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329 results on '"Sun, Liming"'

1. Attainability of the best constant of Hardy-Sobolev inequality with full boundary singularities

Author

Sun, Liming and Wang, Lei

Subjects
Mathematics - Analysis of PDEs, 35A23, 35B09, 35B44, 35J75, 35J91
Abstract

We consider a type of Hardy-Sobolev inequality, whose weight function is singular on the whole domain boundary. We are concerned with the attainability of the best constant of such inequality. In dimension two, we link the inequality to a conformally invariant one using the conformal radius of the domain. The best constant of such inequality on a smooth bounded domain is achieved if and only if the domain is non-convex. In higher dimensions, the best constant is achieved if the domain has negative mean curvature somewhere. If the mean curvature vanishes but is non-umbilic somewhere, we also establish the attainability for some special cases. In the other direction, we also show the best constant is not achieved if the domain is sufficiently close to a ball in $C^2$ sense., Comment: 42 pages

Published
2024

2. Continuous and low-carbon production of biomass flash graphene

Author

Zhu, Xiangdong, Lin, Litao, Pang, Mingyue, Jia, Chao, Xia, Longlong, Shi, Guosheng, Zhang, Shicheng, Lu, Yuanda, Sun, Liming, Yu, Fengbo, Gao, Jie, He, Zhelin, Wu, Xuan, Li, Aodi, Wang, Liang, Wang, Meiling, Cao, Kai, Fu, Weiguo, Chen, Huakui, Li, Gang, Zhang, Jiabao, Wang, Yujun, Yang, Yi, and Zhu, Yong-Guan

Published
2024
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3. Recent Advance in Surface Modification for Proton Exchange Membrance Fuel Cell Metal Bipolar Plate

Author

SUN Deen, ZHENG Jia, ZHANG Jian, CHEN Hai, SUN Liming

Subjects
pemfc, metal bipolar plate, surface modification, corrosion resistance, contact resistance, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

Proton Exchange Membrane Fuel Cell(PEMFC) provide an innovative solution for mitigating the global energy crisis and addressing environmental challenges. In PEMFC, bipolar plates have attracted much attention as key components. Among them, metal bipolar plates have attracted much attention due to their low cost, easy material acquisition, excellent conductivity and ease of mechanical processing. However, metal bipolar plates still face challenges in terms of durability and conductivity. To address these issues, surface modified coatings are commonly used to treat metal bipolar plates. In this work, the research progress on surface modified coatings for metal bipolar plates in recent years was reviewed, which included multiple aspects such as material design, deposition processes and coating properties. On this basis, the influence of different coatings on the surface modification effect of metal bipolar plates was analyzed based on test results such as conductivity, corrosion resistance, film substrate bonding strength and hydrophobicity. Meanwhile, the future research trends of various types of modified coatings were discussed. These research results provided useful guidance and inspiration for improving the performance of metal bipolar plates and further promoting the development of PEMFC surface modification technology.

Published
2024
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4. PRMT5-mediated FUBP1 methylation accelerates prostate cancer progression

Author

Yan, Weiwei, Liu, Xun, Qiu, Xuefeng, Zhang, Xuebin, Chen, Jiahui, Xiao, Kai, Wu, Ping, Peng, Chao, Hu, Xiaolin, Wang, Zengming, Qin, Jun, Sun, Liming, Chen, Luonan, Wu, Denglong, Huang, Shengsong, Yin, Lichen, and Li, Zhenfei

Subjects
Binding proteins -- Health aspects, Medical research, Medicine, Experimental, Methylation -- Health aspects, Prostate cancer -- Physiological aspects -- Development and progression, Methyltransferases -- Health aspects
Abstract

Strategies beyond hormone-related therapy need to be developed to improve prostate cancer mortality. Here, we show that FUBP1 and its methylation were essential for prostate cancer progression, and a competitive peptide interfering with FUBP1 methylation suppressed the development of prostate cancer. FUBP1 accelerated prostate cancer development in various preclinical models. PRMT5-mediated FUBP1 methylation, regulated by BRD4, was crucial for its oncogenic effect and correlated with earlier biochemical recurrence in our patient cohort. Suppressed prostate cancer progression was observed in various genetic mouse models expressing the FUBP1 mutant deficient in PRMT5-mediated methylation. A competitive peptide, which was delivered through nanocomplexes, disrupted the interaction of FUBP1 with PRMT5, blocked FUBP1 methylation, and inhibited prostate cancer development in various preclinical models. Overall, our findings suggest that targeting FUBP1 methylation provides a potential therapeutic strategy for prostate cancer management., Introduction Prostate cancer is a major global health care challenge (1, 2). Androgens from the testis and the adrenal gland bind to androgen receptor (AR) to activate AR signaling and [...]

Published
2024
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5. Remarks on extremals of sharp Sobolev trace inequalities on the unit balls

Author

Ndiaye, Cheikh Birahim and Sun, Liming

Subjects
Mathematics - Analysis of PDEs, 35J40
Abstract

We show explicit forms for extremals of some fourth-order sharp trace inequalities on the unit balls recently proved by Ache-Chang. We also give a classification result of the bi-harmonic equation on $\mathbb{R}^4_+$ with some conformally covariant boundary conditions., Comment: All comments are welcome

Published
2022

6. A slow blow up solution for the four dimensional energy critical semi linear heat equation

Author

Li, Tongtong, Sun, Liming, and Wang, Shumao

Subjects
Mathematics - Analysis of PDEs
Abstract

We consider the energy critical four dimensional semi-linear heat equation \[ \partial_{t}v-\Delta v-v^{3}=0, \quad(t,x)\in \mathbb{R}\times \mathbb{R}^4. \] Formal computation of Filippas et al. (R. Soc. Lond. Proc. 2000) conjectures the existence of a sequence of type II blow-up solutions with various blow-up rates \[ \|v(t)\|_{L^\infty(\mathbb{R}^4)}\approx \frac{|\log(T-t)|^{\frac{2L}{2L-1}}}{(T-t)^L} ,\quad L=1,2,\cdots.\] Schweyer (J. Funct. Anal. 2012) rigorously constructs a type II blow-up solution for the case $L=1$. In this paper, we show the existence of type II blow-up solution for $L=2$. The method here could be generalized to deal with all the cases $L\geq 2$., Comment: All comments are welcome!

