28 results on '"Zoltán Somogyi"'
Search Results
2. In Vitro Microevolution and Co-Selection Assessment of Amoxicillin and Cefotaxime Impact on Escherichia coli Resistance Development
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Ádám Kerek, Bence Török, Levente Laczkó, Zoltán Somogyi, Gábor Kardos, Krisztián Bányai, Eszter Kaszab, Krisztina Bali, and Ákos Jerzsele
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microevolution ,co-selection ,MEGA-plate ,Escherichia coli ,amoxicillin ,cefotaxime ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The global spread of antimicrobial resistance has become a prominent issue in both veterinary and public health in the 21st century. The extensive use of amoxicillin, a beta-lactam antibiotic, and consequent resistance development are particularly alarming in food-producing animals, with a focus on the swine and poultry sectors. Another beta-lactam, cefotaxime, is widely utilized in human medicine, where the escalating resistance to third- and fourth-generation cephalosporins is a major concern. The aim of this study was to simulate the development of phenotypic and genotypic resistance to beta-lactam antibiotics, focusing on amoxicillin and cefotaxime. The investigation of the minimal inhibitory concentrations (MIC) of antibiotics was performed at 1×, 10×, 100×, and 1000× concentrations using the modified microbial evolution and growth arena (MEGA-plate) method. Our results indicate that amoxicillin significantly increased the MIC values of several tested antibiotics, except for oxytetracycline and florfenicol. In the case of cefotaxime, this increase was observed in all classes. A total of 44 antimicrobial resistance genes were identified in all samples. Chromosomal point mutations, particularly concerning cefotaxime, revealed numerous complex mutations, deletions, insertions, and single nucleotide polymorphisms (SNPs) that were not experienced in the case of amoxicillin. The findings suggest that, regarding amoxicillin, the point mutation of the acrB gene could explain the observed MIC value increases due to the heightened activity of the acrAB-tolC efflux pump system. However, under the influence of cefotaxime, more intricate processes occurred, including complex amino acid substitutions in the ampC gene promoter region, increased enzyme production induced by amino acid substitutions and SNPs, as well as mutations in the acrR and robA repressor genes that heightened the activity of the acrAB-tolC efflux pump system. These changes may contribute to the significant MIC increases observed for all tested antibiotics. The results underscore the importance of understanding cross-resistance development between individual drugs when choosing clinical alternative drugs. The point mutations in the mdtB and emrR genes may also contribute to the increased activity of the mdtABC-tolC and emrAB-tolC pump systems against all tested antibiotics. The exceptionally high mutation rate induced by cephalosporins justifies further investigations to clarify the exact mechanism behind.
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- 2024
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3. In Vitro Microevolution and Co-Selection Assessment of Florfenicol Impact on Escherichia coli Resistance Development
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Ádám Kerek, Bence Török, Levente Laczkó, Gábor Kardos, Krisztián Bányai, Zoltán Somogyi, Eszter Kaszab, Krisztina Bali, and Ákos Jerzsele
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microevolution ,co-selection ,MEGA-plate ,Escherichia coli ,florfenicol ,NGS ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The issue of antimicrobial resistance is becoming an increasingly serious challenge in both human and veterinary medicine. Prudent antimicrobial use in veterinary medicine is warranted and supported by international guidelines, with the Antimicrobial Advice Ad Hoc Expert Group (AMEG) placing particular emphasis on the critically important group B antimicrobials. These antimicrobials are commonly employed, especially in the poultry and swine industry. The impact of florfenicol, a veterinary antibiotic, was studied on the resistance development of Escherichia coli. The aim of the study was to investigate the effect of the use of florfenicol on the development of phenotypic and genomic resistances, not only to the drug itself but also to other drugs. The minimum inhibitory concentrations (MICs) of the antibiotics were investigated at 1×, 10×, 100× and 1000× concentrations using the adapted Microbial Evolution and Growth Arena (MEGA-plate) method. The results demonstrate that florfenicol can select for resistance to fluoroquinolone antibiotics (167× MIC value increase) and cephalosporins (67× MIC value increase). A total of 44 antimicrobial resistance genes were identified, the majority of which were consistent across the samples. Chromosomal point mutations, including alterations in resistance-associated and regulatory genes (acrB, acrR, emrR and robA), are thought to trigger multiple drug efflux pump activations, leading to phenotypically increased resistance. The study underscores the impact of florfenicol and its role in the development of antimicrobial resistance, particularly concerning fluoroquinolone antibiotics and cephalosporins. This study is the first to report florfenicol’s dose-dependent enhancement of other antibiotics’ MICs, linked to mutations in SOS-box genes (mdtABC-tolC, emrAB-tolC and acrAB-tolC) and increased multidrug efflux pump genes. Mutations in the regulatory genes acrR, emrR and rpbA support the possibility of increased gene expression. The results are crucial for understanding antimicrobial resistance and its development, highlighting the promising potential of in vitro evolutionary and coselection studies for future research.
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- 2023
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4. Susceptibility of Actinobacillus pleuropneumoniae, Pasteurella multocida and Streptococcus suis Isolated from Pigs in Hungary between 2018 and 2021
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Zoltán Somogyi, Patrik Mag, Réka Simon, Ádám Kerek, László Makrai, Imre Biksi, and Ákos Jerzsele
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Actinobacillus pleuropneumoniae ,Pasteurella multocida ,Streptococcus suis ,MIC ,antibacterial agents ,swine ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Porcine respiratory disease complex (PRDC) has been a major animal health, welfare, and economic problem in Hungary; therefore, great emphasis should be put on both the prevention and control of this complex disease. As antibacterial agents are effective tools for control, antibiotic susceptibility testing is indispensable for the proper implementation of antibacterial therapy and to prevent the spread of resistance. The best method for this is to determine the minimum inhibitory concentration (MIC) by the broth microdilution method. In our study, we measured the MIC values of 164 Actinobacillus pleuropneumoniae, 65 Pasteurella multocida, and 118 Streptococcus suis isolates isolated from clinical cases against the following antibacterial agents: amoxicillin, ceftiofur, cefquinome, oxytetracycline, doxycycline, tylosin, tilmicosin, tylvalosin, tulathromycin, lincomycin, tiamulin, florfenicol, colistin, enrofloxacin, and sulfamethoxazole-trimethoprim. Outstanding efficacy against A. pleuropneumoniae isolates was observed with ceftiofur (100%) and tulathromycin (100%), while high levels of resistance were observed against cefquinome (92.7%) and sulfamethoxazole-trimethoprim (90.8%). Ceftiofur (98.4%), enrofloxacin (100%), florfenicol (100%), and tulathromycin (100%) were found to be highly effective against P. multocida isolates, while 100% resistance was detected against the sulfamethoxazole-trimethoprim combination. For the S. suis isolates, only ceftiofur (100%) was not found to be resistant, while the highest rate of resistance was observed against the sulfamethoxazole-trimethoprim combination (94.3%). An increasing number of studies report multi-resistant strains of all three pathogens, making their monitoring a high priority for animal and public health.
