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To characterize the behavior of three different polymeric agents before and after an erosive challenge on dentin permeability, to analyze their degradation in both conditions, and to analyze their degree of conversion (DC).The permeability of human dentin disks (1.0 ± 0.2 mm) was measured with smear layer, after its removal, after treatment (LpTreat) with Gluma Desensitizer, PRG Barrier Coat (PBC) or Icon infiltrant (n = 11/group) and after exposure to citric acid (LpEro) (6%, pH 2.1, 1 min). The specimens were analyzed under a Laser Scanning Confocal Microscope (n = 2/group) and the products' DC were calculated. Data were subjected to 2-way repeated measures ANOVA and post-hoc Bonferroni (permeability analysis), to paired t-test (for specimens treated with Icon) and to t-test (DC analysis) (α 0.05).Icon showed the lowest LpTreat and LpEro values, while PBC and Gluma did not differ from each other under these conditions. Icon and PBC showed LpEro similar to a dentin with smear layer. Under the Laser Scanning Confocal Microscope, more deposits were noticeable on dentin after treating with PBC. Gluma presented the deepest penetration in dentin. The DC of PBC was the highest.Icon caused the highest reduction on permeability values, followed by PBC and Gluma. PBC generated more deposits covering dentin and seemed to be more efficient after an erosive challenge. The association of a polymeric resin with inorganic ion-releasing fillers seem to be a great strategy to manage dentin hypersensitivity under erosive conditions.

This study aimed to compare the metabolic profile of unstimulated (US) and stimulated (SS) saliva samples from pregnant women with/without obesity and periodontitis. Ninety-six pregnant women were divided into: obesity + periodontitis (OP = 20); obesity/no periodontitis (OWP = 27); normal BMI + periodontitis (NP = 20); and normal BMI/no periodontitis (NWP = 29). US and SS samples were collected by expectoration and chewing of sterilized parafilm gum, respectively, and samples were individually analyzed by Proton Nuclear Magnetic Resonance (1H-NMR). Univariate (t test and correlations) and multivariate (Principal Component Analysis–PCA, and Partial Least Square–Discriminant Analysis—PLS-DA with Variance Importance Projection–VIP scores) and Metabolite Set Enrichment Analysis were done (p < 0.05). Metabolites commonly found in all groups in elevated concentration in US samples were 5-Aminopentoate, Acetic acid, Butyric acid, Propionic acid, Pyruvic acid, and Succinic acid. They were mainly related to the butyrate metabolism, citric acid cycle, amino sugar metabolism, fatty acids biosynthesis, pyruvate metabolism, glutamate metabolism, and Warburg effect. Metabolites commonly found in all groups that were in elevated concentration in SS samples were Citrulline, Fumaric acid, Histidine, N-acetyl glutamine, N-acetylneuraminic acid, para-hydroxyphenylacetic acid, Proline, Tyrosine. Although some differences were found between unstimulated and stimulated saliva samples from pregnant women with/without obesity and periodontitis, stimulated saliva collection seems adequate, demonstrating similar metabolic pathways to unstimulated saliva samples when groups are compared.

Teeth affected by molar incisor hypomineralization (MIH) present micromorphologic changes and hypersensitivity, which increase the risk of developing caries lesions and affect bonding procedures. Considering that practitioners still misdiagnose teeth affected by MIH, there is an urge for more knowledge about this topic in order to propose a more adequate and conservative treatment. The purpose of this study was to report the clinical challenges regarding the restorative management of a patient with MIH. A 13-year-old girl sought dental treatment, complaining about hypersensitivity in posterior teeth. Under clinical exams, notable enamel alterations mainly affecting posterior teeth (including molars) presented particular characteristics frequently attributed to MIH, and visible stains on maxillary central incisors were present. Because the mineral and organic content of MIH-affected enamel differ from sound enamel, it may imply special care for bonding of a restorative material. Thus, in order to promote a minimally invasive approach, selective removal of carious tissue and restoration with microhybrid composite resin was conducted after application of a universal bonding system used as self-etching strategy. After a 2-year follow-up, the restorations presented good clinical performance and the patient had limited hypersensitivity discomfort, suggesting a promising performance.

