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1. Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies

Author

Räuber, Saskia, Schulte-Mecklenbeck, Andreas, Willison, Alice, Hagler, Ramona, Jonas, Marius, Pul, Duygu, Masanneck, Lars, Schroeter, Christina B., Golombeck, Kristin S., Lichtenberg, Stefanie, Strippel, Christine, Gallus, Marco, Dik, Andre, Kerkhoff, Ruth, Barman, Sumanta, Weber, Katharina J., Kovac, Stjepana, Korsen, Melanie, Pawlitzki, Marc, Goebels, Norbert, Ruck, Tobias, Gross, Catharina C., Paulus, Werner, Reifenberger, Guido, Hanke, Michael, Grauer, Oliver, Rapp, Marion, Sabel, Michael, Wiendl, Heinz, Meuth, Sven G., and Melzer, Nico

Published
2024
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2. Real-world evidence on siponimod treatment in patients with secondary progressive multiple sclerosis

Author

Regner-Nelke, Liesa, Pawlitzki, Marc, Willison, Alice, Rolfes, Leoni, Oezalp, Sinem-Hilal, Nelke, Christopher, Kölsche, Tristan, Korsen, Melanie, Grothe, Matthias, Groppa, Sergiu, Luessi, Felix, Engel, Sinah, Nelles, Gereon, Bonmann, Eckhard, Roick, Holger, Friedrich, Anke, Knorn, Philipp, Landefeld, Harald, Biro, Zoltan, Ernst, Michael, Bayas, Antonios, Menacher, Martina, Akgün, Katja, Kleinschnitz, Christoph, Ruck, Tobias, Ziemssen, Tjalf, Pul, Refik, and Meuth, Sven G.

Published
2022
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5. The Use of Nitrosative Stress Molecules as Potential Diagnostic Biomarkers in Multiple Sclerosis

Author

Räuber, Saskia, primary, Förster, Moritz, additional, Schüller, Julia, additional, Willison, Alice, additional, Golombeck, Kristin S., additional, Schroeter, Christina B., additional, Oeztuerk, Menekse, additional, Jansen, Robin, additional, Huntemann, Niklas, additional, Nelke, Christopher, additional, Korsen, Melanie, additional, Fischer, Katinka, additional, Kerkhoff, Ruth, additional, Leven, Yana, additional, Kirschner, Patricia, additional, Kölsche, Tristan, additional, Nikolov, Petyo, additional, Mehsin, Mohammed, additional, Marae, Gelenar, additional, Kokott, Alma, additional, Pul, Duygu, additional, Schulten, Julius, additional, Vogel, Niklas, additional, Ingwersen, Jens, additional, Ruck, Tobias, additional, Pawlitzki, Marc, additional, Meuth, Sven G., additional, Melzer, Nico, additional, and Kremer, David, additional

Published
2024
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8. Eculizumab treatment alters the proteometabolome beyond the inhibiton of complement

Author

Nelke, Christopher, primary, Schroeter, Christina B., additional, Stascheit, Frauke, additional, Huntemann, Niklas, additional, Pawlitzki, Marc, additional, Willison, Alice G., additional, Räuber, Saskia, additional, Melzer, Nico, additional, Distler, Ute, additional, Tenzer, Stefan, additional, Stühler, Kai, additional, Roos, Andreas, additional, Meisel, Andreas, additional, Meuth, Sven G., additional, and Ruck, Tobias, additional

Published
2023
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9. Effect of Previous Disease-Modifying Therapy on Treatment Effectiveness for Patients Treated With Ocrelizumab

Author

Pfeuffer, Steffen, primary, Rolfes, Leoni, additional, Ingwersen, Jens, additional, Pul, Refik, additional, Kleinschnitz, Konstanze, additional, Korsen, Melanie, additional, Räuber, Saskia, additional, Ruck, Tobias, additional, Schieferdecker, Simon, additional, Willison, Alice Grizzel, additional, Aktas, Orhan, additional, Kleinschnitz, Christoph, additional, Hartung, Hans-Peter, additional, Kappos, Ludwig, additional, and Meuth, Sven G., additional

