction in different types of cities.DiscussionTypical barriers in cities in the YRB include the total water resources per capita, energy consumption per unit of GDP, the proportion of research and development investment in fiscal expenditure, the number of books in public libraries per 10,000 people, and land use efficiency. In the future, urban ecological construction should be based on the development conditions of each individual city, and should be improved according to local conditions to achieve the construction high-quality ecological cities.

Differential equation modelling was earlier used to discover better and understand various biological phenomena and social problems. We hope to understand the stability of the system and the Hopf bifurcation based on the characteristic roots of the linear system. Because group competitive sports require participants to have certain competitive skills, those who do not have sports skills but want to develop into activities must receive training and specific training. Therefore, based on the research background, the article proposes a time-lag group competitive martial arts activity model with a time lag effect. Through delay differential equation theory and Hopf bifurcation theory, the stability of the equilibrium point and the existence of periodic solutions generated by the Hopf bifurcation caused by the ‘instability’ of the equilibrium point are discussed. Finally, the theoretical results are simulated and verified with the help of MATLAB software.

Artificial intelligence (AI) aims to mimic human cognitive functions and execute intellectual activities like that performed by humans dealing with an uncertain environment. The rapid development of AI technology provides powerful tools to analyze massive amounts of data, facilitating physicians to make better clinical decisions or even replace human judgment in healthcare. Advanced AI technology also creates novel opportunities for exploring the scientific basis of traditional Chinese medicine (TCM) and developing the standardization and digitization of TCM pulse diagnostic methodology. In the present study, we review and discuss the potential application of AI technology in TCM pulse diagnosis. The major contents include the following aspects: (1) a brief introduction of the general concepts and knowledge of TCM pulse diagnosis or palpation, (2) landmark developments in AI technology and the applications of common AI deep learning algorithms in medical practice, (3) the current progress of AI technology in TCM pulse diagnosis, (4) challenges and perspectives of AI technology in TCM pulse diagnosis. In conclusion, the pairing of TCM with modern AI technology will bring novel insights into understanding the scientific principles underlying TCM pulse diagnosis and creating opportunities for the development of AI deep learning technology for the standardization and digitalization of TCM pulse diagnosis.

Resin-modified glass ionomer cement (RMGIC) has good physical, chemical and biological properties and is suitable for the treatment of deciduous caries, aged root surface caries and wedge-shaped defects. Surface treatment is a common method to improve bonding strength, which can improve physical and chemical retention between different components. This paper mainly introduces the current research status of the influence of different dentin surface treatment methods on the bonding strength of RMGIC. At present, the common dentin surface treatment methods are pretreatment, acid etching, laser treatment, etc. The pretreatment agent can improve the bond strength of RMGIC by increasing the surface area and porosity of dentin. The bond strength of RMGIC could be effectively improved after the dentin was treated by an acid-etching bonding system. The dentin was treated with a laser to obtain a higher bonding strength. However, whether the use of resin adhesives will affect the release of fluoride ions in RMGIC into the deep dentin and thus affect the repair effect also needs further research.

Abstract The management of acquired reactive perforating collagenosis (ARPC) is challenging. Here, we shared two cases of ARPC combined with elderly atopic dermatitis (AD) that did not respond well to conventional treatment but responded well to the monotherapy of dupilumab, which suggests that dupilumab may be an alternative option for the treatment.

Chromosomal microdeletions and microduplications likely represent the main genetic etiologies for children with developmental delay or intellectual disability. Through prenatal chromosomal microarray analysis, some microdeletions or microduplications can be detected before birth to avoid unnecessary abortions or birth defects. Although some microdeletions or microduplications of chromosome 5 have been reported, numerous microduplications remain undescribed. We describe herein a case of a 30-year-old woman carrying a fetus with a chromosome 5q21.1–q21.3 microduplication. Because noninvasive prenatal testing indicated a fetal chromosome 5 abnormality, the patient underwent amniocentesis at 22 weeks 4 days of gestation. Karyotyping and chromosomal microarray analysis were performed on amniotic fluid cells. Fetal behavioral and structural abnormalities were assessed by color and pulsed Doppler ultrasound. Clinical characteristics of the newborn were assessed during the follow-up. The left lateral ventricle appeared widened on ultrasound, but the infant appeared normal at birth. The 5q21.1–q21.3 microduplication in the fetus was inherited from his mother. There are seven genes in this duplication region, but their main functions are unclear. According to this case report, microduplication in this region could represent a benign mutation. Clinicians should pay attention to the breakpoints and the genes involved when counseling patients with microdeletions and microduplications.

Cellulose graphene composite aerogels (CMC/GA) were prepared by one-step hydrothermal reaction based on graphite oxidation with the addition of low cost carboxymethyl cellulose. The functional group structure and microstructure of CMC/GA were characterized. The mechanism and capacity of the adsorption of Methylene Blue (MB) were investigated by CMC/GA in water. The results show that the higher temperature and higher initial concentration of MB are beneficial to the adsorption of CMC/GA. The adsorption isotherm is fitted with Langmuir model, the adsorption activation energy of the system is 57.951 kJ·mol-1, indicating that the adsorption of MB by CMC/GA is monolayer and belongs to chemical adsorption. The adsorption kinetics of MB is fitted with pseudo-second-order kinetics model. The intrapartical diffusion model of MB with different concentration shows that the adsorption process of CMC/GA for MB can be divided into two stages:macroporous diffusion and microporous diffusion, and the diffusion rate of macroporous diffusion is obviously higher than that of microporous diffusion.