Particularities of dental cervical lesions require distinct approaches from preventive to therapeutic managements. Therefore, practitioners depend on their etiology, selected materials and patient involvement to provide conditions to effective performance. Through representative clinical scenarios, the main considerations regarding carious and non-carious cervical lesions (NCCL) are reported for the determination of strategies. Details regarding the disease, lesions aspects, evolution and involvement or not of the periodontal tissues are considered in their decision. In conclusion, their long-lasting resolution is determined by a complex combination of biomechanical factors and therapeutic strategies for each particular lesion, regardless of the cervical location solely.

Objectives Most dental schools have included dentin hypersensitivity (DH) as part of their taught curriculum to educate undergraduates; however, it is possible that the public still does not recognize its symptoms and the factors that predispose to the onset of this condition. Thus, the aim of this study was to assess the knowledge of a Brazilian population regarding the prevention and treatment of DH and to identify what self-reported factors can serve as predictors of the frequency of DH. Materials and Methods An online questionnaire investigated the demographic characteristics, oral health self-perception and attitudes, and DH prevention and treatment measures of 226 participants. Statistical analysis Data were analyzed descriptively and by a multiple linear regression with DH frequency score as the dependent variable (α Results Total 61.1% of females (n = 138) and 38.9% of males (n = 88) (mean age: 35.1 ± 12.2 years) completed the questionnaire. The sample's mean DH frequency score (minimum 0; maximum 20) was 4.2 and classified as low, with 19.1% using desensitizing products and 22.1% reporting having noncarious cervical lesions (NCCLs). When experiencing DH episodes, 21.2% never and 30.1% rarely scheduled dental appointments. Regression analysis retrieved a significant final model (F [5,220] = 12.047; p Conclusion This study identified that 36.7% and 18.6% of the sample were unaware that DH can be both prevented and treated, respectively. Moreover, the presence of NCCLs, frequency of daily toothbrushing, use of desensitizing products, presence of DH modulating factors, and the presence of parafunctional habits symptoms served as predictors of DH frequency.

Objectives: Resin composites containing surface pre-reacted glass (S-PRG) were introduced to reduce demineralization and improve remineralization of the tooth structure. However, water diffusion within the material is necessary for its action, which can impair its overall physical-mechanical properties over time, including the color stability. This study aimed to evaluate the color stability and related degree of conversion (DC) of four resin composites.Materials and Methods: Discs (n=5/group) of microhybrid, nanofilled, nanohybrid, and S-PRG-based nanohybrid composites with two opacities were prepared. Color (CIELab and CIEDE2000) was evaluated after aging in grape juice. The DC was analyzed by using Fourier Transform Infrared Spectroscopy before and after photopolymerization. Data were statistically analyzed by using two-way analysis of variance and post-hoc least significant difference tests (PResults: In the color stabilityanalysis, the interaction between filler type and opacity was significant. S-PRG influenced color stability and DC.Conclusions: The nanohybrid resin composite presented favorable color stability and a greater DC, which is likely related to its organic content. S-PRG based nanohybrid resins require caution since its bioactive benefits depends on interaction with the environment that can be prone to impair color stability.Clinical Relevance: As color stability is mandatoryin specific regions, staining can jeopardize the esthetics of a resin composite. The use of nanohybrid composites with no or reduced BisGMA content and diluents may be more appropriate in these areas. Since materials containing S-PRG can offer relevant benefits, professionals need to balance their higher susceptibility to staining favoring other relevant properties.

