17 results on '"mammary paget disease"'
Search Results
2. Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors
- Author
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Yuri Akishima-Fukasawa, Naoko Honma, Hideaki Ogata, Yoshikiyo Akasaka, and Tetuo Mikami
- Subjects
Mammary Paget disease ,Angiogenesis ,Blood flow ,Basic fibroblast growth factor (bFGF) ,Vascular endothelial growth factor A (VEGFA) ,Immunohistochemistry ,Pathology ,RB1-214 - Abstract
Abstract Background We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) were examined. Methods We calculated the average CD34-positive BVD and podoplanin (D2–40)-positive lymphatic vessel density (LVD) and the proportion of proliferating of endothelial cells in 14 Paget disease, 3 dermatitis biopsy, and 14 age-matched control cases. As a parameter related to blood flow in the nipple, the total CD34-positive blood vessel lumen area relative to the entire nipple area was measured in each Paget disease and control case using an automated image analysis system. Immunohistochemical expression of bFGF and VEGFA in Paget cells was also examined. Results The average BVD and LVD were significantly higher in the Paget disease cases than in the dermatitis (p = 0.003) and control (p
- Published
- 2020
- Full Text
- View/download PDF
3. Pigmentary Mammary Paget Disease: clinical, dermoscopical and histological challenge
- Author
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Angelo Massimiliano D'Erme, Roberta Iozzo, Paolo Viacava, Agata Janowska, Valentina Dini, Marco Romanelli, Cristian Fidanzi, and Giovanni Bagnoni
- Subjects
melanoma ,Pigmentary Mammary Paget Disease ,Mammary Paget Disease ,Dermatology ,RL1-803 - Abstract
A very rare variant of MPD is the Pigmented Mammary Paget Disease (PMPD), first described by Culberson et al. in 1956. It is very difficult to distinguish this variant from melanoma both clinically and dermoscopically. The diagnosis is confirmed by histopathology and immunohistochemistry. Correct diagnosis is crucial for surgical treatment, which is different for these two diseases. We report the case of a 92-year-old woman, who presented an asymptomatic pigmented lesion of the right nipple and areola. The lesion was arisen for about 6 months and was suspected for melanoma because of clinical and dersmoscopic characteristics. Incisional biopsy revealed tumor cells, that proliferate in the major mammary ducts, and tumor cells in the overlying epidermis of the nipple, thus diagnosing pigmented mammary Paget disease (PMPD). The patient underwent radical mastectomy.
- Published
- 2021
- Full Text
- View/download PDF
4. Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database
- Author
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Shijing Chen, Huaquan Chen, Ying Yi, Xuemei Jiang, Hai Lei, Xue Luo, Yu Chen, Sha Liu, Dan Yuan, Xinjian Jia, and Junyan Li
- Subjects
Breast Cancer ,Ductal Carcinoma In Situ ,Infiltrating Ductal Carcinoma ,Mammary Paget Disease ,Surveillance ,Epidemiology ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Most mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone. Methods From the Surveillance, Epidemiology, and End Results (SEER) database, 2000‐2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD‐IDC) and 1489 women who had PD with ductal carcinoma in situ (PD‐DCIS). Independent demographic and clinicopathological variables as well as survival outcomes of these patients were compared to patients with the corresponding breast cancer without concomitant PD. Results PD‐IDC and PD‐DCIS both had worse survival outcomes and poorer tumor characteristics than the corresponding disease without PD. Contrary to in the breast cancer alone groups, in the breast cancer with PD groups, the HR status (P = 0.182 in PD‐IDC and P = 0.371 in PD‐DCIS), HER2 status (P = 0.788 in PD‐IDC and P = 0.643 in PD‐DCIS), and combined molecular subtype (P = 0.196 in PD‐IDC and P = 0.853 in PD‐DCIS) were not found to affect disease prognosis. After matching tumor characteristics and treatment approaches, PD‐IDC as well as PD‐DCIS exhibited no significant difference in disease prognosis with corresponding IDC and DCIS. Finally, by comparative analysis, a kind of PD‐DCIS (ICD‐O‐3 code 8543/3) showed many invasive behaviors (31.8% of 8543/3 patients had stage I‐III cancer) and was associated with worse survival outcomes than the other type of PD‐DCIS. Conclusions Breast cancer with concomitant PD was associated with more aggressive tumor characteristics and worse survival outcomes. The HR status, HER2 status, and combined molecular subtype could not affect the prognosis of breast cancer with PD. Moreover, a portion of the PD‐DCIS cases were invasive breast cancer cases that required special treatment.