Published
2022

11. Quantitative stability of harmonic maps from $\mathbb{R}^2$ to $\mathbb{S}^2$ with higher degree

Author

Deng, Bin, Sun, Liming, and Wei, Juncheng

Subjects
Mathematics - Analysis of PDEs, Mathematics - Differential Geometry, 58E20, 35B35, 35B38
Abstract

For degree $\pm 1$ harmonic maps from $\mathbb{R}^2$ (or $\mathbb{S}^2$) to $\mathbb{S}^2$, Bernand-Mantel, Muratov and Simon \cite{bernand2021quantitative} recently establish a uniformly quantitative stability estimate. Namely, for any map $u:\mathbb{R}^2\to \mathbb{S}^2$ with degree $\pm 1$, the discrepancy of its Dirichlet energy and $4\pi$ can linearly control the $\dot H^1$-difference of $u$ from the set of degree $\pm 1$ harmonic maps. Whether a similar estimate holds for harmonic maps with higher degree is unknown. In this paper, we prove that a similar quantitative stability result for higher degree is true only in local sense. Namely, given a harmonic map, a similar estimate holds if $u$ is already sufficiently near to it (modulo M\"{o}bius transform) and the bound in general depends on the given harmonic map. More importantly, we investigate an example of degree 2 case thoroughly, which shows that it fails to have a uniformly quantitative estimate like the degree $\pm 1$ case. This phenomenon show the striking difference of degree $\pm1$ ones and higher degree ones. Finally, we also conjecture a new uniformly quantitative stability estimate based on our computation., Comment: comments are welcome. To appear in Cal. Var. PDE

Published
2021
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12. Bubble towers in the ancient solution of energy-critical heat equation

Author

Sun, Liming, Wei, Juncheng, and Zhang, Qidi

Subjects
Mathematics - Analysis of PDEs
Abstract

We construct a radially smooth positive ancient solution for energy critical semi-linear heat equation in $\mathbb{R}^n$, $n\geq 7$. It blows up at the origin with the profile of multiple Talenti bubbles in the backward time infinity., Comment: 45 pages; comments welcome

Published
2021

14. Non-degeneracy and quantitative stability of half-harmonic maps from ${\mathbb R}$ to ${\mathbb S}$

Author

Deng, Bin, Sun, Liming, and Wei, Juncheng

Subjects
Mathematics - Analysis of PDEs, Mathematics - Differential Geometry
Abstract

We consider half-harmonic maps from $\mathbb{R}$ (or $\mathbb{S}$) to $\mathbb{S}$. We prove that all (finite energy) half-harmonic maps are non-degenerate. In other words, they are integrable critical points of the energy functional. A full description of the kernel of the linearized operator around each half-harmonic map is given. The second part of this paper devotes to studying the quantitative stability of half-harmonic maps. When its degree is $\pm 1$, we prove that the deviation of any map $\boldsymbol{u}:\mathbb{R}\to \mathbb{S}$ from M\"obius transformations can be controlled uniformly by $\|\boldsymbol{u}\|_{\dot H^{1/2}(\mathbb{R})}^2-deg \boldsymbol{u}$. This result resembles the quantitative rigidity estimate of degree $\pm 1$ harmonic maps $\mathbb{R}^2\to \mathbb{S}^2$ which is proved recently. Furthermore, we address the quantitative stability for half-harmonic maps of higher degree. We prove that if $\boldsymbol{u}$ is already near to a Blaschke product, then the deviation of $\boldsymbol{u}$ to Blaschke products can be controlled by $\|\boldsymbol{u}\|_{\dot H^{1/2}(\mathbb{R})}^2-deg \boldsymbol{u}$. Additionally, a striking example is given to show that such quantitative estimate can not be true uniformly for all $\boldsymbol{u}$ of degree 2. We conjecture similar things happen for harmonic maps ${\mathbb R}^2\to {\mathbb S}^2$., Comment: 36 pages; comments welcome

Published
2021

17. Sharp quantitative estimates of Struwe's Decomposition

Author

Deng, Bin, Sun, Liming, and Wei, Juncheng

Subjects
Mathematics - Analysis of PDEs, Mathematics - Differential Geometry
Abstract

Suppose $u\in \dot{H}^1(\mathbb{R}^n)$. In a seminal work, Struwe proved that if $u\geq 0$ and $\|\Delta u+u^{\frac{n+2}{n-2}}\|_{H^{-1}}:=\Gamma(u)\to 0$ then $dist(u,\mathcal{T})\to 0$, where $dist(u,\mathcal{T})$ denotes the $\dot{H}^1(\mathbb{R}^n)$-distance of $u$ from the manifold of sums of Talenti bubbles. Ciraolo, Figalli and Maggi obtained the first quantitative version of Struwe's decomposition with one bubble in all dimensions, namely $\delta (u) \leq C \Gamma (u)$. For Struwe's decomposition with two or more bubbles, Figalli and Glaudo showed a striking dimensional dependent quantitative estimate, namely $\delta(u)\leq C \Gamma(u)$ when $3\leq n\leq 5$ while this is false for $ n\geq 6$. In this paper, we show that \[dist (u,\mathcal{T})\leq C\begin{cases} \Gamma(u)\left|\log \Gamma(u)\right|^{\frac{1}{2}}\quad&\text{if }n=6, |\Gamma(u)|^{\frac{n+2}{2(n-2)}}\quad&\text{if }n\geq 7.\end{cases}\] Furthermore, we show that this inequality is sharp., Comment: 49 pages; comments are welcome