The aim was to discuss the indications, contraindications, advantages, and disadvantages of Nonmetal clasp dentures (NMCDs), as well as the most relevant properties of its constituent materials. A search was conducted using the keywords: “nonmetal clasp dentures,” “thermoplastic resin,” “flexible resin removable partial denture,” “polyamide,” and “nylon” in databases PubMed/Medline, Lilacs, SciELO, and textbooks between 1955 and 2020. Theses and texts without reliable sources of publication were excluded. Once the analysis instruments were determined, the data were analyzed and discussed. NMCDs present high flexibility, easy adaptation to the abutments, color compatibility and biocompatibility with the oral mucosa, and absence of visible metal clasps. However, they need laboratory relining, grinding, and polishing, do not have criteria for its planning, become rougher and stained over time, and are able to traumatize supporting tissues. The association with metal components seems to be an alternative to increase the success of NMCDs by combining esthetics and biomechanical principles of conventional removable partial dentures. The lack of long-term clinical studies makes the professionals to rely solely on previous experiences or on the manufacturers' recommendations. It suggested that NMCDs must be indicated with caution when not used temporarily.

Obesity and pregnancy may have synergistic effects on maternal periodontal tissues. In contrast, maternal obesity and periodontitis are antagonistic factors for the babies' weight at birth. This study evaluated, during pregnancy (T1) and after delivery (T2), periodontal parameters and salivary levels of cytokines in women with obesity, and the association of these outcomes with the baby's weight at birth.After matching by age, socioeconomic status and systemic health, the sample was composed of pregnant women with obesity (GO = 25; BMI ≥30 kg/mGO showed higher prevalence of periodontitis in T1 and T2 (p 0.001), with higher salivary levels of TNF-α (p = 0.003) and IL-1β (p = 0.009) in T1. IL-1β significantly decreased after delivery in GO. No intergroup differences for leptin levels were found, but both groups had a significant reduction of leptin levels between periods (p 0.001). GO had children with lower birth weight (p = 0.022), being classified as low (2,500 g) or insufficient (2,500-2,999 g) weight.It is suggestive that the inflammatory pattern caused by obesity and periodontitis, mainly related to high levels of TNF-α, impair the babies' weight at birth, resulting in more frequency of low/insufficient weight at birth.

To evaluate the penetration depth (μm) of experimental resin infiltrants containing different percentages of triethylene glycol dimethacrylate (TEGDMA) and phosphoric acid 2-hydroxyethyl methacrylate ester (PAM) in artificial carious white spot lesions (WSL).WSL were produced in 65 bovine flat enamel specimens by pH cycling protocol, which were treated with either Icon (control) or experimental acidic infiltrants based on different percentages of TEGDMA and PAM monomers (acidic), and their association or not with previous acid-etching with phosphoric acid. Ten readings using Confocal Laser Scanning Microscopy were conducted on each specimen and the penetration depth was calculated from the surface until the deepest point with the fluorescent dye Rhodamine B (0.02 mg/mL). The pH and the viscosity of the experimental infiltrants were also tested. Data were statistically analyzed with two-way ANOVA and Tukey tests (α 0.05).The material factor and the interaction material*acid-etching were statistically significant. The lowest penetration depth was observed for the samples treated with the commercial infiltrant after etching with 15% hydrochloric acid. When specimens were pre-treated with PA, highest penetration was seen for specimens treated with 100% TEGDMA, which differed from all other groups. The lowest penetration was seen for those treated with 50:50 TEGDMA:PAM infiltrants. When specimens were not previously etched, highest penetration was seen for Icon, which differed only from those treated with 25% TEGDMA 75% PAM, where the lowest values were seen. The values of viscosity increased and the pH decreased with the addition of PAM in the infiltrant formulations.the association between TEGDMA and PAM seems to allow similar infiltration depth reached by Icon infiltrant without acid etching the enamel surface.

