59 results on '"Taşbakan M"'
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2. Diffüz alveoler hemoraji
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Taşbakan, M. Sezai
- Abstract
Diffüz alveoler hemoraj (DAH) pulmoner mikro-sirkülasyondan kaynaklanan, sıklıkla sistemik bir vaskülitin neden olduğu, alveol içine eritrosit birikmesidir. DAH etiyolojisinde immün ve non-immün nedenler sorumludur. Hemoptizi ve nefes darlığı en sık karşılaşılan klinik semptomlardır. Akciğer grafisinde bilateral buzlu cam dansiteleri izlenir. Hemogram, böbrek fonksiyon testleri ve immünolojik belirteçler tanıya yardımcı laboratuvar testleridir. Bronko-alveoler lavaj sıvısının makroskopik ve mikroskobik bulguları ile tanı konulur. Tedavisinde altta yatan hastalığın tedavisi yanı sıra, yüksek doz kortikosteroid başta olmak üzere immünsupresif tedavi önem taşır.
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- 2021
3. The perspectives of infectious diseases and clinical microbiology specialists on online education applications and Web-based seminars
- Author
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Öztürk Kaygusuz T., A?alar C., Kurtaran B., a? Y., and Taşbakan M.
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Medical education ,postgraduate education ,competence ,webinar ,internet use ,Article ,educational status ,coronavirus disease 2019 ,Web-based conferencing ,male ,cross-sectional study ,human ,e-learning ,travel ,Internet ,training ,access to information ,adult ,medical specialist ,pandemic ,Online medical education ,COVID-19 ,social interaction ,aged ,female ,descriptive research - Abstract
Introduction: In this study, it was aimed to obtain information about the perspectives of infectious diseases and clinical microbiology (IDCM) specialists on online education applications and web-based seminars, and their usage and utilization rates. Materials and Methods: In this descriptive, cross-sectional study, online survey responses of the IDCM specialists in who were members of Infectious Diseases Clinical Microbiology Specialty Society of Turkey (EKMUD) were evaluated. Results: A total of 184 IDCM specialists answered the survey questions. Of the participants, 77.2% thought that the pandemic disrupted postgraduate medical education and 84.8% thought that the pandemic disrupted pre-graduate medical education. Medical educators involved in education during the Coronavirus disease-2019 (COVID-19) pandemic reported that they mostly continued online education. Of the participants, 84.9% reported that they were able to use the internet in an effective way to gain access to information during the COVID-19 pandemic. Of the responders, 58.2% reported that they followed online training programs, such as web-based seminars and lectures, and 51.6% reported that these online programs contributed to their learning. Participants found online training programs such as web-based seminars and lectures useful in terms of learning competence, that online training programs provided people with gain in space and time, and that they found them more instructive because they gave them the chance to receive training in subjects of their interest. Participants reported that these programs provided learning competency in that these programs were more beneficial to the participants in view of place, the subject that they need/they are interested in and saving time for the trainer and the participants. Due to the COVID-19 pandemic, the participants mostly wanted the 2020 EKMUD congress to be held online. A total 92.9% of the participants reported that online congresses and seminars would decrease travel, participation and sponsorship costs. Only 24.5% of the participants considered that online congresses and seminars would be more effective in terms of social interaction and gaining information than face-to-face congresses. Conclusion: The IDCM specialists reported that online educational practices such as webinars were benefical. The rate of participation in webinars and online education practices were high during the COVID-19 pandemic. © Copyright 2021 by the Infectious Diseases and Clinical Microbiology Specialty Society of Turkey Mediterranean Journal of Infection, Microbes and Antimicrobials published by Galenos Yayinevi.
- Published
- 2021
4. The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study
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Batirel, A., Erdem, H., Sengoz, G., Pehlivanoglu, F., Ramosaco, E., Gülsün, S., Tekin, R., Mete, B., Balkan, İ.İ., Sevgi, D.Y., Giannitsioti, E., Fragou, A., Kaya, S., Cetin, B., Oktenoglu, T., Celik, A.D., Karaca, B., Horasan, E.S., Ulug, M., Senbayrak, S., Arslanalp, E., Hasbun, R., Ates-Guler, S., Willke, A., Senol, S., Inan, D., Güclü, E., Ertem, G.T., Koc, M.M., Tasbakan, M., Ocal, G., Kocagoz, S., Kusoglu, H., Güven, T., Baran, A.I., Dede, B., Karadag, F.Y., Yilmaz, H., Aslan, G., Al-Gallad, D.A., Cesur, S., El-Sokkary, R., Sirmatel, F., Savasci, U., Karaahmetoglu, G., and Vahaboglu, H.
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- 2015
- Full Text
- View/download PDF
5. Obstrüktif Uyku Apne Sendromunda PeriorbitalDokuların Değerlendirilmesi
- Author
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Karaca, Irmak, Palamar, Melis, Yağcı, Ayşe, Taşbakan, M. Sezai, and Başoğlu, Özen Kaçmaz
- Abstract
Amaç: Obstrüktif uyku apne sendromu (OUAS) olan hastalarda kapak laksitesi, kirpik ptozisi gibi periorbital dokularda gelişen değişikliklerin değerlendirilmesi amaçlandı.Gereç ve Yöntem: Polisomnografi sonucuna göre orta veya ağır OUAS tanısı almış (Grup 1) 48 hastanın 96 gözü ve basit horlama tanısı almış (Grup 2) 22 hastanın 44 gözü çalışmaya dahil edildi. Detaylı oftalmolojik muayeneyle birlikte, hastalarda kapak laksitesinin değerlendirilmesine yönelik vertikal ve anterior distraksiyon mesafeleri, dermatoşalazis varlığı, interpalpebral mesafe, levator kas fonksiyonu ölçüldü. Kirpik ptozisi varlığı ve eğer var ise derecesi kaydedildi.Bulgular: Hastaların ortalama yaşı Grup 1 ve 2’de sırasıyla 49,9±11,4 (aralık: 26-67) ve 50,6±8,9 (aralık: 27-69) idi (p=0,557). Vertikal ve anterior distraksiyon mesafeleri, Grup 1’de sırasıyla 13,3±4,1 yıl (aralık: 6-27) mm ve 7,4±2,1 yıl (aralık: 3-13,5) mm olup Grup 2’ye kıyasla anlamlı olarak daha yüksek saptandı (p
- Published
- 2020
6. Effect of CPAP Therapy on Clinical Periodontal Status of Patients with Obstructive Sleep Apnea Syndrome: 6-year Follow-up
- Author
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KANMAZ, Burcu, primary, NİZAM, Nejat, additional, KAÇMAZ BAŞOĞLU, Özen, additional, TAŞBAKAN, M. Sezai, additional, and BUDUNELİ, Nurcan, additional
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- 2020
- Full Text
- View/download PDF
7. Biyolojik ajanların pulmoner komplikasyonları
- Author
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Taşbakan, M. Sezai, primary
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- 2019
- Full Text
- View/download PDF
8. Is every foot wound a diabetic foot infection in diabetic patients? A case of Kaposi sarcoma [Diyabetli Hastalarda Gelişen Her Ayak Yarası Diyabetik Ayak Enfeksiyonu Mudur? Bir Kaposi Sarkomu Olgusu]
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Çetinkalp Ş., Mermer S., Ertam Sağduyu I., Akalin T., and Işikgöz Taşbakan M.
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Diabetes mellitus ,Radiotherapy ,Case report ,Chronic wound ,HHV-8 - Abstract
2-s2.0-85079198729, [No abstract available]
- Published
- 2019
9. When to start prophylaxis? An HIV-infected Patient Presenting with Upper Extremity Weakness [Ne Zaman Profilaksi? Üst Ekstremitede Güç Kaybı Yakınması ile Başvuran HIV Sendromu Olgusu]
- Author
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Pullukçu H., Kahraman H., Eraslan C., Sipahi O.R., and Işikgöz Taşbakan M.
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Cerebral toxoplasmosis ,Trimethoprim/sulfamethoxazole ,Kaposi’s sarcoma ,Magnetic resonance imaging ,Toxoplasma gondii - Abstract
2-s2.0-85079139506, [No abstract available]
- Published
- 2019
10. Pulmonary complications of biological agents
- Author
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TAŞBAKAN, M. Sezai
- Subjects
Biyolojik ajanlar,akciğer,pnömoni,tüberküloz,tedavi ,Health Care Sciences and Services ,Biological agents,pulmonary,pneumonia,tuberculosis,treatment ,Sağlık Bilimleri ve Hizmetleri - Abstract
İnflamatuvar romatolojik hastalıklarda biyolojik ajanların kullanımı ile ilgili veri sayısı artmaktadır. Son zamanlarda, biyolojik ajanlarla ilişkili non-enfeksiyöz komplikasyonlar arasında en sık granülomatöz hastalık ve interstisyel akciğer hastalığı görülmektedir. Ek olarak, bu ilaçlarla ilişkili en ciddi yan etkiler bakteriyel pnömoni gibi solunum sistemi enfeksiyonları, tüberküloz ve Pneumocystis jirovecii pnömonisidir. Özellikle, tümör nekroz faktör-alfa (TNF-α) gibi biyolojik ajanlar ile yapılan tedaviler artmış tüberküloz riski ile ilişkilidir. Bu ilaçları alan hastalarda tüberküloz taraması ve latent tüberküloz tedavisi yapılması bu nedenle endikedir, There are increasing data available about use of biologic agents in treatment of systemic inflammatory rheumatologic disorders. Currently reported noninfectious pulmonary complications related to biologic agents use include most commonly granulomatous disease and interstitial lung disease. In addition, the most serious adverse events from these drugs are respiratory infections, especially bacterial pneumonia, tuberculosis, and Pneumocystis jirovecii pneumonia. Treatment with biologic agents, in particular tumor necrosis factor alpha (TNF-α) inhibitors, is associated with an increased risk of tuberculosis. Screening and treatment for latent tuberculosis infection in patients undergoing such treatment is therefore indicated
- Published
- 2018
11. Acute cholecystitis and granulomatous hepatitis caused by brucella melitensis [Brucella melitensis’in neden olduğu akut kolesistit ve granülomatöz hepatit olgusu]
- Author
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Yildirim Ç., Otman Akat E., Işikgöz Taşbakan M., Sipahi O.R., Pullukçu H., Yamazhan T., and Ege Üniversitesi
- Subjects
Brucella melitensis ,Cholecystitis ,Acute ,Brucellosis - Abstract
Human brucellosis is a multisystemic zoonotic disease with a various clinical symptoms that have acute, subacute or chronical forms and it is endemic in our country. The disease often have non-specific symptoms and signs and it can mimic many different clinical manifestations. The disease is transmitted to humans especially after consumption of unpasteurized milk and milk products and less often after direct contact with infected animals. The most common gastrointestinal system complication is granulomatous hepatitis. Billiary involvement in the form of acute cholecystitis is a very rare manifestation. Although the acute cholecystitis is a very rare complication of brucellosis, it should be kept in mind especially in the endemic area like our country. We report a case of a 54-year-old male with acute cholecystitis and granulomatous hepatitis caused by Brucella melitensis in this paper. © 2018 by Türkiye Klinikleri.
