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Trophectoderm (TE) cells are the first differentiating cells in embryo development and have epithelial features. TE cells, which associate with implantation of the blastocyst into the uterine endometrium, contribute to the formation of the placenta. Inner cells mass (ICM) together with TE cells are used for determining embryo quality. The aim of this study was to investigate the role of TE and ICM cells on pregnancy outcome in 5This was a retrospective study using data from all patients who applied for blastocyst transfer IVF between January 2015 and March 2019 at the Reproductive Endocrinology and Infertility Center of Akdeniz University Faculty of Medicine, Department of Obstetrics and Gynecology. ALPHA İstanbul consensus evaluation system was used for grading of the blastocyst. The embryo quality, expansion, ICM and TE morphology of the 5There was a significantly increased risk of preeclampsia (PE) (7.8% vs 1.1%; p=0.041), preterm delivery (PD) (36% vs 17.7%; p=0.037), and antenatal bleeding rates (13.6% vs 5%; p=0.021) in TE-C compared to the TE-A + TE-B blastocysts. Furthermore, a higher rate of obstetric complications was observed in ICM-C compared to ICM-A and B (p=0.003). There was a significant correlation between TE morphology and implantation success, ongoing pregnancy rate, and abortion incidence.These results suggest that TE cell morphology is related to implantation success and pregnancy outcomes, especially in terms of the risk of abortion, PE, PD, and antenatal bleeding. It may be advisable to counsel women concerning possible poor obstetric outcome due to poor ICM quality. Future prospective and controlled studies are needed to clarify this association.

This retrospective cohort study determined the relative efficacy of blastocyst and cleavage-stage transfers in patients with differing numbers of zygotes. A total of 1116 women whose embryo transfers were planned independently of patient characteristics were included. Cleavage-stage (D3) and blastocyst-stage (D5) transfer outcomes were analyzed per number of zygotes. The D5 group included transfer cancellations as the intention-to-treat population. The effect of the embryo transfer date on the clinical outcomes (clinical pregnancy and implantation rates) was analyzed using multivariate logistic regression. Among the patients, 584 and 532 underwent D3 and D5 embryo transfers, respectively. The clinical pregnancy rates were significantly higher in D5 patients with ≥ 6 zygotes (25.7% vs 48.3%). The multivariate logistic regression analysis for clinical pregnancy did not show significant differences between the blastocyst and cleavage-stage transfers in patients with ≤ 5 zygotes (0.874 [0.635-1.204]). Compared to the cleavage-stage, blastocyst-stage transfers for patients with ≥ 6 zygotes resulted in a three-fold increase in clinical pregnancy rates (3.122 [1.797-5.425]). Blastocyst transfers were not inferior to cleavage-stage embryo transfers among patients with few zygotes and were preferable for patients with several zygotes.

Assisted reproduction is presumed to increase monozygotic twin rates, with the possible contribution of laboratory and medical interventions. Monozygotic dichorionic gestations are supposed to originate from the splitting of an embryo during the first four days of development, before blastocyst formation. Single embryo transfers could result in dichorionic pregnancies, currently explained by embryo splitting as described in the worldwide used medical textbooks, or concomitant conception. However, such splitting has never been observed in human in vitro fertilization, and downregulated frozen cycles could also produce multiple gestations. Several models of the possible origins of dichorionicity have been suggested. However, some possible underlying mechanisms observed from assisted reproduction seem to have been overlooked. In this review, we aimed to document the current knowledge, criticize the accepted dogma, and propose new insights into the origin of zygosity and chorionicity.

Purpose This retrospective cohort study determined the relative efficacy of blastocyst and cleavage-stage transfers in patients with differing numbers of zygotes. Methods A total of 1116 women whose embryo transfers were planned independently of patient characteristics were included. Cleavage-stage (D3) and blastocyst-stage (D5) transfer outcomes were analyzed per number of zygotes. The D5 group included transfer cancellations as the intention-to-treat population. The effect of the embryo transfer date on the clinical outcomes (clinical pregnancy and implantation rates) was analyzed using multivariate logistic regression. Results Among the patients, 584 and 532 underwent D3 and D5 embryo transfers, respectively. The clinical pregnancy rates were significantly higher in D5 patients with ≥ 6 zygotes (25.7% vs 48.3%). The multivariate logistic regression analysis for clinical pregnancy did not show significant differences between the blastocyst and cleavage-stage transfers in patients with ≤ 5 zygotes (0.874). Compared to the cleavage-stage, blastocyst-stage transfers for patients with ≥ 6 zygotes resulted in a three-fold increase in clinical pregnancy rates (3.122). Conclusion Blastocyst transfers were not inferior to cleavage-stage embryo transfers among patients with few zygotes and were preferable for patients with several zygotes.

