1. Anti-Obesity and Hypolipidemic Effects of a Proprietary Herb and Fiber Combination (S&S PWH) in Rats Fed High-Fat Diets
- Author
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Hye Jin Kim, Gyeong-Min Do, Song-Hae Bok, Mi-Kyung Lee, Su Kyung Shin, Tae Yeul Ha, Seon-Min Jeon, Myung-Sook Choi, and Myoung-Nam Woo
- Subjects
Dietary Fiber ,Male ,medicine.medical_specialty ,Sterol O-acyltransferase ,Medicine (miscellaneous) ,White adipose tissue ,Biology ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Phenols ,Internal medicine ,Adipocyte ,Adipocytes ,medicine ,Animals ,Triglycerides ,Hypolipidemic Agents ,Epididymis ,Nutrition and Dietetics ,medicine.diagnostic_test ,Triglyceride ,Cholesterol ,Cholesterol, HDL ,Lipid metabolism ,Dietary Fats ,Diet ,Rats ,Lipoprotein Lipase ,Endocrinology ,Liver ,chemistry ,Hepatocytes ,Hydroxymethylglutaryl CoA Reductases ,Anti-Obesity Agents ,Plant Preparations ,Lipid profile ,Corn oil ,Phytotherapy ,Sterol O-Acyltransferase - Abstract
The objective of this study was to investigate the effects of S&S PWH, a proprietary herb and fiber combination (Bionutrigen Inc., Daejon, Republic of Korea), on body weight and lipid metabolism in rats fed with a high-fat diet. Three groups of male Sprague-Dawley rats were fed different diets for a 6-week period: normal control diet containing 5% (wt/wt) corn oil (NC group), high-fat diet containing 10% (wt/wt) lard plus 5% (wt/wt) corn oil (HF group), and high-fat diet supplemented with powdered 5% (wt/wt) S&S PWH (S&S PWH group). The body weights and relative weights of the epididymal and perirenal white adipose tissue were significantly lower in the S&S PWH group than in the HF group. S&S PWH supplementation significantly lowered plasma total cholesterol and triglyceride concentrations, whereas it elevated the ratio of high density lipoprotein-cholesterol/total-cholesterol and improved the atherogenic index. The accumulation of hepatic lipid droplets and the epididymal white adipocyte size were less in the S&S PWH group than in the HF group. Hepatic hydroxyl-3-methylglutaryl-coenzyme A reductase and acyl-coenzyme A:cholesterol acyltransferase activities were significantly lower, while adipocyte lipoprotein lipase activity was significantly higher, in the S&S PWH group than in the HF group. These beneficial effects may be due to the combined properties of the phenolic compounds present in high concentrations (1.89 g/100 g) in the S&S PWH. In conclusion, these results suggest that S&S PWH can be considered as an anti-obesity functional formula that is effective for suppressing body weight gain and enhancing lipid profile.
- Published
- 2008