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- 2018
12. Evaluation of benign/malign primary sacrum tumors and surgical site infections [Benign/malign primer sakrum tümörleri ve cerrahi alan enfeksiyonlarının değerlendirilmesi]
- Author
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Öztürk A.M., Akyol D., Süer O., Keçeci B., Sabah D., Işikgöz Taşbakan M., and Ege Üniversitesi
- Subjects
Sacrum tumors ,Surgical site infection - Abstract
Objective: In literature, sacrum tumors and its surgery are very few. Primary tumors of sacrum are less common than metastatic tumors. In this study, it was aimed to evaluate the characteristics and the surgical site infections after surgery of the cases operated with benign/malign primer sacrum tumor. Material and Methods: We retrospectively reviewed records of cases of operated with diagnosed by pathological examination benign/malign primer sacrum tumors in our clinic between the years of 2012 and 2018. The demographic characteristics of the cases, comorbid diseases, applied surgical treatment modalities, post-operative surgical site infection frequency, post operative features of wound site, vital findings of cases, duration of post-operative infection development, causative microorganism agents in infection, the incidence, duration and causative microorganism of recurrent infections and the survival for five years were evaluated. Results: A total of 9 cases [five male, four female, mean age 38 years (21-74)] were included. 3 cases (33,3%) were cordoma, 3 cases (33,3%) were ewing sarcoma, one case (11,1%) malignant schwannom, one case (11,1%) giant cell tumor and one case (11,1%) were diagnosed with chondrosarcoma in their pathological examinations. Eight patients (88.9%) with malign tumor underwent extensive resection in 6 patients and one patient (11.1%) with intralesional curettage with benign tumor diagnosis. Six of the cases (66.7%) developed surgical site infection after the surgery. Infection was detected in 3 (75%) of the cases who recieved the pre-op and/or post-op radiotherapy and chemotherapy but in all underwent implantation during the surgery. Overall survival was 77.7% at 5 years and 83.3% in who developed surgical site infection. Conclusion: As in the sacrectomy, infections after operations in the operations with extensive resection and close rectal proximity are common problems. Besides antibiotic therapy co-administration of surgical debridement is also important for efficacy in the treatment of surgical site infection. © 2018 by Türkiye Klinikleri.
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- 2018
13. Hepatic involvement in epstein-barr virus and cytomegalovirus infections: Evaluation of 31 cases [Epstein-barr virus ve sitomegalovirus enfeksiyonlariında karaciğer tutulumu: 31 Olgunun değerlendirilmesi]
- Author
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Erdem H.A., Akyol D., Yamazhan T., Pullukçu H., Işikgöz Taşbakan M., Sıpahı O.R., Ulusoy S., and Ege Üniversitesi
- Subjects
Cytomegalovirus infections ,Epstein-barr virus infections ,Hepatitis - Abstract
Objective: Epstein-Barr virus (EBV)and Cytomegalovirus (CMV) are the main causes of infectious mononucleosis (IM) and IM-like sendrom in humans. In this study it was aimed to evaluate the clinical characteristics and liver enzymes changes in cases with EBV and CMV infections accompanying hepatic involvement in our department. Material and Methods: The hospital records of immune competent cases with EBV and CMV infections accompanying hepatic involvement who were followed up in our department between 2008-2016 were evaluated in terms of demographic characteristics, underlying diseases, laboratory, clinical data and treatment results retrospectively. Results: There were a total of 31 patients (19 men, 12 female) aged 27,6±10,6 (24 patients with EBV, 7 with CMV). The most common clinical symptoms were fever (27 patients 87,1%), fatigue (18 patients 58,1%), sore throat (12 patients 38,7%),vomiting (10 patients 32,3%), and swelling in the neck (9 patients 29,9%). Palpable servical lymph nodes (8 patients 25,8%) and hepatosplenomegaly (7 patients 22,5%) were the most common physical findings. Liver enzyme values on the 1st day and an average of 10 days after (10,9±5,8) (Range 3-30 day), 30 patients’ liver enyzmes follow up values are screened. All patients were hospitalized for an average of 6,9 days (±3,1, min: 3-max:20) and discharged as healthy. The icteric hepatitis was seen in 6,5% (2 patients). Conclusion: We conclude that the EBV and CMV serologic markers should be monitored as well as other hepatitis virus markers in the evaluation of cases with increased liver enzymes. © 2017 by Türkiye Klinikleri.
- Published
- 2017
14. The comparison of microscopy and real time polymerase chain reaction methods for the diagnosis of pneumocystis jirovecii pneumonia: Evaluation of clinical parameters [Pneumocystis jirovecii pnömonisi tanısında mikroskopi ve gerçek zamanlı polimeraz zincir reaksiyonu yöntemlerinin karşılaştırılması: Klinik bulgular ile yorumlanması]
- Author
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Töz S., Gündüz C., Tetik A., Taşbakan M., Pullukçu H., Bacakoğlu F., Taşbakan M.S., Gülen F., Ünver A., Turgay N., and Ege Üniversitesi
- Subjects
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,Real time PCR ,ComputingMethodologies_PATTERNRECOGNITION ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Pneumonia ,InformationSystems_MISCELLANEOUS ,Pneumocystis jirovecii - Abstract
PubMed ID: 29135400, Introduction: Pneumocystis jirovecii pneumonia (PCP) causes serious infections, especially in patients with immunosuppressive diseases. In this study, it was aimed to evaluate the results of samples obtained from PCP suspected patients using two different methods together with clinical data. Materials and Methods: Microscopy and real time polymerase chain reaction (real time PCR) methods were performed with bronchoalveolar lavage (BAL) samples sended to Ege University Medical Faculty Direct Parasitology Diagnostic Laboratory between March 2009 and June 2010. Demographic characteristics, clinical and laboratory data were also recorded retrospectively. The data were evaluated using the SPSS 16.0 program. Results: A total of 42 BAL samples collected from patients (24 males, mean age: 31.49 ± 26.14) were included. There were totally 16 P. jirovecii positives either one of the tests. Sixteen and three samples were detected positive by real time PCR and microscopy, respectively. Trimethoprim-sulfamethoxazole was prescribed in 11 PCP diagnosed cases and 6 of them died. Conclusion: Today, despite the growing opportunities in diagnosis and treatment, PCP pneumonia is associated with high mortality. Careful examination of clinical data and immune status of the patients are important. Multidisciplinary approach is required for early PCP diagnosis. © 2017, Ankara University. All rights reserved.
- Published
- 2017
15. Obstrüktif uyku apne sendromu olan hastalarda CPAP tedavisinin klinik periodontal duruma etkisi: Altı yıllık takip.
- Author
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Kanmaz, Burcu, Nizam, Nejat, Başoğlu, Özen K., Taşbakan, M. Sezai, and Buduneli, Nurcan
- Abstract
Copyright of Acta Odontologica Turcica is the property of Acta Odontologica Turcica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
16. Impact of antimicrobial drug restrictions on doctors? behaviors
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Serife Akalin, Mahmut Sunnetcioglu, Aygul Dogan Celik, Salih Hosoglu, Gürdal Yilmaz, Abdulkadir Küçükbayrak, Tumer Guven, Ibak Gonen, Serpil Erol, Oguz Karabay, Koçoğlu Me, Unal Erkorkmaz, Işıkgöz Taşbakan M, Omer Faruk Kokoglu, Ertugrul Guclu, Nurettin Erben, Demirli K, Tuna Demirdal, B. Dede, Fatma Aybala Altay, Ertan Aydin, Turhan, Güner Ae, Bahadir Ceylan, Ömer Evirgen, Recep Tekin, Ilhami Celik, Sebnem Senol, Fatma Sargin, Ayten Kadanali, BAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Koçoğlu, Mücahide Esra, Küçükbayrak, Abdulkadir, Ege Üniversitesi, Karabay, O, Hosoglu, S, Guclu, E, Akalin, S, Altay, FA, Aydin, E, Ceylan, B, Celik, A, Celik, I, Demirdal, T, Demirli, K, Erben, N, Erkorkmaz, U, Erol, S, Evirgen, O, Gonen, I, Guner, AE, Guven, T, Kadanali, A, Kocoglu, ME, Kokoglu, OF, Kucukbayrak, A, Sargin, F, Sunnetcioglu, M, Senol, S, Isikgoz Tasbakan, M, Tekin, R, Turhan, V, Yilmaz, G, Dede, B, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Karabay, Oğuz, Güçlü, Ertuğrul, Erkorkmaz, Ünal, and Hatay Mustafa Kemal Üniversitesi
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0301 basic medicine ,Budget Execution İnstructions ,medicine.medical_specialty ,Antibiotic Usage ,Turkey ,medicine.drug_class ,specialist ,030106 microbiology ,Antibiotics ,Disease ,budget execution instructions ,Specialist ,03 medical and health sciences ,Antibiotic policy ,antibiotic restriction ,antibiotic usage ,budget ,Anti-Infective Agents ,General & Internal Medicine ,Physicians ,Surveys and Questionnaires ,Antibiotic Policy ,medicine ,Intensive care medicine ,Cerrahi ,business.industry ,execution instructions ,Anti-Infective Agents/*pharmacology ,General Medicine ,Antimicrobial drug ,Infectious disease (medical specialty) ,Family medicine ,Antibiotic policy,antibiotic restriction,antibiotic usage,budget execution instructions,specialist ,business ,Antibiotic Restriction - Abstract
Background/aim: Broad-spectrum antibiotics have become available for use only with the approval of infectious disease specialists (IDSs) since 2003 in Turkey. This study aimed to analyze the tendencies of doctors who are not disease specialists (non-IDSs) towards the restriction of antibiotics., Materials and methods: A questionnaire form was prepared, which included a total of 22 questions about the impact of antibiotic restriction (AR) policy, the role of IDSs in the restriction, and the perception of this change in antibiotic consumption. The questionnaire was completed by each participating physician., Results: A total of 1906 specialists from 20 cities in Turkey participated in the study. Of those who participated, 1271 (67.5%) had 5 years of occupational experience in their branch expressed that they followed the antibiotic guidelines more strictly than the JSs (P < 0.05) and 755 of physicians (88%) and 720 of surgeons (84.6%) thought that the AR policy was necessary and useful (P < 0.05)., Conclusion: This study indicated that the AR policy was supported by most of the specialists. Physicians supported this restriction policy more so than surgeons did.