- Published
- 2019
- Full Text
- View/download PDF
5. Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors.
- Author
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Akishima-Fukasawa, Yuri, Honma, Naoko, Ogata, Hideaki, Akasaka, Yoshikiyo, and Mikami, Tetuo
- Subjects
- *
NEOVASCULARIZATION , *VASCULAR endothelial growth factors , *BLOOD flow , *FIBROBLAST growth factor 2 , *BLOOD vessels , *BLOOD testing - Abstract
Background: We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) were examined. Methods: We calculated the average CD34-positive BVD and podoplanin (D2–40)-positive lymphatic vessel density (LVD) and the proportion of proliferating of endothelial cells in 14 Paget disease, 3 dermatitis biopsy, and 14 age-matched control cases. As a parameter related to blood flow in the nipple, the total CD34-positive blood vessel lumen area relative to the entire nipple area was measured in each Paget disease and control case using an automated image analysis system. Immunohistochemical expression of bFGF and VEGFA in Paget cells was also examined. Results: The average BVD and LVD were significantly higher in the Paget disease cases than in the dermatitis (p = 0.003) and control (p < 0.001) cases. The proportion of proliferating endothelial cells was also increased in the Paget disease cases. The ratio of the CD34-positive blood vessel lumen area to nipple area was also significantly higher in the Paget disease than control cases (p = 0.003). The average BVD was correlated with the average LVD (r = 0.734, p < 0.001) and ratio of the blood vessel lumen area to nipple area (r = 0.692, p < 0.001). Immunohistochemical expression of bFGF was strong in all Paget disease cases, with a significantly higher expression score in the Paget disease than dermatitis (p = 0.003) and control (p < 0.001) cases. The bFGF, but not VEGFA, expression score, was strongly correlated with the average BVD (r = 0.818, p < 0.001) and ratio of the blood vessel lumen area to nipple area (r = 0.503, p = 0.006). Conclusion: These results provide direct histopathological evidence of a marked increase in nipple blood flow in Paget disease detected by clinical imaging. bFGF is considered to play a pivotal role in angiogenesis in mammary Paget disease. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
6. Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database.
- Author
-
Chen, Shijing, Chen, Huaquan, Yi, Ying, Jiang, Xuemei, Lei, Hai, Luo, Xue, Chen, Yu, Liu, Sha, Yuan, Dan, Jia, Xinjian, and Li, Junyan
- Subjects
- *
DISEASE complications , *BREAST cancer , *LOBULAR carcinoma , *CARCINOMA in situ , *BREAST cancer prognosis , *DUCTAL carcinoma , *THERAPEUTICS - Abstract
Background: Most mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone. Methods: From the Surveillance, Epidemiology, and End Results (SEER) database, 2000‐2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD‐IDC) and 1489 women who had PD with ductal carcinoma in situ (PD‐DCIS). Independent demographic and clinicopathological variables as well as survival outcomes of these patients were compared to patients with the corresponding breast cancer without concomitant PD. Results: PD‐IDC and PD‐DCIS both had worse survival outcomes and poorer tumor characteristics than the corresponding disease without PD. Contrary to in the breast cancer alone groups, in the breast cancer with PD groups, the HR status (P = 0.182 in PD‐IDC and P = 0.371 in PD‐DCIS), HER2 status (P = 0.788 in PD‐IDC and P = 0.643 in PD‐DCIS), and combined molecular subtype (P = 0.196 in PD‐IDC and P = 0.853 in PD‐DCIS) were not found to affect disease prognosis. After matching tumor characteristics and treatment approaches, PD‐IDC as well as PD‐DCIS exhibited no significant difference in disease prognosis with corresponding IDC and DCIS. Finally, by comparative analysis, a kind of PD‐DCIS (ICD‐O‐3 code 8543/3) showed many invasive behaviors (31.8% of 8543/3 patients had stage I‐III cancer) and was associated with worse survival outcomes than the other type of PD‐DCIS. Conclusions: Breast cancer with concomitant PD was associated with more aggressive tumor characteristics and worse survival outcomes. The HR status, HER2 status, and combined molecular subtype could not affect the prognosis of breast cancer with PD. Moreover, a portion of the PD‐DCIS cases were invasive breast cancer cases that required special treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
7. Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors
- Author
-
Naoko Honma, Yoshikiyo Akasaka, Yuri Akishima-Fukasawa, Hideaki Ogata, and Tetuo Mikami
- Subjects
0301 basic medicine ,Vascular Endothelial Growth Factor A ,Pathology ,medicine.medical_specialty ,Histology ,Angiogenesis ,Paget's Disease, Mammary ,Basic fibroblast growth factor ,Lumen (anatomy) ,Breast Neoplasms ,Vascular endothelial growth factor A (VEGFA) ,Pathology and Forensic Medicine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Vascularity ,Biopsy ,medicine ,Lymphatic vessel ,lcsh:Pathology ,Humans ,Basic fibroblast growth factor (bFGF) ,medicine.diagnostic_test ,Neovascularization, Pathologic ,business.industry ,Research ,Mammary Paget disease ,General Medicine ,Blood flow ,Immunohistochemistry ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,Female ,Fibroblast Growth Factor 2 ,medicine.symptom ,business ,Blood vessel ,lcsh:RB1-214 - Abstract
Background We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) were examined. Methods We calculated the average CD34-positive BVD and podoplanin (D2–40)-positive lymphatic vessel density (LVD) and the proportion of proliferating of endothelial cells in 14 Paget disease, 3 dermatitis biopsy, and 14 age-matched control cases. As a parameter related to blood flow in the nipple, the total CD34-positive blood vessel lumen area relative to the entire nipple area was measured in each Paget disease and control case using an automated image analysis system. Immunohistochemical expression of bFGF and VEGFA in Paget cells was also examined. Results The average BVD and LVD were significantly higher in the Paget disease cases than in the dermatitis (p = 0.003) and control (p p = 0.003). The average BVD was correlated with the average LVD (r = 0.734, p r = 0.692, p p = 0.003) and control (p r = 0.818, p r = 0.503, p = 0.006). Conclusion These results provide direct histopathological evidence of a marked increase in nipple blood flow in Paget disease detected by clinical imaging. bFGF is considered to play a pivotal role in angiogenesis in mammary Paget disease.
- Published
- 2020
8. Pigmentary mammary Paget disease: Clinical, dermoscopical and histological challenge
- Author
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D’Erme, Angelo Massimiliano, Iozzo, Roberta, Viacava, Paolo, De Luca, Filomena, Janowska, Agata, Dini, Valentina, Romanelli, Marco, Fidanzi, Cristian, and Bagnoni, Giovanni
- Subjects
Pigmentary mammary Paget disease ,mammary Paget disease ,RL1-803 ,melanoma ,Case Report ,Dermatology - Abstract
A very rare variant of MPD is the Pigmented Mammary Paget Disease (PMPD), first described by Culberson et al. in 1956. It is very difficult to distinguish this variant from melanoma both clinically and dermoscopically. The diagnosis is confirmed by histopathology and immunohistochemistry. Correct diagnosis is crucial for surgical treatment, which is different for these two diseases. We report the case of a 92-year-old woman, who presented an asymptomatic pigmented lesion of the right nipple and areola. The lesion was arisen for about 6 months and was suspected for melanoma because of clinical and dersmoscopic characteristics. Incisional biopsy revealed tumor cells, that proliferate in the major mammary ducts, and tumor cells in the overlying epidermis of the nipple, thus diagnosing pigmented mammary Paget disease (PMPD). The patient underwent radical mastectomy.
