Introduction: Diabetes mellitus is the most prevalent metabolic disease worldwide. "Adherence to treatment" is critical in the metabolic control of it and described as the action actively and voluntarily engages in the management of the disease. Objective: To determine the influence of neuropsychological and psychological variables in adherence to treatment of patients with type 2 diabetes. Methods: 60 subjects were evaluated: 30 with controlled diabetes (DC) and 30 with uncontrolled diabetes (DNC), submitted by centers-diabetes in the city of Barranquilla, between July and November 2015, to which underwent neuropsychological assessment, perception of health (general health questionnaire Goldberg, GHQ-28) and adherence to treatment (scale adherence treatment of type II Diabetes Mellitus: EATDMIII). The methodological approach was transversal descriptive, case- control analysis, selection of the sample was not probabilistic intentional. U test of Mann-Whitney and linear regression model was used to perform the analysis. Results: We observed significant commitment of attention, memory and executive functions in patients with DNC. We found a significant difference between the two groups in scores on the scale (EATDMIII), in: exercise, hygiene and self-care, diet and fitness assessment. It was identified that anxiety-insomnia variable has a risk of 0.771 (p=0.035), which may influence adherence to treatment. Conclusions: Factors such as physical exercise, hygiene and self-care, diet and fitness assessment are fundamental in metabolic control these patients. Similarly, psychological variables (anxiety-insomnia) are determining adherence to treatment in this group of patients, which; being potentially modifiable they must be considered and controlled early in any therapeutic regimen. [ABSTRACT FROM AUTHOR]