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- 2023
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5. Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kgbw Following Intramuscular Administration
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Zoltán Somogyi, Patrik Mag, Réka Simon, Ádám Kerek, Pál Szabó, Ervin Albert, Imre Biksi, and Ákos Jerzsele
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florfenicol ,pharmacokinetic ,MIC ,AUC ,AUC24h/MIC ,synovial fluid ,Therapeutics. Pharmacology ,RM1-950 - Abstract
A major problem of our time is the ever-increasing resistance to antimicrobial agents in bacterial populations. One of the most effective ways to prevent these problems is to target antibacterial therapies for specific diseases. In this study, we investigated the in vitro effectiveness of florfenicol against S. suis, which can cause severe arthritis and septicemia in swine herds. The pharmacokinetic and pharmacodynamic properties of florfenicol in porcine plasma and synovial fluid were determined. After a single intramuscular administration of florfenicol at 30 mg/kgbw, the AUC0–∞ was 164.45 ± 34.18 µg/mL × h and the maximum plasma concentration was 8.15 ± 3.11 µg/mL, which was reached in 1.40 ± 0.66 h, whereas, in the synovial fluid, these values were 64.57 ± 30.37 µg/mL × h, 4.51 ± 1.16 µg/mL and 1.75 ± 1.16 h, respectively. Based on the MIC values of the 73 S. suis isolates tested, the MIC50 and MIC90 values were 2 µg/mL and 8 µg/mL, respectively. We successfully implemented a killing–time curve in pig synovial fluid as a matrix. Based on our findings, the PK/PD breakpoints of the bacteriostatic (E = 0), bactericidal (E = −3) and eradication (E = −4) effects of florfenicol were determined and MIC thresholds were calculated, which are the guiding indicators for the treatment of these diseases. The AUC24h/MIC values for bacteriostatic, bactericidal and eradication effects were 22.22 h, 76.88 h and 141.74 h, respectively, in synovial fluid, and 22.42 h, 86.49 h and 161.76 h, respectively, in plasma. The critical MIC values of florfenicol against S. suis regarding bacteriostatic, bactericidal and eradication effects in pig synovial fluid were 2.91 ± 1.37 µg/mL, 0.84 ± 0.39 µg/mL and 0.46 ± 0.21 µg/mL, respectively. These values provide a basis for further studies on the use of florfenicol. Furthermore, our research highlights the importance of investigating the pharmacokinetic properties of antibacterial agents at the site of infection and the pharmacodynamic properties of these agents against different bacteria in different media.
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- 2023
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6. Antimicrobial susceptibility profiles of Mycoplasma hyorhinis strains isolated from five European countries between 2019 and 2021.
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Ulrich Klein, Dorottya Földi, Nikolett Belecz, Veronika Hrivnák, Zoltán Somogyi, Michele Gastaldelli, Marianna Merenda, Salvatore Catania, Arkadiusz Dors, Ute Siesenop, Philip Vyt, Zsuzsa Kreizinger, Wouter Depondt, and Miklós Gyuranecz
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Medicine ,Science - Abstract
Mycoplasma hyorhinis is an emerging swine pathogen bacterium causing polyserositis and polyarthritis in weaners and finishers. The pathogen is distributed world-wide, generating significant economic losses. No commercially available vaccine is available in Europe. Therefore, besides improving the housing conditions for prevention, antimicrobial therapy of the diseased animals is the only option to control the infection. Our aim was to determine the minimal inhibitory concentrations (MIC) of ten antimicrobials potentially used against M. hyorhinis infection. The antibiotic susceptibility of 76 M. hyorhinis isolates from Belgium, Germany, Hungary, Italy and Poland collected between 2019 and 2021 was determined by broth micro-dilution method and mismatch amplification mutation assay (MAMA). Low concentrations of tiamulin (MIC90 0.312 μg/ml), doxycycline (MIC90 0.078 μg/ml), oxytetracycline (MIC90 0.25 μg/ml), florfenicol (MIC90 2 μg/ml) and moderate concentrations of enrofloxacin (MIC90 1.25 μg/ml) inhibited the growth of the isolates. For the tested macrolides and lincomycin, a bimodal MIC pattern was observed (MIC90 >64 μg/ml for lincomycin, tulathromycin, tylosin and tilmicosin and 5 μg/ml for tylvalosin). The results of the MAMA assay were in line with the conventional method with three exceptions. Based on our statistical analyses, significant differences in MIC values of tiamulin and doxycycline were observed between certain countries. Our results show various levels of antimicrobial susceptibility among M. hyorhinis isolates to the tested antibiotics. The data underline the importance of susceptibility monitoring on pan-European level and provides essential information for proper antibiotic choice in therapy.