- Published
- 2021
9. Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database
- Author
-
Yi Ying, Huaquan Chen, Luo Xue, Dan Yuan, Lei Hai, Jiang Xuemei, Jia Xinjian, Sha Liu, Shijing Chen, Junyan Li, and Yu Chen
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Epidemiology ,and End Results ,Paget's Disease, Mammary ,Breast Neoplasms ,Disease ,Kaplan-Meier Estimate ,lcsh:RC254-282 ,Mammary Paget Disease ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Paget Disease ,Breast Cancer ,medicine ,Biomarkers, Tumor ,Humans ,Radiology, Nuclear Medicine and imaging ,Stage (cooking) ,skin and connective tissue diseases ,neoplasms ,Original Research ,Aged ,Aged, 80 and over ,Surveillance ,business.industry ,Cancer ,Ductal Carcinoma In Situ ,Ductal carcinoma ,Middle Aged ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,Infiltrating Ductal Carcinoma ,body regions ,030104 developmental biology ,030220 oncology & carcinogenesis ,Concomitant ,Population Surveillance ,Female ,business ,Cancer Prevention ,SEER Program - Abstract
Background Most mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone. Methods From the Surveillance, Epidemiology, and End Results (SEER) database, 2000‐2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD‐IDC) and 1489 women who had PD with ductal carcinoma in situ (PD‐DCIS). Independent demographic and clinicopathological variables as well as survival outcomes of these patients were compared to patients with the corresponding breast cancer without concomitant PD. Results PD‐IDC and PD‐DCIS both had worse survival outcomes and poorer tumor characteristics than the corresponding disease without PD. Contrary to in the breast cancer alone groups, in the breast cancer with PD groups, the HR status (P = 0.182 in PD‐IDC and P = 0.371 in PD‐DCIS), HER2 status (P = 0.788 in PD‐IDC and P = 0.643 in PD‐DCIS), and combined molecular subtype (P = 0.196 in PD‐IDC and P = 0.853 in PD‐DCIS) were not found to affect disease prognosis. After matching tumor characteristics and treatment approaches, PD‐IDC as well as PD‐DCIS exhibited no significant difference in disease prognosis with corresponding IDC and DCIS. Finally, by comparative analysis, a kind of PD‐DCIS (ICD‐O‐3 code 8543/3) showed many invasive behaviors (31.8% of 8543/3 patients had stage I‐III cancer) and was associated with worse survival outcomes than the other type of PD‐DCIS. Conclusions Breast cancer with concomitant PD was associated with more aggressive tumor characteristics and worse survival outcomes. The HR status, HER2 status, and combined molecular subtype could not affect the prognosis of breast cancer with PD. Moreover, a portion of the PD‐DCIS cases were invasive breast cancer cases that required special treatment.
