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Direct alcohol biomarkers are of growing interest for the assessment of alcohol consumption, with particular interest in phosphatidylethanol (PEth) in recent years. PEth is only formed when alcohol is present in the body. However, there is no statement about how much the PEth concentration increases after single moderate alcohol consumption. This study was conducted to determine the increase in PEth concentrations after a single drinking event. Additionally, a new volumetric sampling device (volumetric dried blood spot cards (DBSV)) was evaluated, which was designed to simplify further sampling processes and to allow for easy self-sampling. Dried blood samples from 31 volunteers were collected before and after single alcohol consumption with a mean maximum breath alcohol concentration of 0.4 mg/L (range: 0.30–0.55 mg/L). PEth concentrations were determined after automated extraction by liquid chromatography--tandem mass spectrometry. PEth 16:0/18:1 and PEth 16:0/18:2 concentrations increased to an average of 45 ng/mL each in patients starting below 20 ng/mL (range: 25.0–57.0 ng/mL for PEth 16:0/18:1; range 26.8–62.3 ng/mL for PEth 16:0/18:2). PEth concentrations in patients starting above 20 ng/mL increased by a mean of 30 ng/mL (range: 6.2–71.3 ng/mL for PEth 16:0/18:1; range 8.8–65.3 ng/mL for PEth 16:0/18:2). In addition, the comparison of the new sampling device DBSV with a standard filter paper card (with volumetrically applied 20 µL of blood samples) yielded a close agreement for the determined PEth concentrations in 24 forensic samples and three external controls. Therefore, the sampling device DBSV proved to be suitable for the determination of PEth concentrations in blood. [ABSTRACT FROM AUTHOR]

Background: Harmful Alcohol use is frequent among opioid dependents patients undergoing agonist maintenance treatment. The objective assessment of harmful alcohol use can be done using laboratory measures of serum biomarkers. For community-based patients, there is often a requirement of an alternative method due to lack of onsite laboratory services. The aim of the study was to examine filter paper as a matrix to measure serum biomarkers of harmful alcohol use. Methods: The initial phase involved standardization of the filter-paper-based assay. Conditions were optimised for extraction and estimation of alcohol biomarkers (Aspartate Aminotransferase; AST, Alanine Aminotransferase; ALT, Gamma Glutamyl transferase; GGT and Carbohydrate Deficient Transferrin; CDT) from the filter paper. For clinical validation, serum samples were collected from community clinics. Biomarker levels obtained from both the methods were correlated using linear regression analysis. Limits of agreement between the two methods was estimated using the Intraclass Correlation Coefficient (ICC). Results: The extraction of enzymes (AST, ALT and GGT) from filter paper was carried out using the substrate buffer available with the reagent kit (Randox, UK). CDT was readily extracted from filter paper using deionised water. Serum biomarker levels measured from samples collected from community clinics correlated well with filter paper extracted levels (ICC 0.97-0.99). More than 90% of alcohol biomarker levels were recovered from the filter paper matrix using this method. Conclusion: Filter paper has the potential to be used as a matrix to objectively measure alcohol biomarkers among opioid-dependent patients from community settings lacking onsite laboratory facilities. [ABSTRACT FROM AUTHOR]

Aims: The experiment tested the effects of a web‐push survey research protocol, compared with the standard mailed paper‐and‐pencil protocol, among young adults aged 19–30 years in the 'Monitoring the Future' (MTF) longitudinal study. Design, Setting and Participants: The US‐based MTF study has measured substance use trends among young adults in panel samples followed biennially, using consistent mailed survey procedures from 1977 to 2017. In 2018, young adult participants in the MTF longitudinal component scheduled to be surveyed at ages 19–30 in 2018 (from high school senior cohorts of 2006–17, n = 14 709) were randomly assigned to receive the standard mail/paper survey procedures or new web‐push procedures. Measurements Primary outcomes were responding to the survey and prevalence estimates for past 30‐day use of alcohol, cigarettes, marijuana and illicit drugs. Findings The web‐push response rate was 39.07% [95% confidence interval (CI) = 37.889, 40.258]; this was significantly better than the standard MTF response rate of 35.12% (95% CI = 33.964, 36.285). After adjusting for covariates, the web‐push condition was associated with a 19% increase in the odds of responding compared with standard MTF (adjusted odds ratio = 1.188; 95% CI = 1.096, 1.287). Substance use prevalence estimates were very similar and differences became negligible when using attrition weights and controlling for socio‐demographic characteristics. Conclusions: The web‐push protocol produced a higher response rate than the mailed pencil and paper protocol in the Monitoring the Future panel study, without substantially affecting estimates of substance use once attrition weights and socio‐demographic variables were factored in. [ABSTRACT FROM AUTHOR]

BACKGROUND: Since the inception of the Youth Risk Behavior Surveillance System in 1991, all surveys have been conducted in schools, using paper and pencil instruments (PAPI). For the 2019 YRBSS, sites were offered the opportunity to conduct their surveys using electronic data collection. This study aimed to determine whether differences in select metrics existed between students who completed the survey electronically versus using PAPI. METHODS: Thirty risk behaviors were examined in this study. Data completeness, response rates and bivariate comparisons of risk behavior prevalence between administration modes were examined. RESULTS: Twenty‐nine of 30 questions examined had more complete responses among students using electronic surveys. Small differences were found for student and school response rates between modes. Twenty‐five of 30 adolescent risk behaviors showed no mode effect. CONCLUSIONS: Seven of 44 states and DC participated electronically. Because survey data were more complete; school and student response rates were consistent; and minor differences existed in risk behaviors between modes, the acceptability of collecting data electronically was demonstrated. [ABSTRACT FROM AUTHOR]