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- 2022
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7. Photoreactive Coating Material as an Effective and Durable Antimicrobial Composite in Reducing Bacterial Load on Surfaces in Livestock
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Ádám Kerek, Mátyás Sasvári, Ákos Jerzsele, Zoltán Somogyi, László Janovák, Zsolt Abonyi-Tóth, and Imre Dékány
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titanium dioxide (TiO2) ,zinc oxide (ZnO) ,photoreactive coating ,Escherichia coli ,Biology (General) ,QH301-705.5 - Abstract
Titanium dioxide (TiO2) is a well-known photocatalytic compound that can be used to effectively reduce the presence of pathogens in human and animal hospitals via ROS release. The aim of this study was to investigate the efficacy of a polymer-based composite layer containing TiO2 and zinc oxide (ZnO) against Escherichia coli (E. coli) of animal origin. We showed that the photocatalyst coating caused a significant (p < 0.001) reduction in pathogen numbers compared to the control with an average reduction of 94% over 30 min. We used six light sources of different wattages (4 W, 7 W, 9 W, 12 W, 18 W, 36 W) at six distances (35 cm, 100 cm, 150 cm, 200 cm, 250 cm, 300 cm). Samples (n = 2160) were taken in the 36 settings and showed no significant difference in efficacy between light intensity and distance. We also investigated the influence of organic contaminant that resulted in lower activity as well as the effect of a water jet and a high-pressure device on the antibacterial activity. We found that the latter completely removed the coating from the surface, which significantly (p < 0.0001) reduced its antibacterial potential. As a conclusion, light intensity and distance does not reduce the efficacy of the polymer, but the presence of organic contaminants does.
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- 2022
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8. Synovial and Systemic Pharmacokinetics of Florfenicol and PK/PD Integration against Streptococcus suis in Pigs
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Zoltán Somogyi, Patrik Mag, Dóra Kovács, Ádám Kerek, Pál Szabó, László Makrai, and Ákos Jerzsele
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florfenicol ,pharmacokinetic ,MIC ,AUC ,AUC24h/MIC ,synovial fluid ,Pharmacy and materia medica ,RS1-441 - Abstract
Florfenicol is a member of the phenicol group, a broad-spectrum antibacterial agent. It has been used for a long time in veterinary medicine, but there are some factors regarding its pharmacokinetic characteristics that have yet to be elucidated. The aim of our study was to describe the pharmacokinetic profile of florfenicol in synovial fluid and plasma of swine after intramuscular (i.m.) administration. In addition, the dosage regimen of treatment of arthritis caused by S. suis was computed for florfenicol using pharmacokinetic/pharmacodynamic (PK/PD) indices. As the first part of our investigation, the pharmacokinetic (PK) parameters of florfenicol were determined in the plasma and synovial fluid of six pigs. Following drug administration (15 mg/kgbw, intramuscularly), blood was drawn at the following times: 10, 20, 30, 40, 50 and 60 min, 2, 3, 4, 5, 6, 7, 8, 12, 24, 48 and 72 h; synovial fluid samples were taken after 1, 2, 3, 4, 6, 8, 12, 24, 48 and 72 h. The concentration of florfenicol was determined by a validated liquid chromatography-mass spectrometry (LC-MS/MS) method via multiple reaction monitoring (MRM) modes. As the second part of our research, minimum inhibitory concentration (MIC) values of florfenicol were determined in 45 S. suis strains isolated from clinical samples collected in Hungary. Furthermore, a strain of S. suis serotype 2 (SS3) was selected, and killing-time curves of different florfenicol concentrations (0.5 µg/mL, 1 µg/mL and 2 µg/mL) were determined against this strain. Peak concentration of the florfenicol was 3.58 ± 1.51 µg/mL in plasma after 1.64 ± 1.74 h, while it was 2.73 ± 1.2 µg/mL in synovial fluid 3.4 ± 1.67 h after administration. The half-life in plasma was found to be 17.24 ± 9.35 h, while in synovial fluid it was 21.01 ± 13.19 h. The area under the curve (AUC24h) value was 54.66 ± 23.34 μg/mL·h for 24 h in plasma and 31.24 ± 6.82 μg/mL·h for 24 h in synovial fluid. The drug clearance scaled by bioavailability (Cl/F) in plasma and synovial fluid was 0.19 ± 0.08 L/h/kg and 0.29 ± 0.08 L/h/kg, respectively. The mean residence time (MRT) in plasma and synovial fluid was 24.0 ± 13.59 h and 27.39 ± 17.16 h, respectively. The steady-state volume of distribution (Vss) in plasma was calculated from Cl/F of 0.19 ± 0.08 L/h/kg, multiplied by MRT of 24.0 ± 13.59 h. For the PK/PD integration, average plasma and synovial fluid concentration of florfenicol was used in a steady-state condition. The obtained MIC50 value of the strains was 2.0 µg/mL, and MIC90 proved to be 16.0 µg/mL. PK/PD integration was performed considering AUC24h/MIC breakpoints that have already been described. This study is the first presentation of the pharmacokinetic behavior of florfenicol in swine synovia as well as a recommendation of extrapolated critical MICs of S. suis for therapeutic success in the treatment of S. suis arthritis in swine, but it should be noted that this requires a different dosage regimen to that used in authorized florfenicol formulations.
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- 2022
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9. Motorway Measurement Campaign to Support R&D Activities in the Field of Automated Driving Technologies
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Viktor Tihanyi, Tamás Tettamanti, Mihály Csonthó, Arno Eichberger, Dániel Ficzere, Kálmán Gangel, Leander B. Hörmann, Maria A. Klaffenböck, Christoph Knauder, Patrick Luley, Zoltán Ferenc Magosi, Gábor Magyar, Huba Németh, Jakob Reckenzaun, Viktor Remeli, András Rövid, Matthias Ruether, Selim Solmaz, Zoltán Somogyi, Gábor Soós, Dávid Szántay, Tamás Attila Tomaschek, Pál Varga, Zsolt Vincze, Christoph Wellershaus, and Zsolt Szalay
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vehicle detection ,automated driving ,autonomous vehicles ,measurement campaign ,5G ,vehicle sensors ,Chemical technology ,TP1-1185 - Abstract
A spectacular measurement campaign was carried out on a real-world motorway stretch of Hungary with the participation of international industrial and academic partners. The measurement resulted in vehicle based and infrastructure based sensor data that will be extremely useful for future automotive R&D activities due to the available ground truth for static and dynamic content. The aim of the measurement campaign was twofold. On the one hand, road geometry was mapped with high precision in order to build Ultra High Definition (UHD) map of the test road. On the other hand, the vehicles—equipped with differential Global Navigation Satellite Systems (GNSS) for ground truth localization—carried out special test scenarios while collecting detailed data using different sensors. All of the test runs were recorded by both vehicles and infrastructure. The paper also showcases application examples to demonstrate the viability of the collected data having access to the ground truth labeling. This data set may support a large variety of solutions, for the test and validation of different kinds of approaches and techniques. As a complementary task, the available 5G network was monitored and tested under different radio conditions to investigate the latency results for different measurement scenarios. A part of the measured data has been shared openly, such that interested automotive and academic parties may use it for their own purposes.