Published
2023
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10. Review and meta-analysis of neuropsychological findings in autoimmune limbic encephalitis with autoantibodies against LGI1, CASPR2, and GAD65 and their response to immunotherapy

Author

Mueller, Christoph, Elben, Saskia, Day, Gregory S., Alves, Pedro, Hebert, Julien, Tang-Wai, David F., Holtmann, Olga, Iorio, Raffaele, Perani, Daniela, Titulaer, Maarten J., Hansen, Niels, Bartsch, Thorsten, Johnen, Andreas, Illes, Zslot, Borm, Leah, Willison, Alice G., Wiendl, Heinz, Meuth, Sven G., Kovac, Stjepana, Bölte, Jens, Melzer, Nico, Mueller, Christoph, Elben, Saskia, Day, Gregory S., Alves, Pedro, Hebert, Julien, Tang-Wai, David F., Holtmann, Olga, Iorio, Raffaele, Perani, Daniela, Titulaer, Maarten J., Hansen, Niels, Bartsch, Thorsten, Johnen, Andreas, Illes, Zslot, Borm, Leah, Willison, Alice G., Wiendl, Heinz, Meuth, Sven G., Kovac, Stjepana, Bölte, Jens, and Melzer, Nico

Abstract

Objectives: It is assumed that autoimmune limbic encephalitis (ALE) demonstrates distinct neuropsychological manifestations with differential responses to immunotherapy according to which associated autoantibody (AAB), if any, is identified. Towards investigating whether this is the case, this study aims to summarize respective findings from the primary literature on ALE with AABs binding to cell surface neural antigens and ALE with AABs against intracellular neural antigens. Methods: We chose ALE with AABs against leucine-rich, glioma inactivated protein 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) as the most frequent cell surface membrane antigens, and ALE with AABs to Embryonic Lethal, Abnormal Vision, Like 1 (ELAVL) proteins (anti-Hu) and glutamic acid decarboxylase 65 (GAD65) as the most frequent intracellular neural antigens. The PubMed and Scopus databases were searched on March 1st, 2021 for neuropsychological test and -screening data from patients with ALE of these AAB-types. Findings were reviewed according to AAB-type and immunotherapy status and are presented in a review section and are further statistically evaluated and presented in a meta-analysis section in this publication. Results: Of the 1304 initial hits, 32 studies on ALE with AABs against LGI1, CASPR2, and GAD65 reporting cognitive screening data could be included in a review. In ALE with AABs against LGI1, CASPR2 and GAD65, memory deficits are the most frequently reported deficits. However, deficits in attention and executive functions including working memory, fluency, and psychological function have also been reported. This review shows that ALE patients with AABs against both LGI1 and CASPR2 show higher percentages of neuropsychological deficits compared to ALE patients with AABs against GAD65 before and after initiation of immunotherapy. However, the methodologies used in these studies were heterogenous, and longitudinal studies were not comparable. Moreover, 21 studies in

Published
2023

11. Vaccine-based clinical protection against SARS-CoV-2 infection and the humoral immune response: A 1-year follow-up study of patients with multiple sclerosis receiving ocrelizumab

Author

Räuber, Saskia, primary, Willison, Alice, additional, Korsen, Melanie, additional, Kölsche, Tristan, additional, Golombeck, Kristin S., additional, Plaack, Benedikt, additional, Schüller, Julia, additional, Huntemann, Niklas, additional, Rolfes, Leoni, additional, Schroeter, Christina B., additional, Nelke, Christopher, additional, Regner-Nelke, Liesa, additional, Förster, Moritz, additional, Ringelstein, Marius, additional, Barnett, Michael Harry, additional, Hartung, Hans-Peter, additional, Aktas, Orhan, additional, Albrecht, Philipp, additional, Ruck, Tobias, additional, Melzer, Nico, additional, Meuth, Sven G., additional, and Kremer, David, additional

Published
2022
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12. Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity

Author

Ruck, Tobias, primary, Barman, Sumanta, additional, Schulte-Mecklenbeck, Andreas, additional, Pfeuffer, Steffen, additional, Steffen, Falk, additional, Nelke, Christopher, additional, Schroeter, Christina B., additional, Willison, Alice, additional, Heming, Michael, additional, Müntefering, Thomas, additional, Melzer, Nico, additional, Krämer, Julia, additional, Lindner, Maren, additional, Riepenhausen, Marianne, additional, Gross, Catharina C., additional, Klotz, Luisa, additional, Bittner, Stefan, additional, Muraro, Paolo A., additional, Schneider-Hohendorf, Tilman, additional, Schwab, Nicholas, additional, Meyer zu Hörste, Gerd, additional, Goebels, Norbert, additional, Meuth, Sven G., additional, and Wiendl, Heinz, additional

Published
2022
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14. Gathering Global Perspectives to Establish the Research Priorities and Minimum Data Sets for Degenerative Cervical Myelopathy:Sampling Strategy of the First Round Consensus Surveys of AO Spine RECODE-DCM

Author

Mowforth, Oliver D, Khan, Danyal Z, Wong, Mei Yin, Pickering, George A E, Dean, Lydia, Magee, Joe, Mullarkey, Laura, Hirayama, Yuri, Rihova, Martina, Butler, Max, Stewart, Max, Goulson, Beth, Ahmed, Shahzaib, Fricke, Kai, Popa-Nimigean, Vladimir, Millar, Zack, Venkatesh, Ashwin, Willison, Alice, Senthil, Keerthi, Hazenbiller, Olesja, Sarewitz, Ellen, Sadler, Iwan, Gronlund, Toto, Tetreault, Lindsay, Harrop, James S, Aarabi, Bizhan, Rahimi-Movaghar, Vafa, Kurpad, Shekar N, Guest, James D, Wilson, Jefferson R, Kwon, Brian K, Fehlings, Michael G, McNair, Angus G K, Davies, Benjamin M, and Kotter, Mark R N

Subjects
spondylosis, surveys and questionnaires, Orthopedics and Sports Medicine, Surgery, Neurology (clinical), cervical vertebrae, spinal osteophytosis, spinal cord diseases
Abstract

Study Design Survey. Introduction AO Spine Research Objectives and Common Data Elements for Degenerative Cervical Myelopathy (AO Spine RECODE-DCM) is an international initiative that aims to accelerate knowledge discovery and improve outcomes by developing a consensus framework for research. This includes defining the top research priorities, an index term and a minimum data set (core outcome set and core data elements set – core outcome set (COS)/core data elements (CDE)). Objective To describe how perspectives were gathered and report the detailed sampling characteristics. Methods A two-stage, electronic survey was used to gather and seek initial consensus. Perspectives were sought from spinal surgeons, other healthcare professionals and people with degenerative cervical myelopathy (DCM). Participants were allocated to one of two parallel streams: (1) priority setting or (2) minimum dataset. An email campaign was developed to advertise the survey to relevant global stakeholder individuals and organisations. People with DCM were recruited using the international DCM charity Myelopathy.org and its social media channels. A network of global partners was recruited to act as project ambassadors. Data from Google Analytics, MailChimp and Calibrum helped optimise survey dissemination. Results Survey engagement was high amongst the three stakeholder groups: 208 people with DCM, 389 spinal surgeons and 157 other healthcare professionals. Individuals from 76 different countries participated; the United States, United Kingdom and Canada were the most common countries of participants. Conclusion AO Spine RECODE-DCM recruited a diverse and sufficient number of participants for an international PSP and COS/CDE process. Whilst PSP and COS/CDE have been undertaken in other fields, to our knowledge, this is the first time they have been combined in one process.