• IFCC position paper about CDT outlining caveats, key points, and recommendations. • Alcohol intake versus CDT is discussed as well as the cut-off and expected range. • Comparison studies using inadequate study populations will lead to wrong outcome. • Standardisation has led to test accuracy improvements in national EQAS. Carbohydrate deficient transferrin (CDT) is a biomarker for excessive alcohol consumption utilized in clinical and forensic medicine and workplace testing. Previously, many different analytical methods for CDT were used and the measurand varied considerably, making direct comparison of test results difficult. To end this confusion, the IFCC established a working group on CDT standardisation (WG-CDT) which completed its tasks in 2017. This IFCC position paper by the WG-CDT summarizes state of the art information about the measurand and the analytical methods and gives concise recommendations for its utilization. The results achieved by the CDT standardisation process led to accuracy improvements in national external quality assessment schemes over the years. A brief review of ROC based comparison studies with the traditional biomarkers (GGT, MCV, ALT and AST) discusses the bias resulting from inadequate study populations. In large groups of the general population the superior diagnostic performance of CDT is confirmed. The relationship between alcohol intake versus resulting CDT is discussed as well as the cutoff and measurement uncertainty. Concerning the application in practice, potential pitfalls are considered and recommendations handling both analytical and preanalytical caveats are given. Finally, some examples of serious misunderstandings in publications about CDT are addressed. [ABSTRACT FROM AUTHOR]

Critical bleeding causes over 2 million deaths a year. Early hypofibrinogenemia is a strong predictor of mortality in critically bleeding patients. The early replenishment of fibrinogen can significantly improve outcomes. However, over replenishment can also be dangerous. Furthermore, there is no rapid, cheap, hand-held diagnostic that can aid critically bleeding patients in fibrinogen replacement therapy. In this study, we have developed a hand-held paper diagnostic that measures plasma fibrinogen concentrations. The diagnostic has the potential to be used as a point of care device both inside and outside of hospital settings. It can vastly reduce the time to treatment for fibrinogen replacement therapy. The diagnostic is a two-step process. First, thrombin and plasma are added onto horizontially-orientated paper strips where the fibrinogen is converted into fibrin, drastically increasing the plasma's hydrophobicity. Second, an aqueous blue dye is pipetted onto the strips and allowed to wick through the fibrin. The distance the blue dye wicks through the strip correlates precisely to the fibrinogen concentration. The diagnostic can provide results within a minute. It can distinguish low fibrinogen concentrations (ie. <2 g/L) from normal fibrinogen concentrations. It shows remarkable reproducibility between healthy individuals. It is unaffected by common blood conditions such as acidosis, blood alcohol, severe hypertriglyceridemia, severe haemolysis and warfarin administration. Finally, it is unaffected by humidity and can withstand cold temperatures. Image 1 • We have developed a new hand-held, paper-based blood diagnostic which can measure fibrinogen concentrations. • Testing is completed within 1 minute and needs only 3 μL of plasma – making it ideal for diagnosing hypofibrinogenemia. • The test can withstand acidosis, alcohol use, warfarin use, severe haemolysis and severe hypertriglyceridemia. • The test can also withstand a wide range of temperatures and humidities making it suitable for outdoor use. • The test has the potential to revolutionise point of care testing and save two million lives each year. [ABSTRACT FROM AUTHOR]

The article offers medical news briefs as of September 2017. An analysis of data from the Whitehall II study has found that even moderate alcohol consumption, compared with abstinence, may raise the risk of hippocampal atrophy and faster decline in lexical fluency. Chocolate may reduce the risk of atrial fibrillation. Intrauterine system (IUS) insertion soon after termination leads to better results.

Given the high rate of alcoholism throughout history, its effects on the fetus may have existed for millennia. But, the claim that Greeks and Romans were aware of fetal alcohol syndrome rests on incorrect citations. From 1725, maternal alcohol consumption was associated with retarded fetal growth and neurological anomalies. From 1809, scientists followed Lamarck's theory that the disorders parents acquire during their lifetime are passed on to their offspring. Fetal effects were thought to be inherited mainly from the father. During the 19th century, parental alcoholism became associated with malformations. In 1915, Ballantyne distinguished genetic influence via germ cells from toxin's effect on the embryo. Fetal alcohol syndrome was characterized by Rouquette [Influence de la toxicomanie alcoolique parentale sur le développement physique et psychique des jeunes enfants] in 1957 and Lemoine et al. [Ouest Medical. 1968;21:476–482] in 1968 as consisting of 4 features: (A) facial anomalies (narrow forehead, retracted upper lip, and cupped ears), (B) severe growth retardation (prenatal and postnatal), (C) malformations (limbs, cardiac, and visceral), and (D) central nervous system anomalies (hyperexcitability and mental retardation). But, their studies, written in French, remained disregarded. In 1973, Jones et al. [Lancet. 1973;302:999–1001] reported "the first association between maternal alcoholism and aberrant morphogenesis in the offspring." The history of fetal alcohol syndrome reveals shortcomings in citation practice. Alleged quotations remained unverified, non-English publications neglected, and short quotations taken out of context. Prejudiced by religious and abstinence groups, reports on alcohol damage to the unborn were fraught with emotions, moralizing, social implications, and presentism, the interpretation of past events with present knowledge. [ABSTRACT FROM AUTHOR]

In April of 2006, a team of researchers consisting of both university and community partners from a Mi'kmaq reserve in Nova Scotia began the data-collection phase of a high school-based research study that had been two years in planning. The study examines the possible relationships between youth-reported childhood maltreatment, posttraumatic stress disorder (PTSD) symptoms, depressive symptoms, alcohol misuse, and resiliency factors. The aim of the research study is to provide information about adolescent alcohol misuse that is of practical benefit to community-based service providers, and capable of making a scholarly contribution to the scientific study of the relations of anxiety/mood symptoms and addictive behaviours. The primary aim of this paper is to present both the context from which the project grew, and the steps involved in conducting research with our school partners and the community service providers. A secondary aim is to present some of the preliminary data from the study, with a specific focus on resiliency. [ABSTRACT FROM AUTHOR]