Made available in DSpace on 2020-12-12T01:19:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) This study aimed to produce a new SiO2+Y-TZP ceramic via uniaxial/isostatic compression that was structurally and chemically characterized relating to its translucency and flexural strength. SiO2 and Y-TZP were mixed using a ball mill, pressed and sintered at 1150 °C. The optical and mechanical properties of the specimens were compared to lithium disilicate (LD) and zirconia-reinforced lithium silicate (ZLS) (Kruskal-Wallis, α = 0.05). The Fourier Transform Infrared Spectroscopy bands suggested an interaction between Si, O and Zr. Contrast ratio and translucency parameter of the experimental ceramic were higher and lower, (p = 0.000001) respectively, than those of the LD and ZLS. The experimental ceramic presented similar flexural strength to ZLS, but lower than LD (p < 0.0001). It can be concluded that this processing method is efficient to obtain a SiO2+Y-TZP ceramic and 1150 °C crystallizes SiO2 without inducing t-m transformation. The SiO2+Y-TZP ceramic presented lower translucency and higher masking ability than the commercially available glass-ceramics, but similar flexural strength to one glass-ceramics. Department of Operative Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo Department of Prosthodontics and Periodontics Bauru School of Dentistry University of São Paulo Department of Chemistry UNESP-School of Science São Paulo State University Department of Mechanical Engineering São Carlos School of Engineering University of São Paulo Department of Physics UNESP-School of Science São Paulo State University Department of Biomaterials and Oral Biology School of Dentistry University of São Paulo Department of Pediatric Dentistry Orthodontics and Public Health Bauru School of Dentistry University of São Paulo Department of Chemistry UNESP-School of Science São Paulo State University Department of Physics UNESP-School of Science São Paulo State University FAPESP: 2017/18157-4

Objectives This study evaluated the erosive tooth wear promoted by commercial whitening toothpastes on eroded dentin in vitro. Design Ninety bovine roots were embedded, polished and subjected to the baseline profile analysis. The samples were protected in 2/3 of the dentin surface and were randomly assigned to 6 groups (n = 15/group): Oral-B 3D White; Close-up Diamond Attraction Power White; Sorriso Xtreme White 4D; Colgate Luminous White; Crest and erosion only. All samples were submitted to erosive pH cycles (4 × 90 s in 0.1% citric acid, pH 2.5, per day) and abrasive challenges (2 × 15 s, per day) for 7 days. The samples were subjected to abrasion, using toothbrushing machine, soft toothbrushes and slurries of the tested toothpastes (1.5 N, 1:3 water). Between the challenges, the samples were immersed in artificial saliva. The final profile was overlaid to the baseline profile for the calculation of the erosive dentin wear (μm). The data were subjected to Kruskal-Wallis/Dunn tests (p Results Colgate Luminous White (4.7 μm) and Sorriso Xtreme White 4D (4.0 μm) promoted the highest wear, similarly to Oral-B 3D White (2.3 μm). Oral-B 3D White promoted similar wear compared to Crest (1.1 μm) and Close-up Diamond Attraction Power White (1.2 μm); however, it induced significant higher dentin wear compared to erosion only (1.0 μm). Close-up Diamond Attraction Power White and Crest did not increase the erosive wear compared to erosion only. Conclusion Some whitening toothpastes increase the wear of eroded dentin, which should be considered by the dentist when prescribing them to patient with root exposure.