- Published
- 2016
17. Publication rates of Turkish medical specialty and doctorate theses on Medical Microbiology Clinical Microbiology and Infectious Diseases disciplines in international journals [Ülkemizde tibbi mikrobiyoloji, klinik mikrobiyoloji ve enfeksiyon hastaliklari dallarinda yapilan tipta uzmanlik ve doktora tezlerinin uluslararasi dergilerde yayina don¨ü¸¨sum oranlari]
- Author
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Sipahi O.R., Çaglayan Serin D., Pullukçu H., Taşbakan M., Köseli Ulu D., Yamazhan T., Arda B., Sipahi H., Ulusoy S., and Ege Üniversitesi
- Subjects
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,Thesis ,Turkey ,Bibliometrics ,Specialty ,Doctorate ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Infectious diseases ,Publication ,InformationSystems_MISCELLANEOUS ,Microbiology - Abstract
PubMed ID: 24819272, Writing a thesis is mandatory for getting a postgraduate medical degree in Turkey. Publication of the results of the thesis in an indexed journal makes the results available to researchers, however publication rate is usually low. The aim of this retrospective observational study was to investigate the publication rate of Turkish Infectious Diseases and Clinical Microbiology, Medical Microbiology specialty theses and Microbiology doctorate theses in international peer-review journals. On August 17th 2007, the thesis database of the Council of Higher Education of the Republic of Turkey (YOK) where all specialization and doctorate theses are recorded obligatorily, was searched for Infectious Diseases and Clinical Microbiology and Medical Microbiology specialty and Microbiology doctorate theses. Assuming that publication of a thesis would last at least six months, theses dated to February 2007 and after were excluded. The publication rate of those theses was found out by searching Science Citation Index-Expanded database for thesis author and supervisor between August 17-September 12, 2007. Chi-square test was used for statistical analysis. Our search yielded a total of 834 theses dated from 1997 to 2007, however 10 of them were excluded, since they were dated to February 2007 or after. It was found that the overall publication rate was 11.4% (94/824). The publication rates for Microbiology doctorate, Medical Microbiology and Infectious Diseases and Clinical Microbiology specialty theses were 13.7% (34/249), 10.7% (33/309) and 10.2% (27/266), respectively, with no statistical significance (p> 0.05). It was determined that nine (9.6%) of the 94 published theses belonged to 1997-2001 period, whereas 85 (80.4%) were in 2002-2007 period (p< 0.05). The probable reason for this increase was thought to be related with the updated criteria of YOK carried out in 2000 for academic promotions, nevertheless the publication rate of the investigated theses in international peer-review journals was still low. Thesis is an important part of specialty and doctorate education and necessitates intense work. The created knowledge usually contains important data about the country and the world. Publication of the theses supplies dissemination of new knowledge and completes the process of a scientific study. Solutions must be generated to promote the publication of specialty and doctorate theses.
- Published
- 2014
18. Evaluation of zygomycosis cases by pooled analysis method reported from Turkey [Türkiye'den bildirilen zigomikoz olgularinin havuz analiz yöntemi ile degerlendirilmesi]
- Author
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Zeka A.N., Taşbakan M., Pullukçclu H., Sipahi O.R., Yamazhan T., Arda B., and Ege Üniversitesi
- Subjects
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,Zygomycosis ,Risk factors ,Turkey ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,InformationSystems_MISCELLANEOUS ,Antifungal therapies ,Pooled analysis - Abstract
PubMed ID: 24237440, Zygomycosis is a rapidly-progressive invasive fungal disease with high mortality rates. Mucor, Rhizopus, Rhizomucor and Absidia species classified in Mucorales order, are the main causative agents of zygomycosis. Uncontrolled diabetes, hematologic malignancies, long term corticosteroid use and immunosuppressive therapies are the main predisposing factors for mucormycosis. In this study, we aimed to evaluate the mucormycosis cases from Turkey published in national and international databases in the last 17 years by means of age, gender, co-morbidities, signs and symptoms, diagnostic methods, therapeutic modalities, and mortality rate by pooling analysis. In our study, two national (http://uvt.ulak-bim.gov.tr, http://www.turkmedline.net) and two international (www.ncbi.nlm.nih.gov, http://apps.we-bofknowledge.com) databases were used. A total of 64 manuscript (34 from national and 30 from international databases) published between 1995 and 2012, which were eligible for the study criteria and accessible as full text were included in the study. A total of 151 mucormycosis patients (71 female, 80 male; mean age: 45.4 ± 21.4 years) from these studies, with definitive diagnosis of invasive fungal infections according to the criteria of European Organization for Research and Treatment of Cancer (EORTC) have been evaluated. Of 151 patients 91 (60%) were diagnosed as rhinocerebral, 42 (%27.8) were si-noorbital, 7 (4.6%) were pulmonary, 6 (3.9%) were disseminated, 3 (1.9%) were skin, and 2 (1.3%) were gastrointestinal mycormycosis. The most common symptoms and signs were; swelling of eye and face (n= 95, 63%), fever (n= 72,48%), nasal obstruction (n= 60,40%), headache (n= 58, 38%) and opth-talmoplegia (n= 48, 32%). The most common co-morbidity was diabetes (49%) followed by hematological malignancies (39.7%). Mycological cultures were performed for 82 patients, and fungal growth were detected in the clinical specimens of 51 cases. The distribution of strains isolated in culture were as follows: Mucor spp. (n= 19, 37.2%), Rhizopus spp. (n= 13, 25.5%), Zygomycetes (n= 9, 17.6%), Rhi-zopus oryzae (n= 4, 7.8%), Rhizopus spp. + yeast (n= 3, 5.9%), Rhizomucor spp. (n= 2, 3.9%) and Rhi-zosporium spp. (n= 1, 1.9%). In 133 patients, histopathological investigation and in 126 patients radiological examinations were performed for diagnosis. Both surgical debridement and antifungal therapy were employed in 115 patients. Four patients had received only surgical debridement and 30 only antifungal therapies. Classical amphotericin B (AMP-B) therapy for 77 cases, liposomal AMP-B for 60 cases, liposomal AMP-B + posaconazole for six cases and lipid complex AMP-B for two cases have been started as antifungal therapies. Total mortality rate was detected as 54.3% (82/151). In conclusion, despite new diagnostic tools and therapeutic agents, mortality rates in mucormycosis are still very high. For the management, mucormycosis should be considered early in risky patients, and surgical debridement together with effective antifungal therapy should be applied as soon as possible.
- Published
- 2013
19. Solunumsal yoğun bakım ünitesinde mekanik ventilasyon uygulanan olgularda üst gastro-intestinal sistem kanamaları
- Author
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S, Taşbakan M, S, Deniz, A, Gürgün, Ö, Başoğlu, and F, Bacakoğlu
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Solunumsal yoğun bakım ünitesi,mekanik ventilasyon,üst gastro-intestinal sistem kanaması,stres ülser profilaksisi ,Respiratory intensive care unit,mechanical ventilation,upper gastrointestinal system bleeding,stress ulcer prophylaxis - Abstract
Aim: The aims of this study were to evaluate the frequency, risk factors and outcomes of upper gastro-intestinal system (GIS) bleeding in respiratory intensive care unit (ICU) patients who received mechanical ventilation. Material and Methods: Fifty-six patients (39 males, mean age 64.2±16.6 years), who were treated in the respiratory ICU for more than 5 days were included in the study. Risk factors and clinical outcomes of patients with gastrointestinal bleeding were evaluated. Results: Out of 56 patients, 10 (17.9%) developed upper GIS bleeding and 30 (53.6%) had ventilator associated pneumonia (VAP) and 22 of them (39.3%) died. There was no relationship between stress ulcer prophylaxis, feeding type and upper GIS bleeding, VAP. In patients with upper GIS bleeding, the frequency of VAP was higher (p=0.011), the duration of mechanical ventilation, stay in ICU and hospital were longer (p=0.05, p=0.023 and p=0.038, respectively) and mortality rate was found to be higher (p=0.006). There was no relationship between upper GIS bleeding and disease severity on admission, use of systemic corticosteroid, anti-coagulant therapy and coagulation disorders. Conclusion: Upper GIS bleeding increases the risk of VAP and mortality; prolongs the durations of stay in the ICU and hospital. Therefore, we conclude that upper GIS bleeding is a poor prognostic factor for respiratory ICU patients., Amaç: Bu çalışmada, mekanik ventilasyon uygulanan solunumsal yoğun bakım ünitesi (YBÜ) olgularında gelişen üst gastro-intestinal sistem (GİS) kanaması sıklığının, risk faktörlerinin ve sonuçlarının araştırılması amaçlanmıştır. Yöntem ve Gereç: Çalışmaya, solunumsal YBÜ'de beş günden uzun süre izlenen 56 olgu (39'u erkek, yaş ortalaması 64.2±16.6) alınmıştır. Gastro-intestinal sistem kanaması gelişen olguların risk faktörleri ve klinik sonuçları değerlendirilmiştir. Bulgular: 54 olgunun, 10'unda (% 17.9) üst GİS kanaması, 30'unda (% 53.6) ventilatör ilişkili pnömoni (VİP) gelişmiş ve 22'si (% 39.3) eksitus olmuştur. Stres ülser profilaksisi ve beslenme tipi ile üst GİS kanaması ve VİP gelişmesi arasında ilişki saptanmamıştır. Üst GİS kanaması ortaya çıkan olgularda; VİP gelişme oranı daha fazla (p=0.011), mekanik ventilasyon (MV) uygulama, YBÜ ve hastanede yatış süreleri daha uzun (sırasıyla, p=0.05, p=0.023 ve p=0.038) ve mortalite oranı daha yüksek (p=0.006) bulunmuştur. Başvurudaki hastalık ciddiyeti, sistemik kortikosterod kullanımı, anti-koagülan tedavi ve koagülasyon bozuklukları ile üst GİS kanaması arasında ilişki saptanmamıştır. Sonuç: Üst GİS kanaması VİP gelişme ve mortalite oranlarını artırmakta, YBÜ ve hastanede yatış sürelerini uzatmaktadır. Bu nedenle, solunumsal YBÜ olguları için üst GİS kanamasının kötü prognostik faktör olduğu sonucuna varılmıştır.
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- 2010
20. Pooled Analysis of Resistance Patterns of Escherichia coli Strains Isolated From Urine Cultures in Turkey: Comparison of 1997–2001 and 2002–2007 Periods
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Tasbakan, M., Pullukcu, H., Sipahi, O.R., Yamazhan, T., Arda, B., and Ulusoy, S.
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- 2008
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21. Did the pandemic have an impact on influenza vaccination attitude? a survey among health care workers
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Pullukçu Hüsnü, Taşbakan Meltem, Sipahi Oğuz, Yamazhan Tansu, Durusoy Raika, Arda Bilgin, Erdem Esra, and Ulusoy Sercan
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Health care workers' (HCWs) influenza vaccination attitude is known to be negative. The H1N1 epidemic had started in mid 2009 and made a peak in October-November in Turkey. A national vaccination campaign began on November 2nd, 2009. Despite the diligent efforts of the Ministry of Health and NGOs, the attitudes of the media and politicians were mostly negative. The aim of this study was to evaluate whether HCWs' vaccination attitudes improved during the pandemic and to assess the related factors. Methods This cross-sectional survey was carried out at the largest university hospital of the Aegean Region-Turkey. A self-administered questionnaire with 12 structured questions was applied to 807 HCWs (sample coverage 91.3%) before the onset of the vaccination programme. Their final vaccination status was tracked one week afterwards, using immunization records. Factors influencing vaccination rates were analyzed using ANOVA, t-test, chi-square test and logistic regression. Results Among 807 participants, 363 (45.3%) were doctors and 293 (36.6%) nurses. A total of 153 (19.0%) had been vaccinated against seasonal influenza in the 2008-2009 season. Regarding H1N1 vaccination, 143 (17.7%) were willing to be vaccinated vs. 357 (44.2%) unwilling. The number of indecisive HCWs was 307 (38.0%) one week prior to vaccination. Only 53 (11.1%) stated that they would vaccinate their children. Possible side effects (78%, n = 519) and lack of comprehensive field evaluation before marketing (77%, n = 508) were the most common reasons underlying unwillingness or hesitation. Among the 749 staff whose vaccination status could be tracked, 228 (30.4%) actually received the H1N1 vaccine. Some of the 'decided' staff members had changed their mind one week later. Only 82 (60%) of those willing, 108 (37%) of those indecisive and 38 (12%) of those unwilling were vaccinated. Indecisive HCWs were significantly younger (p = 0.017). Females, nurses, and HCWs working in surgical departments were more likely to reject vaccination (p < 0.05). Doctors, HCWs working in medical departments, and HCWs previously vaccinated against seasonal influenza were more likely to accept vaccination (p < 0.05). Being younger than 50 and having been vaccinated in the previous season were important predictors of attitude towards pandemic influenza vaccination. Conclusions Vaccination rates increased substantially in comparison to the previous influenza season. However, vaccination rates could have been even higher since hesitation to be vaccinated increased dramatically within one week (only 60% of those willing and the minority of those indecisive were finally vaccinated). We speculate that this may be connected with negative media at the time.