- Published
- 2019
10. Expression of PD-1 and PD-L1 in Extramammary Paget Disease: Implications for Immune-Targeted Therapy
- Author
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Carlos A. Torres-Cabala, Jennifer A. Wargo, Doina Ivan, Victor G. Prieto, Aysegul A. Sahin, Alan E. Siroy, Curtis A. Pettaway, Jonathan L. Curry, Courtney W. Hudgens, Priyadharsini Nagarajan, Shakuntala H. Mauzo, Denái R. Milton, Michael T. Tetzlaff, and Phyu P. Aung
- Subjects
PD-L1 ,Cancer Research ,CD3 ,medicine.medical_treatment ,lcsh:RC254-282 ,Article ,Targeted therapy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,PD-1 ,medicine ,biology ,business.industry ,mammary Paget disease ,Cancer ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Immune checkpoint ,immune infiltrate ,extramammary Paget disease ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Biomarker (medicine) ,business ,CD8 - Abstract
Extramammary Paget disease (EMPD) is a locally aggressive cutaneous malignancy that usually arises in anogenital or axillary skin. Immune checkpoint inhibitors targeting programmed cell death receptor (PD-1) and/or its ligand (PD-L1) are approved for the treatment of several types of cancer, and response to these generally correlates with increased PD-L1 expression by tumor cells. The expression of PD-L1 and composition and density of the tumor-associated immune infiltrate in EMPD have been little studied. To determine whether EMPD might be amenable to immune checkpoint blockade, we analyzed the expression of PD-1 and PD-L1 and the composition and density of the tumor-associated immune infiltrate in EMPD and evaluated associations between biomarker expression and clinicopathologic parameters. Twenty-one EMPD tumors were evaluated for tumor cell PD-L1 expression and for relative expression and distribution of CD3, CD8, PD-1, and PD-L1 in the tumor-associated immune infiltrate by using a combination of visual and image analysis (Aperio ImageScope). In addition, PD-L1 expression was assessed in 10 cases of mammary Paget disease (MPD). In EMPD cases, PD-L1 was expressed by tumor cells (3/21, 14%) and the tumor-associated immune infiltrate (15/21, 71%), and PD-1 was expressed by the tumor-associated immune infiltrate in all cases analyzed (18/18). However, PD-L1 expression by EMPD tumor cells did not correlate with the density of CD3-, CD8-, or PD-1-positive cells in the tumor-associated immune infiltrate or other clinicopathologic parameters. Furthermore, the density of CD3, CD8, PD-1, and PD-L1 in the tumor-associated immune infiltrate did not correlate with any clinicopathologic parameters evaluated with the exception that CD3 positive values were significantly higher in patients who were still alive (median, 1310 cells/mm2, range, 543&ndash, 2115, ) than in those who died (median, 611 cells/mm2, range, 481&ndash, 908, p = 0.049). In all MPD cases, PD-L1 was absent in tumor cells but present in the tumor-associated immune infiltrate, and PD-L1 expression in lymphocytes was lower in patients with HER2/neu-positive than in those with HER2/neu-negative disease (p = 0.07). Our findings raise the possibility of therapeutic targeting of the PD-1/PD-L1 axis in EMPD.
- Published
- 2019
11. Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ : A Case Report.
- Author
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Rao S, Wang A, Liu W, Yin H, Li J, Tsang LS, Wu Y, and Shi W
- Abstract
Several cases of pigmented mammary Paget's disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mammary Paget disease (MPD) which was misdiagnosed as melanoma in situ due to the interpretation of the staining of melanocytic markers S-100, Melan-A, and HMB-45. The tumor cells strongly expressed CK7 and GATA3, and a dual-labeling showed negative PHH3 labeling for the melanocytes. Pathologists need to be aware of the caveat of colonization of melanocytes in Paget disease., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Rao, Wang, Liu, Yin, Li, Tsang, Wu and Shi.)
- Published
- 2022
- Full Text
- View/download PDF
12. Pigmented Mammary Paget Disease Misdiagnosed as Malignant Melanoma
- Author
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Soo Chan Kim, Tae Hyung Kim, You Chan Kim, Mi Ryung Roh, and Ji Hye Lee
- Subjects
musculoskeletal diseases ,Pathology ,medicine.medical_specialty ,Malignant melanoma ,business.industry ,Melanoma ,Mammary paget disease ,Case Report ,Dermatology ,medicine.disease ,body regions ,Pigmented Mammary Paget Disease ,Paget Disease ,medicine ,otorhinolaryngologic diseases ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
