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Naringin Has an Antiatherogenic Effect With the Inhibition of Intercellular Adhesion Molecule-1 in Hypercholesterolemic Rabbits
- Source :
- Journal of Cardiovascular Pharmacology. 38:947-955
- Publication Year :
- 2001
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2001.
-
Abstract
- Naringin, a bioflavonoid found in citrus fruit peel, is known to have an antioxidative effect, but its effect on atherosclerosis has not been studied. This study evaluated the effect of naringin on blood lipid levels and aortic fatty streaks, and its action mechanism in hypercholesterolemic rabbits. Male New Zealand white rabbits were fed a 0.25% cholesterol diet and divided into an untreated group (n = 4), a naringin-treated group (n = 5; 500 mg/kg per day), and a lovastatin-treated group (n = 5; 20 mg/kg per day). After 8 weeks, blood was sampled and analyzed biochemically. Aorta and liver were harvested and examined histologically. Cholesterol level in rabbits fed the 0.25% cholesterol diet reached 17 times normal and decreased in the rabbits fed naringin and lovastatin, whose effects were not statistically significant (p0.05). However, both naringin and lovastatin effectively decreased the area of fatty streak in thoracic aorta on macroscopic analysis (p0.05) and significantly reduced subintimal foam cell infiltration on microscopic morphometry (p0.05). These foam cells were macrophages on immunohistochemical analysis. Naringin treatment inhibited hypercholesterolemia-induced intercellular adhesion molecule-1 (ICAM-1) expression on endothelial cells. Hypercholesterolemia caused fatty liver and elevation of liver enzymes, which was prevented by naringin but not by lovastatin. Naringin significantly reduced fatty streak formation and neointimal macrophage infiltration and also inhibited the expression of ICAM-1 in endothelial cells, suggesting that suppression of ICAM-1 contributed to the antiatherogenic effect. Naringin, unlike lovastatin, has a hepatoprotective action.
- Subjects :
- Male
Time Factors
Antioxidant
Arteriosclerosis
medicine.medical_treatment
Hypercholesterolemia
Flavonoid
Intercellular Adhesion Molecule-1
Blood lipids
Aorta, Thoracic
Pharmacology
chemistry.chemical_compound
medicine
Animals
Lovastatin
Naringin
Triglycerides
Flavonoids
chemistry.chemical_classification
business.industry
Anticholesteremic Agents
Cholesterol, HDL
food and beverages
Immunohistochemistry
Cholesterol
Liver
chemistry
Mechanism of action
Biochemistry
Flavanones
Diet, Atherogenic
Bioflavonoid
Rabbits
Hydroxymethylglutaryl-CoA Reductase Inhibitors
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Foam Cells
medicine.drug
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Pharmacology
- Accession number :
- edsair.doi.dedup.....594e544310d819ef33bfedcf44d1683f