The rapid, selective, and sensitive determination of cyanide anion ( CN−) using a simple paper strip is highly attractive because cyanide is acutely lethal to living organisms via all routes of administration, including alcohol consumption and inhaling cigarette smoke. Here, a synthetic probe ( 1) was designed for the selective determination of cyanide. The probe displays rapid and large blue spectral change (Δλabs =148 nm, Δλem = 165 nm) with respect to target recognition. Probe 1 exhibits a strong push-pull electronic effect and comprises a dimethylaminoaryl group as a donor and malononitrile as an acceptor; the π-conjugation system can be destroyed by the Michael-type addition of cyanide at the electrophilic β-positions of the nitrile groups, resulting in the marked emergence of a peak at λem = 515 nm. The developed probe was successfully applied to a paper test strip because of its noticeable optical changes upon reaction with cyanide. The fabricated dumbbell-shaped paper strip with an internal reference allowed the cyanide detection, which is indispensable for quantitative analysis in point-of-care testing. The paper strip test showed selective response to cyanide, with a linear correlation in the range of 0-25 mM in a simple and cost-effective manner. [ABSTRACT FROM AUTHOR]

In many situations like car accidents, troubles and crime scenes we need to know if someone is drunk. This research includes rapid test to detect the alcohol drinking for those that not exhibit any signs of drunk like ataxia and vomiting, and to detect the beverage containing alcohols. The study included 30 volunteers of alcoholics and five types of beverages (Whisky, vodka, beer, wine and barbican). The sampling includes random quantity of sputum and 2 ml of blood from the volunteers. The sputum and beverages are examined by qualitative method depending on the change of dichromate solution color which is saturated and dried up on a filter paper piece in polyethylene container ready for use. If the color changes from yellow to blue-green this means that the sample contains alcohol and the result is positive, and if the color of dichromate dose not changed the result is negative and the sample dose not contains alcohol. The blood samples were examined by the measuring of GGT enzyme to confirm alcohol drinking. All of the sputum samples showed positive results by changing the color of dichromate. All of the beverages except barbican showed positive results this means that these beverages contain alcohol while barbican not. The values of GGT for volunteers were higher than the normal values which confirm the test of sputum. [ABSTRACT FROM AUTHOR]

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Introduction: The use of chatbots in healthcare is an area of study receiving increased academic interest. As the knowledge base grows, the granularity in the level of research is being refined. There is now more targeted work in specific areas of healthcare, for example, chatbots for anxiety and depression, cancer care, and pregnancy support. The aim of this paper is to systematically review and summarize the research conducted on the use of chatbots in the field of addiction, specifically the use of chatbots as supportive agents for those who suffer from a substance use disorder (SUD). Methods: A systematic search of scholarly databases using the broad search criteria of ("drug" OR "alcohol" OR "substance") AND ("addiction" OR "dependence" OR "misuse" OR "disorder" OR "abuse" OR harm*) AND ("chatbot" OR "bot" OR "conversational agent") with an additional clause applied of "publication date" ≥ January 01, 2016 AND "publication date" ≤ March 27, 2022, identified papers for screening. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used to evaluate eligibility for inclusion in the study, and the Mixed Methods Appraisal Tool was employed to assess the quality of the papers. Results: The search and screening process identified six papers for full review, two quantitative studies, three qualitative, and one mixed methods. The two quantitative papers considered an adaptation to an existing mental health chatbot to increase its scope to provide support for SUD. The mixed methods study looked at the efficacy of employing a bespoke chatbot as an intervention for harmful alcohol use. Of the qualitative studies, one used thematic analysis to gauge inputs from potential users, and service professionals, on the use of chatbots in the field of addiction, based on existing knowledge, and envisaged solutions. The remaining two were useability studies, one of which focussed on how prominent chatbots, such as Amazon Alexa, Apple Siri, and Google Assistant can support people with an SUD and the other on the possibility of delivering a chatbot for opioid-addicted patients that is driven by existing big data. Discussion/Conclusion: The corpus of research in this field is limited, and given the quality of the papers reviewed, it is suggested more research is needed to report on the usefulness of chatbots in this area with greater confidence. Two of the papers reported a reduction in substance use in those who participated in the study. While this is a favourable finding in support of using chatbots in this field, a strong message of caution must be conveyed insofar as expert input is needed to safely leverage existing data, such as big data from social media, or that which is accessed by prevalent market leading chatbots. Without this, serious failings like those highlighted within this review mean chatbots can do more harm than good to their intended audience. [ABSTRACT FROM AUTHOR]

This paper investigates the factors influencing the probability of fatality in various types of maritime accidents, including grounding, capsizing, sinking, man overboard incidents, and fatal falls, with a focus on several contributing factors—alcohol consumption, meteorological conditions, and visibility. Through comprehensive analysis, the alcohol consumption was examined in order to show how it impairs judgment and physical abilities, significantly increasing the risk of fatal outcomes in these accidents. The paper explores the interplay between alcohol consumption and other contributing factors, such as time of day (daytime/night) and weather conditions, providing a comprehensive understanding of how these variables collectively influence fatality rates in EU maritime transportation. The findings underscore the critical need for stringent alcohol regulations and enhanced safety protocols to mitigate the heightened risks associated with alcohol-impaired maritime operations. [ABSTRACT FROM AUTHOR]

