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29 results on '"Wang, Baojia"'

11. Fabrication of visible-light-responsive ZnIn2S4 nanosheets wrapped onto MIL-125(Ti) hybrid structure with improved photocatalytic H2-evolution performance.

Author

Liu, Tianyu, Wang, Baojia, Wang, Min, Gu, Jiayu, Wang, Wei, Shen, Hailin, and Zhang, Jintao

Subjects
*HYDROGEN evolution reactions, *METAL-organic frameworks, *NANOSTRUCTURED materials, *CHARGE transfer, *PHOTOCATALYSTS, *ENERGY conversion
Abstract

In this study, an efficient visible light responsive MIL-125(Ti)/ZnIn2S4 hybrid structure (MIL-1.2/ZIS) was synthesized through two-step method with improved photocatalytic H2-evolution performance. The MIL-1.2/ZIS nanocomposites could retained the characteristic features including the highly surface area of metal organic frameworks and the hierarchical sheet-like structure of ZnIn2S4. The optimal sample could exhibit the H2 generation rate of 873.4 μmol g−1·h−1, and the improved photocatalytic activity could be ascribed to the well-matched band structure and the formation of hybrid interfaces, which could lead to the effective charge transfer and separation of photo-excited electron–hole pairs. We hope this paper could broad the potential utilization of MOF-based nanocomposites in photocatalytic energy conversion fields. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophilaand mouse

Author

Song, Tingting, Qin, Wusa, Lai, Zeliang, Li, Haoyu, Li, Daihan, Wang, Baojia, Deng, Wuquan, Wang, Tingzhang, Wang, Liming, and Huang, Rui

Abstract

Obesity imposes a global health threat and calls for safe and effective therapeutic options. Here, we found that protein-rich diet significantly reduced body fat storage in fruit flies, which was largely attributed to dietary cysteine intake. Mechanistically, dietary cysteine increased the production of a neuropeptide FMRFamide (FMRFa). Enhanced FMRFa activity simultaneously promoted energy expenditure and suppressed food intake through its cognate receptor (FMRFaR), both contributing to the fat loss effect. In the fat body, FMRFa signaling promoted lipolysis by increasing PKA and lipase activity. In sweet-sensing gustatory neurons, FMRFa signaling suppressed appetitive perception and hence food intake. We also demonstrated that dietary cysteine worked in a similar way in mice via neuropeptide FF (NPFF) signaling, a mammalian RFamide peptide. In addition, dietary cysteine or FMRFa/NPFF administration provided protective effect against metabolic stress in flies and mice without behavioral abnormalities. Therefore, our study reveals a novel target for the development of safe and effective therapies against obesity and related metabolic diseases.

Published
2023
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29. Kangfuxin Oral Liquid Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF- β 1/Smad Pathway.

Author

Yao H, Wei S, Xiang Y, Wu Z, Liu W, Wang B, Li X, Xu H, Zhao J, and Gao Y

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease with a poor prognosis characterized by transforming growth factor (TGF)- β -induced proliferation, migration, and differentiation of fibroblasts, resulting in excessive extracellular matrix (ECM) deposition. Whether Kangfuxin oral liquid (KFXOL) has a protective function in pulmonary fibrosis is largely unknown. The goal of this study was to investigate the potential efficacy of KFXOL, as well as the underlying mechanism by which KFXOL regulates pulmonary fibrosis in vivo and in vitro . We found that KFXOL dramatically attenuated intratracheal bleomycin (BLM)-induced pulmonary fibrosis in terms of both severe alveolar architecture destruction and collagen deposition. KFXOL treatment significantly inhibited the proliferation, migration, and differentiation of pulmonary fibroblasts following activation using BLM/TGF- β 1 and normalized the expression of ECM deposition-related proteins, including matrix metalloproteinase (MMP)-1, MMP-9, and tissue inhibitor of metalloproteinases 1. These effects were mediated via the inhibition of TGF- β 1 and phosphorylated Smad2/3 activation in vivo . Taken together, our data suggest that KFXOL attenuates the development of pulmonary fibrosis via the TGF- β 1/Smad signaling pathway and thus has potential utility in the treatment of pulmonary fibrosis., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper., (Copyright © 2019 Huan Yao et al.)

Published
2019
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