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One‐year outcomes of rate versus rhythm control of atrial fibrillation in the Kerala‐AF Registry.
- Source :
- Journal of Arrhythmia; Aug2024, Vol. 40 Issue 4, p822-829, 8p
- Publication Year :
- 2024
-
Abstract
- Background: There is ongoing debate around rate versus rhythm control strategies for managing atrial fibrillation (AF), however, much of the data comes from Western cohorts. Kerala‐AF represents the largest prospective AF cohort study from the Indian subcontinent. Objectives: To compare 12‐month outcomes between rate and rhythm control strategies. Methods: Patients aged ≥18 years with non‐transient AF were recruited from 53 hospitals across Kerala. Patients were stratified by rate or rhythm control. The primary outcome was a composite of all‐cause mortality, arterial thromboembolism, acute coronary syndrome or hospitalization due to heart failure or arrhythmia at 12 months. Secondary outcomes included bleeding events and individual components of the primary. Predictors of the composite outcome were analysed by logistic regression. Results: A total of 2901 patients (mean age 64.6 years, 51% female) were included (2464 rate control, 437 rhythm control). Rates of the primary composite outcome did not differ between groups (29.7% vs 30.0%; p =.955), nor did any component of the primary. Bleeding outcomes were also similar (1.6% vs 1.9%; p =.848). Independent predictors of the primary composite outcome were older age (aOR 1.01; p =.013), BMI <18 (aOR 1.51; p =.025), permanent AF (aOR 0.78; p =.010), HFpEF (aOR 1.40; p =.023), HFrEF (aOR 1.39; p =.004), chronic kidney disease (aOR 1.36; p <.001), and prior thromboembolism (aOR 1.31; p =.014). Conclusion: In the Kerala‐AF registry, 12‐month outcomes did not differ between rate and rhythm control cohorts. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHRONIC kidney failure complications
HEMORRHAGE risk factors
ATRIAL fibrillation treatment
THROMBOEMBOLISM risk factors
ANTICOAGULANTS
DEATH
BODY mass index
VENTRICULAR ejection fraction
T-test (Statistics)
HOSPITAL care
LOGISTIC regression analysis
MAJOR adverse cardiovascular events
FISHER exact test
TREATMENT effectiveness
REPORTING of diseases
HOSPITALS
HEART failure
AGE distribution
DESCRIPTIVE statistics
CHI-squared test
MULTIVARIATE analysis
ACUTE coronary syndrome
ARRHYTHMIA
ODDS ratio
ATRIAL fibrillation
STATISTICS
DATA analysis software
PATIENT aftercare
SENSITIVITY & specificity (Statistics)
DISEASE risk factors
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 18832148
- Volume :
- 40
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Arrhythmia
- Publication Type :
- Academic Journal
- Accession number :
- 178973167
- Full Text :
- https://doi.org/10.1002/joa3.13059