217 results on '"Vernoux, P."'
Search Results
2. The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells
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Lounas, Amel, Breton, Yann, Lebrun, Ariane, Laflamme, Isabelle, Vernoux, Nathalie, Savage, Julie, Tremblay, Marie-Ève, Pelletier, Martin, Germain, Marc, and Richard, François J.
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- 2024
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3. A quantitative gibberellin signaling biosensor reveals a role for gibberellins in internode specification at the shoot apical meristem
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Bihai Shi, Amelia Felipo-Benavent, Guillaume Cerutti, Carlos Galvan-Ampudia, Lucas Jilli, Geraldine Brunoud, Jérome Mutterer, Elody Vallet, Lali Sakvarelidze-Achard, Jean-Michel Davière, Alejandro Navarro-Galiano, Ankit Walia, Shani Lazary, Jonathan Legrand, Roy Weinstain, Alexander M. Jones, Salomé Prat, Patrick Achard, and Teva Vernoux
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Science - Abstract
Abstract Growth at the shoot apical meristem (SAM) is essential for shoot architecture construction. The phytohormones gibberellins (GA) play a pivotal role in coordinating plant growth, but their role in the SAM remains mostly unknown. Here, we developed a ratiometric GA signaling biosensor by engineering one of the DELLA proteins, to suppress its master regulatory function in GA transcriptional responses while preserving its degradation upon GA sensing. We demonstrate that this degradation-based biosensor accurately reports on cellular changes in GA levels and perception during development. We used this biosensor to map GA signaling activity in the SAM. We show that high GA signaling is found primarily in cells located between organ primordia that are the precursors of internodes. By gain- and loss-of-function approaches, we further demonstrate that GAs regulate cell division plane orientation to establish the typical cellular organization of internodes, thus contributing to internode specification in the SAM.
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- 2024
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4. The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells
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Amel Lounas, Yann Breton, Ariane Lebrun, Isabelle Laflamme, Nathalie Vernoux, Julie Savage, Marie-Ève Tremblay, Martin Pelletier, Marc Germain, and François J. Richard
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Medicine ,Science - Abstract
Abstract Oocyte maturation is a key process during which the female germ cell undergoes resumption of meiosis and completes its preparation for embryonic development including cytoplasmic and epigenetic maturation. The cumulus cells directly surrounding the oocyte are involved in this process by transferring essential metabolites, such as pyruvate, to the oocyte. This process is controlled by cyclic adenosine monophosphate (cAMP)-dependent mechanisms recruited downstream of follicle-stimulating hormone (FSH) signaling in cumulus cells. As mitochondria have a critical but poorly understood contribution to this process, we defined the effects of FSH and high cAMP concentrations on mitochondrial dynamics and function in porcine cumulus cells. During in vitro maturation (IVM) of cumulus-oocyte complexes (COCs), we observed an FSH-dependent mitochondrial elongation shortly after stimulation that led to mitochondrial fragmentation 24 h later. Importantly, mitochondrial elongation was accompanied by decreased mitochondrial activity and a switch to glycolysis. During a pre-IVM culture step increasing intracellular cAMP, mitochondrial fragmentation was prevented. Altogether, the results demonstrate that FSH triggers rapid changes in mitochondrial structure and function in COCs involving cAMP.
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- 2024
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5. The first intron of ARF7 is required for expression in root tips
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Jingyi Han, Thomas Welch, Ute Voß, Teva Vernoux, Rahul Bhosale, and Anthony Bishopp
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Molecular biology ,plant biology ,Botany ,Science - Abstract
Summary: Auxin regulates plant growth and development through the transcription factors of the AUXIN RESPONSE FACTOR (ARF) gene family. ARF7 is one of five activators that bind DNA and elicit downstream transcriptional responses. In roots, ARF7 regulates growth, gravitropism and redundantly with ARF19, lateral root organogenesis. In this study we analyzed ARF7 cis-regulation, using different non-coding sequences of the ARF7 locus to drive GFP. We show that constructs containing the first intron led to increased signal in the root tip. Although bioinformatics analyses predicted several transcription factor binding sites in the first intron, we were unable to significantly alter expression of GFP in the root by mutating these. We instead observed the intronic sequences needed to be present within the transcribed sequences to drive expression in the root meristem. These data support a mechanism by which intron-mediated enhancement regulates the tissue specific expression of ARF7 in the root meristem.
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- 2024
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6. Cramp–Fasciculation Syndrome Associated with Natural and Added Chemicals in Popular Food Items
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Emmeline Lagrange, Jean-Paul Vernoux, Celia Chambon, William Camu, and Peter S. Spencer
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muscle cramp–fasciculations ,motoneuron disease ,glutamate ,lupin ,Chemical technology ,TP1-1185 - Abstract
Cramp–fasciculation syndrome (CFS) is a rare and benign neuromuscular disorder that may initially masquerade as motor neuron disease/amyotrophic lateral sclerosis. While CFS may have a familial disposition, we report on cases associated with high consumption of popular food items. One set of patients reversibly experienced acute onset of headache, flushing, muscle stiffness and fasciculations following the consumption of umami-flavored food containing a large concentration of monosodium glutamate. A second group of patients consuming food derived from lupin seed developed acute cholinergic toxicity, CFS, and, with chronic intake, significant, self-limiting, but incompletely reversible upper and lower motor neuron deficits. While these cases may improve our knowledge about the possible causes of CFS, our series also demonstrates that excessive consumption of some popular foods is not harmless. This warrants further research on their safety at all stages of human development from a neurological point of view.