Published
2021

18. Classification of ancient flows by sub-affine-critical powers of curvature in $\mathbb{R}^2$

Author

Choi, Kyeongsu and Sun, Liming

Subjects
Mathematics - Differential Geometry, Mathematics - Analysis of PDEs, 53C44, 53A04
Abstract

We classify closed convex $\alpha$-curve shortening flows for sub-affine-critical powers $\alpha \leq \frac{1}{3}$. In addition, we show that closed convex smooth finite entropy $\alpha$-curve shortening flows with $\frac{1}{3}<\alpha$ is a shrinking circle. After normalization, the ancient flows satisfying the above conditions converge exponentially fast to smooth closed convex shrinkers at the backward infinity. In particular, when $\alpha=\frac{1}{k^2-1}$ with $3\leq k \in \mathbb{N}$, the round circle shrinker has non-trivial Jacobi fields, but the ancient flows do not evolve along the Jacobi fields.

Published
2020

19. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Published
2023
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20. Ancient finite entropy flows by powers of curvature in $\mathbb{R}^2$

Author

Choi, Kyeongsu and Sun, Liming

Subjects
Mathematics - Differential Geometry, 53C44, 53A04
Abstract

We show the existence of non-homothetic ancient flows by powers of curvature embedded in $\mathbb{R}^2$ whose entropy is finite. We determine the Morse indices and kernels of the linearized operator of shrinkers to the flows and construct ancient flows by using unstable eigenfunctions of the linearized operator., Comment: Minor changes in some paragraphs. We add several new references in this version

Published
2020

21. Uniformization Theorems: Between Yamabe and Paneitz

Author

Ndiaye, Cheikh Birahim, Sire, Yannick, and Sun, Liming

Subjects
Mathematics - Analysis of PDEs
Abstract

This paper is devoted to several existence results for a generalized version of the Yamabe problem. First, we prove the remaining global cases for the range of powers $\gamma\in (0,1)$ for the generalized Yamabe problem introduced by Gonzalez and Qing. Second, building on a new approach by Case and Chang for this problem, we prove that this Yamabe problem is solvable in the Poincar\'{e}-Einstein case for $\gamma\in (1,\min\{2,n/2\})$ provided the associated fractional GJMS operator satisfies the strong maximum principle.

Published
2019

22. Divergent operator with degeneracy and related sharp inequalities

Author

Dou, Jingbo, Sun, Liming, Wang, Lei, and Zhu, Meijun

Subjects
Mathematics - Analysis of PDEs, 35A23, 35J70, 35B06, 35B65, 30C70
Abstract

In this paper we classify all positive extremal functions to a sharp weighted Sobolev inequality on the upper half space, which involves divergent operators with degeneracy on the boundary. As an application of the results, we can derive a sharp Sobolev type inequality involving Baouendi-Grushin operator, and classify certain extremal functions for all $\tau>0$ and $m\ne2 $ or $ n\ne1$., Comment: In the latest revision, we polished our writing and made some minor corrections

Published
2019

23. Convexity of constant mean curvature graphs in $\mathbb{R}^{n+1}$ with planar boundary

Author

Spruck, Joel and Sun, Liming

Subjects
Mathematics - Differential Geometry, Mathematics - Analysis of PDEs, Primary: 53A10, 35E10, Secondary: 35J60, 35J25
Abstract

We study the Dirichlet problem for a graph $\Sigma$ in $\mathbb{R}^{n+1}$ with normalized constant mean curvature $H>0$ and planar boundary $\Gamma=\partial \Omega$. Our main result is that the optimal solvability condition, namely that the normalized mean curvature $h$ of $\Gamma$ satisfies $h\geq H$, also suffices when $\Omega$ is strictly convex, to prove the strict convexity of $\Sigma$., Comment: Need to fix some error in the paper. In the last step of the proof, the hypersurface of the minimal principle curvature equal to zero may be tangent to the boundary of the domain

Published
2019

24. Convexity of 2-convex translating solitons to the mean curvature flow in $\mathbb{R}^{n+1}$

Author

Spruck, Joel and Sun, Liming

Subjects
Mathematics - Differential Geometry
Abstract

We prove that any complete immersed globally orientable uniformly 2-convex translating soliton $\Sigma \subset \mathbb{R}^{n+1}$ for the mean curvature flow is locally strictly convex. It follows that a uniformly 2-convex entire graphical translating soliton in $\mathbb{R}^{n+1},\, n\geq 3 $ is the axisymmetric "bowl soliton"., Comment: To be published on the Journal of Geometric Analysis

Published
2019
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25. The research framework and main topics of the modernization of national mineral resources security strategic management driven by big data

Author

PENG Zhongyi, SUN Liming

Subjects
big data, mineral resources security, strategic management, modernization, research framework, main topics, Environmental sciences, GE1-350, Biology (General), QH301-705.5
Abstract