Background: Ethyl alcohol (ethanol) consumption is ostensibly known to increase the risk of morbidity and mortality during hot weather and heatwaves. However, how alcohol independently alters physiological, perceptual, and behavioral responses to heat stress remains poorly understood. Therefore, we conducted a systematic scoping review to understand how alcohol consumption affects thermoregulatory responses to the heat. Methods: We searched five databases employing the following eligibility criteria, studies must have: 1) involved the oral consumption of ethanol, 2) employed a randomized or crossover-control study design with a control trial consisting of a volume-matched, non-alcoholic beverage, 3) been conducted in healthy adult humans, 4) reported thermophysiological, perceptual, hydration status markers, and/or behavioral outcomes, 5) been published in English, 6) been conducted in air or water at temperatures of > 28°C, 7) involved passive rest or exercise, and 8) been published before October 4th, 2023. Results: After removing duplicates, 7256 titles were screened, 29 papers were assessed for eligibility and 8 papers were included in the final review. Across the 8 studies, there were a total of 93 participants (93 male/0 female), the average time of heat exposure was 70 min and average alcohol dose was 0.68 g·kg1. There were 23 unique outcome variables analyzed from the studies. The physiological marker most influenced by alcohol was core temperature (lowered with alcohol consumption in 3/4 studies). Additionally, skin blood flow was increased with alcohol consumption in the one study that measured it. Typical markers of dehydration, such as increased urine volume (1/3 studies), mass loss (1/3 studies) and decreased plasma volume (0/2 studies) were not consistently observed in these studies, except for in the study with the highest alcohol dose. Conclusion: The effect of alcohol consumption on thermoregulatory responses is understudied, and is limited by moderate doses of alcohol consumption, short durations of heat exposure, and only conducted in young-healthy males. Contrary to current heat-health advice, the available literature suggests that alcohol consumption does not seem to impair physiological responses to heat in young healthy males. [ABSTRACT FROM AUTHOR]

AbstractObjective:Our study was aimed at comparing health behavior data collected from a Web-based self-administered questionnaire (Web SAQ) versus a paper-and-pencil self-administered questionnaire and assessing the feasibility of the application.Materials and Methods:One hundred and ninety (n= 190) pupils (ages 14–16 years) of senior high schools anonymously completed a questionnaire, with demographics and queries about lifestyle, alcohol, and tobacco use. For each class, the adolescents were randomly assigned to complete either the paper version of the questionnaire or the equivalent Web-based one, which used a customized platform developed for the purposes of this survey.Results:Females who filled out the Web SAQ required significantly less time and completed a significantly higher percentage of its items. Although the majority of questions on tobacco and alcohol did not differ significantly across the two administration modes, there were gender-related differences in some sensitive information. Male adolescents on the Web SAQ accounted higher per hour drink consumption (r= 0.27,p= 0.015) and more numerous episodes of inebriety (r= 0.26,p= 0.010), whereas females seemed to state a younger age of alcohol onset (r= 0.33,p= 0.002). Females were more likely to report being monthly smokers on the Web SAQ (odds ratio = 0.37). Adolescents felt significantly less observed and females referred being more independent while compiling the Web SAQ.Conclusions:The findings of the study suggest that differences in reporting of some behavior of adolescents when using a Web SAQ do exist, despite the small-to-medium effect sizes. Exploiting the Web requires further investigation for extensive comprehension of the reasons for such differences. [ABSTRACT FROM AUTHOR]

Objectives: The term oral potentially malignant disorders (OPMD) was recommended at the WHO workshop held in 2005 and published in 2007, and increasingly large number of papers related to OPMD are published. The objective of the bibliometric analysis was to investigate the citation characteristics and analyze research trends of OPMD. Methods: A comprehensive search was performed and identified in the Scopus database since 2007 for the bibliometric list of OPMD in the syntax. Results: A total of 795 papers on OPMD were retrieved and the total number of citations was 8870. The mean number of citations is 11.2, with a range of 0 to 580. A substantial increasing tread in the number of citation is observed since 2007. Leukoplakia (42%) and lichen planus (23%) were the two most individual disorders among the general OPMD. A controlled/comparative study (43%) and a retrospective study (16%) were the two most study designs. India (n = 267) and the UK (n = 99) were the two most contributing countries. Tobacco and alcohol use and betel quid chewing (n = 351) are the most common keywords. Notably, early detection and diagnosis of oral cancer (n = 255) and biomarkers of oral carcinogenesis (n = 178) top the list, which may indicate a trend of key topics. Conclusions: The current study for the first time reported the bibliometric characteristics and research trends of the papers on OPMD in the syntax. Clinical relevance: The bibliometric analysis highlights the key topics and studies which have shaped the understanding and management of OPMD. [ABSTRACT FROM AUTHOR]

Background Despite research highlighting the role of alcohol in military life, specifically in relation to mental health and certain combat experiences, there is no synthesised evidence looking at the relationship between military service and alcohol use. Aims To synthesize and examine evidence exploring the relationship between military service and alcohol use. Methods Six databases were examined across a 10-year period. Papers were included if they involved a military population and focused on alcohol use. From 4046 papers identified, 29 papers were included in the review. Results Military characteristics and experience were linked to high levels of alcohol use across military populations. Societal and cultural factors also played a role in alcohol use in military populations. Predatory behaviour of alcohol establishments, pressures to conform, an acceptance of alcohol use, and the role of religious services and military affiliated social networks were all considered. Excessive drinking impacted physical and mental health. Those diagnosed with PTSD and associated symptoms appeared to have greater alcohol use. Conclusions This review identified certain characteristics and experiences of military service that are associated with higher levels of alcohol use. It is important to identify risk factors for alcohol misuse to develop appropriate policy, targeting prevention. [ABSTRACT FROM AUTHOR]

The use of screening questionnaires to detect early problem drinking has been stimulated by the development of the AUDIT (Alcohol-Use Disorders Identification Test). A comparison of a computerized version of the test and its paper and pencil original was conducted on 110 consecutive attenders at an alcoholism day-treatment facility. The findings suggest that the computer version is as acceptable as the paper and pencil one and that scores on the two formats are comparable. [ABSTRACT FROM PUBLISHER]

This study compares estimates of self-reported substance use and psychological well-being obtained in computer-assisted and paper-and-pencil self-administered surveys. We examine the extent to which mode effects on survey responses are moderated by respondent characteristics and respondent attitudes, including attitudes toward computers, attitudes about confidentiality and privacy, and their general mistrust of others. Respondents age 12-34 were selected through a multistage area probability sample of urban and suburban areas nationally and were randomly assigned to interview mode. There were few main effects of mode on self-reported substance use and well-being. Significant mode-by-age interaction terms revealed that adolescents were more sensitive to mode of administration than older respondents. Adolescents reported significantly higher levels of alcohol use, illicit drug use, and psychological distress in the computer mode than on paper self-administered questionnaires. Significant mode-by-mistrust interactions were also found. Respondents with higher levels of mistrust in others were less likely to report substance use in the computer mode than in the paper-and-pencil format. [ABSTRACT FROM AUTHOR]