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- 2011
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22. Importance of Source Control in the Subgroup of Intra-Abdominal Infections for Septic Shock Patients: Analysis of 390 Cases.
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Önal U, Akyol Seyhan D, Ketenoğlu OB, Mert Vahabi M, Başkol Elik D, Memetali SC, Şanlıdağ İşbilen G, Bulut Avşar C, Kaya A, Uyan-Önal A, Yalçın N, Guliyeva G, Dirik Ş, Acet O, Akdağ D, Görür MD, Bozbıyık O, Göktepe B, Gümüş T, Çankayalı İ, Demirağ K, Uyar M, Sipahi H, Erdem HA, Işıkgöz Taşbakan M, Arda B, Aydemir Ş, Ulusoy S, and Sipahi OR
- Abstract
Background: This study aimed to evaluate the epidemiology of septic shock (SS) associated with intraabdominal infections (IAI) as well as associated mortality and efficacy of early source control in a tertiary-care educational hospital., Methods: Patients who had SS with IAI and consulted by Infectious Diseases consultants between December 2013 and October 2022 during night shifts in our centre were analyzed retrospectively., Results: A total number of 390 patients were included. Overall, 30-day mortality was 42.5% on day 3, while day 14 and 30 mortality rates were 63.3% and 71.3%, respectively. Source control by surgical or percutaneous operation was performed in 123 of 390 cases (31.5%), and the mortality rate was significantly lower in cases that were performed source control at any time during SS (65/123-52.8% vs 213/267-79.8%, p<0.001). In 44 of 123 cases (35.7%), source control was performed during the first 12 hours, and mortality was significantly lower in this group versus others (24/44-54.5% vs 254/346-73.4%, p=0.009). On the other hand, female gender (p<0.001, odds ratio(OR)= 2.943, 95%CI=1.714-5.054), diabetes mellitus (p= 0.014, OR=2.284, 95%CI=1.179-4.424), carbapenem-resistant Gram-negative etiology (p=0.011, OR=4.386, 95%CI=1.398-13.759), SOFA≥10 (p<0.001, OR=3.036, 95%CI=1.802-5.114), lactate >3 mg/dl (p<0.001, OR=2.764, 95%CI=1.562-4.891) and lack of source control (p=0.001, OR=2.796, 95%CI=1.523-5.133) were significantly associated with 30-day mortality in logistic regression analysis., Conclusion: Source control has a vital importance in terms of mortality rates for IAI-related septic shock patients. Our study underscores the need for additional research, as the present analysis indicates that early source control does not manifest as a protective factor in logistic regression., Competing Interests: Competing interests: The authors declare no conflict of Interest.
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- 2024
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23. Immunogenicity and protection efficacy of a COVID-19 DNA vaccine encoding spike protein with D614G mutation and optimization of large-scale DNA vaccine production.
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Gül A, Erkunt Alak S, Can H, Karakavuk M, Korukluoğlu G, Altaş AB, Gül C, Karakavuk T, Köseoğlu AE, Ülbeği Polat H, Yazıcı Malkoçoğlu H, Taş Ekiz A, Abacı İ, Aksoy Ö, Enül H, Adıay C, Uzar S, Saraç F, Ün C, Gürüz AY, Kantarcı AG, Akbaba H, Erel Akbaba G, Yılmaz H, Değirmenci Döşkaya A, Taşbakan M, Pullukçu H, Karasulu E, Tekin Ş, and Döşkaya M
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- Animals, Humans, Mice, HEK293 Cells, Female, Immunogenicity, Vaccine, Immunoglobulin G blood, Immunoglobulin G immunology, Vaccines, DNA immunology, Vaccines, DNA administration & dosage, Vaccines, DNA genetics, Spike Glycoprotein, Coronavirus immunology, Spike Glycoprotein, Coronavirus genetics, SARS-CoV-2 immunology, SARS-CoV-2 genetics, COVID-19 prevention & control, COVID-19 immunology, Mice, Inbred BALB C, COVID-19 Vaccines immunology, COVID-19 Vaccines administration & dosage, Mutation, Antibodies, Viral immunology, Antibodies, Viral blood, Antibodies, Neutralizing immunology, Antibodies, Neutralizing blood
- Abstract
Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due to emerging variants of concern. DNA vaccines gained importance during the pandemic due to their advantages such as induction of both arms of immune response, rapid development, stability, and safety profiles. Here, we report the immunogenicity and protective efficacy of a DNA vaccine encoding spike protein with D614G mutation (named pcoSpikeD614G) and define a large-scale production process. According to the in vitro studies, pcoSpikeD614G expressed abundant spike protein in HEK293T cells. After the administration of pcoSpikeD614G to BALB/c mice through intramuscular (IM) route and intradermal route using an electroporation device (ID + EP), it induced high level of anti-S1 IgG and neutralizing antibodies (P < 0.0001), strong Th1-biased immune response as shown by IgG2a polarization (P < 0.01), increase in IFN-γ levels (P < 0.01), and increment in the ratio of IFN-γ secreting CD4
+ (3.78-10.19%) and CD8+ (5.24-12.51%) T cells. Challenging K18-hACE2 transgenic mice showed that pcoSpikeD614G administered through IM and ID + EP routes conferred 90-100% protection and there was no sign of pneumonia. Subsequently, pcoSpikeD614G was evaluated as a promising DNA vaccine candidate and scale-up studies were performed. Accordingly, a large-scale production process was described, including a 36 h fermentation process of E. coli DH5α cells containing pcoSpikeD614G resulting in a wet cell weight of 242 g/L and a three-step chromatography for purification of the pcoSpikeD614G DNA vaccine., (© 2024. The Author(s).)- Published
- 2024
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24. Genetic characterization of Toxoplasma gondii strains isolated from humans living in İzmir, Türkiye.
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Karakavuk M, Can H, Çeltik A, Karakavuk T, Gül C, Erdem HA, Pullukçu H, Taşbakan M, Taşbakan MS, Gürüz AY, Döşkaya M, and Değirmenci Döşkaya A
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- Humans, Male, Female, Adult, Middle Aged, Protozoan Proteins genetics, Seroepidemiologic Studies, Real-Time Polymerase Chain Reaction, Immunocompromised Host, Animals, Antigens, Protozoan genetics, Antibodies, Protozoan blood, Young Adult, Cats, Adolescent, Aged, Child, Toxoplasma genetics, Toxoplasma isolation & purification, Toxoplasma immunology, Toxoplasma classification, Toxoplasmosis parasitology, Toxoplasmosis epidemiology, Genotype, DNA, Protozoan genetics
- Abstract
Purpose: Toxoplasma gondii is an obligate intracellular zoonotic parasite that can infect all warm-blooded animals, including humans. Currently, clinical findings of toxoplasmosis are being related to T. gondii strains such as Type I genotype may cause high pathogenicity and Type II genotype causes a milder clinical presentation. We have showed in our previous that Type II genotype is the most frequent strain detected in stray cats and wild birds living in natural life of İzmir. The aim of this study was to assess toxoplasmosis seroprevalence in immunocompromised patients, investigate the presence of T. gondii DNA in their blood samples, and genotype the PCR positive ones., Methods: The 42 buffy-coat and serum samples were collected from immunocompromised patients who were from various clinics. Thereafter, Real-Time PCR targeting RE gene of T. gondii was performed with DNA samples obtained from buffy-coat samples. Genotyping was performed by sequencing of GRA6 and GRA7 gene regions of positive DNA samples obtained from tissues of bioassay and PCR positive samples., Results: According to Real-Time PCR results, T. gondii DNA was detected in 23.8% (10/42) samples. Among these 10 samples, two samples were determined as T. gondii Type II genotype. Anti-Toxoplasma IgG antibodies were detected in 28.57% (12/42) samples., Conclusions: Overall, the detection of Type II genotype in humans in İzmir province suggested that T. gondii infection in humans, stray cats, and wild animals may be associated to each other in terms of transmission., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.)
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- 2024
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25. The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study.
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Başkol Elik D, Kaya Ş, Alkan S, Demirdal T, Sener A, Kaya S, Güzel Tunçcan Ö, Kayaaslan B, Güner R, Eser F, Kahraman H, Birengel S, Sarıcaoğlu EM, Eroğlu E, Çölkesen F, Öztürk E, Berk Cam H, Mermutluoğlu Ç, Özer Balin Ş, Sincan G, Altın N, Sili U, Suntur BM, Arslan Gülen T, Deveci B, Saba R, İncecik Ş, Eser Karlıdağ G, Hakko E, Akdağ D, Erdem HA, Sipahi H, Çicek C, Taşbakan MS, Taşbakan M, Pullukçu H, Yamazhan T, Arda B, Ulusoy S, and Sipahi OR
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- Humans, Female, Retrospective Studies, SARS-CoV-2, Prognosis, Shock, Septic, COVID-19, Neutropenia
- Abstract
This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.639-16.280); (ii) need for ICU: receiving glycopeptide therapy at any time during the COVID-19/FEN episode (p = 0.001, OR 6.566, 95% CI 2.137-20.172), the need for mechanical ventilation (p < 0.001, OR 62.042, 95% CI 9.528-404.011); (iii) need for mechanical ventilation: failure to recover from neutropenia (p < 0.001, OR 17.869, 95% CI 3.592-88.907), receiving tocilizumab therapy (p = 0.028, OR 32.227, 95% CI 1.469-707.053), septic shock (p = 0.001, OR 15.4 96% CI 3.164-75.897), and the need for ICU (p < 0.001, OR 91.818, 95% CI 15.360-548.873), (iv) OMM: [mechanical ventilation (p = 0.001, OR 19.041, 95% CI 3.229-112.286) and septic shock (p = 0.010, OR 5.589,95% CI 1.509-20.700)]. Although it includes a relatively limited number of patients, our findings suggest that COVID-19 and FEN are associated with significant mortality and morbidity., (© 2024. The Author(s).)