[Objective] This study aims to explore the internal mechanism of big data-driven modernization of national mineral resource security strategic management, and provide reference for promoting the modernization of China’s mineral resource security strategic management. [Methods] Based on the status quo of global mineral resource security strategy development and management, this paper reveals the situation of China’s mineral resources security, challenges and problems in strategic management. sorting out the theory and practice of big data applied in the field of mineral resource security management, systematically discussing the feasibility, internal logic, basic issues and research framework of the modernization of national mineral resource security strategic management driven by big data driving, and proposing main research topics. [Results] The technology, policy and experience of big data applied to government management are becoming mature, and the data foundation of mineral resource security is sound. It is feasible for big data to drive the modernization of national mineral resources security strategy management. Big data-driven national mineral resource security strategic management can effectively promote the diversification of mineral resource security strategic management subjects, scientific and precise decision-making, synergy of early warning and disposal, and systematically solve the practical problems of China’s mineral resource security strategic management. Using big data to drive the modernization of the national mineral resources security strategy management, the core is to solve the two basic problems of “creating” big data and “using” big data. The research framework can be constructed from three levels of "theoretical analysis-technical operation-countermeasure design. [Conclusion] The research on the modernization of national mineral resources security strategic management driven by big data can be further carried out from the direction of consolidating the foundation of big data, building a new decision-making system, reengineering systems and mechanisms, and improving the policy system.

Published
2023
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26. Convergence of the fractional Yamabe flow for a class of initial data

Author

Chan, Hardy, Sire, Yannick, and Sun, Liming

Subjects
Mathematics - Analysis of PDEs
Abstract

This work is a follow-up on the work of the second author with P. Daskalopoulos and J.L. V\'{a}zquez. In this latter work, we introduced the Yamabe flow associated to the so-called fractional curvature and prove some existence result of mild (semi-group) solutions. In the present work, we continue this study by proving that for some class of data one can prove actually convergence of the flow in a more general context. We build on the approach simplified in the book of M. Struwe.

Published
2018
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27. The Han-Li conjecture in constant scalar curvature and constant boundary mean curvature problem on compact manifolds

Author

Chen, Xuezhang, Ruan, Yuping, and Sun, Liming

Subjects
Mathematics - Differential Geometry, Mathematics - Analysis of PDEs
Abstract

The Han-Li conjecture states that: Let $(M,g_0)$ be an $n$-dimensional $(n\geq 3)$ smooth compact Riemannian manifold with boundary having positive (generalized) Yamabe constant and $c$ be any real number, then there exists a conformal metric of $g_0$ with scalar curvature $1$ and boundary mean curvature $c$. Combining with Z. C. Han and Y. Y. Li's results, we answer this conjecture affirmatively except for the case that $n\geq 8$, the boundary is umbilic, the Weyl tensor of $M$ vanishes on the boundary and has a non-zero interior point.

Published
2018

32. Existence of conformal metrics with constant scalar curvature and constant boundary mean curvature on compact manifolds

Author

Chen, Xuezhang and Sun, Liming

Subjects
Mathematics - Differential Geometry, Mathematics - Analysis of PDEs, Primary 53C21, 35J65, Secondary 58J05, 35J20
Abstract

We study the problem of deforming a Riemannian metric to a conformal one with nonzero constant scalar curvature and nonzero constant boundary mean curvature on a compact manifold of dimension $n\geq 3$. We prove the existence of such conformal metrics in the cases of $n=6,7$ or the manifold is spin and some other remaining ones left by Escobar. Furthermore, in the positive Yamabe constant case, by normalizing the scalar curvature to be $1$, there exists a sequence of conformal metrics such that their constant boundary mean curvatures go to $+\infty$., Comment: to appear in Comm. Contem. Math

Published
2016

33. Prescribed scalar curvature plus mean curvature flows in compact manifolds with boundary of negative conformal invariant

Author

Chen, Xuezhang, Ho, Pak Tung, and Sun, Liming

Subjects
Mathematics - Differential Geometry, Mathematics - Analysis of PDEs
Abstract

We employ three different methods to prove the following result on prescribed scalar curvature plus mean curvature problem: Let $(M^n,g_0)$ be a $n$-dimensional smooth compact manifold with boundary, where $n \geq 3$, assume the conformal invariant $Y(M,\partial M)<0$. Given any negative smooth functions $f$ in $M$ and $h$ on $\partial M$, there exists a unique conformal metric of $g_0$ such that its scalar curvature equals $f$ and mean curvature curvature equals $h$. The first two methods are sub-super-solution method and subcritical approximation, and the third method is a geometric flow. In the flow approach, assume another conformal invariant $Q(M,\pa M)$ is a negative real number, for some class of initial data, we prove the short time and long time existences of the so-called prescribed scalar curvature plus mean curvature flows, as well as their asymptotic convergence. Via a family of such flows together with some additional variational arguments, under the flow assumptions we prove existence and uniqueness of positive minimizers of the associated energy functional and also the above result by analyzing asymptotic limits of the flows and the relations among some conformal invariants., Comment: Theorem 1.1 improved, one reference added, typos fixed

Published
2016
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34. Convergence of the Yamabe flow on manifolds with minimal boundary

Author

Almaraz, Sergio and Sun, Liming

Subjects
Mathematics - Differential Geometry, 53C44, 53C21, 53C25
Abstract

We study the Yamabe flow on compact Riemannian manifolds of dimensions greater than two with minimal boundary. Convergence to a metric with constant scalar curvature and minimal boundary is established in dimensions up to seven, and in any dimensions if the manifold is spin., Comment: Final version. Accepted to Annali della Scuola Normale Superiore di Pisa (Classe di Scienze). arXiv admin note: text overlap with arXiv:1206.1184"

Published
2016
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35. Classification theorems for solutions of higher order boundary conformally invariant problems, I

Author

Sun, Liming and Xiong, Jingang

Subjects
Mathematics - Analysis of PDEs, Mathematics - Differential Geometry
Abstract