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The paper examines the impact of alcoholism on the values of family relationships and highlights the destructive consequences of alcohol abuse. The paper uses qualitative research methods and focuses on two distinct groups: middle-aged women from well-off families and children from children's homes who have experienced alcoholism from a family member. The paper reveals the pervasive consequences of parental alcohol abuse, such as low self-esteem, emotional instability and difficulties in establishing and maintaining healthy relationships. The findings highlight the urgent need for greater awareness and prevention efforts regarding the broader social and familial impacts of alcohol consumption. This research contributes to the understanding of relational dynamics in families affected by alcoholism. [ABSTRACT FROM AUTHOR]

There has been increasing interest in using of web-based surveys--rather than paper based surveys--for collecting data on alcohol and other drug use in middle and high schools in the US. However, prior research has indicated that respondent confidentiality is an underlying concern with online data collection especially when computer-assisted surveys are administered in group settings such as computer labs and classrooms. Using a sample of 341 high school students, we conducted a study comparing alcohol risk behavior prevalence rates from the web-based surveys with paper-form version of the same survey. The online surveys used in the study implemented several programming safeguards to enhance privacy. The goal of our study was to see if the risk-behavior items--when transitioned to an online format with these additional safeguards--would provide prevalence estimates that are comparable to its paper form version. Results showed that overall alcohol prevalence rates did not vary significantly between the two conditions. However, there was a significant interaction between gender and survey mode. Females reported lower mean risk indicator rates compared to males, possibly indicating stronger privacy concerns among the former group. The results suggest that online survey administration may require targeted efforts to help alleviate confidentiality concerns among adolescent girls. [ABSTRACT FROM AUTHOR]

Background The research of alcohol consumption-related problems is a multidisciplinary field. The aim of this study is to analyze the worldwide scientific production in the area of alcohol-drinking and alcohol-related problems from 2005 to 2009. Methods A MEDLINE and Scopus search on alcohol (alcohol-drinking and alcohol-related problems) published from 2005 to 2009 was carried out. Using bibliometric indicators, the distribution of the publications was determined within the journals that publish said articles, specialty of the journal (broad subject terms), article type, language of the publication, and country where the journal is published. Also, authorship characteristics were assessed (collaboration index and number of authors who have published more than 9 documents). The existing research groups were also determined. Results About 24,100 documents on alcohol, published in 3,862 journals, and authored by 69,640 authors were retrieved from MEDLINE and Scopus between the years 2005 and 2009. The collaboration index of the articles was 4.83 ± 3.7. The number of consolidated research groups in the field was identified as 383, with 1,933 authors. Documents on alcohol were published mainly in journals covering the field of ' Substance- Related Disorders,' 23.18%, followed by ' Medicine,' 8.7%, ' Psychiatry,' 6.17%, and ' Gastroenterology,' 5.25%. Conclusions Research on alcohol is a consolidated field, with an average of 4,820 documents published each year between 2005 and 2009 in MEDLINE and Scopus. Alcohol-related publications have a marked multidisciplinary nature. Collaboration was common among alcohol researchers. There is an underrepresentation of alcohol-related publications in languages other than English and from developing countries, in MEDLINE and Scopus databases. [ABSTRACT FROM AUTHOR]

The article argues that the 2002 Comparative Risk Assessment (CRA) study conducted by the World Health Organization (WHO) did not treat alcohol like most of other risk factors of diseases. The author thinks that alcohol usage has both beneficial and adverse outcomes and thus is too general to be an activity to usually serve as risk factor, contrary to the claims of J. Rehm and U. Frick. It is argued here that it is justified to distinguish between risky and nonhazardous drinking and that combining detrimental and protective outcomes of drinking into a single statistical indicator can be misleading.

Overview This study investigated the general and oral health status and behaviours and the dental treatment requirements of remand prisoners. It makes recommendations on how their oral health care needs may be met. Method A convenience sample of 78 remand prisoners participated in the study within HMP Brixton. The study involved a structured interview, to establish health status and behaviours as well as perceived oral health needs, combined with an oral examination to establish normative treatment need. Results Prisoners' general health was compromised. In particular, there were high levels of mental illness and infectious disease. Unhealthy behaviours such as tobacco smoking, alcohol use, drug dependency, and high sugar diets were commonplace. This affected the remand prisoners' oral health, which presented with high levels of decay and relatively low levels of both missing and filled teeth. Whilst prisoners made high use of prison dental services, they made little use of dental services outside of prison. The high turnover of remand prisoners and high demand for emergency care made the delivery of preventive and routine care difficult. Conclusion Remand prisoners have compromised general and oral health compared with the general population. They exhibit poor oral health, which is contributed to by their lifestyles and health behaviours. [ABSTRACT FROM AUTHOR]

