1. Time Relationship between the Occurrence of a Thromboembolic Event and the Diagnosis of Hematological Malignancies.
- Author
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Kępski, Jarosław, Szmit, Sebastian, and Lech-Marańda, Ewa
- Subjects
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THROMBOEMBOLISM risk factors , *RISK assessment , *HEMATOLOGIC malignancies , *RESEARCH funding , *VEINS , *MYELOPROLIFERATIVE neoplasms , *DESCRIPTIVE statistics , *ODDS ratio , *THROMBOEMBOLISM , *LYMPHOBLASTIC leukemia , *CONFIDENCE intervals , *TIME , *DISEASE complications - Abstract
Simple Summary: The development of cancer is associated with coagulation disorders. Blood cancers should be particularly associated with hypercoagulability and thus thromboembolic complications. An essential finding of this study is that arterial thromboembolism (myocardial infarction or stroke) occurs significantly more often than venous thromboembolism (pulmonary embolism or/and thrombosis) preceding the diagnosis of hematological malignancy. Interestingly, venous thromboembolism occurs significantly more often in acute leukemia (myeloid or lymphocytic) and chronic myeloproliferative disease. However, the chance of venous thromboembolism is increased before and after the diagnosis of myeloproliferative disease. More research is needed on the relationship between venous thromboembolism development and myeloproliferative disease progression. Objectives. Venous and arterial thromboembolism (VTE/ATE) often coexist with onco-hematologic diagnosis. This study aimed to assess the time relationship between the diagnosis of VTE/ATE and blood cancers. The second aim was to identify VTE/ATE risk factors related to the type of hematology disease and cardiac history. Methods. A total of 1283 patients underwent cardio-oncology evaluation at the Institute of Hematology and Transfusion Medicine in Warsaw from March 2021 through March 2023 (2 years), and 101 (7.8%) cases were identified with VTE/ATE. Results. ATE compared with VTE significantly occurred more often before the diagnosis and treatment of hematologic malignancy: 33/47 (70.2%) vs. 15/54 (27.8%), p < 0.0001. The risk of a VTE episode is exceptionally high in the first months after the diagnosis of an onco-hematological disease and the initiation of anticancer treatment. The higher frequency of VTE was associated with acute myeloid leukemia (17 cases/270 patients/6.30%/p = 0.055), acute lymphocytic leukemia (7 cases/76 patients/9.21%/p = 0.025), and chronic myeloproliferative disease (7 cases/48 patients/14.58%/p = 0.0003). Only the risk of VTE was significantly increased before (OR = 6.79; 95% CI: 1.85–24.95; p = 0.004) and after diagnosis of myeloproliferative disease (OR = 3.12; 95% CI: 1.06–9.16; p = 0.04). Conclusions. ATEs occur more often than VTE before a diagnosis of blood cancer. The risk of VTE is exceptionally high before and after diagnosis of chronic myeloproliferative disease. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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