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- 2021
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10. Fóris Ágota, Bölcskei Andrea (főszerk.) Alkalmazott nyelvészeti kutatások a 21. századi információs térben. 1. Terminológia, lexikográfia, fordítás
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Zoltán Somogyi
- Abstract
Jelen kötet a 27. alkalommal megrendezett Magyar Alkalmazott Nyelvészeti Kong- resszus előadásainak terminológiával, lexikográfiával és fordítással kapcsolatos előadásainak írott változatát tartalmazza. A kongresszust 2019. április 15. és 16. között rendezte meg közösen a Magyar Alkalmazott Nyelvészek és Nyelvtanárok Egyesülete (MANYE), valamint a Károli Gáspár Református Egyetem Bölcsészet- és Társadalomtudományi Karának Magyar Nyelvtudományi Tanszéke.
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- 2021
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11. Investigation of the environmental presence of multidrug-resistant bacteria at small animal hospitals in Hungary
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Zoltán Somogyi, Dóra Kovács, Ádám Kerek, Ákos Jerzsele, and Ágnes Sterczer
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Staphylococcus pseudintermedius ,040301 veterinary sciences ,medicine.drug_class ,Staphylococcus ,Antibiotics ,Microbial Sensitivity Tests ,medicine.disease_cause ,Vancomycin-Resistant Enterococci ,030308 mycology & parasitology ,Microbiology ,0403 veterinary science ,Hospitals, Animal ,03 medical and health sciences ,Antibiotic resistance ,medicine ,Animals ,Hungary ,0303 health sciences ,General Veterinary ,biology ,04 agricultural and veterinary sciences ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,Anti-Bacterial Agents ,Penicillin ,Enterococcus ,Staphylococcus aureus ,medicine.drug ,Enterococcus faecium - Abstract
Multidrug-resistant bacteria can cause severe nosocomial infections in both human and veterinary clinics. The aim of this study was to investigate the presence and antibiotic susceptibility of Enterococcus, Staphylococcus and Pseudomonas strains at four small animal clinics of Hungary in 2018, as these bacteria can reliably represent the level of antimicrobial resistance in the investigated environment. A total of 177 Staphylococcus colonies were found, including 22 Staphylococcus pseudintermedius and 13 Staphylococcus aureus. As regards enterococci, 9 Enterococcus faecium, 2 E. faecalis and further 286 Enterococcus strains were isolated. The number of Pseudomonas aeruginosa isolates (n = 34) was considered too low for relevant susceptibility testing. Among staphylococci, the highest resistance was found to sulphamethoxazole (82.9%), penicillin (65.7%) and erythromycin (54.3%), while in the case of enterococci, resistance to norfloxacin and rifampicin was the most common, with 25.5% of the strains being resistant to both antibiotics. Ten methicillin-resistant S. pseudintermedius (MRSP) and six vancomycin-resistant Enterococcus (VRE) strains could be identified. Only 5.7% of the Staphylococcus isolates were susceptible to all tested agents, while this ratio was 36.2% among enterococci. The results of this study have revealed a high prevalence of antibiotic-resistant bacteria in Hungarian small animal clinics, which highlights the importance of regular disinfection processes and stringent hygiene measures in veterinary clinics.
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- 2021
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12. Guided inquiry-based learning in secondary-school chemistry classes: a case study
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Gábor Orosz, Veronika Németh, Lajos Kovács, Zoltán Somogyi, and Erzsébet Korom
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Chemistry (miscellaneous) ,05.03. Oktatástudomány ,01.04. Kémiai tudományok ,Education - Abstract
Guided inquiry-based learning has been shown to be a promising method for science education; however, despite its advantages it is rarely used in chemistry teaching in Hungary. One of the reasons for this is the lack of tried-and-tested inquiry-based teaching materials with detailed guides that teachers can readily use in their classrooms. As part of a four-year research project, new teaching materials were designed to foster scientific reasoning and scientific process skills in chemistry education in Hungary. From these materials, in this study, a guided inquiry-based chemistry task was tested with 9th-grade students (N = 88) who had no previous experience with the method. Before the activity, the students’ mid-term grades were collected, and the Lawson Classroom Test of Scientific Reasoning (LCTSR) was administered to describe the sample. During the activity, students worked in groups (n = 21). Data were collected through content analysis of the student worksheets, classroom observations using a rubric, and student questionnaires to explore the learning paths and identify possible obstacles. Our findings support that guided inquiry learning is suitable for students who are new to the method if appropriate scaffolding is given. The data showed the phases of the inquiry cycle in which more guidance is necessary. Formulating hypotheses, recording observations, and evaluating the hypotheses based on the evidence were found to be the most critical steps in the learning process. More than half of the groups disregarded the collected evidence and accepted their original hypotheses, despite their unproven validity, suggesting that they did not understand the true nature of the scientific inquiry. Chemistry grades and the LCTSR scores could not predict reliably the students’ success in solving the inquiry task. The results of the student questionnaire showed that the students enjoyed the inquiry session. They mostly found their work successful, but they overestimated the level of their inquiry skills in some cases.
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- 2022
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13. Characterization and ex vivo evaluation of excised skin samples as substitutes for human dermal barrier in pharmaceutical and dermatological studies
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Dorottya Kocsis, Victoria Klang, Eva‐Maria Schweiger, Zsófia Varga‐Medveczky, Anna Mihály, Csaba Pongor, Zsolt Révész, Zoltán Somogyi, and Franciska Erdő
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Swine ,Water ,Dermatology ,Ceramides ,Water Loss, Insensible ,Rats ,Mice ,Pharmaceutical Preparations ,Animals ,Humans ,Keratins ,Urea ,Epidermis ,Skin - Abstract
Excised animal and human skins are frequently used in permeability testing in pharmaceutical research. Several factors exist that may have influence on the results. In the current study some of the skin parameters that may affect drug permeability were analysed for human, mouse, rat and pig skin.Classic biophysical skin parameters were measured (e.g. pH, hydration, permittivity, transepidermal water loss). Physiological characteristics of the skins were also analysed by confocal Raman spectroscopy, scanning electron microscopy and two-photon microscopy.Based on biophysical testing, skin barrier function was damaged in psoriatic mouse skin and in marketed pig skin. Hydration and pH values were similar among the species, but freezing and thawing reduced the water content of the skins and shifted the surface pH to acidic. Aging reduced hydration and permittivity, resulting in impaired barrier function. Mechanical sensitization used in permeability studies resulted in proportional thinning of dead epidermis.Results indicate that depending on the scientific question it should be considered whether fresh or frozen tissue is used, and for certain purposes rodent skins are well usable. The structure of the skin tissue (ceramide, cholesterol, keratin, natural moisturizing factor or urea) is similar in rats and mice, but due to the higher skin thickness the lipid distribution is different in porcine skin. Psoriasis led to irregular chemical composition of the skin.A comprehensive evaluation of skin samples of four species was performed. The biophysical and microscopic observations should be considered when selecting drug penetration models and experimental conditions.