In this paper, we prove that nonnegative polyharmonic functions on the upper half space satisfying a conformally invariant nonlinear boundary condition have to be the "\emph{polynomials} plus \emph{bubbles}" form. The nonlinear problem is motivated by the recent studies of boundary GJMS operators and the $Q$-curvature in conformal geometry. The result implies that in the conformal class of the unit Euclidean ball there exist metrics with a single singular boundary point which have flat $Q$-curvature and constant boundary $Q$-curvature. Moreover, all of such metrics are classified. This phenomenon differs from that of boundary singular metrics which have flat scalar curvature and constant mean curvature, where the singular set contains at least two points. A crucial ingredient of the proof is developing an approach to separate the higher order linear effect and the boundary nonlinear effect so that the kernels of the nonlinear problem are captured., Comment: fixed grammar errors; to be in J. Funct. Anal

Published
2016

50. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Associazione Italiana per la Ricerca sul Cancro, Italian Institute for Genomic Medicine, Compagnia di San Paolo, Vitale, Ilio [0000-0002-5918-1841], Pietrocola, Federico [0000-0002-2930-234X], Guilbaud, Emma [0000-0001-5261-1944], Aaronson, Stuart A. [0000-0002-4643-0474], Dieter, Adam [0000-0002-5668-5032], Agostini, Massimiliano [0000-0003-3124-2072], Agostinis, Patrizia [0000-0003-1314-2115], Alnemri, Emad S. [0000-0002-7295-3383], Altucci, Lucia [0000-0002-7312-5387], Amelio, Ivano [0000-0002-9126-5391], Andrews, David W. [0000-0002-9266-7157], Aqeilan, Rami I. [0000-0002-6034-023X], Arama, Eli [0000-0001-5953-0629], Balachandran, Siddharth [0000-0003-2084-1803], Bano, Daniele [0000-0002-9617-5504], Bartek, Jiri [0000-0003-2013-7525], Bazan, Nicolas G. [0000-0002-9243-5444], Bernassola, Francesca [0000-0002-8883-8654], Bertrand, Mathieu J. M. [0000-0001-9000-0626], Bianchi, Marco Emilio [0000-0002-5329-6445], Blander, J. Magarian [0000-0001-9207-1700], Blandino, Giovanni [0000-0002-6970-2241], Blomgren, Klas [0000-0002-0476-7271], Bortner, Carl D. [0000-0002-5444-6628], Bove, Pierluigi [0000-0002-4788-2982], Boya, Patricia [0000-0003-3045-951X], Broz, Petr [0000-0002-2334-7790], Damgaard, Rune Busk [0000-0002-1709-6534], Calin, George A. [0000-0002-7427-0578], Campanella, Michelangelo [0000-0002-6948-4184], Candi, Eleonora [0000-0001-8332-4825], Carbone, Michele [0000-0001-8928-8474], Carmona-Gutierrez, Didac [0000-0001-7548-7771], Cecconi, Francesco [0000-0002-5614-4359], Chen, Guo‑Qiang [0000-0002-7226-1782], Cheng, Emily H. [0000-0002-3595-2648], Chipuk, Jerry E. [0000-0002-1337-842X], Cidlowski, John A. [0000-0003-1420-0516], Ciechanover, Aaron [0000-0001-9184-8944], Ciliberto, Gennaro [0000-0003-2851-8605], Conrad, Marcus [0000-0003-1140-5612], Czabotar, Peter E. [0000-0002-2594-496X], D’Angiolella, Vincenzo [0000-0001-8365-9094], Daugaard, Mads [0000-0001-8383-055X], Dawson, Valina L. [0000-0002-2915-3970], De Maria, Ruggero [0000-0003-2255-0583], Debatin, Klaus-Michael [0000-0002-8397-1886], Deberardinis, Ralph J. [0000-0002-2705-7432], Degterev, Alexei [0000-0002-8240-7132], Del Sal, Giannino [0000-0003-2185-6003], Deshmukh, Mohanish [0000-0002-2597-5862], Di Virgilio, Francesco [0000-0003-3566-1362], Diederich, Marc [0000-0003-0115-4725], Dixon, Scott J. [0000-0001-6230-8199], El-Deiry, Wafik S. [0000-0002-9577-8266], Elrod, John W. [0000-0003-3925-2224], Engeland, Kurt [0000-0003-3525-0440], Fimia, Gian María [0000-0003-4438-3325], Ganini, Carlo [0000-0002-5839-3965], García-Sáez, Ana J. [0000-0002-3894-5945], Garg, Abhishek D. [0000-0002-9976-9922], Garrido, Carmen [0000-0003-1368-1493], Gavathiotis, Evripidis [0000-0001-6319-8331], Ghosh, Sourav [0000-0001-5990-8708], Green, Douglas R. [0000-0002-7332-1417], Gronemeyer, Hinrich [0000-0001-9454-2449}, Häcker, Georg [0000-0003-1058-5746], Hajnóczky, György [0000-0003-3813-2570], Hardwick, J. Marie [0000-0002-4847-2045], Haupt, Ygal [0000-0001-5925-0096], He, Sudan [0000-0002-0846-1210], Heery, David M. [0000-0002-5035-2392], Hengartner, Michael O. [0000-0002-7584-596X], Hetz, Claudio [0000-0003-1120-7966], Hildeman, David A. [0000-0002-0421-8483], Ichijo, Hidenori [0000-0002-5005-6438], Jäättelä, Marja [0000-0001-5950-7111], Janic, Ana [0000-0002-4200-2560], Joseph, Bertrand [0000-0001-5655-9979], Jost, Philipp J. [0000-0003-2454-0362], Kanneganti, Thirumala-Devi [0000-0002-6395-6443], Karin, Michael [0000-0002-2758-6473], Kashkar, Hamid [0000-0003-2796-1429], Kaufmann, Thomas [0000-0001-9906-874X], Kelly, Gemma L. [0000-0002-6533-1201], Kepp, Oliver [0000-0002-6081-9558], Kimchi, Adi [0000-0002-8236-8989], Klionsky, Daniel J. [0000-0002-7828-8118], Kluck, Ruth [0000-0002-7101-1925], Krysko, Dmitri V. [0000-0002-9692-2047], Kulms, Dagmar [0000-0001-6874-0548], Kumar, Sharad [0000-0001-7126-9814], Lavandero, Sergio [0000-0003-4258-1483], Lavrik, Inna N. [0000-0002-9324-309X], Liccardi, Gianmaria [0000-0002-2662-1281], Linkermann, Andreas [0000-0001-6287-9725], Lipton, Stuart A. [0000-0002-3490-1259], Lockshin, Richard A. [0000-0002-4389-4898], López-Otín, Carlos [0000-0001-6964-1904], Luedde, Tom [0000-0002-6288-8821], MacFarlane, Marion [0000-0001-7886-1159], Madeo, Frank [0000-0002-5070-1329], Malorni, Walter [0000-0002-1223-7000], Manic, Gwenola [0000-0003-3759-8029], Marchi, Saverio [0000-0003-2708-1843], Marine, Jean-Christophe [0000-0003-2433-9837], Martin, Seamus J. [0000-0002-8539-3143], Martinou, Jean-Claude [0000-0002-9847-2051], Mastroberardino, Pier G. [0000-0003-2364-4258], Medema, Jan Paul [0000-0003-3045-2924], Mehlen, Patrick [0000-0003-1743-5417], Meier, Pascal [0000-0003-2760-6523], Melino, Gerry [0000-0001-9428-5972], Melino, Sonia [0000-0001-7694-5279], Miao, Edward A. [0000-0001-7295-3490], Moll, Ute M. [0000-0003-1908-7516], Muñoz-Pinedo, Cristina [0000-0002-9120-664X], Murphy, Daniel J. [0000-0002-5538-5468], Niklison-Chirou, Maria Victoria [0000-0002-2147-370X], Novelli, Flavia [0000-0002-3746-7478], Oberst, Andrew [0000-0002-9500-7912], Ofengeim, Dimitry [0000-0003-2348-3642], Opferman, Joseph T. [0000-0002-1147-5621], Oren, Moshe [0000-0003-4311-7172], Pagano, Michele [0000-0003-3210-2442], Panaretakis, Theocharis [0000-0001-5754-6950], Pasparakis, Manolis [0000-0002-9870-0966], Penninger, Josef M. [0000-0002-8194-3777], Pentimalli, Francesca [0000-0003-4740-6801], Pereira, David M. [0000-0003-0384-7592], Pervaiz, Shazib [0000-0002-4738-019X], Peter, Marcus E. [0000-0003-3216-036X], Pinton, Paolo [0000-0001-7108-6508], Porta, Giovanni [0000-0001-5260-2415], Puthalakath, Hamsa [0000-0001-5178-1175], Rabinovich, Gabriel A. [0000-0002-0947-8735], Rajalingam, Krishnaraj [0000-0002-4175-9633], Ravinchandran, Kodi S. [0000-0001-9049-1410], Rehm, Markus [0000-0001-6149-9261], Ricci, Jean-Ehrland [0000-0003-1585-8117], Rizzuto, Rosario [0000-0001-7044-5097], Robinson, Nirmal [0000-0002-7361-9491], Rotblat, Barak [0000-0003-2985-7115], Rothlin, Carla V. [0000-0002-5693-5572], Rubinsztein, David C. [0000-0001-5002-5263], Rufini, Alessandro [0000-0002-5855-655X], Ryan, Kevin M. [0000-0002-1059-9681], Sarosiek, Kristopher A. [0000-0002-4618-5085], Sawa, Akira [0000-0003-1401-3008], Sayan, Emre [0000-0002-5291-1485], Schroder, Kate [0000-0001-9261-3805], Scorrano, Luca [0000-0002-8515-8928], Sesti, Federico [0000-0002-2761-9693], Shi, Yufang [0000-0001-8964-319X], Sica, Giuseppe [0000-0002-7407-0584], Silke, John [0000-0002-7611-5774], Simon, Hans-Uwe [0000-0002-9404-7736], Sistigu, Antonella [0000-0002-2528-1238], Stockwell, Brent R. [0000-0002-3532-3868], Strappazzon, Flavie [0000-0003-0285-7449], Sun, Liming [0000-0002-0136-5605], Sun, Erwei [0000-0001-5664-513X], Szabadkai, G [0000-0002-3006-3577], Tait, Stephen W. G. [0000-0001-7697-132X], Tang, Daolin [0000-0002-1903-6180], Tavernarakis, Nektarios [0000-0002-5253-1466], Turk, Boris [0000-0002-9007-5764], Urbano, Nicoletta [0000-0003-1822-155X], Vandenabeele, Peter [0000-0002-6669-8822], Vanden Berghe, Tom [0000-0002-1633-0974], Vander Heiden, Matthew G. [0000-0002-6702-4192], Vanderluit, Jacqueline L. [0000-0002-4960-920X], Verkhratsky, A. [0000-0003-2592-9898], Villunger, Andreas [0000-0001-8259-4153], Von Karstedt, Silvia [0000-0002-7816-5919], Voss, Anne K. [0000-0002-3853-9381], Vucic, Domagoj [0000-0003-3614-8093], Vuri, Daniela [0000-0001-8693-3845], Wagner, Erwin F. [0000-0001-7872-0196], Walczak, Henning [0000-0002-6312-4591], Wallach, David [0000-0003-2724-9757], Wang, Ruoning [0000-0001-9798-8032], Weber, Achim [0000-0003-0073-3637], Yamazaki, Takahiro [0000-0002-7420-4394], Zakeri, Zahra [0000-0003-4386-8072], Zawacka-Pankau, Joanna E. [0000-0002-7415-2942], Zhivotovsky, Boris [0000-0002-2238-3482], Piacentini, Mauro [0000-0003-2919-1296], Kroemer, Guido [0000-0002-9334-4405], Galluzzi, Lorenzo [0000-0003-2257-8500 ], Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Dieter, Adam, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco Emilio, Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Bomer, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, T., Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chen, Guo‑Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, B., Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian María, Galassi, Claudia, Ganini, Carlo, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravinchandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strappazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, G, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, A., Villunger, Andreas, Von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Zahra, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibin, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo, Associazione Italiana per la Ricerca sul Cancro, Italian Institute for Genomic Medicine, Compagnia di San Paolo, Vitale, Ilio [0000-0002-5918-1841], Pietrocola, Federico [0000-0002-2930-234X], Guilbaud, Emma [0000-0001-5261-1944], Aaronson, Stuart A. [0000-0002-4643-0474], Dieter, Adam [0000-0002-5668-5032], Agostini, Massimiliano [0000-0003-3124-2072], Agostinis, Patrizia [0000-0003-1314-2115], Alnemri, Emad S. [0000-0002-7295-3383], Altucci, Lucia [0000-0002-7312-5387], Amelio, Ivano [0000-0002-9126-5391], Andrews, David W. [0000-0002-9266-7157], Aqeilan, Rami I. [0000-0002-6034-023X], Arama, Eli [0000-0001-5953-0629], Balachandran, Siddharth [0000-0003-2084-1803], Bano, Daniele [0000-0002-9617-5504], Bartek, Jiri [0000-0003-2013-7525], Bazan, Nicolas G. [0000-0002-9243-5444], Bernassola, Francesca [0000-0002-8883-8654], Bertrand, Mathieu J. M. [0000-0001-9000-0626], Bianchi, Marco Emilio [0000-0002-5329-6445], Blander, J. Magarian [0000-0001-9207-1700], Blandino, Giovanni [0000-0002-6970-2241], Blomgren, Klas [0000-0002-0476-7271], Bortner, Carl D. [0000-0002-5444-6628], Bove, Pierluigi [0000-0002-4788-2982], Boya, Patricia [0000-0003-3045-951X], Broz, Petr [0000-0002-2334-7790], Damgaard, Rune Busk [0000-0002-1709-6534], Calin, George A. [0000-0002-7427-0578], Campanella, Michelangelo [0000-0002-6948-4184], Candi, Eleonora [0000-0001-8332-4825], Carbone, Michele [0000-0001-8928-8474], Carmona-Gutierrez, Didac [0000-0001-7548-7771], Cecconi, Francesco [0000-0002-5614-4359], Chen, Guo‑Qiang [0000-0002-7226-1782], Cheng, Emily H. [0000-0002-3595-2648], Chipuk, Jerry E. [0000-0002-1337-842X], Cidlowski, John A. [0000-0003-1420-0516], Ciechanover, Aaron [0000-0001-9184-8944], Ciliberto, Gennaro [0000-0003-2851-8605], Conrad, Marcus [0000-0003-1140-5612], Czabotar, Peter E. [0000-0002-2594-496X], D’Angiolella, Vincenzo [0000-0001-8365-9094], Daugaard, Mads [0000-0001-8383-055X], Dawson, Valina L. [0000-0002-2915-3970], De Maria, Ruggero [0000-0003-2255-0583], Debatin, Klaus-Michael [0000-0002-8397-1886], Deberardinis, Ralph J. [0000-0002-2705-7432], Degterev, Alexei [0000-0002-8240-7132], Del Sal, Giannino [0000-0003-2185-6003], Deshmukh, Mohanish [0000-0002-2597-5862], Di Virgilio, Francesco [0000-0003-3566-1362], Diederich, Marc [0000-0003-0115-4725], Dixon, Scott J. [0000-0001-6230-8199], El-Deiry, Wafik S. [0000-0002-9577-8266], Elrod, John W. [0000-0003-3925-2224], Engeland, Kurt [0000-0003-3525-0440], Fimia, Gian María [0000-0003-4438-3325], Ganini, Carlo [0000-0002-5839-3965], García-Sáez, Ana J. [0000-0002-3894-5945], Garg, Abhishek D. [0000-0002-9976-9922], Garrido, Carmen [0000-0003-1368-1493], Gavathiotis, Evripidis [0000-0001-6319-8331], Ghosh, Sourav [0000-0001-5990-8708], Green, Douglas R. [0000-0002-7332-1417], Gronemeyer, Hinrich [0000-0001-9454-2449}, Häcker, Georg [0000-0003-1058-5746], Hajnóczky, György [0000-0003-3813-2570], Hardwick, J. Marie [0000-0002-4847-2045], Haupt, Ygal [0000-0001-5925-0096], He, Sudan [0000-0002-0846-1210], Heery, David M. [0000-0002-5035-2392], Hengartner, Michael O. [0000-0002-7584-596X], Hetz, Claudio [0000-0003-1120-7966], Hildeman, David A. [0000-0002-0421-8483], Ichijo, Hidenori [0000-0002-5005-6438], Jäättelä, Marja [0000-0001-5950-7111], Janic, Ana [0000-0002-4200-2560], Joseph, Bertrand [0000-0001-5655-9979], Jost, Philipp