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- 2024
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7. Tuning the metal loading of Pt/CeO2 catalysts for the water-gas shift reaction
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Clément Molinet-Chinaglia, Luis Cardenas, Philippe Vernoux, Laurent Piccolo, and Stéphane Loridant
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Pt/CeO2 catalyst ,Water-gas shift reaction ,Oxidized Pt single atoms and clusters ,Metallic Pt nanoparticles ,Structural dynamics ,Chemistry ,QD1-999 - Abstract
Identifying active platinum species at the surface of Pt/CeO2 catalysts is still a hot topic in the literature. In this work, an oxidizing pretreatment at 500 °C was applied to generate ultradispersed PtOx species before the reaction. It is shown that the molar activity of such catalysts for the water-gas shift reaction is strongly dependent on the platinum content, increasing by a factor of 2.5 from 0.1 to 0.6 wt% and stabilizing from 0.6 to 1.4 wt%. The tracking of Pt species present under reaction conditions (230 °C, H2O/CO=4) was performed using operando DRIFT spectroscopy, CO-TPR and STEM in connection with the catalytic activity. A major structural change was found for Pt loadings above 0.6 wt% through the formation of metallic Pt0 nanoparticles of ca 1.4 nm from oxidized Pt single atoms and clusters. Conversely, for Pt contents below 0.6 wt%, Pt species possess a stronger interaction with CeO2 as well as a lower nuclearity, limiting their activation under reaction conditions. This strongly suggests that metallic Pt nanoparticles, prevalent at high loading, are more active than oxidic Pt single atoms and small clusters, which are predominantly present at low loading. This study highlights the key role of PtOx reducibility and the importance to optimize the Pt loading to obtain active catalysts for the water-gas shift reaction.
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- 2024
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8. A 3D analysis revealed complexe mitochondria morphologies in porcine cumulus cells
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Amel Lounas, Ariane Lebrun, Isabelle Laflamme, Nathalie Vernoux, Julie Savage, Marie-Ève Tremblay, Marc Germain, and François J. Richard
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Medicine ,Science - Abstract
Abstract In the ovarian follicle, a bilateral cell-to-cell communication exists between the female germ cell and the cumulus cells which surround the oocyte. This communication allows the transit of small size molecules known to impact oocyte developmental competence. Pyruvate derivatives produced by mitochondria, are one of these transferred molecules. Interestingly, mitochondria may adopt a variety of morphologies to regulate their functions. In this study, we described mitochondrial morphologies in porcine cumulus cells. Active mitochondria were stained with TMRM (Tetramethylrhodamine, Methyl Ester, Perchlorate) and observed with 2D confocal microscopy showing mitochondria of different morphologies such as short, intermediate, long, and very long. The number of mitochondria of each phenotype was quantified in cells and the results showed that most cells contained elongated mitochondria. Scanning electron microscopy (SEM) analysis confirmed at nanoscale resolution the different mitochondrial morphologies including round, short, intermediate, and long. Interestingly, 3D visualisation by focused ion-beam scanning electron microscopy (FIB-SEM) revealed different complex mitochondrial morphologies including connected clusters of different sizes, branched mitochondria, as well as individual mitochondria. Since mitochondrial dynamics is a key regulator of function, the description of the mitochondrial network organisation will allow to further study mitochondrial dynamics in cumulus cells in response to various conditions such as in vitro maturation.
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- 2022
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9. Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research
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Peter S. Spencer, Valerie S. Palmer, Glen E. Kisby, Emmeline Lagrange, B. Zane Horowitz, Raquel Valdes Angues, Jacques Reis, Jean-Paul Vernoux, Cédric Raoul, and William Camu
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genotoxin ,gyromitrin ,agaritine ,monomethylhydrazine (MMH) ,methylazoxymethanol (MAM) ,lifetime exposome ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
The identity and role of environmental factors in the etiology of sporadic amyotrophic lateral sclerosis (sALS) is poorly understood outside of three former high-incidence foci of Western Pacific ALS and a hotspot of sALS in the French Alps. In both instances, there is a strong association with exposure to DNA-damaging (genotoxic) chemicals years or decades prior to clinical onset of motor neuron disease. In light of this recent understanding, we discuss published geographic clusters of ALS, conjugal cases, single-affected twins, and young-onset cases in relation to their demographic, geographic and environmental associations but also whether, in theory, there was the possibility of exposure to genotoxic chemicals of natural or synthetic origin. Special opportunities to test for such exposures in sALS exist in southeast France, northwest Italy, Finland, the U.S. East North Central States, and in the U.S. Air Force and Space Force. Given the degree and timing of exposure to an environmental trigger of ALS may be related to the age at which the disease is expressed, research should focus on the lifetime exposome (from conception to clinical onset) of young sALS cases. Multidisciplinary research of this type may lead to the identification of ALS causation, mechanism, and primary prevention, as well as to early detection of impending ALS and pre-clinical treatment to slow development of this fatal neurological disease.
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- 2023
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10. A 3D analysis revealed complexe mitochondria morphologies in porcine cumulus cells
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Lounas, Amel, Lebrun, Ariane, Laflamme, Isabelle, Vernoux, Nathalie, Savage, Julie, Tremblay, Marie-Ève, Germain, Marc, and Richard, François J.
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- 2022
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11. Protection of NOx Sensors from Sulfur Poisoning in Glass Furnaces by the Optimization of a 'SO2 Trap'
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Carole Naddour, Mathilde Rieu, Antoinette Boreave, Sonia Gil, Philippe Vernoux, and Jean-Paul Viricelle
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NOx sensor ,glass furnaces ,sulfur poisoning ,SO2 trap ,CuO/BaO-based traps ,Chemical technology ,TP1-1185 - Abstract
Electrochemical NOx sensors based on yttria-stabilized zirconia (YSZ) provide a reliable onboard way to control NOx emissions from glass-melting furnaces. The main limitation is the poisoning of this sensor by sulfur oxides (SOx) contained in the stream. To overcome this drawback, an “SO2 trap” with high SOx storage capacity and low affinity to NOx is required. Two CuO/BaO/SBA-15 traps with the same CuO loading (6.5 wt.%) and different BaO loadings (5 and 24.5 wt.%, respectively) were synthetized, thoroughly characterized and evaluated as SO2 traps. The results show that the 6.5%CuO/5%BaO/SBA-15 trap displays the highest SO2 adsorption capacity and can fully adsorb SO2 for a specific period of time, while additionally displaying a very low NO adsorption capacity. A suitable quantity of this material located upstream of the sensor could provide total protection of the NOx sensor against sulfur poisoning in glass-furnace exhausts.