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- 2024
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26. COVID-19 Antibody Levels among Various Vaccination Groups, One-Year Antibody Follow-Up in Two University Hospitals from Western and Central Turkey.
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Soylu M, Sağıroğlu P, Özarslan MA, Acet O, Yüce ZT, İzci Çetinkaya F, Durmaz S, Parkan ÖM, Akyol D, Zeytinoğlu A, Kalın Ünüvar G, Taşbakan M, Gökahmetoğlu S, Atalay MA, Durusoy İR, Çiçek C, Pullukçu H, Yıldız O, Sertöz ŞR, and Erensoy MS
- Abstract
Various clinical outcomes, reinfections, vaccination programs, and antibody responses resulted from the COVID-19 pandemic. This study investigated the time-dependent changes in SARS-CoV-2 antibody responses in infected and/or vaccinated and unvaccinated individuals and to provide insights into spike and nucleocapsid antibodies, which fluctuate during infectious and non-infectious states. This cohort study was carried out at the Ege University Faculty of Medicine hospital in İzmir (western Turkey) and the Erciyes University Faculty of Medicine hospital in Kayseri (central Turkey) between December 2021 and January 2023, which coincided with the second half of COVID-19 pandemic. The study included 100 COVID-19 PCR-positive patients and 190 healthcare workers (HCWs). Antibody levels were followed up via quantitative anti-SARS-CoV-2 spike and qualitative anti-nucleocapsid immunoassays (Elecsys™). Antibody levels declined after infection but persisted for at least 6-8 months. Individuals who had received only CoronaVac had higher anti-nucleocapsid antibody levels in the early months than those who received mixed vaccination. However, anti-spike antibodies persisted longer and at higher levels in individuals who had received mixed vaccinations. This suggests that combining two different vaccine platforms may provide a synergistic effect, resulting in more durable and broad-spectrum immunity against SARS-CoV-2. The study provides information about the vaccination and antibody status of healthcare workers in the second half of the pandemic and provides valuable insights into the dynamics of antibody responses to COVID-19 infection and vaccination.
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- 2024
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27. Importance of screening severe COVID-19 patients for IFN-λ1, IL-6 and anti-S1 IgG levels.
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Kenanoğlu OB, Gül A, Can H, Karakavuk M, Erkunt Alak S, Korukluoğlu G, Altaş AB, Pullukçu H, Değirmenci Döşkaya A, Karakavuk T, Gül C, Çiçek C, Taşbakan MS, Çinkooğlu A, Ün C, Gürüz AY, Avcı M, Karasulu E, Tekin Ş, Döşkaya M, and Işıkgöz Taşbakan M
- Abstract
Cytokine storm is an important cause of death in COVID-19 patients. A recent clinical study showed that administration of recombinant interferon lambda 1 (IFN-λ1 or IL-29) may prevent severe COVID-19. On the other hand, IL-6 has been associated as a prognostic marker of worsening for COVID-19 patients. The objective of this study is to screen IFN-λ1, IL-6 and antibody levels in consecutive serum sample sets of COVID-19 patients. A total of 365 serum samples collected from 208 hospitalized COVID-19 patients were analyzed for IFN-λ1 and IL-6 levels as well as SARS-CoV-2 neutralizing antibodies and anti-S1 IgG antibodies. Analyses of serum samples for cytokine levels showed that IFN-λ1 (>8 pg/mL) and IL-6 (>2 pg/mL) were detected in approximately 64% and 21% patients, respectively. A decrement in IFN-λ1 levels and IL-6 levels above 35 pg/mL can be sign of clinical severity and upcoming dead. An increment in IL-6 levels wasn't detected in every COVID-19 patient but a decrement in IL-6 levels was related to clinical improvement. Importantly, the detection of IFN-λ1 level together with an increase in anti-S1 IgG antibody response were observed in clinically improved patients. Screening severe COVID-19 patients for IFN-λ1, IL-6, and anti-S1 IgG antibody levels during their hospital stay especially in intensive care units may be beneficial to monitor the clinical status and management of treatment strategies. Importantly, detection of IFN-λ1 together with protective IgG antibody response can be an indication of clinical improvement in severe COVID-19 patients and these patients may be discharged from the hospital soon., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
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- 2023
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28. Multidrug resistance in pathogens of community-acquired urinary tract infections in Turkey: a multicentre prospective observational study
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Şencan İ, Karabay O, Altay FA, Yıldız SS, Şimşek H, Gözükara MG, Kuzi S, Karlıdağ GE, Kaya Ş, Kul G, Türkoğlu E, Sezer BE, Korkmaz N, Kaya SY, Sayar MS, Bulut D, Akgül F, Çağ Y, Ağalar C, Dursun ZB, Taşbakan M, Aydemir SŞ, Seyman D, Yıldırım M, Habip Z, Altın N, Uzar H, Bektaş B, Engin DÖ, Erdem HA, and Sürme S
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- Humans, Male, Escherichia coli, Universities, Drug Resistance, Multiple, Bacterial, Klebsiella, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents pharmacology, Microbial Sensitivity Tests, Escherichia coli Infections microbiology, Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting complications, Urinary Tract Infections drug therapy, Urinary Tract Infections epidemiology, Community-Acquired Infections drug therapy, Community-Acquired Infections epidemiology, Community-Acquired Infections microbiology
- Abstract
Background: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options., Methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed., Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advancedage, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions., Discussion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factorsfor antibacterial resistance individually. Community-acquired UTIs should be followed up time- and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.
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- 2023
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29. Efficacy of coronavirus disease 2019 vaccines in patients with rheumatic diseases.
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Taştekin F, Taşbakan M, Çiçek C, Soylu M, and Yargucu Zihni F
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Objectives: In this study, we report the immune response to the BNT162b2 vaccine and CoronaVac vaccine after a two-dose vaccination and the effects of conventional drugs, immunosuppressive drugs, and new-generation therapies on vaccine responses in patients with rheumatic and musculoskeletal diseases (RMDs)., Patients and Methods: This is a prospective observational study conducted with 94 patients (65 males, 29 females; mean age: 42.7±12.1 years; range, 19 to 69 years) between May 2021 and January 2022. The immunogenicity of the two-dose regimens of the BNT162b2 and CoronaVac vaccines in adult patients with RMD was analyzed according to disease and treatments. Serum immunoglobulin G antibody levels against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike proteins were measured four weeks after the second dose of vaccines., Results: Patients on regimens including mycophenolate, rituximab, and steroids were less likely to develop an antibody response (p=0.001, p=0.06, and p=0.001, respectively). Impairment of vaccine response by other conventional disease-modifying antirheumatic drugs and by anti-tumor necrosis factor treatments was not shown. Younger participants appeared more likely to develop an antibody response. The CoronaVac vaccine was less likely to develop an antibody response compared to the BNT162b2 vaccine (p=0.002). Systemic lupus erythematosus and vasculitis had the lowest antibody titers compared to other RMDs., Conclusion: Patients receiving mycophenolate mofetil, rituximab, and steroids should be warned about the risk of a suboptimal vaccine response. If possible, vaccination strategies should be changed, and the dose modification of drugs should be made during the vaccination. Further studies are required to determine the responses to SARS-CoV-2 vaccination and optimization of vaccine response in patients with RMDs., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article., (Copyright © 2023, Turkish League Against Rheumatism.)
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- 2023
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30. Sensitivity Affected by Disease Severity and Serum Sampling Time: a Performance Evaluation of Six SARS-CoV-2 Antibody Immunoassays.
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Şener B, Kırbaş E, Sancak B, Gözalan A, Evren E, Karahan ZC, Zeytinoğlu A, Dinç B, Alp A, Dizman GT, Metan G, Birengel S, Gülten E, Taşbakan M, and Ayhan M
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- Antibodies, Viral, Humans, Immunoglobulin G, SARS-CoV-2, Sensitivity and Specificity, Severity of Illness Index, Spike Glycoprotein, Coronavirus, COVID-19 diagnosis, Immunoassay methods
- Abstract
Comparative validation and clinical performance data are essential for the reliable interpretation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody test results. This study aimed to assess the performance of six SARS-CoV-2 IgG immunoassays in the context of different disease severities. Four automated chemiluminescence immunoassays (Access [Beckman Coulter], Architect [Abbott], Atellica-IM [Siemens], and Elecsys [Roche]) as well as two ELISA assays (SARS-CoV-2 IgG-S1-based and NCP IgG [Euroimmun]) were evaluated using samples from 143 patients as well as 50 pre-pandemic control serum samples. Accuracy and precision tests were performed for validation purposes. Overall sensitivity ranged between 73.38-88.65% and was higher in spike protein-based assays, while the specificity was ≥98% in all immunoassays. The clinical performance of the immunoassays differed depending on disease severity and target antigen. For instance, the IgG response was lower for samples taken <20 days post-symptom onset (87.30%) compared with those taken ≥20 days post-symptom onset (94.80%). Moreover, moderate disease levels led to the highest levels of IgG. Higher levels of antibodies were detected in the clinically moderate disease group. In asymptomatic and mild groups, more antibody positivity was detected with spike protein-based assays. All the assays tested could be used to detect SARS-CoV-2 IgG. However, spike-based assays revealed relatively higher sensitivity rates than nucleoprotein-based assays, particularly in cases of asymptomatic and mild disease.
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- 2022
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31. Investigation of miRNA and cytokine expressions in latent tuberculosis infection and active tuberculosis.
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Çavuşoğlu C, Çoğulu Ö, Durmaz A, Cengisiz Z, Yılmaz FF, Taşbakan MS, Taşbakan M, Gündüz C, Biçmen C, Karaman O, Taşlıdere H, Akın H, Akarca T, and Dereli Ş
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- Humans, Cytokines, Latent Tuberculosis genetics, MicroRNAs genetics, MicroRNAs metabolism, Tuberculosis genetics, Mycobacterium tuberculosis genetics
- Abstract
Background: In tuberculsosis (TB), miRNA has been used as a biomarker to distinguish between healthy individuals and TB patients. The aim of this study was to investigate (i) the association of the miRNA and cytokine expression levels, the course of tuberculosis infection, clinical forms and response to treatment, and (ii) the effects of genotypic features of bacteria on the course of tuberculosis and the relationship between miRNA and cytokine expressions and bacterial genotypes., Methods: A total of 200 cases (100: culture positive active tuberculosis, 50: quantiferon positive latent tuberculosis infection and 50: quantiferon negative healthy controls) were included in the study. For the tuberculosis group at the time of admission and after treatment, for the latent tuberculosis infection and healthy control groups at the time of admission, miRNA and cytokine expressions were determined. Genotyping of M.tuberculosis isolates was performed by spoligotyping method., Results: While, in the comparison of miRNA expressions between the pretreatment patient group and the healthy control group, there was a statistically significant decrease in the expression of miR-454-3p, miR-15a-5p, miR-590-5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients. When the cytokine expressions of the patient group and the healthy control group were compared before treatment, the expressions of all cytokines in the patient group decreased. However, the only cytokine that showed a significantly lower expression was IL12A in PTB patients., Discussion: There is no significant relationship between the clinical course of the disease, cytokine and miRNA expression, and the genotype of the bacteria.