Aim: To explore the association between nurse education levels and patient‐related factors with hypertension self‐care. Background: Although self‐care development is recognized as a healthcare provider–patient encounter, the attribution of nurse education level to hypertension self‐care is not well addressed. Design: A cross‐sectional study. Methods: Hypertensive patients from 15 primary care facilities were sampled, and self‐care was assessed using the Self‐Care of Hypertension Inventory version 2.0, with standardized scores ≥70 indicating adequate self‐care. Data on patient‐related factors were obtained from electronic health records, self‐reports and laboratory tests, while nurse education levels were categorized as standard (baccalaureate‐prepared) or higher (post‐baccalaureate specialty). Results: A total of 1493 participants were included in this study, with a median age of 66 years and 77.7% being female. Approximately 10% of participants had adequate self‐care, and 66% received care from higher educated nurses. The study showed the relation between nurse education levels and the self‐care of the patients. Adequate hypertension self‐care was significantly associated with higher educated nurse providers and patient‐related factors, including intermediate to higher education, non‐overweight/obese and the absence of age‐related comorbidities. Conclusions: Hypertensive patients who had been provided care by higher educated nurses and their favourable sociodemographic, lower cardiometabolic risk and no concomitant disease were more likely to demonstrate adequate self‐care. Summary statement: What is already known about this topic? Improving hypertension self‐care requires attention to both patient‐related and healthcare‐related factors.Clinical trial studies have established the effectiveness of nurse‐enhanced hypertension self‐care.There is currently a lack of evidence regarding the impact of nurse‐related factors, such as nurse education level, on hypertension outcomes in routine primary care practice and observational studies.What this paper adds? We confirmed that patient‐related factors, such as having intermediate to higher education, being non‐overweight/obese and not having aging‐related comorbidities, were associated with better hypertension self‐care.Patients who received care from higher educated nurses demonstrated better hypertension self‐care.The implications of this paper: To enhance hypertension self‐care, clinicians should prioritize individuals who have low levels of education, are overweight/obese and have aging‐related comorbidities.Preparing nurses with advanced competence through higher education could be a viable approach to improving hypertension outcomes in primary care settings. [ABSTRACT FROM AUTHOR]

Background: Unhealthy alcohol use represents a significant risk for morbidity and mortality among people living with HIV (PLWH), in part through its impact on HIV management. Chronic pain, a common comorbidity, exacerbates suboptimal engagement in the HIV care continuum and has reciprocal detrimental effects on alcohol outcomes. There are no integrated, accessible approaches that address these comorbid conditions among PLWH to date. This paper describes a research study protocol of an integrated telehealth intervention to reduce unhealthy drinking and chronic pain among PLWH (Motivational and Cognitive-Behavioral Management for Alcohol and Pain [INTV]). Methods: Two-hundred and fifty PLWH with unhealthy drinking and chronic pain will be recruited nationally via online advertisement. Informed consent and baseline assessments occur remotely, followed by 15 days of ecological momentary assessment to assess alcohol use, chronic pain, functioning, and mechanisms of behavior change. Next, participants will be randomized to either the INTV or Control (CTL) condition. Individuals in both conditions will meet with a health counselor through videoconferencing following randomization, and those in the INTV condition will receive 6 additional sessions. At 3- and 6-months post-baseline, participants will complete outcome assessments. It is hypothesized that the INTV condition will result in reduced unhealthy alcohol use and pain ratings compared to the CTL condition. Conclusion: This protocol paper describes a randomized controlled trial which tests the efficacy of a novel, integrated telehealth approach to reduce unhealthy alcohol use and chronic pain for PLWH, two common comorbid conditions that influence the HIV treatment cascade. ClinicalTrials.gov identifier: NCT05503173. Highlights: Unhealthy alcohol use and chronic pain are common in people living with HIV. An integrated telehealth intervention may improve alcohol, pain, and HIV outcomes. Ecological momentary assessment will examine processes underlying behavior change. [ABSTRACT FROM AUTHOR]

Oral health remains one of the most taken for granted parts of human body health, even though poor oral health has now been linked to various diseases, such as cancers, diabetes, autoimmune complications, neurological disorders, and cardiovascular disease, just to name a few. As we review in this paper, substance use or abuse, including alcohol, smoking, recreational drugs, and pharmaceutical drugs can have significant implications on oral health, which in turn can lead to more systemic diseases. In this paper, we show that oral microbiome dysbiosis and inflammatory cytokine pathways are two of the most significant mechanisms contributing to oral health complications from substance use. When substance use decreases beneficial oral species and increases periodontopathogenic strains, a subsequent cascade of oncogenic and inflammatory cytokines is triggered. In this review, we explore these mechanisms and others to determine the consequences of substance use on oral health. The findings are of significance clinically and in research fields as the substance-use-induced deterioration of oral health significantly reduces quality of life and daily functions. Overall, the studies in this review may provide valuable information for future personalized medicine and safer alternatives to legal and pharmaceutical substances. Furthermore, they can lead towards better rehabilitation or preventative initiatives and policies, as it is critical for healthcare and addiction aid specialists to have proper tools at their disposal. [ABSTRACT FROM AUTHOR]

Alcohol withdrawal syndrome (AWS) is defined as the cessation or reduction in heavy and prolonged alcohol use within several hours to a few days of cessation. The recommended first-line therapy for AWS ranging from mild to severe or complicated remains benzodiazepines; in cases where benzodiazepines are not adequate in controlling persistent autonomic hyperactivity or anxiety, dexmedetomidine could be utilized. The possible advantage of dexmedetomidine compared to benzodiazepines is that it does not cause respiratory depression, thus reducing the risk of intubation and hospitalization in the ICUs, with the potential reduction in healthcare costs. The purpose of this systematic review and meta-analysis (PROSPERO CRD42018084370) is to evaluate the effectiveness and safety of dexmedetomidine as adjunctive therapy to the standard of care for the treatment of AWS. We retrieved literature from PubMed, EMBASE, and CENTRAL until 10 January 2024. Eligible studies were both randomized trials and nonrandomised studies with a control group, published in the English language and peer-reviewed journals. The primary outcome was tracheal intubation; secondary outcomes were (i) bradycardia and (ii) hypotension. A total of 3585 papers were retrieved: 2635 from EMBASE, 930 from Medline, and 20 from CENTRAL. After eliminating duplicates, 2960 papers were screened by title and abstract; 75 out of the 2960 papers were read in full text. The qualitative synthesis included nine of all manuscripts read in full text. The quantitative synthesis included eight studies for the primary outcome (tracheal intubation), seven for the secondary outcome bradycardia, and six for the secondary outcome hypotension. The meta-analysis showed that Dexmedetomidine, as adjunctive therapy, is not more effective than standard therapy in reducing the risk of tracheal intubation in AWS [RR: 0.57, 95% CI: 0.25–1.3, p = 0.15]. It also appears to be less safe than sedative therapy as it significantly increases the risk of bradycardia [RR: 2.68, 95% CI: 1.79–4.16, p = 0.0016]. Hypotension was not significantly different in patients who received dexmedetomidine [RR: 1.5, 95% CI: 0.69–3.49, p = 0.21]. [ABSTRACT FROM AUTHOR]