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- 2023
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12. Ciguatera Fish Poisoning in the Caribbean Sea and Atlantic Ocean: Reconciling the Multiplicity of Ciguatoxins and Analytical Chemistry Approach for Public Health Safety
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Ivannah Pottier, Richard J. Lewis, and Jean-Paul Vernoux
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ciguatera fish poisoning ,Caribbean ciguatoxins ,Caribbean Sea and Atlantic Ocean ,fish toxins ,marine biotoxins ,phycotoxins ,Medicine - Abstract
Ciguatera is a major circumtropical poisoning caused by the consumption of marine fish and invertebrates contaminated with ciguatoxins (CTXs): neurotoxins produced by endemic and benthic dinoflagellates which are biotransformed in the fish food-web. We provide a history of ciguatera research conducted over the past 70 years on ciguatoxins from the Pacific Ocean (P-CTXs) and Caribbean Sea (C-CTXs) and describe their main chemical, biochemical, and toxicological properties. Currently, there is no official method for the extraction and quantification of ciguatoxins, regardless their origin, mainly due to limited CTX-certified reference materials. In this review, the extraction and purification procedures of C-CTXs are investigated, considering specific objectives such as isolating reference materials, analysing fish toxin profiles, or ensuring food safety control. Certain in vitro assays may provide sufficient sensitivity to detect C-CTXs at sub-ppb levels in fish, but they do not allow for individual identification of CTXs. Recent advances in analysis using liquid chromatography coupled with low- or high-resolution mass spectrometry provide new opportunities to identify known C-CTXs, to gain structural insights into new analogues, and to quantify C-CTXs. Together, these methods reveal that ciguatera arises from a multiplicity of CTXs, although one major form (C-CTX-1) seems to dominate. However, questions arise regarding the abundance and instability of certain C-CTXs, which are further complicated by the wide array of CTX-producing dinoflagellates and fish vectors. Further research is needed to assess the toxic potential of the new C-CTX and their role in ciguatera fish poisoning. With the identification of C-CTXs in the coastal USA and Eastern Atlantic Ocean, the investigation of ciguatera fish poisoning is now a truly global effort.
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- 2023
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13. bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana
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Eliana Mor, Markéta Pernisová, Max Minne, Guillaume Cerutti, Dagmar Ripper, Jonah Nolf, Jennifer Andres, Laura Ragni, Matias D. Zurbriggen, Bert De Rybel, and Teva Vernoux
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Natural sciences ,Biological sciences ,Plant biology ,Molecular plant pathology ,Science - Abstract
Summary: Root, shoot, and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic helix-loop-helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.
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- 2022
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14. Design of an intermediate representation for query languages
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Vernoux, Romain
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Computer Science - Programming Languages - Abstract
Data oriented applications, usually written in a high-level, general-purpose programming language (such as Java) interact with database through a coarse interface. Informally, the text of a query is built on the application side (either via plain string concatenation or through an abstract notion of statement) and shipped to the database over the wire where it is executed. The results are then serialized and sent back to the "client-code" where they are translated in the language's native datatypes. This round trip is detrimental to performances but, worse, such a programming model prevents one from having richer queries, namely queries containing user-defined functions (that is functions defined by the programmer and used e.g. in the filter condition of a SQL query). While some databases also possess a "server-side" language (e.g. PL/SQL in Oracle database), its integration with the very-optimized query execution engine is still minimal and queries containing (PL/SQL) user-defined functions remain notoriously inefficient. In this setting, we reviewed existing language-integrated query frameworks, highlighting that existing database query languages (including SQL) share high-level querying primitives (e.g., filtering, joins, aggregation) that can be represented by operators, but differ widely regarding the semantics of their expression language. In order to represent queries in an application language- and database-agnostic manner, we designed a small calculus, dubbed "QIR" for Query Intermediate Representation. QIR contains expressions, corresponding to a small extension of the pure lambda-calculus, and operators to represent usual querying primitives. In the effort to send efficient queries to the database, we abstracted the idea of "good" query representations in a measure on QIR terms. Then, we designed an evaluation strategy rewriting QIR query representations into "better" ones.
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- 2016
15. Transcriptional reprogramming during floral fate acquisition
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Antoine Larrieu, Géraldine Brunoud, Aurore Guérault, Stéphanie Lainé, Lauriane Hennet, Arnaud Stigliani, Iris Gildea, Jeremy Just, Ludivine Soubigou-Taconnat, Sandrine Balzergue, Brendan Davies, Enrico Scarpella, Ykä Helariutta, François Parcy, and Teva Vernoux
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Plant biology ,Plant development ,Omics ,Transcriptomics ,Science - Abstract
Summary: Coordinating growth and patterning is essential for eukaryote morphogenesis. In plants, auxin is a key regulator of morphogenesis implicated throughout development. Despite this central role, our understanding of how auxin coordinates cell fate and growth changes is still limited. Here, we addressed this question using a combination of genomic screens to delve into the transcriptional network induced by auxin at the earliest stage of flower development, prior to morphological changes. We identify a shoot-specific network suggesting that auxin initiates growth through an antagonistic regulation of growth-promoting and growth-repressive hormones, quasi-synchronously to floral fate specification. We further identify two DNA-binding One Zinc Finger (DOF) transcription factors acting in an auxin-dependent network that could interface growth and cell fate from the early stages of flower development onward.
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- 2022
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16. Analysis of Unregulated VOCs Downstream a Three-Way Catalyst in a Simulated Gasoline Engine Exhaust under Non-Optimum Conditions
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Essyllt Louarn, Antoinette Boreave, Guy Raffin, Christian George, and Philippe Vernoux
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VOC ,unregulated VOC ,TWC ,gasoline ,emission ,light-off ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
Urban air pollution is partly due to exhaust emissions from road transport. Vehicle emissions have been regulated for more than 30 years in many countries around the world. Each motor type is equipped with a specific emission control system. In gasoline vehicles, a three-way catalytic converter (TWC) is implemented to remove at the same time hydrocarbons (HC), carbon monoxide (CO), and nitrogen oxides (NOx). However, TWCs are only efficient above 200 °C and at a stoichiometric air-to-fuel ratio in the exhaust. However, deviations from stoichiometry occur during fast accelerations and decelerations. This study reports the analysis of unregulated VOCs commercial mini-TWC fed by model gasoline gas mixtures. A synthetic gas bench was used to control the model exhaust containing two model hydrocarbons (propene and propane) to identify the conditions at which VOCs are created under non-optimal conditions. Most of the pollutants such as N2O and VOCs were emitted between 220 and 500 °C with a peak at around 280 °C, temperature which corresponds to the tipping point of the TWC activity. The combination of different mass spectrometric analysis (online and offline) allowed to identify many different VOCs: carbonated (acetone, acetaldehyde, acroleine), nitrile (acetonitrile, propanenitrile, acrylonitrile, cyanopropene) and aromatic (benzene, toluene) compounds. Growth mechanisms from propene and to a lesser extend propane are responsible for the formation of these higher aromatic compounds that could lead to the formation of secondary organic aerosol in a near-field area.