New glass ceramics enriched by polycrystalline materials has been produced by different processing methods. However, for these materials to be used as restorative dental materials in esthetical areas they must count with good optical properties, which are directly influenced by their structure and chemical composition. For these reasons, the aim of this study was to produce a new glass ceramic containing SiO2+Y-TZP via uniaxial/isostatic powder compression and to structurally and chemically characterize this material relating to its optical properties. SiO2 and Zpex® were used as starting powders. These two powders were mixed (97w%-3% ratio) and pressed in uniaxial (80MPa) and isostatic (206MPa) press and sintered at 1150ºC for 2h. The starting powders, the mixed powder (before sintering) and the sintered specimens were submitted to Scanning Electron Microscope/Energy Dispersive X-ray Spectroscopy (SEM/EDX), Transmission Electron Microscope (TEM), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). The materials density was measured. The contrast ratio and translucency parameter of the sintered specimen were compared to lithium disilicate (IPS e.max® CAD HT A1) and zirconia-reinforced lithium silicate (Celtra Duo® HT A1), using Kruskal-Wallis and post-hoc Dunn tests with a significance level set at 5%. Agglomerations of SiO2 and Zpex could be seen under SEM/EDX analysis due to their reduced particle size, yet, when sintered, some remaining porosities could be seen. The TEM analysis evidenced the spherical character of SiO2 grains and the crystallographic pattern of the Zpex particles. When mixed, Zpex can be seen inside the grain of SiO2. XDR analysis pointed out that SiO2 was amorphous, and Zpex presented monoclinic (m) and tetragonal (t) peaks. After sintering, crystallization of SiO2 can be seen without new m peaks. The FTIR spectra bands suggested an interaction between Si, O and Zr. The theoretical density value of the experimental ceramics was 1.663 g/cm3. The contrast ratio and the translucency parameter of the experimental ceramic were higher (p=0,000001) and lower (p=0,000001), respectively, than those of lithium disilicate and zirconia-reinforced lithium silicate. It can be concluded that the uniaxial/isostatic powder compression is an efficient method to obtain experimental ceramics for dental purposes and 1150ºC for 2h is sufficient to crystallize SiO2 without inducing t-m transformation of zirconia. Yet, this sintering protocol seems to be insufficient to densify the experimental ceramic, which may the reason for its lack of translucency. Novas cerâmicas vítreas enriquecidas por materiais policristalinos tem sido produzidas por diferentes métodos de processamento. Entretanto, para que sejam utilizados como materiais restauradores odontológicos em áreas estéticas, eles devem apresentar boas propriedades ópticas, que estão diretamente influenciadas por sua estrutura e composição química. Por esses motivos, o objetivo deste estudo foi produzir uma nova cerâmica vítrea contendo SiO2+Y-TZP através da via uniaxial/isostática, e caracterizar este material estrutural e quimicamente, relacionando às suas propriedades ópticas. SiO2 e Zpex® foram usados como pós de partida, misturados (97m%-3m%), prensados em prensa uniaxial (80MPa) e isostática (206MPa) e sinterizados à 1150ºC por 2h. Os pós de partida, o pó após a mistura (prévio à sinterização) e a amostra sinterizada foram submetidos à Microscopia Eletrônica de Varredura/Espectroscopia por Energia Dispersiva de Raios-X (MEV-EDX), Microscopia Eletrônica de Transmissão (MET), Difração de Raios-X (DRX) e Espectroscopia de Infravermelho com Transformada de Fourier (FTIR). A densidade do material foi mensurada. A razão de contraste e o parâmetro de translucidez da amostra sinterizada foram comparados aos do dissilicato de lítio (IPS e.max® CAD HT A1) e do silicato de lítio reforçado por zircônia (Celtra Duo® HT A1), utilizando os testes de Kruskal-Wallis e post-hoc Dunn com nível de significância de 5%. Aglomerações SiO2 e Zpex foram vistas sob MEV/EDX devido ao tamanho reduzido das partículas, porém, quando sinterizado, algumas porosidades puderam ser vistas. A análise em MET evidenciou o caráter esférico dos grãos de SiO2 e o padrão cristalográfico das partículas de Zpex. Quando misturados, Zpex pode ser visto dentro de uma partícula de SiO2. A análise em DRX destacou que a SiO2 era amorfo e Zpex apresentava picos monoclínicos (m) e tetragonais (t). Após a sinterização, a cristalização da SiO2 pode ser vista sem a formação de novos picos m. As bandas do espectro do FTIR sugeriram uma interação entre Si, O e Zr. A densidade do material foi 1,663g/cm3. A razão de contraste e o parâmetro de translucidez da cerâmica foi maior (p=0,000001) e menor (p=0,000001), respectivamente, que os do silicato de lítio e do silicato de lítio reforçado por zircônia. Podese concluir que a compressão dos pós em prensa uniaxial/isostática é um método eficiente em produzir cerâmicas experimentais para uso odontológico, e que 1150ºC por 2h é suficiente para cristalizar o SiO2 sem induzir transformação t-m na zirconia. Contudo, esse protocolo de sinterização parece ser insuficiente para densificar a cerâmica experimental, o que pode prejudicar sua translucidez.