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- 2022
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32. Treatment of SARS-CoV-2 pneumonia with favipiravir: early results from the Ege University cohort, Turkey
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Erdem HA, Korkma PE, Çağlayan D, Işıkgöz Taşbakan M, Yamazhan T, Taşbakan MS, Sayıner A, and Gökengin D
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- Adult, Aged, Antiviral Agents therapeutic use, COVID-19 epidemiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Time Factors, Treatment Outcome, Turkey epidemiology, Amides therapeutic use, Intensive Care Units statistics & numerical data, Pandemics, Pyrazines therapeutic use, SARS-CoV-2, COVID-19 Drug Treatment
- Abstract
Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia., Materials and Methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia., Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) when this paper was written., Conclusion: This study provides relevant information for the treatment of COVID-19, suggesting that favipiravir was associated with significant clinical and laboratory improvements in the majority of the patients, is a safe drug with no serious side effects and would merit further investigation., Competing Interests: The authors declare that they have no conflict of interest., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
- Published
- 2021
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33. Retrospective evaluation of 377 patients with penetrating foreign body injuries: a university hospital experience (a present case of missed sponge foreign body injury)
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Öztürk AM, Aljasim O, Şanlıdağ G, and Taşbakan M
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- Adolescent, Adult, Child, Emergency Service, Hospital, Hospitals, University, Humans, Middle Aged, Radiography, Retrospective Studies, Young Adult, Foreign Bodies complications, Foreign Bodies diagnostic imaging, Surgical Sponges, Wounds, Penetrating
- Abstract
Background/aim: This study aimed to retrospectively analyse patients with foreign body (FB) injuries in our hospital and to present a patient with missed penetrating sponge FB injury., Materials and Methods: This study lasted 12 years (2008–2020) and reviewed all patients with FB injuries who were admitted to the emergency department (ED) of our hospital. Along with our overall results, we present a case with missed penetrating sponge FB injury in detail., Results: Approximately 377 patients were included in the study (age: 28.3 ± 18.3 years, m/f: 229/148). The foot (n = 148, 39.3%) and the hand (n = 143, 37.9%) were the most frequently injured body parts. Regarding FB types, sewing needles (n = 140, 37.1%), metal pieces (n = 91, 24.1%), and glass (n = 80, 21.2%) were the most frequently observed objects. Most of the patients were injured at home, often by needles or glass. The injury-admission mean time was 7.38 ± 2.5 days. FBs were frequently removed in the ED (n = 176, 46.7%). Plain radiography is the first line in identifying FBs. Soft tissue infection was the most common complication. MRIs were much useful than USGs in detecting the missed penetrating sponge injury of the single patient in the study., Conclusion: For diagnosis of FBs, besides recording the patient’s history, obtaining a two-sided radiogram is of great importance. For nonradiolucent or deeply located FBs, further clinical or radiological investigation must be considered to avoid complications. Although most of the FBs can be removed in the ED, patients may require hospitalisation and operation for FB removal, depending upon FB location and age., Competing Interests: none declared., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
- Published
- 2021
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34. Evaluation of the performance of QuantiFERON®-TB Gold plus test in active tuberculosis patients.
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Çavuşoğlu C, Yaşar-Duman M, Sezai Taşbakan M, Işıkgöz-Taşbakan M, and Nurullah Orman M
- Abstract
The aim was to evaluate the sensitivity and the possible factors affecting the sensitivity of the QuantiFERON®-TB Gold Plus (QFT-Plus) assay in culture-positive active TB (Tuberculosis) patients, to investigate the possible causes of negative and indeterminate results in active TB patients, and to compare the QFT-Plus results of active TB patients and latent tuberculosis infection (LTBI) cases. The QFT-Plus assay was performed in 46 active TB patients and 64 LTBI. The sensitivity of the test was found as 79.5% in all culture-positive patients, 72.7% in the immunocompromised patients, and 86.4% in the non-immunocompromised patients. Compared to active TB, individuals with LTBI had a lower T-cell response and lower IFN-ɣ concentrations. It was determined that the immunocompromisation reduced the sensitivity of the test and the secreted IFN-ɣ concentrations and increased the indeterminate results in patients with active TB. There was no difference in secreted IFN-ɣ concentrations between M. tuberculosis clones, but higher IFN-ɣ concentrations in patients infected with M. tuberculosis strains compared to patients infected with zoonotic strains. Compared with active TB, response to "only to TB2" was significantly higher in LTBI. In conclusion, it was concluded that TB2 tube increased sensitivity in LTBI but may not contribute to sensitivity in active TB., (© 2021 The Authors. Published by Elsevier Ltd.)
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- 2021
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35. COVID-19-related anxiety in people living with HIV: an online cross-sectional study
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Kuman Tunçel Ö, Pullukçu H, Erdem HA, Kurtaran B, Taşbakan SE, and Taşbakan M
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- Adult, Female, Humans, Male, Psychological Distress, Qualitative Research, Risk Factors, SARS-CoV-2, Self-Assessment, Socioeconomic Factors, Surveys and Questionnaires, Turkey epidemiology, Anxiety diagnosis, Anxiety epidemiology, Anxiety etiology, COVID-19 epidemiology, COVID-19 prevention & control, COVID-19 psychology, HIV Infections epidemiology, HIV Infections psychology, Mental Health statistics & numerical data
- Abstract
Background/aim: The emergence of the coronavirus disease 2019 (COVID-19) outbreak has had an enormous emotional impact on some vulnerable groups, such as people living with human immunodeficiency virus (HIV) (PLHIV). This study was planned with the aim of assessing the anxiety levels of PLHIV and the sources of their anxiety., Materials and Methods: A web-based questionnaire was sent to PLHIV using the virtual snowball sampling method. The questionnaire included questions about sociodemographic status, information about HIV infection, and the Beck Anxiety Inventory (BAI). Additionally, some opinions of the participants about COVID-19 were asked., Results: A total of 307 respondents, with a median age of 33 years, from 32 different cities, participated in the study. More than half of the respondents reported the belief that COVID-19 was not sufficiently well-known by the medical community and nearly 45% believed that they would have more complications if they contracted COVID-19. One-fourth of the participants had anxiety. Having a preexisting psychiatric disorder, perceiving that they were practicing insufficient preventive measures, not being sure about the presence of any individuals with COVID-19 in their environment, and living with a household member with a chronic disease were found to be the risk factors of PLHIV for having anxiety during this pandemic. The BAI scores were correlated with the patient-reported anxiety levels about the spread of COVID-19 in Turkey, acquiring COVID-19, transmitting COVID-19 to another person, and transmitting HIV to another person. Among the stated conditions, the most common concern was the spread of COVID-19 all over the country, while the least common was transmitting HIV to someone else., Conclusion: The results revealed that a significant proportion of the sample had anxiety, and the findings were essential for developing evidence-based strategies for decreasing the anxiety of PLHIV, especially for those who had risk factors and to provide them with better health care during this pandemic or other pandemic-like crises., Competing Interests: The authors have no conflicts of interest to report., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
- Published
- 2020
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36. Infections developing in patients undergoing liver transplantation: Recipients of living donors may be more prone to bacterial/fungal infections.
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Yamazhan T, Bulut Avşar C, Zeytunlu M, Taşbakan M, Sertöz R, Zeytinoğlu A, Aydemir Ş, Ünalp Ö, Ergün O, Uğuz A, Özgenç F, Günşar F, Turan İ, Ulukaya S, Deniz N, Yilmaz F, Nart D, Güler E, Turhan K, and Karasu Z
- Subjects
- Adolescent, Adult, Aged, End Stage Liver Disease immunology, End Stage Liver Disease surgery, Female, Humans, Liver Transplantation methods, Living Donors, Male, Middle Aged, Postoperative Complications immunology, Postoperative Complications microbiology, Retrospective Studies, Risk Factors, Severity of Illness Index, Young Adult, Bacterial Infections immunology, Immunosuppression Therapy adverse effects, Liver Transplantation adverse effects, Mycoses immunology, Postoperative Complications mortality
- Abstract
Background/aims: Despite surgical advances in liver transplantation and effective prophylactic strategies, posttransplant infections are the most important cause of morbidity and mortality. Diagnosis and management of infections because of developing immunosuppression is difficult and adversely affects mortality. This study aimed to review bacterial and fungal infections in patients after liver transplantation and to reveal the resistance rates., Materials and Methods: A total of 107 patients who underwent liver transplantation between January 2017 and February 2018 were evaluated retrospectively with regard to demographic characteristics, causes of transplantation, conditions that may lead to infection, postoperative infections, pathogens, and resistance patterns., Results: Of the 107 patients who underwent liver transplantation, 48 (44.8%) had an infection. Bacterial infections were detected in 41% of the patients, and fungal infections were found in 13%. When we compared living and cadaveric transplants in terms of infection development, these rates were found to be 53% and 33%, respectively (p=0.034). No statistically significant results could be obtained when evaluating conditions such as sex, presence of underlying primary disease, Model for End-Stage Liver Disease MELD score, diabetes status, total parenteral nutrition, and risk factors for infection., Conclusion: After liver transplantation, infections are often seen in the first month of the postoperative period. Knowing the most common pathogens and resistance states in this process reduces infection-related deaths by providing appropriate treatment regimens at the right time.
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- 2020
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37. Real-life experience of ledipasvir and sofosbuvir single-tablet regimen among chronic hepatitis C patients in Turkey.
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Yamazhan T, Turan İ, Ersöz G, Günşar F, Pullukçu H, Danış N, Ünal NG, Vardar R, Oruç N, Tekin F, Taşbakan M, Sipahi OR, and Akarca US
- Subjects
- Aged, Female, Hepatitis C, Chronic virology, Humans, Male, Middle Aged, Tablets, Treatment Outcome, Turkey, Antiviral Agents administration & dosage, Benzimidazoles administration & dosage, Fluorenes administration & dosage, Hepacivirus drug effects, Hepatitis C, Chronic drug therapy, Sofosbuvir administration & dosage
- Abstract
Background/aims: Ledipasvir (LDV) and sofosbuvir (SOF) as single-tablet regimen (STR) has been approved for treatment of chronic HCV infection (CHC) for treatment-naïve or experienced cirrhotic or non-cirrhotic patients. Our aim was to analyse the effectiveness and safety of 12-24 weeks treatment of LDV/SOF (90mg/400 mg)±ribavirin in a real-life setting in Turkey., Materials and Methods: Between May-Dec 2016, 104 treatment-naïve or experienced adult patients with CHC and with or without cirrhosis (including decompensated cirrhosis) were included in this observational study. Patients were administered LDV/SOF STR± ribavirin once daily for 12 -24 weeks. SVR12 rates and effects of the baseline characteristics on SVR12 rates were assessed., Results: Out of 104 enrolled patients (61.5% female, mean age 62.0 years); 60.6% were cirrhotic, 76.0% previously used peg-IFN, 94.2% had GT1. At the end of the treatment, 77.8% (77/99, no data for 21 patients) had undetectable HCV-RNA and 98.9% (94/95) had SVR12. In the baseline characteristics subgroups, the SVR12 rates varied between 94.4% and 100%, and none of the baseline characteristics had a significant effect on the SVR12 rates. During the study, 6 (5.8%) patients died and none of the deaths was suspected to be related to the LDV/SOF. No treatment-emergent adverse event was reported., Conclusion: In conclusion, LDV/SOF±ribavirin yielded very high SVR12 rates, without any safety or tolerability concern in Turkey. The effectiveness of the LDV/SOF treatment was not affected by the patient demographics or medical characteristics such as fibrosis level, cirrhosis status, previous treatment status, HCV-RNA level or HCV genotype.