- Published
- 2014
13. Pigmentary mammary Paget disease: Clinical, dermoscopical and histological challenge.
- Author
-
D'Erme AM, Iozzo R, Viacava P, De Luca F, Janowska A, Dini V, Romanelli M, Fidanzi C, and Bagnoni G
- Abstract
A very rare variant of mammary Paget disease (MPD) is the pigmented MPD, first described in 1956. It is very difficult to distinguish this variant from melanoma both clinically and dermoscopically. The diagnosis is confirmed by histopathology and immunohistochemistry. Correct diagnosis is crucial for surgical treatment, which is different for these two diseases. We report the case of a 92-year-old woman, who presented an asymptomatic pigmented lesion of the right nipple and areola. The lesion was arisen for about 6 months and was suspected for melanoma because of clinical and dersmoscopic characteristics. Incisional biopsy revealed tumor cells, that proliferate in the major mammary ducts, and tumor cells in the overlying epidermis of the nipple, thus diagnosing pigmented mammary Paget disease. The patient underwent radical mastectomy., Competing Interests: Conflict of interest: The authors declare no potential conflict of interest., (©Copyright: the Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
14. Reflectance Confocal Microscopy for Diagnosis of Mammary Paget’s Disease
- Author
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Cesare Massone, Iris Zalaudek, Rainer Hofmann-Wellenhof, André Oliveira, Edith Arzberger, Oliveira, Andrã©, Zalaudek, Iri, Arzberger, Edith, Massone, Cesare, and Hofmann-Wellenhof, Rainer
- Subjects
0301 basic medicine ,Reflectance confocal microscopy ,030103 biophysics ,Pathology ,medicine.medical_specialty ,Biopsy ,Paget's Disease, Mammary ,Breast Neoplasms ,Dermoscopy ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,HSAC DER ,0302 clinical medicine ,Microscopy ,Humans ,Medicine ,Mammary Paget's Disease ,Aged ,Retrospective Studies ,Aged, 80 and over ,adenocarcinoma ,Microscopy, Confocal ,medicine.diagnostic_test ,business.industry ,mammary paget disease ,General Medicine ,Middle Aged ,Immunohistochemistry ,body regions ,Paget s disease ,Austria ,Female ,business - Abstract
Mammary Paget’s disease (MPD) is an uncommon intra-epidermal adenocarcinoma of the nipple-areola complex, occurring in 1–5% of all breast carcinomas (1). MPD is difficult to diagnose clinically as it mimics a variety of both inflammatory and neoplastic skin diseases (2). Pigmented mammary Paget’s disease (PMPD) corresponds to an even less common variant, frequently simulating other pigmented lesions of the nipple, including melanoma (3–5). According to the epidermotropic theory, Paget cells (PCs) originate from cancer cells that migrate via the lactiferous ducts along the basal membrane, to invade the epidermis of the nipple and areola (6, 7). Considering its intra-epidermal spreading, PCs are therefore potentially demonstrable using non-invasive diagnostic techniques with near-cellular resolution, such as reflectance confocal microscopy (RCM) (8). The aim of this study was retrospectively to describe the RCM features of 5 cases of MPD, with dermoscopic and histopathological correlation.
- Published
- 2016
15. Expression of PD-1 and PD-L1 in Extramammary Paget Disease: Implications for Immune-Targeted Therapy.
- Author
-
Mauzo, Shakuntala H., Tetzlaff, Michael T., Milton, Denái R., Siroy, Alan E., Nagarajan, Priyadharsini, Torres-Cabala, Carlos A., Ivan, Doina, Curry, Jonathan L., Hudgens, Courtney W., Wargo, Jennifer A., Sahin, Aysegul A., Pettaway, Curtis A., Prieto, Victor G., and Aung, Phyu P.
