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Reflectance Confocal Microscopy for Diagnosis of Mammary Paget’s Disease
- Source :
- Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos), Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação, instacron:RCAAP
- Publication Year :
- 2016
- Publisher :
- Medical Journals Sweden AB, 2016.
-
Abstract
- Mammary Paget’s disease (MPD) is an uncommon intra-epidermal adenocarcinoma of the nipple-areola complex, occurring in 1–5% of all breast carcinomas (1). MPD is difficult to diagnose clinically as it mimics a variety of both inflammatory and neoplastic skin diseases (2). Pigmented mammary Paget’s disease (PMPD) corresponds to an even less common variant, frequently simulating other pigmented lesions of the nipple, including melanoma (3–5). According to the epidermotropic theory, Paget cells (PCs) originate from cancer cells that migrate via the lactiferous ducts along the basal membrane, to invade the epidermis of the nipple and areola (6, 7). Considering its intra-epidermal spreading, PCs are therefore potentially demonstrable using non-invasive diagnostic techniques with near-cellular resolution, such as reflectance confocal microscopy (RCM) (8). The aim of this study was retrospectively to describe the RCM features of 5 cases of MPD, with dermoscopic and histopathological correlation.
- Subjects :
- 0301 basic medicine
Reflectance confocal microscopy
030103 biophysics
Pathology
medicine.medical_specialty
Biopsy
Paget's Disease, Mammary
Breast Neoplasms
Dermoscopy
Dermatology
030207 dermatology & venereal diseases
03 medical and health sciences
HSAC DER
0302 clinical medicine
Microscopy
Humans
Medicine
Mammary Paget's Disease
Aged
Retrospective Studies
Aged, 80 and over
adenocarcinoma
Microscopy, Confocal
medicine.diagnostic_test
business.industry
mammary paget disease
General Medicine
Middle Aged
Immunohistochemistry
body regions
Paget s disease
Austria
Female
business
Subjects
Details
- ISSN :
- 00015555
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Acta Dermato Venereologica
- Accession number :
- edsair.doi.dedup.....20a4d34fdff80a43e0aa53696decab6e