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- 2023
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17. From plastic-waste to H2: Electrolysis of a Poly(methyl methacrylate) model molecule on polymer electrolyte membrane reactors
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Grimaldos-Osorio, N., Sordello, F., Passananti, M., Vernoux, P., and Caravaca, A.
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- 2020
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18. A network of transcriptional repressors modulates auxin responses
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Truskina, Jekaterina, Han, Jingyi, Chrysanthou, Elina, Galvan-Ampudia, Carlos S., Lainé, Stéphanie, Brunoud, Géraldine, Macé, Julien, Bellows, Simon, Legrand, Jonathan, Bågman, Anne-Maarit, Smit, Margot E., Smetana, Ondřej, Stigliani, Arnaud, Porco, Silvana, Bennett, Malcolm J., Mähönen, Ari Pekka, Parcy, François, Farcot, Etienne, Roudier, Francois, Brady, Siobhan M., Bishopp, Anthony, and Vernoux, Teva
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- 2021
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19. The SQL++ Query Language: Configurable, Unifying and Semi-structured
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Ong, Kian Win, Papakonstantinou, Yannis, and Vernoux, Romain
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Computer Science - Databases - Abstract
NoSQL databases support semi-structured data, typically modeled as JSON. They also provide limited (but expanding) query languages. Their idiomatic, non-SQL language constructs, the many variations, and the lack of formal semantics inhibit deep understanding of the query languages, and also impede progress towards clean, powerful, declarative query languages. This paper specifies the syntax and semantics of SQL++, which is applicable to both JSON native stores and SQL databases. The SQL++ semi-structured data model is a superset of both JSON and the SQL data model. SQL++ offers powerful computational capabilities for processing semi-structured data akin to prior non-relational query languages, notably OQL and XQuery. Yet, SQL++ is SQL backwards compatible and is generalized towards JSON by introducing only a small number of query language extensions to SQL. Recognizing that a query language standard is probably premature for the fast evolving area of NoSQL databases, SQL++ includes configuration options that formally itemize the semantics variations that language designers may choose from. The options often pertain to the treatment of semi-structuredness (missing attributes, heterogeneous types, etc), where more than one sensible approaches are possible. SQL++ is unifying: By appropriate choices of configuration options, the SQL++ semantics can morph into the semantics of existing semi-structured database query languages. The extensive experimental validation shows how SQL and four semi-structured database query languages (MongoDB, Cassandra CQL, Couchbase N1QL and AsterixDB AQL) are formally described by appropriate settings of the configuration options. Early adoption signs of SQL++ are positive: Version 4 of Couchbase's N1QL is explained as syntactic sugar over SQL++. AsterixDB will soon support the full SQL++ and Apache Drill is in the process of aligning with SQL++., Comment: 13 pages, [14166]
- Published
- 2014
20. Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet
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Maude Bordeleau, Chloé Lacabanne, Lourdes Fernández de Cossío, Nathalie Vernoux, Julie C. Savage, Fernando González-Ibáñez, and Marie-Ève Tremblay
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Hippocampus ,Immune priming ,Maternal high-fat diet ,Microglia ,Sex difference ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Maternal nutrition is critical for proper fetal development. While increased nutrient intake is essential during pregnancy, an excessive consumption of certain nutrients, like fat, can lead to long-lasting detrimental consequences on the offspring. Animal work investigating the consequences of maternal high-fat diet (mHFD) revealed in the offspring a maternal immune activation (MIA) phenotype associated with increased inflammatory signals. This inflammation was proposed as one of the mechanisms causing neuronal circuit dysfunction, notably in the hippocampus, by altering the brain-resident macrophages—microglia. However, the understanding of mechanisms linking inflammation and microglial activities to pathological brain development remains limited. We hypothesized that mHFD-induced inflammation could prime microglia by altering their specific gene expression signature, population density, and/or functions. Methods We used an integrative approach combining molecular (i.e., multiplex-ELISA, rt-qPCR) and cellular (i.e., histochemistry, electron microscopy) techniques to investigate the effects of mHFD (saturated and unsaturated fats) vs control diet on inflammatory priming, as well as microglial transcriptomic signature, density, distribution, morphology, and ultrastructure in mice. These analyses were performed on the mothers and/or their adolescent offspring at postnatal day 30. Results Our study revealed that mHFD results in MIA defined by increased circulating levels of interleukin (IL)-6 in the mothers. This phenotype was associated with an exacerbated inflammatory response to peripheral lipopolysaccharide in mHFD-exposed offspring of both sexes. Microglial morphology was also altered, and there were increased microglial interactions with astrocytes in the hippocampus CA1 of mHFD-exposed male offspring, as well as decreased microglia-associated extracellular space pockets in the same region of mHFD-exposed offspring of the two sexes. A decreased mRNA expression of the inflammatory-regulating cytokine Tgfb1 and microglial receptors Tmem119, Trem2, and Cx3cr1 was additionally measured in the hippocampus of mHFD-exposed offspring, especially in males. Conclusions Here, we described how dietary habits during pregnancy and nurturing, particularly the consumption of an enriched fat diet, can influence peripheral immune priming in the offspring. We also found that microglia are affected in terms of gene expression signature, morphology, and interactions with the hippocampal parenchyma, in a partially sexually dimorphic manner, which may contribute to the adverse neurodevelopmental outcomes on the offspring.
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- 2020
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21. WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis
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Yanfei Ma, Andrej Miotk, Zoran Šutiković, Olga Ermakova, Christian Wenzl, Anna Medzihradszky, Christophe Gaillochet, Joachim Forner, Gözde Utan, Klaus Brackmann, Carlos S. Galván-Ampudia, Teva Vernoux, Thomas Greb, and Jan U. Lohmann
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Science - Abstract
Spatial control of auxin signaling maintains a balance between stem-cell self-renewal and differentiation at the plant shoot apex. Here Ma et al. show that rheostatic control of auxin response by the WUSCHEL transcription factor maintains stem cells by conferring resistance to auxin mediated differentiation.