Statement of problem Although the 2D analysis of prosthesis cementation space has been popular, its correlation with volumetric comparison (3D data) of cement space is unclear. Purpose The purpose of this in vitro study was to evaluate the cement space in computer-aided design and computer-aided manufacturing (CAD-CAM) crowns of different materials and correlate 2D measurements of cement space with their corresponding 3D values (volume of cement space) by using microcomputed tomography (μCT) analysis of regions of interest. Material and methods Ten molar crowns were milled in lithium disilicate (LD), resin nanoceramic (RN), and zirconia (Z) ceramics. Silicone replicas were produced and used as the analog cement layer and scanned with a desktop X-ray microfocus CT scanner. Twenty-eight slices were evaluated in 3 regions: marginal, axial, and occlusal (n=84 measurement points/specimen). After 3D reconstruction of the cement space, the volume was calculated. Data were statistically evaluated through 2-way ANOVA and Bonferroni test (α=.05). The Pearson correlation test was used to investigate the correlation between the 2D and 3D data. Results The volumes of the occlusal (LD 10 ±1 mm3; RN 9 ±1 mm3) and axial regions (LD 9 ±2 mm3; RN 8 ±1 mm3) were significantly higher than the volume of the marginal region for LD and RN specimens (LD 6 ±2 mm3; RN 4 ±1 mm3) (both P Conclusions Z showed more volume of cement space, as well as thicker cement space than LD and RN. The μCT analysis is an efficient method of analyzing cement thickness and volume in ceramic crowns at the selected regions of interest. A moderate positive correlation was found between the 2D and 3D analyses for the axial and marginal regions of ceramic crowns.

Objectives This study evaluated the staining potential of TiF4 varnish and TiF4/NaF solution on both sound and previously eroded enamel in vitro. Methods One hundred and eighty bovine enamel samples were polished; half of them remained sound and the other half was eroded (4 × 90 s each, using a 0.1% citric acid). Thereafter, the baseline color reading was performed (T0). The samples were then subdivided into the following treatments: TiF4 varnish (24,500 ppm F, 1 × 6 h), NaF varnish (24,500 ppm F, 1 × 6 h), placebo varnish (1 × 6 h), TiF4/NaF solution (500 ppm F, 6 × 1 min), Erosion Protection-Elmex® (500 ppm F, 6 × 1 min) and control (water, 6 × 1 min). Between the applications, the samples were exposed to artificial saliva for 30 min. The color changes were measured immediately after the applications (T1-T6) and after the exposure to artificial saliva (S1-S6) by using a spectrophotometer (Vita EasyShade®). The ΔE00, L*, a* and b* data were compared using 2-way ANOVA/Tukey (p Results TiF4 varnish induced significantly higher color change (ΔE00) compared to NaF and placebo varnishes on sound enamel immediately after application, but not after saliva exposure. TiF4/NaF solution induced lower ΔE00 values compared to control on sound enamel; however, no differences were found between TiF4/NaF and Elmex®. For eroded, no differences were seen between the tested varnishes and solutions. Both types of fluoride solutions increased the yellow appearance of enamel, while the varnishes did not. Conclusions The color changes induced by the experimental TiF4 products are similar to the commercial ones. Clinical significance Both TiF4 varnish and TiF4/NaF solution have shown staining potential similar to commercially available varnish (NaF) and solution (Elmex®) on sound and eroded enamel. These findings support the conduction of clinical trials, which, in the future, may lead to the commercialization of these products.

This study evaluated the protective effect of TiF4 varnish, after pre-treatment with proantocyanidin or chlorhexidine, on the progression of erosive dentin loss (EDL), under the presence or absence of the demineralized organic matrix (DOM). Bovine root dentin samples were eroded for 30 min (0.1% citric acid, pH 2.5) and the loss was measured by profilometry. Half of them were subjected to the DOM removal using collagenase for 4 days, while the other half remained immersed in water. The removal of DOM was checked by profilometry. Samples were divided into 24 groups (n = 15) according to the factors: 1– With or without DOM; 2– Pre-treatment with 0.012% chlorhexidine gel, 10% proanthocyanidin gel or untreated for 1 min; 3–Final Treatment with TiF4 varnish, NaF varnish, placebo varnish or untreated for 6 h. The samples were submitted to a pH cycling for 5 days: 0.1% citric acid (4 × 90s/day) and artificial saliva between the challenges. The final profile was obtained for the calculation of EDL (μm, three-way ANOVA/Tukey test). When DOM was preserved, the EDL was lower compared to the condition without DOM (7.08 ± 4.03 μm and 9.80 ± 3.79 μm, p