- Published
- 2021
14. Motorway Measurement Campaign to Support RD Activities in the Field of Automated Driving Technologies
- Author
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Huba Németh, Pal Varga, Dávid Szántay, Daniel Ficzere, Christoph Knauder, Viktor Tihanyi, Zoltan Ferenc Magosi, Selim Solmaz, Leander B. Hormann, Zsolt Szalay, Gabor Soos, Maria Anneliese Klaffenböck, Viktor Remeli, Arno Eichberger, Kálmán Gangel, András Rövid, Gábor Magyar, Tamás Attila Tomaschek, Mihály Csonthó, Jakob Reckenzaun, Zsolt Vincze, Tamás Tettamanti, Christoph Wellershaus, Zoltán Somogyi, Matthias Ruether, and Patrick Patrick Luley
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0209 industrial biotechnology ,Field (physics) ,Computer science ,Real-time computing ,Automotive industry ,02 engineering and technology ,Dynamic web page ,UHD map ,lcsh:Chemical technology ,Biochemistry ,Field (computer science) ,Article ,Analytical Chemistry ,020901 industrial engineering & automation ,Vehicle detection ,0202 electrical engineering, electronic engineering, information engineering ,lcsh:TP1-1185 ,Aerospace engineering ,Electrical and Electronic Engineering ,vehicle sensors ,Instrumentation ,infrastructure sensors ,automotive_engineering ,Ground truth ,business.industry ,measurement campaign ,Differential (mechanical device) ,Atomic and Molecular Physics, and Optics ,Data set ,GNSS applications ,automated driving ,vehicle detection ,020201 artificial intelligence & image processing ,Scenario testing ,autonomous vehicles ,business ,5G - Abstract
A spectacular measurement campaign was carried out on a real-world motorway stretch of Hungary with the participation of international industrial and academic partners. The measurement resulted in vehicle based and infrastructure based sensor data that will be extremely useful for future automotive R&D activities due to the available ground truth for static and dynamic content. The aim of the measurement campaign was twofold. On the one hand, road geometry was mapped with high precision in order to build Ultra High Definition (UHD) map of the test road. On the other hand, the vehicles—equipped with differential Global Navigation Satellite Systems (GNSS) for ground truth localization—carried out special test scenarios while collecting detailed data using different sensors. All of the test runs were recorded by both vehicles and infrastructure. The paper also showcases application examples to demonstrate the viability of the collected data having access to the ground truth labeling. This data set may support a large variety of solutions, for the test and validation of different kinds of approaches and techniques. As a complementary task, the available 5G network was monitored and tested under different radio conditions to investigate the latency results for different measurement scenarios. A part of the measured data has been shared openly, such that interested automotive and academic parties may use it for their own purposes.
- Published
- 2021
15. Projected effects of climate change on the carbon stocks of European beech (Fagus sylvatica L.) forests in Zala County, Hungary
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Zoltán Somogyi
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0106 biological sciences ,010504 meteorology & atmospheric sciences ,biology ,Agroforestry ,Ecology (disciplines) ,forest carbon balance ,Forestry ,silviculture ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,mortality ,European beech ,Plant science ,climate change ,Fagus sylvatica ,Effects of global warming ,Environmental science ,lcsh:SD1-669.5 ,lcsh:Forestry ,Beech ,Carbon stock ,0105 earth and related environmental sciences - Abstract
Recent studies suggest that climate change will lead to the local extinction of many tree species from large areas during this century, affecting the functioning and ecosystem services of many forests. This study reports on projected carbon losses due to the assumed local climate change-driven extinction of European beech (Fagus sylvatica L.) from Zala County, South-Western Hungary, where the species grows at the xeric limit of its distribution. The losses were calculated as a difference between carbon stocks in climate change scenarios assuming an exponentially increasing forest decline over time, and those in a baseline scenario assuming no climate change. In the climate change scenarios, three different sets of forest management adaptation measures were studied: (1) only harvesting damaged stands, (2) additionally salvaging dead trees that died due to climate change, and (3) replacing, at an increasing rate over time, beech with sessile oak (Quercus petraea Matt. Lieb.) after final harvest. Projections were made using the open access carbon accounting model CASMOFOR based on modeling or assuming effects of climate change on mortality, tree growth, root-to-shoot ratio and decomposition rates. Results demonstrate that, if beech disappears from the region as projected by the end of the century, over 80% of above-ground biomass carbon, and over 60% of the carbon stocks of all pools (excluding soils) of the forests will be lost by 2100. Such emission rates on large areas may have a discernible positive feedback on climate change, and can only partially be offset by the forest management adaptation measures.
- Published
- 2016
16. A framework for quantifying environmental sustainability
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Zoltán Somogyi
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Ecological footprint ,010504 meteorology & atmospheric sciences ,Ecology ,business.industry ,Environmental resource management ,General Decision Sciences ,Climate change ,010501 environmental sciences ,Environmental economics ,01 natural sciences ,Environmental Sustainability Index ,Component (UML) ,Greenhouse gas ,Sustainability ,Economics ,Environmental capacity ,Sustainability organizations ,business ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences - Abstract
Recent concepts of environmental sustainability have focused on narrative economic and societal aspects rather than quantitative ones. Many key sustainability indicators also lack a consistent definition of sustainability, have perspectives that are too short-term, and are unable to model the dynamics of complex environmental utilization which can then result in inappropriate projection of long-term sustainability and/or sustainability indication. Here I propose a generalized quantitative framework of environmental sustainability requiring that (1) environmental capacities and utilization rates are identified, (2) their complex temporal dynamics are quantitatively modeled or estimated (3) while also adjusting for uncertainties, and finally, (4) using one of three options, determining which cumulative utilization pathways can be sustained for a (usually well-defined) period of time. Using the example of wood volume and its growth as capacities and harvest as utilization, and the example of global greenhouse gas emissions as the utilization component and the capacity of the air to absorb these emissions, I demonstrate how the proposed framework can be applied in practice, how sustainability indicators could be developed, and also how they can inform policies and measures to ensure sustainability.
- Published
- 2016
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17. Alkalmazott nyelvészeti kutatások a 21. századi információs térben. 1. Terminológia, lexikográfia, fordítás.
- Author
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Zoltán, Somogyi
- Published
- 2021
- Full Text
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18. Erdőművelés aljnövényzetre gyakorolt hatásainak vizsgálata zselici bükkösben
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Zoltán Somogyi
- Abstract
The studied beech forest is situated in south-west Hungary. This paper describe the surveyed forest stand and try to introducing the influence of applied forest management method. The analysis use phytosociological characters, flora elements, life forms and social behaviour types of plant spe-cies. The composition of herb layer was changed in the steps of regeneration cutting.
- Published
- 2014
- Full Text
- View/download PDF
19. Sustainability of Forest Cover under Climate Change on the Temperate-Continental Xeric Limits
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Zoltán Gribovszki, András Bidló, Ernő Führer, Anikó Hirka, György Csóka, Gábor Illés, Imre Berki, Csaba Mátyás, Zoltán Somogyi, Borbála Gálos, and Kornél Czimber
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0106 biological sciences ,site potential change ,growth decline ,decision support system ,010504 meteorology & atmospheric sciences ,Climate change ,adaptation ,Deserts and xeric shrublands ,Vitality ,010603 evolutionary biology ,01 natural sciences ,Forest cover ,Temperate climate ,adaptive forestry ,0105 earth and related environmental sciences ,drought stress ,Elevation ,Forestry ,sessile oak ,lcsh:QK900-989 ,mortality ,pests and diseases ,Sustainability ,lcsh:Plant ecology ,trailing limits ,Environmental science ,Physical geography ,Groundwater - Abstract
Climate change particularly threatens the xeric limits of temperate-continental forests. In Hungary, annual temperatures have increased by 1.2 °C–1.8 °C in the last 30 years and the frequency of extreme droughts has grown. With the aim to gain stand-level prospects of sustainability, we have used local forest site variables to identify and project effects of recent and expected changes of climate. We have used a climatic descriptor (FAI index) to compare trends estimated from forest datasets with climatological projections; this is likely for the first time such a comparison has been made. Four independent approaches confirmed the near-linear decline of growth and vitality with increasing hot droughts in summer, using sessile oak as model species. The correlation between droughts and the expansion of pest and disease damages was also found to be significant. Projections of expected changes of main site factors predict a dramatic rise of future drought frequency and, consequently, a substantial shift of forest climate classes, especially at low elevation. Excess water-dependent lowland forests may lose supply from groundwater, which may change vegetation cover and soil development processes. The overall change of site conditions not only causes economic losses, but also challenges long-term sustainability of forest cover at the xeric limits.
- Published
- 2018
- Full Text
- View/download PDF
20. Recent Drought-Induced Vitality Decline of Black Pine (Pinus nigra Arn.) in South-West Hungary—Is This Drought-Resistant Species under Threat by Climate Change?
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Attila Jagicza, Adrienn Horváth, Ervin Rasztovits, Borbála Gálos, Gábor Illés, Zoltán Somogyi, Zoltán Vekerdy, Balázs Garamszegi, András Bidló, Norbert Móricz, Department of Water Resources, Faculty of Geo-Information Science and Earth Observation, and UT-I-ITC-WCC
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0106 biological sciences ,Mediterranean climate ,010504 meteorology & atmospheric sciences ,NDVI ,Drought tolerance ,drought ,P. nigra ,soil water balance modelling ,01 natural sciences ,Normalized Difference Vegetation Index ,Dendrochronology ,Aridity index ,0105 earth and related environmental sciences ,NDII ,Forestry ,relative extractable water ,lcsh:QK900-989 ,Vegetation ,Arid ,tree rings ,ITC-ISI-JOURNAL-ARTICLE ,Soil water ,lcsh:Plant ecology ,Environmental science ,ITC-GOLD ,010606 plant biology & botany - Abstract
This paper analyses the recent recurring dieback and growth decline of Black pine (P. nigra Arn. var austriaca) in the Keszthely mountains of south-west Hungary, and their relations to water deficits due to droughts. These relations were studied in five stands with low soil water storage capacity for the period 1981&ndash, 2016. The vitality was assessed using 60 tree-ring samples and changes in remotely sensed vegetation activity indices, i.e., the normalized difference vegetation index (NDVI) and the normalized difference infrared index (NDII). Water deficit was estimated by using meteorological drought indices such the standardized precipitation&ndash, evapotranspiration index (SPEI) and the forestry aridity index (FAI), as well as the relative extractable water (REW), calculated by the Brook90 hydrological model. Results revealed a strong dependency of annual tree ring width on the amount of water deficit as measured by all the above estimators, with the highest correlation shown by the summer REW. Droughts also showed a long-term superimposed effect on tree growth. NDII seemed to be more sensitive to drought conditions than NDVI. The robust dependency of tree growth on the summer water availability combined with the projected increasing aridity might lead to decreasing growth of Black pine in Hungary towards the end of the century. We thus argue that the suggestion by several papers that Black pine can be a possible substitute species in the Alpine and Mediterranean region in the future should be revisited.
- Published
- 2018
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21. Allometric biomass and carbon factors database
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Sandro Federici, V. Pagliari, Giorgio Matteucci, Giacomo Grassi, Zoltán Somogyi, Maurizio Teobaldelli, and G. Seufert
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Climate Change ,Climate change ,Greenhouse gas inventory ,AFOLU ,computer.software_genre ,Forest Inventory ,Database ,Land use, land-use change and forestry ,lcsh:Forestry ,BEF ,Silviculture ,Nature and Landscape Conservation ,Forest inventory ,Ecology ,Land use ,business.industry ,Environmental resource management ,LULUCF ,Kyoto Protocol ,Forestry ,UNFCCC ,Greenhouse gas ,Greenhouse Gas Inventory ,lcsh:SD1-669.5 ,Environmental science ,business ,computer - Abstract
The "Allometric, Biomass and Carbon factors" database (ABC factors database) was designed to facilitate the estimation of the biomass carbon stocks of forests in order to support the development and the verification of greenhouse gas inventories in the LULUCF sector (Land Use, Land Use Change and Forestry). The database contains several types of expansion, conversion and combined factors, by various tree species or species groups that can be used to calculate biomass or carbon of forests of Eurasian region from proxy variables (e.g., tree volume) that may come from forest inventories. In addition to the factors, and depending on the information that was available in the cited source, the database indicates: (1) the biomass compartments involved when the factor was developed; and (2) the possible applicability of the factor, e.g. by country or by ecological regions. The applicability of the factors is either suggested by the source itself, or the type of source (e.g. National Greenhouse Gas Inventory Report), or was based on the expert judgement by the compilers of the database. Finally, in order to facilitate the selection of the most appropriate of the data, the web-based interface provides the possibility to compare several factors that may come from different sources. The ABC factors database is freely available at the URL: http://afoludata.jrc.it/data_fs.cfm, in the web site AFOLU-DATA, funded and hosted by the Joint Research Centre (European Commission, DG-JRC)., JRC.H.2-Climate change
- Published
- 2008
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22. Including land use, land-use change, and forestry in future climate change, agreements: thinking outside the box
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Ewald Rametsteiner, C. P. Forner, N. Pena, María José Sanz, Sandro Federici, R. Benndorf, and Zoltán Somogyi
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Land use ,Natural resource economics ,business.industry ,Geography, Planning and Development ,Environmental resource management ,Climate change ,Management, Monitoring, Policy and Law ,Biosequestration ,Climate change mitigation ,Transparency (graphic) ,Greenhouse gas ,Kyoto Protocol ,Land use, land-use change and forestry ,Business - Abstract
This paper presents a framework that encompasses a full range of options for including land use, land-use change, and forestry (LULUCF) within future agreements under the United Nations Convention on Climate Change (UNFCCC). The intent is to provide options that can address the broad range of greenhouse gas (GHG) emissions and removals as well as to bring the broadest possible range of nations into undertaking mitigation efforts. We suggest that the approach taken for the Kyoto Protocol's first commitment period is only one within a much larger universe of possible approaches. This larger universe includes partially or completely “de-linking” LULUCF commitments from those in other sectors, and allowing commitments specified in terms other than tonnes of greenhouse gases. Such approaches may provide clarity and transparency concerning the role of the various sectors in the agreements and encourage participation in agreements by a more inclusive, diverse set of countries, resulting in a more effective use of LULUCF in addressing climate change.
- Published
- 2007
- Full Text
- View/download PDF
23. Ökotoxikológiai vizsgálatok televényférgekkel (Annelida: Enchytraeidae)
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István Kiss, Zoltán Somogyi, and Gábor Bakonyi
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Soil Science ,Anatomy ,Enchytraeidae ,Biology ,biology.organism_classification ,Agronomy and Crop Science ,Molecular biology - Abstract
Az Enchytraeidae (Oligochaeta, Annelida) családba tartozó kistestű televényférgek, fontos szerepet töltenek be sok ökoszisztémában. Rendkívül érzékenyek az antropogén stresszfaktorokra, mégis sokáig elhanyagolták őket, mint tesztállatokat. Az Enchytraeus Reprodukciós Teszt (ERT) különböző kémiai anyagok hatásvizsgálatára, valamint talajminőség megállapításához fejlesztették ki. A kidolgozott új módszer révén lehetőség nyílt a korábbi, különböző tesztek eredményeiben megfigyelhető nagy változatosság csökkentésére, valamint tanulmányozhatóvá vált a televényférgek különböző antropogén stresszfaktorokkal szemben mutatott érzékenysége. Az ERT alapján dolgoztak ki és fogadtak el több szabványosított teszteljárást (ASTM E 1676-97; ISO 16387; OECD 220). Mindezek mellett folyamatban van új eljárások kidolgozása is, melyek egyrészt a televényférgek magatartás vizsgálatán, másrészt a bioakkumulációs hatásokon alapulnak. A számos különböző kísérlet, a már elfogadott és a még folyamatban lévő nemzetközi szabványok mind-mind megerősítik, hogy ez az állatcsoport (Enchytraeidae) és ezen belül is alapvetően három faj ( E. albidus, E. crypticus és E. luxuriosus ) különösen alkalmas talajokon végzett ökotoxikológiai tesztekre.
- Published
- 2005
- Full Text
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24. Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
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Orsolya Palócz, Csaba Juhász, Zoltán Somogyi, Paul Clayton, Zoltán Dinya, György Csikó, and János Gál
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Male ,Veterinary medicine ,Pasteurella multocida ,beta-Glucans ,medicine.drug_class ,animal diseases ,Pasteurella Infections ,Antibiotics ,β-glucan ,Rabbit ,Microbiology ,otorhinolaryngologic diseases ,medicine ,Enrofloxacin ,Animals ,Infection control ,New zealand white ,Adverse effect ,Glucans ,General Veterinary ,biology ,business.industry ,General Medicine ,biology.organism_classification ,veterinary(all) ,Alternative treatment ,Anti-Bacterial Agents ,Dietary Supplements ,Female ,Rabbits ,business ,Research Article ,Fluoroquinolones ,medicine.drug - Abstract
Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1–3), (1–6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1–3), (1–6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1–3), (1–6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. Electronic supplementary material The online version of this article (doi:10.1186/s12917-014-0276-6) contains supplementary material, which is available to authorized users.
- Published
- 2014
- Full Text
- View/download PDF
25. Aboveground Biomass Carbon in the Alpine and Arctic Treeline Ecotones in the Ural Region
- Author
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Vladimir A. Usoltsev, Zoltán Somogyi, Viktor Petrovich Chasovskikh, and Yuliya V. Noritsina
- Subjects
geography ,geography.geographical_feature_category ,Floodplain ,Arctic ,Ecology ,Transition zone ,Environmental science ,Climate change ,Ecotone ,Permafrost ,Sea level ,Tundra - Abstract
This paper reports on measured carbon stocks in the forests of two treeline ecotones of the Ural region where climate change might improve growing conditions. The first is an alpine ecotone that is represented by an altitudinal gradient of the spruce-dominated forests on the Western slope of the Tylaiskii Kamen Mountain (Western part of the Konzhakovskii-Tylaiskii-Serebryanskii Mountain system, 59 0 30'N, 59 0 00'E), at the alpine timber line that has risen from 864 to 960 m above sea level in the course of the last 100 years. The second is an arctic ecotone in larch-dominated forests at the lower course of the Pur River (67 0 N, 78 0 E), at the transition zone between closed floodplain forests and open or island-like communities of upland forests on tundra permafrost. According to our results, there are large differences in the carbon of the aboveground biomass of both ecotones across environmental gradients. In the alpine treeline ecotone, a 19-fold drop of the carbon stocks was detected between the lower and higher altitudinal levels. In the arctic ecotone the aboveground biomass carbon stock of forests of similar densities (1300 to 1700 trees per ha) was 7 times as much in the river flood bed, and 5 times as much in mature, dense forests as the low density forests at higher elevations.
- Published
- 2014
- Full Text
- View/download PDF
26. Climatic Gradients of Biomass and Net Primary Production of Mixed Picea-Abies Forests in Eurasia
- Author
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Viktor Petrovich Chasovskikh, Yuliya V. Noritsina, Zoltán Somogyi, and Vladimir A. Usoltsev
- Subjects
Biomass (ecology) ,Humid continental climate ,South china ,biology ,Ecology ,Environmental science ,Primary production ,Statistical analysis ,Regression analysis ,Picea abies ,Understory ,Physical geography ,biology.organism_classification - Abstract
This paper presents the results of the statistical analysis of biomass and NPP estimates from vast forest areas in relation to climatic conditions. The analysis was based on biomass data in 1236 sample plots as well as both NPP and biomass estimates in 480 sample plots that were established in mixed spruce and fir stands. Data were available for the entire Eurasian territory from the UK to South China and Japan, and included information on both total biomass and various biomass components. The climatic conditions of the sampled forests were characterized by using specific indices of zonality and continentality. A system of recursive equations was fitted to the data using standard regression analysis. For both the aboveground and total NPP, we found a statistically significant increase from the North to the South, but also a decrease from both the Atlantic and Pacific coasts towards the continental center of Siberia. We also found that lower upper-story NPP is compensated by higher understory NPP and vice versa. On the other hand, inconsistencies were identified concerning the share of root biomass in relation to the continentality index.
- Published
- 2014
- Full Text
- View/download PDF
27. A synopsis of land use, land-use change and forestry (LULUCF) under the Kyoto Protocol and Marrakech Accords
- Author
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A. Labat, Naomi Pena, Axel Michaelowa, Gregg Marland, Annette Freibauer, Michael Dutschke, L. Montanarella, Zoltán Somogyi, Paulo Moutinho, Margaret Skutsch, Andreas Fischlin, Z. Rakonczay, T. R. Johns, Anatoly Shvidenko, Neil Bird, Peter C. Frumhoff, Ewald Rametsteiner, Yoshiki Yamagata, Joachim Rock, Bernhard Schlamadinger, Philip M. Fearnside, Lorenzo Ciccarese, E. Trines, M. Ward, Pete Smith, Daniel Murdiyarso, Kim Pingoud, C. P. Forner, N. . Hoehne, Miko U. F. Kirschbaum, Uwe A. Schneider, Sandra Brown, María José Sanz, Josep G. Canadell, J. Fiedler, Faculty of Behavioural, Management and Social Sciences, and Department of Governance and Technology for Sustainability
- Subjects
Marrakech accords ,media_common.quotation_subject ,Geography, Planning and Development ,IR-78861 ,Climate change ,Removals ,Management, Monitoring, Policy and Law ,bioenergy ,United Nations Framework Convention on Climate Change ,Deforestation ,Political science ,SDG 13 - Climate Action ,non-permanence ,gross-net accounting ,deforestation ,Land use, land-use change and forestry ,Environmental planning ,media_common ,SDG 15 - Life on Land ,Net-net accounting ,Non-permanence ,Land use ,business.industry ,carbon ,saturation ,Environmental resource management ,emissions ,LULUCF ,Sequestration ,Kyoto Protocol ,Saturation ,carbon sequestration ,Carbon ,removals ,carbon stocks ,Negotiation ,Carbon stocks ,climate change ,Emissions ,Greenhouse gas ,Kyoto protocol ,Bio-energy ,business ,Marrakech Accords ,Gross-net accounting - Abstract
The complexities inherent in land use, land-use change and forestry (LULUCF) activities have led to contentious and prolonged debates about the merits of their inclusion in the 2008–2012 first commitment period of the Kyoto Protocol. Yet the inclusion of these activities played a key role in agreement on the general framework of the Kyoto Protocol, and LULUCF will likely continue to play a substantial part in negotiations on national commitments post-2012. The Marrakech Accords dictate which LULUCF activities are to be included under the Kyoto Protocol and provide rules on how they are to be accounted in the first commitment period. However, these rules have limitations and drawbacks that may be avoided in the structure of future commitments beyond 2012. Through adherence to the objectives of the United Nations Framework Convention on Climate Change (UNFCCC), and the incorporation of several critical features, a future framework can more effectively address the mitigation challenges and opportunities of this sector.
- Published
- 2007
- Full Text
- View/download PDF
28. HEART SOUNDS CHARACTERISTICS FROM A 3D ACCELEROMETER IN HEART FAILURE PATIENTS
- Author
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Felix Schoenrath, Olena Nemchyna, John Gill, Luke C. McSpadden, Nikolaos Politis, Zoltan Somogyi, Gene A. Bornzin, Nikolaos Cholevas, Isabell A. Just, Evgenij Potapov, Christoph T. Starck, and Volkmar Falk
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Medical technology ,R855-855.5 - Published
- 2022
- Full Text
- View/download PDF
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