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- 2019
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22. Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring
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Maude Bordeleau, PhD, Lourdes Fernández de Cossío, PhD, Chloé Lacabanne, PhD, Julie C. Savage, PhD, Nathalie Vernoux, PhD, Mallar Chakravarty, PhD, and Marie-Ève Tremblay, PhD
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Maternal high-fat diet ,Myelin ,Cytosolic channels ,Oligodendrocytes ,Microglia ,Adolescence ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Prenatal exposure to maternal high-fat diet (mHFD) acts as a risk factor for various neurodevelopmental alterations in the progeny. Recent studies in mice revealed that mHFD results in both neuroinflammation and hypomyelination in the exposed offspring. Microglia, the brain-resident macrophages, play crucial roles during brain development, notably by modulating oligodendrocyte populations and performing phagocytosis of myelin sheaths. Previously, we reported that mHFD modifies microglial phenotype (i.e., morphology, interactions with their microenvironment, transcripts) in the hippocampus of male and female offspring. In the current study, we further explored whether mHFD may induce myelination changes among the hippocampal-corpus callosum-prefrontal cortex pathway, and result in behavioral outcomes in adolescent offspring of the two sexes. To this end, female mice were fed with control chow or HFD for 4 weeks before mating, during gestation, and until weaning of their litter. Histological and ultrastructural analyses revealed an increased density of myelin associated with a reduced area of cytosolic myelin channels in the corpus callosum of mHFD-exposed male compared to female offspring. Transcripts of myelination-associated genes including Igf1 –a growth factor released by microglia– were also lower, specifically in the hippocampus (without changes in the prefrontal cortex) of adolescent male mouse offspring. These changes in myelin were not related to an altered density, distribution, or maturation of oligodendrocytes, instead we found that microglia within the corpus callosum of mHFD-exposed offspring showed reduced numbers of mature lysosomes and increased synaptic contacts, suggesting microglial implication in the modified myelination. At the behavioral level, both male and female mHFD-exposed adolescent offspring presented loss of social memory and sensorimotor gating deficits. These results together highlight the importance of studying oligodendrocyte-microglia crosstalk and its involvement in the long-term brain alterations that result from prenatal mHFD in offspring across sexes.
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- 2021
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23. Ethylene epoxidation on Ag/YSZ electrochemical catalysts: Understanding of oxygen electrode reactions
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Cavoué, T., Caravaca, A., Kalaitzidou, I., Gaillard, F., Rieu, M., Viricelle, J.P., and Vernoux, P.
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- 2019
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24. Pd Supported on Pr-Rich Cerium–Zirconium–Praseodymium Mixed Oxides for Propane and CO Oxidation
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Simon Fahed, Rémy Pointecouteau, Mimoun Aouine, Antoinette Boreave, Sonia Gil, Philippe Bazin, Alain Demourgues, Marco Daturi, and Philippe Vernoux
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mixed cerium oxides ,emission control ,Pd ,single-atom catalysts ,bulk oxygen mobility ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
The activity of emission control catalysts must be improved in urban mode at low temperatures. One possible way is to tailor the metal-support interaction between platinum group metals (PGMs) and ceria to stabilize small clusters or single atoms, optimizing the utilization of costly PGMs. In this study, a small loading of Pd (0.45Zr0.10Pr0.45O2−x). After the initial calcination at 800 °C, Pd was mainly in the form of dispersed isolated cations which were found to be efficient for low-temperature CO oxidation but inactive for propane combustion. Nevertheless, a pre-reduction step can trigger the formation of Pd nanoparticles and promote the propane oxidation. Pd nanoparticles, formed during the reduction step, coupled with the high oxygen mobility of CZP45, lead to outstanding catalytic activity for propane oxidation starting from 250 °C. However, the re-oxidation of Pd nanoparticles and their partial re-dispersion, promoted by the fast oxygen mobility of the mixed oxide, rapidly deactivate the catalysts in lean conditions.
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- 2022
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25. Synergy between Ag nanoparticles and yttria-stabilized zirconia for soot oxidation
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Serve, A., Boreave, A., Cartoixa, B., Pajot, K., and Vernoux, P.
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- 2019
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26. Towards a sustainable technology for H2 production: Direct lignin electrolysis in a continuous-flow Polymer Electrolyte Membrane reactor
- Author
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Angel Caravaca, Wendy Eunice Garcia-Lorefice, Sonia Gil, Antonio de Lucas-Consuegra, and Philippe Vernoux
- Subjects
Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
We have performed, for the very first time in literature, the production of pure H2 via “electrolysis of lignin solutions in continuous-flow mode in a Polymer Electrolyte Membrane (PEM) reactor”. A Pt-Ru//Fumapem (OH− conductor)//Pt/C (Anode//Anion Exchange membrane//Cathode) electrochemical cell was used. Under the explored conditions, we have demonstrated that lignin can be electrolyzed at much lower electrical potentials (from ~0.45 V) compared to that of water electrolysis (thermodynamically favored from ~1.2 V). In addition, we observed that increasing the reaction temperature gives rise to an enhanced activity towards the electrolysis of lignin, increasing therefore the production of pure H2. Finally, in-situ cyclic voltammetry experiments were performed in the PEM cell to demonstrate that lignin electro-oxidation takes place at potentials lower than that for O2 evolution. These experiments also showed that the whole system did not suffer a significant deactivation during the electrolysis experiments, which pointed out the promising stability and reproducibility of the proposed technology. Further studies should be performed to identify the products of the lignin electro-oxidation at the anode.This study establishes a very important step-forward towards the direct electrochemical valorization of lignin (usually considered as a biomass residue) for a sustainable production of pure H2 using renewable sources. Keywords: Hydrogen production, Lignin valorization, Polymer Electrolyte Membrane electrolyser, Biomass electrolysis
- Published
- 2019
- Full Text
- View/download PDF
27. Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
- Author
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Victor Bellver-Landete, Floriane Bretheau, Benoit Mailhot, Nicolas Vallières, Martine Lessard, Marie-Eve Janelle, Nathalie Vernoux, Marie-Ève Tremblay, Tobias Fuehrmann, Molly S. Shoichet, and Steve Lacroix
- Subjects
Science - Abstract
The role of microglia following spinal cord injury is not fully understood. Here, using transgenic approaches to selectively label microglia and not macrophages in mice, the authors show that microglia are highly active and accumulate at the edge of the lesion in the first weeks post injury, and also that inhibiting microglia activation impairs recovery in the early stages after spinal cord injury.