Background: This commentary discusses the recent paper by , placing their results into perspective. Results: Quinn and Fromme's meta-analysis is an important and useful synthesis of a complex literature. It is clear, well written, and well reasoned, with conclusions that are relevant to both the Low Level of Response Model and the Differentiator Model. Conclusions: Drs. Quinn and Fromme use a thorough and thoughtful approach, and I encourage researchers to address the important questions raised by their meta-analysis. [ABSTRACT FROM AUTHOR]

Background and Aims: There is a growing literature using event‐level methods to estimate associations between contextual characteristics of drinking occasions, consumption levels and acute harms. This literature spans many research traditions and has not been brought together as a whole. This mapping review aimed to identify and describe the theoretical approaches to conceptualizing drinking occasions, study designs, predictors and outcome measures used in existing research with a view to identifying dominant approaches, research gaps and areas for further synthesis. Methods: Eligible papers studied adults' drinking occasions using quantitative event‐level methods and considered one or more contextual characteristics (e.g. venue, timing or company) and at least one event‐level consumption or acute alcohol‐related harm outcome. We systematically searched Ovid MEDLINE, PsycInfo and the Web of Science Social Sciences Citation Index, extracting data on studies' theoretical approach, data collection methods, settings, populations, drinking occasion characteristics and outcome measures. Results: Searches identified 278 eligible papers (from 1975 to 2019), predominantly published after 2010 (n = 181; 65.1%). Most papers reported research conducted in the United States (n = 170; 61.2%) and half used student participants (n = 133; 47.8%). Papers typically lacked a stated theoretical approach (n = 203; 73.0%). Consistent with this, only 53 (19.1%) papers studied three or more occasion characteristics and most used methods that assume occasion characteristics do not change during an occasion (n = 189; 68.0%). The most common outcome type considered was consumption (n = 224; 80.6%) and only a few papers studied specific acute harm outcomes such as unprotected sex (n = 24; 8.6%), drink driving (n = 14; 5.0%) or sexual violence (n = 9; 3.2%). Conclusions: Studies from 1975 to 2019 using event‐level methods to estimate associations between contextual characteristics of drinking occasions, consumption levels and acute harms were largely focused on students and consumption outcomes, and most have considered a limited range of contextual characteristics. [ABSTRACT FROM AUTHOR]

Introduction and aim. Alcohol is a factor that promotes injury- related death - poisoning, vehicle accidents, falls, drownings. Moreover, alcohol consumption contributes to the increase in suicide rate - blood alcohol content is present in many cases. Occasionally, its concentration is so high that it is questionable whether it is possible to commit a suicide or drive with such a high BAC. The study aimed to investigate if individuals with BAC over 3.5‰ can remain active and die of other reason than alcohol intoxication. Material and methods. Retrospective analysis of sectional protocols of people with BAC over 3.5‰ who did not die because of lethal blood concentration of alcohol from the Department of Forensic Medicine in Cracow in the years 2014-2022 was conducted. After finding cases with BAC over 3.5‰ who did not die as a result of alcohol intoxication, the analysis of the causes of their deaths was performed. Results. Having excluded subjects that did not meet our requirements, we obtained 43 cases in total -- 27 pedestrians hit by some vehicle, 4 drivers, 5 murdered victims, 5 died by hanging and 2 by falling from a height. We also searched for the highest possible BAC in general as well as in particular groups that enabled them remain active, and so we documented a pedestrian with BAC 4.8‰ who died in a road accident while crossing the road. Conclusion. Intoxicated people with BAC over 3.5‰ are able to perform different kinds of activities, which eventually become the cause of their death. Some people are still able to walk, hang themselves or even drive a car. The vast majority of our cases died in car accidents. The results of our research may thus undermine the claim that people with high blood alcohol levels are not capable of committing suicide. [ABSTRACT FROM AUTHOR]

Aim: This study aimed to determine the knowledge, attitudes, and practices of male nurses towards human papillomavirus (HPV) and HPV vaccination and to examine whether knowledge about the HPV vaccine affects attitudes and beliefs about HPV vaccines. Background: HPV is responsible for ≈5% of all cancers worldwide. Therefore, vaccination against HPV is recommended to prevent HPV infections and HPV‐related cancers in men and women. Methods: The study group included 383 male nurses who were asked to complete online questionnaires. The data were collected using the following tools: a sociodeomographical characteristics form, the Human Papillomavirus Knowledge Scale (HPVKS), and The Carolina HPV Immunization Attitudes and Beliefs Scale (CHIAS). Results: It was determined that the general HPV knowledge of the male nurses participating in the study was at a moderate level, but their knowledge of HPV screening test, HPV vaccination, and current HPV vaccination programmes were at a low level. Male nurses' HPV vaccination rates were relatively low, and most of them did not intend to be vaccinated. In addition, CHIAS Attitudes and Beliefs scores of the male nurses were at an average level and HPV knowledge affected the attitudes and beliefs of the nurses. Conclusion: These results demonstrate an opportunity to improve information and awareness about HPV and vaccines by nursing education. Summary statement: What is already known about the topic? Although HPV vaccination is recommended to prevent HPV infections and HPV‐related cancers in men and women, vaccination rates are far behind the target, especially for men. What this paper adds? Findings showed that male nurses' HPV vaccination rates were relatively low.Male nurses' knowledge about HPV and HPV vaccine was not sufficient.HPV knowledge affected the attitudes and beliefs of these male nurses. The implications of this paper: Nurses need to be aware of the HPV vaccine during their undergraduate education. [ABSTRACT FROM AUTHOR]