J. [0000-0003-2454-0362], Kanneganti, Thirumala-Devi [0000-0002-6395-6443], Karin, Michael [0000-0002-2758-6473], Kashkar, Hamid [0000-0003-2796-1429], Kaufmann, Thomas [0000-0001-9906-874X], Kelly, Gemma L. [0000-0002-6533-1201], Kepp, Oliver [0000-0002-6081-9558], Kimchi, Adi [0000-0002-8236-8989], Klionsky, Daniel J. [0000-0002-7828-8118], Kluck, Ruth [0000-0002-7101-1925], Krysko, Dmitri V. [0000-0002-9692-2047], Kulms, Dagmar [0000-0001-6874-0548], Kumar, Sharad [0000-0001-7126-9814], Lavandero, Sergio [0000-0003-4258-1483], Lavrik, Inna N. [0000-0002-9324-309X], Liccardi, Gianmaria [0000-0002-2662-1281], Linkermann, Andreas [0000-0001-6287-9725], Lipton, Stuart A. [0000-0002-3490-1259], Lockshin, Richard A. [0000-0002-4389-4898], López-Otín, Carlos [0000-0001-6964-1904], Luedde, Tom [0000-0002-6288-8821], MacFarlane, Marion [0000-0001-7886-1159], Madeo, Frank [0000-0002-5070-1329], Malorni, Walter [0000-0002-1223-7000], Manic, Gwenola [0000-0003-3759-8029], Marchi, Saverio [0000-0003-2708-1843], Marine, Jean-Christophe [0000-0003-2433-9837], Martin, Seamus J. [0000-0002-8539-3143], Martinou, Jean-Claude [0000-0002-9847-2051], Mastroberardino, Pier G. [0000-0003-2364-4258], Medema, Jan Paul [0000-0003-3045-2924], Mehlen, Patrick [0000-0003-1743-5417], Meier, Pascal [0000-0003-2760-6523], Melino, Gerry [0000-0001-9428-5972], Melino, Sonia [0000-0001-7694-5279], Miao, Edward A. [0000-0001-7295-3490], Moll, Ute M. [0000-0003-1908-7516], Muñoz-Pinedo, Cristina [0000-0002-9120-664X], Murphy, Daniel J. [0000-0002-5538-5468], Niklison-Chirou, Maria Victoria [0000-0002-2147-370X], Novelli, Flavia [0000-0002-3746-7478], Oberst, Andrew [0000-0002-9500-7912], Ofengeim, Dimitry [0000-0003-2348-3642], Opferman, Joseph T. [0000-0002-1147-5621], Oren, Moshe [0000-0003-4311-7172], Pagano, Michele [0000-0003-3210-2442], Panaretakis, Theocharis [0000-0001-5754-6950], Pasparakis, Manolis [0000-0002-9870-0966], Penninger, Josef M. [0000-0002-8194-3777], Pentimalli, Francesca [0000-0003-4740-6801], Pereira, David M. [0000-0003-0384-7592], Pervaiz, Shazib [0000-0002-4738-019X], Peter, Marcus E. [0000-0003-3216-036X], Pinton, Paolo [0000-0001-7108-6508], Porta, Giovanni [0000-0001-5260-2415], Puthalakath, Hamsa [0000-0001-5178-1175], Rabinovich, Gabriel A. [0000-0002-0947-8735], Rajalingam, Krishnaraj [0000-0002-4175-9633], Ravinchandran, Kodi S. [0000-0001-9049-1410], Rehm, Markus [0000-0001-6149-9261], Ricci, Jean-Ehrland [0000-0003-1585-8117], Rizzuto, Rosario [0000-0001-7044-5097], Robinson, Nirmal [0000-0002-7361-9491], Rotblat, Barak [0000-0003-2985-7115], Rothlin, Carla V. [0000-0002-5693-5572], Rubinsztein, David C. [0000-0001-5002-5263], Rufini, Alessandro [0000-0002-5855-655X], Ryan, Kevin M. [0000-0002-1059-9681], Sarosiek, Kristopher A. [0000-0002-4618-5085], Sawa, Akira [0000-0003-1401-3008], Sayan, Emre [0000-0002-5291-1485], Schroder, Kate [0000-0001-9261-3805], Scorrano, Luca [0000-0002-8515-8928], Sesti, Federico [0000-0002-2761-9693], Shi, Yufang [0000-0001-8964-319X], Sica, Giuseppe [0000-0002-7407-0584], Silke, John [0000-0002-7611-5774], Simon, Hans-Uwe [0000-0002-9404-7736], Sistigu, Antonella [0000-0002-2528-1238], Stockwell, Brent R. [0000-0002-3532-3868], Strappazzon, Flavie [0000-0003-0285-7449], Sun, Liming [0000-0002-0136-5605], Sun, Erwei [0000-0001-5664-513X], Szabadkai, G [0000-0002-3006-3577], Tait, Stephen W. G. [0000-0001-7697-132X], Tang, Daolin [0000-0002-1903-6180], Tavernarakis, Nektarios [0000-0002-5253-1466], Turk, Boris [0000-0002-9007-5764], Urbano, Nicoletta [0000-0003-1822-155X], Vandenabeele, Peter [0000-0002-6669-8822], Vanden Berghe, Tom [0000-0002-1633-0974], Vander Heiden, Matthew G. [0000-0002-6702-4192], Vanderluit, Jacqueline L. [0000-0002-4960-920X], Verkhratsky, A. [0000-0003-2592-9898], Villunger, Andreas [0000-0001-8259-4153], Von Karstedt, Silvia [0000-0002-7816-5919], Voss, Anne K. [0000-0002-3853-9381], Vucic, Domagoj [0000-0003-3614-8093], Vuri, Daniela [0000-0001-8693-3845], Wagner, Erwin F. 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G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, A., Villunger, Andreas, Von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Zahra, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibin, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

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