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Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures.
- Source :
-
Polish journal of pharmacology [Pol J Pharmacol] 2003 Mar-Apr; Vol. 55 (2), pp. 235-8. - Publication Year :
- 2003
-
Abstract
- Betulin and betulinic acid, plant-derived triterpenoid compounds, have been described to possess anti-inflammatory activity. In this paper, we examine the ability of both compounds to induce and modulate cytokine production in human whole blood cell cultures. The results indicate that betulin is a modest TNF-alpha inducer and also an enhancer of mitogen-induced TNF-alpha production. In contrast to betulin, betulinic acid is a modulator of cytokine production by Th1/Th2 cell subpopulations which slightly enhances IL-10 formation and inhibits IFN-gamma production, reducing IFN-gamma/IL-10 ratio from 3.6 to 2.6.
- Subjects :
- Blood Cells metabolism
Cells, Cultured
Cytokines blood
Humans
Interferon-gamma biosynthesis
Interferon-gamma blood
Interleukin-10 biosynthesis
Interleukin-10 blood
Leukocytes drug effects
Leukocytes metabolism
Pentacyclic Triterpenes
Tumor Necrosis Factor-alpha biosynthesis
Betulinic Acid
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Blood Cells drug effects
Cytokines biosynthesis
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1230-6002
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Polish journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 12926552