- Subjects
- *
ADENOCARCINOMA , *APOPTOSIS , *CELL lines , *CELL receptors , *EPIDERMAL growth factor , *GENE expression , *LYMPHOCYTES , *NURSING models - Abstract
Extramammary Paget disease (EMPD) is a locally aggressive cutaneous malignancy that usually arises in anogenital or axillary skin. Immune checkpoint inhibitors targeting programmed cell death receptor (PD-1) and/or its ligand (PD-L1) are approved for the treatment of several types of cancer, and response to these generally correlates with increased PD-L1 expression by tumor cells. The expression of PD-L1 and composition and density of the tumor-associated immune infiltrate in EMPD have been little studied. To determine whether EMPD might be amenable to immune checkpoint blockade, we analyzed the expression of PD-1 and PD-L1 and the composition and density of the tumor-associated immune infiltrate in EMPD and evaluated associations between biomarker expression and clinicopathologic parameters. Twenty-one EMPD tumors were evaluated for tumor cell PD-L1 expression and for relative expression and distribution of CD3, CD8, PD-1, and PD-L1 in the tumor-associated immune infiltrate by using a combination of visual and image analysis (Aperio ImageScope). In addition, PD-L1 expression was assessed in 10 cases of mammary Paget disease (MPD). In EMPD cases, PD-L1 was expressed by tumor cells (3/21; 14%) and the tumor-associated immune infiltrate (15/21; 71%), and PD-1 was expressed by the tumor-associated immune infiltrate in all cases analyzed (18/18). However, PD-L1 expression by EMPD tumor cells did not correlate with the density of CD3-, CD8-, or PD-1-positive cells in the tumor-associated immune infiltrate or other clinicopathologic parameters. Furthermore, the density of CD3, CD8, PD-1, and PD-L1 in the tumor-associated immune infiltrate did not correlate with any clinicopathologic parameters evaluated with the exception that CD3 positive values were significantly higher in patients who were still alive (median, 1310 cells/mm2; range, 543–2115;) than in those who died (median, 611 cells/mm2; range, 481–908; p = 0.049). In all MPD cases, PD-L1 was absent in tumor cells but present in the tumor-associated immune infiltrate, and PD-L1 expression in lymphocytes was lower in patients with HER2/neu-positive than in those with HER2/neu-negative disease (p = 0.07). Our findings raise the possibility of therapeutic targeting of the PD-1/PD-L1 axis in EMPD. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
16. Pigmented Mammary Paget Disease
- Author
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Caterina Longo, Anna Maria Cesinaro, Giovanni Pellacani, Stefania Seidenari, Fabrizio Fantini, and Sara Bassoli
- Subjects
medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Paget's Disease, Mammary ,Confocal ,Mammary gland ,H&E stain ,Dermoscopy ,Dermatology ,Diagnosis, Differential ,Hyperpigmentation ,medicine ,Humans ,Melanoma ,Aged ,Dermatoscopy ,Microscopy, Confocal ,medicine.diagnostic_test ,mammary Paget disease ,business.industry ,Anatomical pathology ,General Medicine ,medicine.disease ,Immunohistochemistry ,In vivo reflectance-mode confocal microscopy ,medicine.anatomical_structure ,Pagetoid ,Female ,sense organs ,business - Abstract
Background Pigmented mammary Paget disease represents a rare variant of mammary Paget disease that clinically and dermoscopically simulates a melanoma. We report a case of pigmented mammary Paget disease mimicking a melanoma and describe the dermoscopic, reflectance-mode confocal microscopic, histological, and immunohistochemical features. Observations A 70-year-old woman had a 5.5 × 4-cm pigmented plaque with a thin, scaly surface on her left breast; the plaque had slowly but progressively grown during the preceding 10 years. Dermoscopic examination showed a diffuse, light brown pigmentation with irregular black dots, small gray-blue structures, and irregular vessels. Confocal microscopic features, such as large reflecting cells with dark nuclei spreading upward in pagetoid fashion, were suggestive of melanoma. Histological evaluation integrated with immunohistochemical staining showed pigmented mammary Paget disease. Conclusions This case demonstrates that the diagnosis of pigmented mammary Paget disease cannot be determined by clinical examination and dermoscopy alone. Therefore, immunohistochemical staining should be performed in growing lesions with equivocal clinical and dermoscopic aspects that are characterized by abundant pagetoid infiltration in hematoxylin-eosin–stained sections to avoid overlooking pigmented mammary Paget disease.
- Published
- 2007
17. Pigmented mammary paget disease misdiagnosed as malignant melanoma.
- Author
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Lee JH, Kim TH, Kim SC, Kim YC, and Roh MR
- Abstract
Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
- Published
- 2014
- Full Text
- View/download PDF
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