- Published
- 2019
- Full Text
- View/download PDF
28. Correction: Lagrange, E.; Vernoux, J.-P. Warning on False or True Morels and Button Mushrooms with Potential Toxicity Linked to Hydrazinic Toxins: An Update. Toxins 2020, 12, 482
- Author
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Emmeline Lagrange and Jean-Paul Vernoux
- Subjects
n/a ,Medicine - Abstract
The authors wish to make corrections to their paper [...]
- Published
- 2022
- Full Text
- View/download PDF
29. Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet
- Author
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Bordeleau, Maude, Lacabanne, Chloé, Fernández de Cossío, Lourdes, Vernoux, Nathalie, Savage, Julie C., González-Ibáñez, Fernando, and Tremblay, Marie-Ève
- Published
- 2020
- Full Text
- View/download PDF
30. A long-range plasmonic optical waveguide corner mirror chip
- Author
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Laurent Markey, Christian Vernoux, Kamal Hammani, Juan Arocas, Jean-Claude Weeber, and Alain Dereux
- Subjects
Integrated waveguide ,Plasmon ,Plasmonic ,Optical interconnect ,Planar lightwave circuits ,Electronics ,TK7800-8360 ,Technology (General) ,T1-995 - Abstract
We provide the experimental proof of concept of on-chip 90° corner waveguide arrays based on ultra-long-range surface plasmon polariton waveguides working in TM-polarization at 1.55 μm. The single-mode waveguides comprise a thin gold-photoresist core embedded into SU-8 claddings and show typical propagation loss of ~1 dB/mm. A prismatic cavity integrated into the cladding layers and aligned with the waveguide's corner assures the total internal reflection. We present a fabrication method to integrate the waveguide corner mirror based on self-alignment of multiple lithography steps. This chip has potential as low-loss perpendicular interface for single-mode high speed communication interconnects.
- Published
- 2020
- Full Text
- View/download PDF
31. Temporal integration of auxin information for the regulation of patterning
- Author
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Carlos S Galvan-Ampudia, Guillaume Cerutti, Jonathan Legrand, Géraldine Brunoud, Raquel Martin-Arevalillo, Romain Azais, Vincent Bayle, Steven Moussu, Christian Wenzl, Yvon Jaillais, Jan U Lohmann, Christophe Godin, and Teva Vernoux
- Subjects
shoot apical meristem ,plant biology ,Auxin ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Positional information is essential for coordinating the development of multicellular organisms. In plants, positional information provided by the hormone auxin regulates rhythmic organ production at the shoot apex, but the spatio-temporal dynamics of auxin gradients is unknown. We used quantitative imaging to demonstrate that auxin carries high-definition graded information not only in space but also in time. We show that, during organogenesis, temporal patterns of auxin arise from rhythmic centrifugal waves of high auxin travelling through the tissue faster than growth. We further demonstrate that temporal integration of auxin concentration is required to trigger the auxin-dependent transcription associated with organogenesis. This provides a mechanism to temporally differentiate sites of organ initiation and exemplifies how spatio-temporal positional information can be used to create rhythmicity.
- Published
- 2020
- Full Text
- View/download PDF
32. A mechanistic framework for auxin dependent Arabidopsis root hair elongation to low external phosphate
- Author
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Rahul Bhosale, Jitender Giri, Bipin K. Pandey, Ricardo F. H. Giehl, Anja Hartmann, Richard Traini, Jekaterina Truskina, Nicola Leftley, Meredith Hanlon, Kamal Swarup, Afaf Rashed, Ute Voß, Jose Alonso, Anna Stepanova, Jeonga Yun, Karin Ljung, Kathleen M. Brown, Jonathan P. Lynch, Liam Dolan, Teva Vernoux, Anthony Bishopp, Darren Wells, Nicolaus von Wirén, Malcolm J. Bennett, and Ranjan Swarup
- Subjects
Science - Abstract
Plant root hairs elongate in response to low soil phosphate. Here Bhosale et al. show that root hair elongation requires auxin synthesis mediated by TAA1, auxin transport by AUX1 in the lateral root cap and epidermis, and signaling via the auxin-inducible ARF19, RSL2 and RSL4 transcription factors.
- Published
- 2018
- Full Text
- View/download PDF
33. Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice
- Author
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M. Florencia Iulita, Diane Vallerand, Mélissa Beauvillier, Nathalie Haupert, Corinne A. Ulysse, Audrey Gagné, Nathalie Vernoux, Sonia Duchemin, Michaël Boily, Marie-Ève Tremblay, and Hélène Girouard
- Subjects
Angiotensin II ,Hypertension ,Inflammation ,Blood pressure ,Microglia ,TNF-α ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Angiotensin II (Ang II), a peptide hormone involved in the development of hypertension, causes systemic and cerebral inflammation, affecting brain regions important for blood pressure control. The cause-and-effect relationship between hypertension and inflammation is two-way, but the role of blood pressure in the induction of cerebral inflammation is less clear. The vulnerability of specific brain regions, particularly those important for memory, is also of interest. Methods We used molecular biology approaches, immunohistochemistry, and electron microscopy to examine the interdependence between the hypertensive and pro-inflammatory effects of Ang II. We examined the effect of blood pressure by administering a subpressive (200 ng/kg/min) or a pressive Ang II dose (1000 or 1900 ng/kg/min) with and without hydralazine (150 mg/L) for 1 week and used phenylephrine to increase blood pressure independently of the renin-angiotensin system. Results Ang II increased ionized calcium-binding adaptor molecule 1 (Iba-1) levels (marker of microgliosis) in the whole brain and in the hippocampus in a dose-dependent manner. Pressive Ang II induced specific changes in microglial morphology, indicating differences in functional phenotype. An increase in hippocampal glial fibrillary acidic protein (GFAP) was seen in mice receiving pressive Ang II, while no induction of cerebral gliosis was observed after 7 days of subpressive Ang II infusion. Although phenylephrine led to increased astrogliosis, it did not affect Iba-1 expression. Pressive Ang II stimulated TNF-α production in the hippocampus, and daily treatment with hydralazine prevented this increase. Hydralazine also reduced GFAP and Iba-1 levels. With longer perfusion (14 days), subpressive Ang II led to some but not all the inflammatory changes detected with the pressive doses, mainly an increase in CD68 and Iba-1 but not of GFAP or TNF-α. Conclusions Blood pressure and Ang II differentially contribute to hippocampal inflammation in mice. Control of blood pressure and Ang II levels should prevent or reduce brain inflammation and therefore brain dysfunctions associated with hypertension.