The development of fast sensory analysis techniques is almost mandatory to meet the demand of the food and beverages industry, which requires quick responses that do not involve the investment of many resources. The increase in demand for sensory services, and the need for new methods that provide quick and useful data to the beverages industry, has caused a significant rise in sensory-related research. Sensory science is a young discipline that has proven to be very useful for the food and beverage industry, not only to guarantee the quality of the organoleptic properties of raw materials and processed foods/beverages, but also to increase the probability of the success of new developments, to understand consumer response and detect potential consumer niches, and to monitor competitors. [Extracted from the article]

Issues: Numerous studies have explored alcohol consumption in pregnancy, but less is known about women's drinking in the early parenting period (EPP, 0–5 years after childbirth). We synthesise research related to three questions: (i) How are women's drinking patterns and trajectories associated with socio‐demographic and domestic circumstances?; (ii) What theoretical approaches are used to explain changes in consumption?; (iii) What meanings have been given to mothers' drinking? Approach: Three databases (Ovid‐MEDLINE, Ovid‐PsycINFO and CINAHL) were systematically searched. Citation tracking was conducted in Web of Science Citation Index and Google Scholar. Eligible papers explored mothers' alcohol consumption during the EPP, focusing on general population rather than clinical samples. Studies were critically appraised and their characteristics, methods and key findings extracted. Thematic narrative synthesis of findings was conducted. Key Findings: Fourteen quantitative and six qualitative studies were identified. The (sub)samples ranged from n = 77,137 to n = 21 women. Mothers' consumption levels were associated with older age, being White and employed, not being in a partnered relationship, higher education and income. Three theoretical approaches were employed to explain these consumption differences: social role, role deprivation, social practice theories. By drinking alcohol, mothers expressed numerous aspects of their identity (e.g., autonomous women and responsible mothers). Implications and Conclusion: Alcohol‐related interventions and policies should consider demographic and cultural transformations of motherhood (e.g., delayed motherhood, changes in family structures). Mothers' drinking should be contextualised carefully in relation to socio‐economic circumstances and gender inequalities in unpaid labour. The focus on peer‐reviewed academic papers in English language may limit the evidence. [ABSTRACT FROM AUTHOR]

Issues: Globally, adolescent drinking is a major public health concern. Alcohol measurements are influenced by local consumption practices, patterns and perceptions of alcohol‐related harm. This is the first review to examine what tools are used to measure alcohol consumption, or screen for or assess harmful use in African adolescents, and how these tools take into account the local context. Approach: A systematic scoping review was conducted in line with the Arksey and O'Malley framework. A search in MEDLINE, CINAHL, Global Health and the Cochrane Database covered the period of 2000–2020. Key Findings: The search identified 121 papers across 25 African countries. A range of single‐ and multi‐item tools were identified. Very few adaptations of existing questions were specified, and this search identified no tools developed by local researchers that were fundamentally different from established tools often designed in the USA or Europe. Inconsistencies were found in the use of cut‐off scores; many studies used adult cut‐off scores. Implications and Conclusion: The possible impact of African drinking practices and culture on the accuracy of alcohol screening tools is currently unknown, but is also not taken into account by most research. This, in combination with a limited geographical distribution of alcohol‐related research across the continent and inconsistent use of age‐ and gender‐specific cut‐off scores, points towards probable inaccuracies in current data on adolescent alcohol use in Africa. [ABSTRACT FROM AUTHOR]

Issues: Meta‐analysis was used to estimate the effect of forming implementation intentions (i.e., if‐then plans) on weekly alcohol consumption and heavy episodic drinking (HED). Sample type, mode of delivery, intervention format and timeframe were tested as moderator variables. Approach: Cochrane, EThOS, Google Scholar, PsychArticles, PubMed and Web of Science were searched for relevant publications to 31 March 2021. Random‐effects meta‐analysis was used to estimate the effect size difference (d) between individuals forming versus not forming implementation intentions on weekly consumption and HED. Key Findings: Sixteen studies were included in meta‐analyses. The effect size difference for forming implementation intentions on weekly alcohol consumption was d+ = −0.14 confidence interval (CI) [−0.24; −0.03]. Moderator analyses highlighted stronger effects for: (i) community (d+ = −0.38, CI [−0.58; −0.18]) versus university (d+ = −0.04, CI [−0.13; 0.05]) samples; (ii) paper (d+ = −0.26, CI [−0.43; −0.09]) versus online (d+ = −0.04, CI [−0.14; 0.06]) mode of delivery; and (iii) volitional help sheet (d+ = −0.34, CI [−0.60; −0.07]) versus implementation intention format (d+ = −0.07, CI [−0.16; 0.02]). In addition, effects diminished over time (B = 0.02, SE = 0.01, CI [0.03; 0.01]). Forming implementation intentions had a null effect on HED, d+ = −0.01 CI [−0.10; 0.08]. Implications: Forming implementation intentions reduces weekly consumption but has no effect on HED. Conclusion: This review identifies boundary conditions on the effectiveness of implementation intentions to reduce alcohol consumption. Future research should focus on increasing the effectiveness of online‐delivered interventions and integrating implementation intention and motivational interventions. [ABSTRACT FROM AUTHOR]

This article uses archival sources to reconstruct an alternate history of Milton Friedman's A Theory of the Consumption Function, spotlighting the contributions of his collaborators Margaret Reid, Dorothy Brady, and Rose Friedman. Although Milton Friedman offered public credit to his wife and their two close friends, none received formal recognition or reward for their contribution to the permanent income hypothesis. The article documents this hypothesis as an example in professional economics of the well-known "Matilda effect," in which women's intellectual contributions are systemically devalued, while arguing it is important to distinguish between formal and informal credit. Further, the article connects the lower status of women's consumption economics to broader shifts in the economics discipline across the twentieth century. [ABSTRACT FROM AUTHOR]