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12 results on '"Wejksza, Katarzyna"'

4. Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked Bregs via peroxisome proliferator-activated receptor alpha

Author

Wejksza, Katarzyna, Lee-Chang, Catalina, Bodogai, Monica, Bonzo, Jessica, Gonzalez, Frank J., Lehrmann, Elin, Becker, Kevin, and Biragyn, Arya

Subjects
Mice, Knockout, Mice, Inbred BALB C, Mice, 129 Strain, Lipoxygenase, B-Lymphocyte Subsets, Melanoma, Experimental, Article, Mice, Inbred C57BL, Mice, Cell Line, Tumor, Animals, Female, PPAR alpha, Tumor Escape, Neoplasm Metastasis, Cells, Cultured
Abstract

Breast cancer cells facilitate distant metastasis through the induction of immunosuppressive regulatory B cells, designated tBregs. We report in this study that, to do this, breast cancer cells produce metabolites of the 5-lipoxygenase pathway such as leukotriene B4 to activate the peroxisome proliferator-activated receptor α (PPARα) in B cells. Inactivation of leukotriene B4 signaling or genetic deficiency of PPARα in B cells blocks the generation of tBregs and thereby abrogates lung metastasis in mice with established breast cancer. Thus, in addition to eliciting fatty acid oxidation and metabolic signals, PPARα initiates programs required for differentiation of tBregs. We propose that PPARα in B cells and/or tumor 5-lipoxygenase pathways represents new targets for pharmacological control of tBreg-mediated cancer escape.

Published
2013

11. Kynurenic acid in human saliva--does it influence oral microflora?

Author

Kuc D, Rahnama M, Tomaszewski T, Rzeski W, Wejksza K, Urbanik-Sypniewska T, Parada-Turska J, Wielosz M, and Turski WA

Subjects
Abscess drug therapy, Abscess microbiology, Adult, Anti-Bacterial Agents pharmacology, Child, Fibroblasts drug effects, Fibroblasts metabolism, Gingiva cytology, Humans, Lipopolysaccharides pharmacology, Male, Kynurenic Acid pharmacology, Mouth microbiology, Saliva chemistry
Abstract

Kynurenic acid (KYNA) is an endogenous antagonist of alpha7 nicotinic receptors and all ionotropic glutamate receptors. Its neuroprotective activity has been suggested. In this study, the presence of KYNAin human saliva and its potential bactericidal role was investigated. KYNAwas found in all samples of human saliva with mean concentration of 3.4 nM. The concentration of KYNA in saliva obtained from patients with odontogenic abscesses was 3.5 times higher than in healthy subjects. We have shown that the human gingival fibroblasts produce KYNAand an inflammatory stimulant, lipopolysaccharide, enhanced its synthesis in vitro. The bactericidal effect of KYNA was also presented. We hypothesize that KYNA may contribute to the control of oral microflora.

Published
2006

12. Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures.

Author

Zdzisińska B, Rzeski W, Paduch R, Szuster-Ciesielska A, Kaczor J, Wejksza K, and Kandefer-Szerszeń M

Subjects
Blood Cells metabolism, Cells, Cultured, Cytokines blood, Humans, Interferon-gamma biosynthesis, Interferon-gamma blood, Interleukin-10 biosynthesis, Interleukin-10 blood, Leukocytes drug effects, Leukocytes metabolism, Pentacyclic Triterpenes, Tumor Necrosis Factor-alpha biosynthesis, Betulinic Acid, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Blood Cells drug effects, Cytokines biosynthesis, Triterpenes pharmacology
Abstract

Betulin and betulinic acid, plant-derived triterpenoid compounds, have been described to possess anti-inflammatory activity. In this paper, we examine the ability of both compounds to induce and modulate cytokine production in human whole blood cell cultures. The results indicate that betulin is a modest TNF-alpha inducer and also an enhancer of mitogen-induced TNF-alpha production. In contrast to betulin, betulinic acid is a modulator of cytokine production by Th1/Th2 cell subpopulations which slightly enhances IL-10 formation and inhibits IFN-gamma production, reducing IFN-gamma/IL-10 ratio from 3.6 to 2.6.

Published
2003

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