Published
2021

15. Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis

Author

Vogelsang, Anna, primary, Eichler, Susann, additional, Huntemann, Niklas, additional, Masanneck, Lars, additional, Böhnlein, Hannes, additional, Schüngel, Lisa, additional, Willison, Alice, additional, Loser, Karin, additional, Nieswandt, Bernhard, additional, Kehrel, Beate E., additional, Zarbock, Alexander, additional, Göbel, Kerstin, additional, and Meuth, Sven G., additional

Published
2021
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18. Gathering Global Perspectives to Establish the Research Priorities and Minimum Data Sets for Degenerative Cervical Myelopathy: Sampling Strategy of the First Round Consensus Surveys of AO Spine RECODE-DCM

Author

Davies, Benjamin M., Kwon, Brian K., Fehlings, Michael G., Kotter, Mark R. N., Mowforth, Oliver D., Khan, Danyal Z, Wong, Mei Yin, Pickering, George A. E., Dean, Lydia, Magee, Joe, Mullarkey, Laura, Hirayama, Yuri, Rihova, Martina, Butler, Max, Stewart, Max, Goulson, Beth, Ahmed, Shahzaib, Fricke, Kai, Popa-Nimigean, Vladimir, Millar, Zack, Venkatesh, Ashwin, Willison, Alice, Senthil, Keerthi, Hazenbiller, Olesja, Sarewitz, Ellen, Sadler, Iwan, Gronlund, Toto, Tetreault, Lindsay, Harrop, James S., Aarabi, Bizhan, Rahimi-Movaghar, Vafa, Kurpad, Shekar N, Guest, James D., Wilson, Jefferson R., Kwon, Brian K., Fehlings, Michael G., McNair, Angus G.K., Davies, Benjamin M., and Kotter, Mark R.N.

Abstract

Study Design Survey.Introduction AO Spine Research Objectives and Common Data Elements for Degenerative Cervical Myelopathy (AO Spine RECODE-DCM) is an international initiative that aims to accelerate knowledge discovery and improve outcomes by developing a consensus framework for research. This includes defining the top research priorities, an index term and a minimum data set (core outcome set and core data elements set – core outcome set (COS)/core data elements (CDE)).Objective To describe how perspectives were gathered and report the detailed sampling characteristics.Methods A two-stage, electronic survey was used to gather and seek initial consensus. Perspectives were sought from spinal surgeons, other healthcare professionals and people with degenerative cervical myelopathy (DCM). Participants were allocated to one of two parallel streams: (1) priority setting or (2) minimum dataset. An email campaign was developed to advertise the survey to relevant global stakeholder individuals and organisations. People with DCM were recruited using the international DCM charity Myelopathy.organd its social media channels. A network of global partners was recruited to act as project ambassadors. Data from Google Analytics, MailChimp and Calibrum helped optimise survey dissemination.Results Survey engagement was high amongst the three stakeholder groups: 208 people with DCM, 389 spinal surgeons and 157 other healthcare professionals. Individuals from 76 different countries participated; the United States, United Kingdom and Canada were the most common countries of participants.Conclusion AO Spine RECODE-DCM recruited a diverse and sufficient number of participants for an international PSP and COS/CDE process. Whilst PSP and COS/CDE have been undertaken in other fields, to our knowledge, this is the first time they have been combined in one process.

Published
2022
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20. Gathering Global Perspectives to Establish the Research Priorities and Minimum Data Sets for Degenerative Cervical Myelopathy: Sampling Strategy of the First Round Consensus Surveys of AO Spine RECODE-DCM.

Author

Mowforth, Oliver D., Khan, Danyal Z, Wong, Mei Yin, Pickering, George A. E., Dean, Lydia, Magee, Joe, Mullarkey, Laura, Hirayama, Yuri, Rihova, Martina, Butler, Max, Stewart, Max, Goulson, Beth, Ahmed, Shahzaib, Fricke, Kai, Popa-Nimigean, Vladimir, Millar, Zack, Venkatesh, Ashwin, Willison, Alice, Senthil, Keerthi, and Hazenbiller, Olesja

Published
2022
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21. Acknowledgment to the Reviewers of Cells in 2022.

Subjects
SCHOLARLY publishing
Abstract

Regardless of whether the articles they examined were ultimately published, the editors would like to express their appreciation and thank the following reviewers for the time and dedication that they have shown I Cells i : those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). I Cells i was able to uphold its high standards for published papers due to the outstanding efforts of our reviewers. Thanks to the efforts of our reviewers in 2022, the median time to first decision was 16 days and the median time to publication was 42 days. [Extracted from the article]

Published
2023
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