1. Extrapulmonary Pneumocystis carinii infections
- Author
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Jonathan W. M. Gold, Richard J. Cote, Donald Armstrong, Edward E. Telzak, and Suzanne Wise Campbell
- Subjects
Microbiology (medical) ,Adult ,Male ,Opportunistic infection ,Autopsy ,Opportunistic Infections ,Acquired immunodeficiency syndrome (AIDS) ,parasitic diseases ,Pneumocystosis ,Medicine ,Humans ,Sarcoma, Kaposi ,Acquired Immunodeficiency Syndrome ,business.industry ,Pneumocystis ,Pneumonia, Pneumocystis ,bacterial infections and mycoses ,medicine.disease ,respiratory tract diseases ,Pneumonia ,Infectious Diseases ,Pneumocystis carinii ,Mycoses ,Immunology ,Viral disease ,business ,Pentamidine ,medicine.drug - Abstract
A case of disseminated infection with Pneumocystis carinii is presented, and the Englishlanguage literature is reviewed for cases of documented extrapulmonary infection with this organism. In this case- with P. carinii diffusely replacing the bone marrow and causing hepatic, adrenal, and glomerular tuft necrosis - the clinical illness and multiple-organ dysfunction attributed to disseminated P carinii were more severe than had previously been described. Because the rate of extrapulmonary R carinii infection found at autopsy in patients with AIDS is at least 2.5% at our institution, we caution against the routine use of aerosol rather than parenteral pentamidine for treatment of P carinii pneumonia until additional data are available. Pneumocystis carinii is the most common agent causing opportunistic infection in patients with AIDS. Over 60% of patients with AIDS reported to the Centers for Disease Control have presented with P carinii pneumonia (PCP) as their initial op
- Published
- 1990