Made available in DSpace on 2022-04-28T19:04:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-10-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Society has changed its own lifestyle, specially its eating habits and physical activities, leading to excessive weight and a sedentary behavior, which has contributed to obesity increase. Bariatric surgery is the most effective treatment to obesity, allowing weight loss and its maintenance. However, it has been related high levels of iron deficiency after surgery. A person's nutritional status might be affected by total or partial tooth loss. The aim of this longitudinal prospective cohort study was to evaluate the levels of serum ferritin before and after bariatric surgery and to identify if there is a relation with tooth loss. The sample was composed of 50 patients selected and assisted at Amaral Carvalho Hospital, located in Jaú city, Brazil. The use and necessity of prosthesis, dental absence or presence, and serum ferritin dosage were evaluated. Student's t test, Univariate analysis, Chi-square and Odds Ratio were adopted (p

To compare the effect of 5 desensitizing agents on the hydraulic conductance (Lp) of dentin and to analyze its surface under a Laser Scanning Confocal Microscope (LSCM) before and after an erosive challenge.Lp was analyzed in the following sequence: in the presence of smear layer (pMin), after a 15-second acid etching (pMax), after treatment with a desensitizing agent (pTreat) and after a 1-minute erosive challenge (6% citric acid - pEro). Fifty 1.0 ± 0.2 mm-thick dentin disks were prepared from sound human third molars and were randomly distributed into 5 groups (n = 10): FG-Fluoride gel (control), SA-Sensiactive, PR-Sensitive Pro-Relief, NP-Desensibilize Nano-P and EV-Enamel Pro Varnish. Data were analyzed by two-way ANOVA and Tukey tests (α0.05). Additional specimens were analyzed under a Laser Scanning Confocal Microscope (LSCM) and by Energy Dispersive X-ray Spectroscopy (EDS).All materials reduced the Lp in some extent, except for FG and EV. After the erosive challenge, SA was the only material effectively able to keep the same Lp of the post-treatment phase, while the other products showed lower resistance upon an erosive challenge. Under the LSCM, the SA and NP materials were more effective to obliterate the opened dentin tubules and demonstrated higher resistance upon an erosive challenge. The EDS analysis evidenced levels of Ca, O, P, Si, Na and S.Product containing potassium oxalate was the most effective in reducing Lp of dentin samples before and after an erosive challenge. Under a LSCM, products containing potassium oxalate or hydroxyapatite crystals seemed to be occluding the dentin tubules after an erosive challenge.

Objectives: this study systematically reviewed the literature in order to better understand the association among COVID-19, pregnancy and neonates. Methods: MEDLINE, EMBASE, Web of Science, BVS and SCOPUS were assessed, considering the terms: (covid 19 OR covid-19 OR novel coronavirus OR 2019 novel coronavirus OR 2019-nCoV OR sarscov 2 OR sars-cov-2 OR sarscov2 OR sars cov-2) AND (pregnancy OR pregnant OR pregnant women OR gestation OR gestational) AND (infant OR fetal OR neonatal). Thirty full-text were included (408 pregnant women, 11 non-pregnant women and 279 neonates). Results: fever (45.83%) and cough (31.61%) were the main symptoms of COVID-19 during the pregnancy. Low levels of lymphocytes (32.10%), elevated levels of C-reactive protein (32.35%); leukocytosis (29.41%); neutrophil (5.88%); and radiographic alterations on chest CT, x-ray or ultrasound (45.84%) were the main laboratorial findings. Cesarean delivery and preterm were registered in 239 and 49 cases, respectively. Ten neonates tested positive for SARS-CoV-2. Conclusion: when COVID-19 pneumonia affects women during pregnancy, the symptoms are similar to those experienced by non-pregnant women. In addition, there is still no plausible evidence suggesting vertical transmission of SARS-CoV-2 virus from mother to child.