- Published
- 2018
- Full Text
- View/download PDF
34. Systems biology of meristems: an interview with Teva Vernoux
- Author
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Teva Vernoux
- Subjects
Plant development ,Systems biology ,Shoot apical meristem ,Plant hormones ,Phyllotaxis ,Developmental biology ,Biology (General) ,QH301-705.5 - Abstract
Abstract Teva Vernoux is a plant developmental biologist and holds positions as the Director of the Institute for Reproduction and Development of Plants at ENS de Lyon, and as a Research Director at Centre National de la Recherche Scientifique. Teva spoke to us about the need for multidisciplinary approaches to tackle multi-scale problems, how to go beyond a list of genes, and the importance of constructive reviews.
- Published
- 2018
- Full Text
- View/download PDF
35. Synthesis, thermal evolution and catalytic properties of Pt-Pd-O thin films
- Author
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Horwat, D., Endrino, J.L., Pierson, J.F., Anders, A., Boreave, A., Karoum, R., and Vernoux, P.
- Subjects
cathodic arc ,coating ,Pt ,Pd ,oxide ,catalysis - Published
- 2008
36. Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
- Author
-
Bellver-Landete, Victor, Bretheau, Floriane, Mailhot, Benoit, Vallières, Nicolas, Lessard, Martine, Janelle, Marie-Eve, Vernoux, Nathalie, Tremblay, Marie-Ève, Fuehrmann, Tobias, Shoichet, Molly S., and Lacroix, Steve
- Published
- 2019
- Full Text
- View/download PDF
37. WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis
- Author
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Ma, Yanfei, Miotk, Andrej, Šutiković, Zoran, Ermakova, Olga, Wenzl, Christian, Medzihradszky, Anna, Gaillochet, Christophe, Forner, Joachim, Utan, Gözde, Brackmann, Klaus, Galván-Ampudia, Carlos S., Vernoux, Teva, Greb, Thomas, and Lohmann, Jan U.
- Published
- 2019
- Full Text
- View/download PDF
38. Carbon Nitride Quantum Dots Modified TiO2 Inverse Opal Photonic Crystal for Solving Indoor VOCs Pollution
- Author
-
Jie Yu, Angel Caravaca, Chantal Guillard, Philippe Vernoux, Liang Zhou, Lingzhi Wang, Juying Lei, Jinlong Zhang, and Yongdi Liu
- Subjects
carbon nitride ,quantum dots ,inverse opal ,photocatalysis ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
Indoor toxic volatile organic compounds (VOCs) pollution is a serious threat to people’s health and toluene is a typical representative. In this study, we developed a composite photocatalyst of carbon nitride quantum dots (CNQDs) in situ-doped TiO2 inverse opal TiO2 IO for efficient degradation of toluene. The catalyst was fabricated using a sol-gel method with colloidal photonic crystals as the template. The as-prepared catalyst exhibited excellent photocatalytic performance for degradation of toluene. After 6 h of simulated sunlight irradiation, 93% of toluene can be converted into non-toxic products CO2 and H2O, while only 37% of toluene is degraded over commercial P25 in the same condition. This greatly enhanced photocatalytic activity results from two aspects: (i) the inverse opal structure enhances the light harvesting while providing adequate surface area for effective oxidation reactions; (ii) the incorporation of CNQDs in the framework of TiO2 increases visible light absorption and promotes the separation of photo-generated charges. Collectively, highly efficient photocatalytic degradation of toluene has been achieved. In addition, it can be expanded to efficient degradation of organic pollutants in liquid phase such as phenol and Rhodamine B. This study provides a green, energy saving solution for indoor toxic VOCs removal as well as for the treatment of organic wastewater.
- Published
- 2021
- Full Text
- View/download PDF
39. Evolution of the Auxin Response Factors from charophyte ancestors.
- Author
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Raquel Martin-Arevalillo, Emmanuel Thévenon, Fanny Jégu, Thomas Vinos-Poyo, Teva Vernoux, François Parcy, and Renaud Dumas
- Subjects
Genetics ,QH426-470 - Abstract
Auxin is a major developmental regulator in plants and the acquisition of a transcriptional response to auxin likely contributed to developmental innovations at the time of water-to-land transition. Auxin Response Factors (ARFs) Transcription Factors (TFs) that mediate auxin-dependent transcriptional changes are divided into A, B and C evolutive classes in land plants. The origin and nature of the first ARF proteins in algae is still debated. Here, we identify the most 'ancient' ARF homologue to date in the early divergent charophyte algae Chlorokybus atmophyticus, CaARF. Structural modelling combined with biochemical studies showed that CaARF already shares many features with modern ARFs: it is capable of oligomerization, interacts with the TOPLESS co-repressor and specifically binds Auxin Response Elements as dimer. In addition, CaARF possesses a DNA-binding specificity that differs from class A and B ARFs and that was maintained in class C ARF along plants evolution. Phylogenetic evidence together with CaARF biochemical properties indicate that the different classes of ARFs likely arose from an ancestral proto-ARF protein with class C-like features. The foundation of auxin signalling would have thus happened from a pre-existing hormone-independent transcriptional regulation together with the emergence of a functional hormone perception complex.
- Published
- 2019
- Full Text
- View/download PDF
40. Ethylene epoxidation on Ag/YSZ electrochemical catalysts: Understanding of oxygen electrode reactions
- Author
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T. Cavoué, A. Caravaca, I. Kalaitzidou, F. Gaillard, M. Rieu, J.P. Viricelle, and P. Vernoux
- Subjects
Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
In this study, we have investigated, for the very first time, the oxygen electrode reactions on Ag/YSZ electrochemical catalysts both in oxygen and under reaction conditions compatible with the ethylene epoxidation reaction. Electrochemical Impedance Spectroscopy (EIS) in combination with in-situ Raman spectroscopy and catalytic activity measurements were used to identify and understand the main oxygen reaction pathways. The results obtained suggested that the rate limiting step under an O2 reaction atmosphere (at 300 °C) is the O2 adsorption/dissociation process on the Ag catalyst-electrode. In addition, the polarization resistance increased with time under the presence of O2. This was attributed to the formation of Ag2O on the catalyst surface or near surface, which limits the oxygen electrode reactions. Finally, we observed that the addition of ethylene in the feed stream hinders the electrode reaction, due to its competitive chemisorption with oxygen on Ag. These results give new insights into the design of selective Ag/YSZ catalyst for ethylene epoxidation. Keywords: Electrochemical Impedance Spectroscopy (EIS), Oxygen electrode reaction, Ag/YSZ, Ethylene epoxidation
