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Kangfuxin Oral Liquid Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF- β 1/Smad Pathway.
- Source :
-
Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2019 Nov 03; Vol. 2019, pp. 5124026. Date of Electronic Publication: 2019 Nov 03 (Print Publication: 2019). - Publication Year :
- 2019
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Abstract
- Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease with a poor prognosis characterized by transforming growth factor (TGF)- β -induced proliferation, migration, and differentiation of fibroblasts, resulting in excessive extracellular matrix (ECM) deposition. Whether Kangfuxin oral liquid (KFXOL) has a protective function in pulmonary fibrosis is largely unknown. The goal of this study was to investigate the potential efficacy of KFXOL, as well as the underlying mechanism by which KFXOL regulates pulmonary fibrosis in vivo and in vitro . We found that KFXOL dramatically attenuated intratracheal bleomycin (BLM)-induced pulmonary fibrosis in terms of both severe alveolar architecture destruction and collagen deposition. KFXOL treatment significantly inhibited the proliferation, migration, and differentiation of pulmonary fibroblasts following activation using BLM/TGF- β 1 and normalized the expression of ECM deposition-related proteins, including matrix metalloproteinase (MMP)-1, MMP-9, and tissue inhibitor of metalloproteinases 1. These effects were mediated via the inhibition of TGF- β 1 and phosphorylated Smad2/3 activation in vivo . Taken together, our data suggest that KFXOL attenuates the development of pulmonary fibrosis via the TGF- β 1/Smad signaling pathway and thus has potential utility in the treatment of pulmonary fibrosis.<br />Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper.<br /> (Copyright © 2019 Huan Yao et al.)
Details
- Language :
- English
- ISSN :
- 1741-427X
- Volume :
- 2019
- Database :
- MEDLINE
- Journal :
- Evidence-based complementary and alternative medicine : eCAM
- Publication Type :
- Academic Journal
- Accession number :
- 31885648
- Full Text :
- https://doi.org/10.1155/2019/5124026