Photocurable coal-series kaolin slurry was prepared based on photocurable resin system. The rheological properties of the slurry were characterized by a rheometer. The effect of dispersant and plasticizer addition on the rheological properties of the slurry was studied. The results show that oleic acid as a dispersant has the effect of reducing the viscosity of the slurry. When the mass fraction of oleic acid added is 1% of the kaolin powder, the viscosity of the slurry is the lowest, while the viscosity of the 40%(volume fraction) kaolin slurry is 49.56 Pa·s. Adding plasticizer PEG-300 can further reduce the viscosity of the slurry. The viscosity of the slurry decreases with the addition of plasticizer. When the plasticizer is added in the mass fraction of 20% of the photosensitive resin, the viscosity of the slurry decreases to 19.77 Pa·s, at which the requirement for good recoating is well met. The slurry with optimized rheological properties is formed in a stereolithography apparatus. After debinding and sintering, kaolin ceramics with complex shape are obtained.

Photocurable coal-series kaolin slurry was prepared based on photocurable resin system. The rheological properties of the slurry were characterized by a rheometer. The effect of dispersant and plasticizer addition on the rheological properties of the slurry was studied. The results show that oleic acid as a dispersant has the effect of reducing the viscosity of the slurry. When the mass fraction of oleic acid added is 1% of the kaolin powder, the viscosity of the slurry is the lowest, while the viscosity of the 40%(volume fraction) kaolin slurry is 49.56 Pa·s. Adding plasticizer PEG-300 can further reduce the viscosity of the slurry. The viscosity of the slurry decreases with the addition of plasticizer. When the plasticizer is added in the mass fraction of 20% of the photosensitive resin, the viscosity of the slurry decreases to 19.77 Pa·s, at which the requirement for good recoating is well met. The slurry with optimized rheological properties is formed in a stereolithography apparatus. After debinding and sintering, kaolin ceramics with complex shape are obtained.

The TiO2/reduced graphene oxide composite, synthesized by a facile one-pot hydrothermal method, was characterized with X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), Raman spectrum, and ultraviolet-visible (UV-Vis) spectroscopy to observe the crystal structure, intensity of functional group, microstructure and optical property. The composite material was synthesized by using glucose, sodium dodecyl sulfate (SDS), polyvinylpyrrolidone (PVP) as inducing agents, respectively. The structure and photocatalytic activity for degradation of methyl orange (MO) of the composite were investigated. The results reveal that the composite induced by glucose and SDS shows the highest activity, whose degradation rate can be up to 92% in 30min. However, 120 minutes is necessary for the commercial P25 to remove 90% methyl orange (MO). Compared with the composite prepared by self-assembly with no inducing agent, there are no obvious difference existing in the one induced by polyvinylpyrrolidone (PVP) in terms of photocatalytic reactivity.

Objective To assess family environmental factors that impact caries in children during a follow ⁃ up study for family⁃based community oral health promotion models. Methods This study was conducted from June to De⁃ cember 2015. A total of 200 households were selected from Jinzhou community in Nanning with the random sampling method. The data were collected through oral examinations and questionnaire surveys of family members. A logistic re⁃ gression model was used to analyze the relationship between family environment factors, such as socioeconomic and fam⁃ ily⁃related behaviors, and caries in children. Results After adjustment for confounding factors, families in which more than 1, 000 mL of sugar drinks were purchased per month; those in which the family members had a low frequency of brushing (occasionally or not); those in which the mother had a high frequency of drinking sweet drinks (more than one time each day), brushed with low frequency (less than 2 times), had no regular oral examination in the past year, or had low scores in oral health attitude and knowledge; those in which the father/mother had a low level of education (short⁃cy⁃ cle courses and under); and those with a low annual household income (less than 50, 000 RMB) had children with high rates of dental caries. Families purchasing sugar drinks >1 000 mL per month were 2.22 times more likely than families purchasing sugar drinks ≤1 000 mL per month to have caries in children. Conclusion Family environmental factors exert a certain influence on children􀆳s caries, and this information is a useful reference for a follow⁃up study.

In order to realize comprehensive and massive treatment of boron mud secondary resource, fundamental study on boron mud applied to oxidized pellets production as additive was carried out in the paper under laboratory conditions. The effects of boron mud on the performance of oxidized pellets were investigated systemically, and boron mud was combined with other boron-rich material innovatively. The results showed that, within certain limits, boron mud can improve properties of oxidized pellets. The bentonite content decreased to 0.3 % when adding 1.0 % boron mud additive and the pellets met blast furnace requirements. With the combination additive content 0.8 %, bentonite content can be further decreased to 0.2 %, and the pellets properties were better than base pellet. Therefore, it was an effective way to reduce environmental pollution and optimize blast furnace operation by developing boron mud secondary resource as pellets additive.

The flow stress behavior of 15%SiCP/8009 aluminum matrix composite at deformation temperature of 400-550 ℃ and strain rate of 0.001-1 s-1 was studied by hot compression testing on the Gleeble-3500 thermal-mechanical simulator. The results show that the flow stress increases initially and reaches a plateau after peak stress value with the increase of strain. The peak stress increases with the increase of strain rate and deformation temperature. The flow stress behavior can be described by the hyperbolic sine constitutive equation with the deformation activation energy Q of 488.3853 kJ/mol and the stress index n of 7.19022.

A new type of designing scheme of spur gear differential used in vehicle drive axle is put forward,its operating principle and characters are analyzed in detail. According to the design project,the design and assemble of axle shaft gear,planet gear,planet carrier and others are created in Pro / E,and imported into ADAMS / View. Then the kinematic simulation and analysis of its two different working conditions of straight driving and handling driving are carried out. The analysis results show that spur gear differential not only can achieve automobile driving axle differential function,but also have advantage of simple construction and easy machining.