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- 2020
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38. Carbapenem-resistant Klebsiella pneumonia infection outbreak in a tertiary urology clinic: analysis of influencing factors with a controlled trial
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Kizilay F, Aliyev B, Şimşir A, Kalemci S, Köse T, Taşbakan M, and Pullukçu H
- Subjects
- Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Carbapenem-Resistant Enterobacteriaceae, Humans, Klebsiella Infections drug therapy, Middle Aged, Urinary Tract Infections drug therapy, Carbapenems pharmacology, Disease Outbreaks, Klebsiella Infections epidemiology, Klebsiella pneumoniae drug effects
- Abstract
Background/aim: Carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections encountered in urology patients differentiate from infections caused by other factors, both in respect to prophylaxis and treatment stage, and require a special approach. We aimed to analyse the predisposing factors and the antibiotherapies for CR-KP infection outbreak in a tertiary urology clinic., Materials and Methods: There were 75 patients in the CR-KP positive group (Group I) and 146 patients in the CR-KP negative group (Group II). Analysis of the predisposing factors for CR-KP infection and comparison of the reinfection rate and the antibiotherapies in the 2 groups were the endpoints., Results: In the first group, age, comorbidity, previous antibiotic use, and nephrostomy tube rates were higher (P = 0.015, P = 0.001, P = 0.004, and P < 0.001, respectively). In the second group, open urological surgery rate, and the proportion of patients presenting with flank pain, lower urinary tract symptoms, and haematuria were higher (P = 0.029, P < 0.001, P < 0.001, and P = 0.007). In the first group, the proportion of patients treated with transurethral bladder tumour resection was higher, whereas, percutaneous nephrolithotomy was higher in the second group (P = 0.045 for both). While hospitalization and Foley catheterization duration were longer in the first group (P < 0.001 for both), double J stent and nephrostomy duration were longer in the second group (P < 0.001 and P = 0.005). Mean leukocyte count at admission was higher in the first group (P < 0.001)., Conclusion: Advanced age, comorbidities, previous antibiotic use, and prolonged Foley catheterization duration are predisposing factors for this infection in the urology department. Two-week administration of combination antibiotic regimens containing carbapenem were effective for the treatment of this infection., Competing Interests: None declared, (This work is licensed under a Creative Commons Attribution 4.0 International License.)
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- 2020
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39. [Tuberculous tenosynovitis in wrist flexor tendons].
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Demir M, Küçük L, Mermut G, Pullukçu H, Çavuşoğlu C, and Işıkgöz Taşbakan M
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- Humans, Male, Tendons microbiology, Tenosynovitis microbiology, Tuberculosis, Osteoarticular microbiology, Wrist, Mycobacterium tuberculosis isolation & purification, Tendons diagnostic imaging, Tenosynovitis diagnosis, Tuberculosis, Osteoarticular diagnosis, Wrist Joint
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- 2019
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40. A neglected causative agent in diabetic foot infection: a retrospective evaluation of 13 patients with fungal etiology
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Öztürk AM, Taşbakan M, Metin DY, Yener C, Uysal S, Yıldırım Şımşır I, Ertam İ, Pullukçu H, Arda B, and Çetinkalp Ş
- Subjects
- Aged, Amputation, Surgical, Candida, Candidiasis, Invasive microbiology, Diabetic Foot surgery, Female, Humans, Male, Middle Aged, Retrospective Studies, Wound Infection surgery, Diabetic Foot complications, Wound Infection microbiology
- Abstract
Background/aim: Clinicians often neglect fungal infections and do not routinely investigate deep tissue from the wound for fungal culture and sensitivity due to insufficient information in the literature. In this study, we aimed to evaluate fungal etiology of invasive fungal diabetic foot which is rarely reported in the literature., Materials and Methods: The patients who were unresponsive to antibiotic therapy and those with positive fungal in bone or deep tissue culture were enrolled in the study. Detailed hospital records were retrieved for demographics and clinical features., Results: A total of 13 patients who were diagnosed with invasive fungal diabetic foot (ten females, three males, mean age 59.8 ± 9 years) were included. All of the patients had type-2 diabetes mellitus. Eleven (84.6%) patients had mixed infection. The most common cause of fungal infections of diabetic foot ulcers was the Candida species. Ten (76.9%) patients underwent amputation, two (15.4%) patients refused amputation, and one patient died before surgery., Conclusion: Invasive fungal infections may also be a causative pathogen in deep tissue infections. Therefore, fungal pathogens should be considered in patients unresponsive to long-term antibiotic therapy. Early detection of fungal infections in high-risk individuals is critical for the prevention of severe consequences such as foot amputation.
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- 2019
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41. Results of 1001 liver transplantations in 23 years: Ege University experience.
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Zeytunlu M, Uğuz A, Ünalp Ö, Ergün O, Karasu Z, Günşar F, Akarca U, Yılmaz F, Turan İ, Nart D, Tekin F, Özütemiz Ö, Ulukaya S, Deniz N, Aydoğdu S, Özgenç F, Tasçı E, Sertöz R, Parıldar M, Elmas N, Harman M, Güler E, Kısmalı E, Akyol R, Yamazhan T, Taşbakan M, Tiftikcioğlu Y, Bacakoğlu F, Nalbantgil S, Noyan A, Karapınar B, Kılınç A, Uyar M, Demirağ K, Özalp S, Özdemir N, Aras S, and Altuğ N
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, End Stage Liver Disease etiology, End Stage Liver Disease mortality, Female, Graft Survival, Hospitals, University statistics & numerical data, Humans, Infant, Liver Transplantation statistics & numerical data, Living Donors statistics & numerical data, Male, Middle Aged, Retrospective Studies, Survival Rate, Time Factors, Treatment Outcome, Turkey, Young Adult, End Stage Liver Disease surgery, Liver Transplantation mortality
- Abstract
Background/aims: Liver transplantation (LT) is now the standard of care for most end-stage liver diseases. Over the next 30 years, advances in medicine and technology will greatly improve the survival rates of patients after this procedure. The aim of the present study was to analyze retrospectively the results of 1001 patients withLT., Materials and Methods: Medical reports of 989 patients were analyzed retrospectively. Data were obtained from the patient's data chart. Descriptive statistics were used to describe continuous variables (mean, median, and standard deviation)., Results: A total of 1001 LTs for 989 recipients were performed at Ege University Organ Transplantation and Research Center between 1994 and 2017. Therewere 639 male and 350 female recipients. Among 1001 LTs, there were 438 deceased donors and 563 living donors. The age interval of the patients was 4 months to 71 years old. The median Model for End-Stage Liver Disease score was 20. There were 12 deceased liver donors using the split method. There were 12 cases subject to retransplantation. In living donor LT grafts, 423 right lobes, 46 left lobes, and 94 left lateral sectors were used. In the first monitoring,the total annual mortality rate was 130 cases (13%). The mortality rate in retransplantation was found to be 66%. A 1-year survival rate of 87% was generally stablished., Conclusion: LThas been improving consistently over the last two decades. Ege University is one of the biggest liver transplant centers in Turkey for both technical and educational perspective.
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- 2018
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42. [Culture proven extra pulmonary tuberculosis: drug susceptibility and genetic profile analysis].
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Taşbakan MS, Akdağ D, Kahraman H, Akyol D, Taşbakan M, and Çavuşoğlu C
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- Adult, Aged, Female, Genetic Variation, Humans, Male, Middle Aged, Mycobacterium tuberculosis isolation & purification, Risk Assessment, Genetic Profile, Genotype, Mycobacterium tuberculosis genetics, Tuberculosis, Pulmonary microbiology
- Abstract
Introduction: Tuberculosis is seen generally in the lungs. Besides, all organs in the body can be affected by tuberculosis. Diagnosis of extra pulmonary tuberculosis (EPTB) is more difficult than pulmonary tuberculosis (PTB). Although, the isolation of Mycobacterium tuberculosis is gold standard of diagnosis of EPTB, the rate of bacteriologic isolation is low especially in EPTB. If M. tuberculosis is detected, it gives some information about the epidemiological features of the disease and drug susceptibility., Materials and Methods: In this study, extra pulmonary samples isolated M. tuberculosis in mycobacteriology laboratory were evaluated between 2009-2016. The identification of the genotype of isolated bacteria and drug sensitivity tests were conducted. Spoligotyping was accomplished using a standard technique as described previously., Result: During the study period, M. tuberculosis were cultured in 171 extra pulmonary samples of 165 patients (75 male, 90 female, mean age: 53.35 ± 19.92). Initial direct microscopically examination was revealed M. tuberculosis in 44 patients. There were more than one extra pulmonary organ involvement in six patients. The most common EPTB forms were lymph node TB in 60 patients, pleural tuberculosis in 32 patients and bone tuberculosis in 25 patients. Immunosuppression was detected in 44 (%26.6) patients. Among these, seven patients were infected with HIV. In 21 of 175 samples, drug resistance was detected. Rifampicin resistance in 7 samples, high level isoniazid resistance in 11 samples and rifampicin plus isoniazid resistance (multiply drug resistance) in 6 samples were demonstrated. One hundred thirty-five clinical isolates were cultured from tuberculosis patient's different samples, of which the genetic profile was determined by using Spoligotyping. The major Spoligotypes were T (n= 62; 45.9%), LAM7-TUR (ST41) (n= 11; 8.1%) and H1 (n= 9; 6%) genotypes., Conclusions: The most common EPTB form was lymph node tuberculosis in culture proven patients. In these patients group, multiply drug resistance rate was low (3.6%). Spoligotypes T (45.9%) was detected as most common genetic profile.
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- 2018
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43. Hand infection in patients with diabetes: a series of 17 cases and a pooled analysis of the literature
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Öztürk AM, Uysal S, Yıldırım Şımşır I, Hüngör H, and Işıkgöz Taşbakan M
- Abstract
Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two different clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www.scopus.com and www.pubmed.com). Results: Of the 17 patients (mean age 61.7 ± 8.5 years), 8 (47.1%) were female. All cases were type 2 diabetes mellitus. The mean duration of diabetes was 9.0 ± 5.96 years and the mean HbA1c was 7.86 ± 1.88%. There was necrosis in 8 patients (47.1%). The most common causes were injury during saw and hammer use in 5 patients (29.4%) and injury due to inappropriate nail cutting in 3 patients (17.6 %). Nine (52.9%) patients were operated on. No patients underwent any major amputations or died. In 32 publications, 704 patients with diabetic hand infections were found. The average age was 53.43 years (n = 591) and 84.29% of patients (322/382) were found to have type 2 DM. The mean duration of diabetes was 4.12 years (n = 317) and the mean HbA1c was 10.58% (n = 140). The rate of surgical operation was 74.59% (323/433). Conclusion: Diabetic hand injuries often occur when using hand tools such as hammers, saws, and knives, and when cutting nails. It is necessary to use conservative treatment rather than amputation. These patients should consult experienced health care professionals.
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- 2018
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44. Comparison of standard agglutination tests, enzyme immunoassay, and Coombs gel test used in laboratory diagnosis of human brucellosis
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Koçman EE, Erensoy MS, Taşbakan M, and Çiçeklioğlu M
- Subjects
- Adolescent, Adult, Agglutination, Brucellosis blood, Brucellosis microbiology, Clinical Laboratory Techniques methods, Enzyme-Linked Immunosorbent Assay methods, Female, Humans, Male, Rose Bengal, Sensitivity and Specificity, Agglutination Tests methods, Antibodies, Bacterial blood, Brucella growth & development, Brucellosis diagnosis, Coombs Test methods, Immunoglobulin G blood, Immunoglobulin M blood
- Abstract
Background/aim: It was aimed to evaluate the results of Rose Bengal (RB), ELISA total tests (IgM and IgG), and the Brucella Coombs gel test (BCGT), which are used as screening tests, with the combined results of a tube agglutination test (standard Wright test: SWT) and a tube agglutination test with antihuman globulin (AHG TAT). Materials and methods: Samples from 97 patients prediagnosed with brucellosis (age ≥18 years) were screened with RB, ELISA, and BCGT. SWT < 160 samples and RB-negative but ELISA- or BCGT-positive samples were tested by AHG TAT. SWT ≥ 160 or AHG TAT ≥ 160 was taken as reference. Results: Thirty-two of 56 RB-positive samples and one RB-negative but ELISA- and BCGT-positive sample were found to be ≥160 with SWT or AHG TAT. Sensitivity, specificity, accuracy, and agreement (kappa) values according to SWT ≥ 160 or AHG TAT ≥ 160 positivity were as follows, respectively: RB 96.9%, 62.5%, 74.2%, and 0.509; ELISA total 100%, 60.9%, 74.2%, and 0.515; BCGT test 97%, 70.3%, 79.4%, and 0.594. Conclusion: Sensitivities of the screening tests are similar, but positivities should be confirmed by more specific tests. Positive samples from screening tests should be tested with AHG if the SWT value is <160.
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- 2018
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45. Stenotrophomonas maltophilia pericarditis.
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Bulut Avşar C, Aydemir Ş, Taşbakan M, Pullukçu H, Ulusoy S, Kayıkçıoğlu LM, and Sipahi OR
- Subjects
- Aged, Diagnosis, Differential, Echocardiography, Gram-Negative Bacterial Infections diagnostic imaging, Gram-Negative Bacterial Infections microbiology, Humans, Male, Pericarditis diagnostic imaging, Pericarditis microbiology, Gram-Negative Bacterial Infections diagnosis, Lung Neoplasms, Pericarditis diagnosis, Stenotrophomonas maltophilia isolation & purification
- Published
- 2017
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46. Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases
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Işıkgöz Taşbakan M, Yıldırım Şimşir I, Mermer S, Uysal S, Öztürk M, and Çetinkalp Ş
- Abstract
Background/aim: Intralesional recombinant epidermal growth factor (EGF) is a new treatment approach for diabetic foot ulcer, approved in 2006. EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen. EGF accelerates the healing of diabetic foot ulcers and reduces healing time. This single-center study was conducted to evaluate the outcomes of intralesional EGF therapy in patients with diabetic foot ulcers.Materials and methods: We present the data of the follow-up patients treated in our clinics. Fifteen patients with diabetic foot ulcers or infections, who had been followed up and treated in our clinics, were included in this retrospective study. All patients were administered intralesional injections of 75 μg of EGF after treatment for infection on their diabetic foot ulcers, three times a week on alternate days. The patients were monitored with respect to treatment response and side effects of EGF.Results: Thirteen patients (86.7%) developed new granulation tissue, 10 patients (66.7%) had complete wound closure, and three patients (20%) showed partial wound closure. No serious side effects requiring discontinuation of EGF therapy were observed. A total of twenty-one bacterial agents were isolated in thirteen patients, and no bacterial growth was observed in the tissue cultures of two patients. Pseudomonas aeruginosa was the most common isolated infectious agent in the tissue cultures (n: 6, 28%). Conclusion: Intralesional injection of EGF on top of the standard treatment regimen appears to be a useful adjuvant therapy option in selected patients.
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- 2017
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47. Use of Tigecycline for Diabetic Foot Infections
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Arda B, Uysal S, Taşbakan M, Şimşir IY, Öztürk M, Ertam İ, Uysal A, and Ulusoy S
- Abstract
Objective: The aim of this study is to evaluate tigecycline for diabetic foot infections (DFIs)., Materials and Methods: In this prospective observational study, the investigators included patients who had consultation with the Diabetic Foot Council of Ege University Faculty of Medicine (Izmir, Turkey) between March 2013 and July 2015 and who used tigecycline during their treatment. Treatment success was assessed by design-specific criteria for each evaluation., Results: The study included 105 cases. Of those, 37 (35.2%) were women (mean [± standard deviation] age, 61.9 ± 11.9 years). The success rate of tigecycline treatment was 93.3% in mild infections, 56.2% in moderate, 57.7% in severe, and 61.9% in all cases. The authors found a 9-fold decrease (P = .046) in the success of tigecycline treatment among those who developed moderate or severe DFIs and a 6.4-fold decrease (P < .0001) among those who had arterial stenosis. For 33 (71.7%) of 46 (43.8%) patients who experienced a side effect, tigecycline treatment was continued as it could be tolerated., Conclusions: If tigecycline is to be the treatment choice, extra attention must be paid to patients with arterial stenosis, severe DFIs, and side effects. The common disadvantage is the high side effect rate, especially nausea. However, it is generally not necessary to discontinue the medication in cases with nausea. Therefore, tigecycline may be used as a choice of therapy in mild DFIs.
- Published
- 2017
48. [The comparison of microscopy and real time polymerase chain reaction methods for the diagnosis of Pneumocystis Jirovecii pneumonia: evaluation of clinical parameters].
- Author
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Töz S, Gündüz C, Tetik A, Taşbakan M, Pullukçu H, Bacakoğlu F, Taşbakan MS, Gülen F, Ünver A, and Turgay N
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Pneumonia, Pneumocystis diagnosis, Retrospective Studies, Turkey, Bronchoalveolar Lavage Fluid microbiology, Pneumocystis carinii isolation & purification, Pneumonia, Pneumocystis microbiology, Real-Time Polymerase Chain Reaction methods
- Abstract
Introduction: Pneumocystis jirovecii pneumonia (PCP) causes serious infections, especially in patients with immunosuppressive diseases. In this study, it was aimed to evaluate the results of samples obtained from PCP suspected patients using two different methods together with clinical data., Materials and Methods: Microscopy and real time polymerase chain reaction (real time PCR) methods were performed with bronchoalveolar lavage (BAL) samples sended to Ege University Medical Faculty Direct Parasitology Diagnostic Laboratory between March 2009 and June 2010. Demographic characteristics, clinical and laboratory data were also recorded retrospectively. The data were evaluated using the SPSS 16.0 program., Result: A total of 42 BAL samples collected from patients (24 males, mean age: 31.49 ± 26.14) were included. There were totally 16 P. jirovecii positives either one of the tests. Sixteen and three samples were detected positive by real time PCR and microscopy, respectively. Trimethoprim-sulfamethoxazole was prescribed in 11 PCP diagnosed cases and 6 of them died., Conclusions: Today, despite the growing opportunities in diagnosis and treatment, PCP pneumonia is associated with high mortality. Careful examination of clinical data and immune status of the patients are important. Multidisciplinary approach is required for early PCP diagnosis.
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- 2017
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- View/download PDF
49. Antibacterial resistance patterns and incidence of hospital-acquired Staphylococcus aureus bacteremia in a tertiary care educational hospital in Turkey: a perspective from 2001 to 2013
- Author
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Sipahi OR, Uysal S, Aydemir SŞ, Pullukçu H, Taşbakan M, Tünger A, Çilli FF, Yamazhan T, Arda B, Sipahi H, and Ulusoy S
- Abstract
Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB. Results: The methicillin-resistant S. aureus (MRSA) rate in 2001 was 73.8% whereas it was 36.2% in 2013. When the 2001-2003 and 2011?2013 periods were compared, resistance to oxacillin, levofloxacin, gentamicin, erythromycin, and clindamycin decreased significantly (P < 0.05). When we evaluated the total S. aureus, MRSA, and methicillin-sensitive S. aureus (MSSA) bacteremia rates per 1000 days and 1000 patients, there was an increase in the 2004?2005 period, which was followed by a slight decrease until 2013 (P < 0.05). There was a plateau in MCNB-related S. aureus rates between 2008 and 2011. Conclusion: There was a decrease in overall S. aureus and MRSA bacteremia incidence as well as MRSA rates except for a plateau between 2008 and 2011. This steady decrease in the resistance rates is most probably due to the 2003 budget application and application of antimicrobial stewardship.
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- 2017
- Full Text
- View/download PDF
50. Screening of immunocompromised patients at risk of strongyloidiasis in western Turkey using ELISA and real-time PCR.
- Author
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Erdem Kivrak E, Atalay Şahar E, Can H, Döşkaya M, Yilmaz M, Pullukçu H, Caner A, Töz H, Gürüz AY, and Işikgöz Taşbakan M
- Subjects
- Animals, Antibodies, Helminth blood, Cohort Studies, Graft Rejection drug therapy, Graft Rejection prevention & control, Humans, Immunosuppressive Agents therapeutic use, Kidney Failure, Chronic, Kidney Transplantation, Strongyloides genetics, Strongyloides immunology, Turkey, Enzyme-Linked Immunosorbent Assay methods, Immunocompromised Host, Immunosuppressive Agents adverse effects, Real-Time Polymerase Chain Reaction methods, Strongyloidiasis diagnosis
- Abstract
Background/aim: Strongyloides stercoralis causes life-threatening hyperinfection or disseminated strongyloidiasis in immunocompromised patients such as HIV-positive, organ transplantation, and cancer patients. This study investigated the presence of strongyloidiasis in immunocompromised patients for the first time in Turkey., Materials and Methods: Serum and stool samples were collected from 108 patients (25.9% of them were chronic renal failure and 74.1% were renal transplantation patients) who were admitted to Ege University Medical School in İzmir, located in western Turkey. Serum samples were analyzed by ELISA (DRG, Germany) and the presence of 18S rRNA gene of S. stercoralis was detected in stool samples by real-time PCR., Results: The analysis of serum samples showed that only one patient was anti- S. stercoralis IgG antibody and real-time PCR positive (0.92%). The patient was treated twice with albendazole (400 mg/day for 3 days) at 2-week intervals. Follow up real-time PCR was negative and the patient became seronegative 6 months after the initial diagnosis., Conclusion: This screening showed that the prevalence of strongyloidiasis in this small group of patients who were at risk of strongyloidiasis was 0.92%. Overall, the results showed that more systematic studies are required in Turkey to show the prevalence of strongyloidiasis.
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- 2017
- Full Text
- View/download PDF
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