- Published
- 2019
- Full Text
- View/download PDF
41. Dissecting the pathways coordinating patterning and growth by plant boundary domains.
- Author
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Aude Maugarny-Calès, Millán Cortizo, Bernard Adroher, Nero Borrega, Beatriz Gonçalves, Geraldine Brunoud, Teva Vernoux, Nicolas Arnaud, and Patrick Laufs
- Subjects
Genetics ,QH426-470 - Abstract
Boundary domains play important roles during morphogenesis in plants and animals, but how they contribute to patterning and growth coordination in plants is not understood. The CUC genes determine the boundary domains in the aerial part of the plants and, in particular, they have a conserved role in regulating leaf complexity across Angiosperms. Here, we used tooth formation at the Arabidopsis leaf margin controlled by the CUC2 transcription factor to untangle intertwined events during boundary-controlled morphogenesis in plants. Combining conditional restoration of CUC2 function with morphometrics as well as quantification of gene expression and hormone signaling, we first established that tooth morphogenesis involves a patterning phase and a growth phase. These phases can be separated, as patterning requires CUC2 while growth can occur independently of CUC2. Next, we show that CUC2 acts as a trigger to promote growth through the activation of three functional relays. In particular, we show that KLUH acts downstream of CUC2 to modulate auxin response and that expressing KLUH can compensate for deficient CUC2 expression during tooth growth. Together, we reveal a genetic and molecular network that allows coordination of patterning and growth by CUC2-defined boundaries during morphogenesis at the leaf margin.
- Published
- 2019
- Full Text
- View/download PDF
42. Influence of Electrodes Polarization on the Response of Resistive Soot Sensor
- Author
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Grondin, D., Geara, S., Breuil, P., Viricelle, J.P., and Vernoux, P.
- Published
- 2016
- Full Text
- View/download PDF
43. NO2-Selective Electrochemical Sensors for Diesel Exhausts
- Author
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Viricelle, J-P., Vernoux, P., Gao, J., Romanytsia, I., Breuil, P., and Pijolat, C.
- Published
- 2016
- Full Text
- View/download PDF
44. Publisher Correction: A network of transcriptional repressors modulates auxin responses
- Author
-
Truskina, Jekaterina, Han, Jingyi, Chrysanthou, Elina, Galvan-Ampudia, Carlos S., Lainé, Stéphanie, Brunoud, Géraldine, Macé, Julien, Bellows, Simon, Legrand, Jonathan, Bågman, Anne-Maarit, Smit, Margot E., Smetana, Ondřej, Stigliani, Arnaud, Porco, Silvana, Bennett, Malcolm J., Mähönen, Ari Pekka, Parcy, François, Farcot, Etienne, Roudier, Francois, Brady, Siobhan M., Bishopp, Anthony, and Vernoux, Teva
- Published
- 2021
- Full Text
- View/download PDF
45. La/Sr-based perovskites as soot oxidation catalysts for Gasoline Particulate Filters
- Author
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Hernández, W.Y., Tsampas, M.N., Zhao, C., Boreave, A., Bosselet, F., and Vernoux, P.
- Published
- 2015
- Full Text
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46. A Discussion on the Unique Features of Electrochemical Promotion of Catalysis (EPOC): Are We in the Right Path Towards Commercial Implementation?
- Author
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Angel Caravaca, Jesús González-Cobos, and Philippe Vernoux
- Subjects
electrochemical promotion of catalysis (EPOC) ,non-Faradaic electrochemical modification of catalytic activity (NEMCA) ,ionic conductor materials ,ionic promoters ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
The phenomenon of “Non-Faradaic Electrochemical Modification of Catalytic Activity (NEMCA)” or “Electrochemical Promotion of Catalysis (EPOC)” has been extensively studied for the last decades. Its main strength, with respect to conventionally promoted catalytic systems, is its capability to modify in-situ the activity and/or selectivity of a catalyst by controlling the supply and removal of promoters upon electrical polarization. Previous reviews have summarized the main achievements in this field from both the scientific and technological points of view. However, to this date no commercial application of the EPOC phenomenon has been developed, although numerous advances have been made on the application of EPOC on catalyst nanostructures (closer to those employed in conventional catalytic systems), and on the development of scaled-up reactors suitable for EPOC application. The main bottleneck for EPOC commercialization is likely the choice of the right chemical process. Therefore, from our point of view, future efforts should focus on coupling the latest EPOC advances with the chemical processes where the EPOC phenomenon offers a competitive advantage, either from an environmental, a practical or an economic point of view. In this article, we discuss some of the most promising cases published to date and suggest future improvement strategies. The considered processes are: (i) ethylene epoxidation with environmentally friendly promoters, (ii) NOx storage and reduction under constant reaction atmosphere, (iii) CH4 steam reforming with in-situ catalyst regeneration, (iv) H2 production, storage and release under fixed temperature and pressure, and (v) EPOC-enhanced electrolysers.
- Published
- 2020
- Full Text
- View/download PDF
47. Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells
- Author
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Lounas, Amel, Vernoux, Nathalie, Germain, Marc, Tremblay, Marie-Eve, and Richard, François J.
- Published
- 2019
- Full Text
- View/download PDF
48. Systems biology of meristems: an interview with Teva Vernoux
- Author
-
Vernoux, Teva
- Published
- 2018
- Full Text
- View/download PDF
49. Investigations of soot combustion on yttria-stabilized zirconia by environmental transmission electron microscopy (ETEM)
- Author
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Serve, A., Epicier, T., Aouine, M., Cadete Santos Aires, F.J., Obeid, E., Tsampas, M., Pajot, K., and Vernoux, P.
- Published
- 2015
- Full Text
- View/download PDF
50. Development of a Particulate Matter Sensor for Diesel Engine
- Author
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Grondin, D., Breuil, P., Viricelle, J.P., and Vernoux, P.
- Published
- 2015
- Full Text
- View/download PDF
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