1. Threaded Structure of a Pathological Oblivion.
- Author
-
Prida, Liset M de la
- Subjects
BRAIN diseases ,PYRAMIDAL neurons ,MEMORY disorders ,EPILEPTIFORM discharges ,ALZHEIMER'S disease ,LABORATORY mice - Abstract
Alzheimer's disease (AD) is one of the most common causes of progressive dementia in older people, and synaptic loss is a major correlate of cognitive severity.[1] Studying brain diseases has traditionally informed understanding of brain function. Keywords: sharp waves; ripples; replay; Alzheimer's disease EN sharp waves ripples replay Alzheimer's disease 457 459 3 12/14/21 20211101 NES 211101 I Alzheimer's Pathology Causes Impaired Inhibitory Connections and Reactivation of Spatial Codes During Spatial Navigation i Prince SM, Paulson AL, Jeong N, Zhang L, Amigues S, Singer AC. During sequence replay, neurons fire in a chain, and it is proposed that it is the interplay between pyramidal cells and interneurons that pace the ripple.[7] Therefore, if the interneuron-to-pyramidal cell thread weakens, the chain should be broken. By measuring synaptic efficacy as mice navigate in a virtual reality task, we find deficits in interneuron connection strength onto pyramidal cells in hippocampal CA1 in the 5 relevant human familial mutations (5XFAD) of the mouse model of AD. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF