Back to Search
Start Over
Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
- Source :
- BMC Veterinary Research
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1–3), (1–6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1–3), (1–6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1–3), (1–6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. Electronic supplementary material The online version of this article (doi:10.1186/s12917-014-0276-6) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
Veterinary medicine
Pasteurella multocida
beta-Glucans
medicine.drug_class
animal diseases
Pasteurella Infections
Antibiotics
β-glucan
Rabbit
Microbiology
otorhinolaryngologic diseases
medicine
Enrofloxacin
Animals
Infection control
New zealand white
Adverse effect
Glucans
General Veterinary
biology
business.industry
General Medicine
biology.organism_classification
veterinary(all)
Alternative treatment
Anti-Bacterial Agents
Dietary Supplements
Female
Rabbits
business
Research Article
Fluoroquinolones
medicine.drug
Subjects
Details
- ISSN :
- 17466148
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- BMC Veterinary Research
- Accession number :
- edsair.doi.dedup.....cfbdf78e53b6f12c03d646c70c765782
- Full Text :
- https://doi.org/10.1186/s12917-014-0276-6