Objective To evaluate whether uterine artery Doppler velocimetry during peak uterine contraction is a useful marker for the prediction of preterm delivery. Methods In this prospective cohort study, 172 patients admitted with preterm (24–35 weeks of gestation) uterine contractions were evaluated by uterine artery Doppler velocimetry during peak uterine contraction and common obstetric measures including the cervical length. For uterine artery Doppler velocimetry, flow velocity waveforms during peak uterine contraction (determined visually from the tocodynamometer) were recorded during three consecutive heart cycles, and the mean uterine artery pulsatility index was calculated. Results During the peak of contraction, the uterine artery pulsatility index was significantly higher in patients who delivered within 7 days than in the patients who did not deliver (p

GİRİŞ ve AMAÇ: Oosit toplama günü semen örneklerinde rastlantısal olarak izole lökospermi saptanan olguların in vitro fertilizasyon / intrasitoplasmik sperm enjeksiyonu (İVF/İCSİ) tedavi sonuçlarını değerlendirmek. YÖNTEM ve GEREÇLER: Akdeniz Üniversitesi Tıp Fakültesi Üremeye Yardımcı Tedavi Merkezi’nde, Ocak 2015 ve Mart 2016 tarihleri arasında, İVF/İCSİ tedavisi uygulanmış hastalara ait bilgiler elektronik veri tabanı kullanılarak gözden geçirildi. Oosit toplama günü yapılan incelemede izole lökospermi (≥1x10(6)/mL) saptanan hastaların (n=70) belirlenmesinin ardından, indeks olguya en yakın dönemde oosit toplama işlemi gerçekleştirilmiş; kadın yaşı, metafaz 2 (M2) oosit ve önceki tedavi sayıları eşleştirilmiş ancak lökospermi saptanmayan (˂1x10(6)/mL) hastalar (n=70) seçilerek kontrol grubu oluşturuldu. Fertilizasyon oranları, embriyo kaliteleri ve gebelik sonuçları gruplar arasında karşılaştırıldı. BULGULAR: Gruplar arasında M2 oosit ve 2-pronuclei ortalamaları benzer bulundu (p>0.05). Ancak fertilizasyon oranının lökospermi grubunda daha düşük olduğu saptandı (%61.4 ve %69.7, p=0.012). Klivaj evresi (2-3. gün) yüksek kalite embriyo sayıları ve fertilize oositten yüksek kalitede klivaj embriyo gelişim oranı benzer bulundu (p>0.05). Hasta başına yüksek kalitede blastokist sayısı ve yüksek kaliteli klivaj evresindeki embriyolardan yine yüksek kaliteli blastokist gelişim oranında istatistiksel farklılık saptanmadı (p>0.05). Buna karşılık, total fertilizasyon başarısızlığının (%14.3 ve %2.9, p=0.016) ve siklus iptallerinin (%34.3 ve %17.1, p=0.020) lökospermi grubunda daha sık olduğu saptandı. Gebelik sonuçları incelendiğinde, kontrol grubunda siklus başına pozitif beta-insan koryonik gonadotropin (β-hCG) oranı daha yüksek bulunmasına karşın (p=0.033), embriyo transferi başına pozitif β-hCG ve klinik gebelik oranlarında gruplar arasında istatistiksel olarak anlamlı fark izlenmedi (p>0.05).TARTIŞMA ve SONUÇ: Lökospermi fertilizasyonu etkileyebileceğinden total fertilizasyon başarısızlığına ve siklus iptallerine neden olabilir. Ancak, fertilizasyonun sağlıklı şekilde gerçekleşmesi halinde embriyo kalitesinin ve gebelik sonuçlarının olumsuz etkilenmediği söylenebilir., INTRODUCTION: To investigate the effect of isolated leukocytospermia detected incidentally at the day of oocyte retrieval on in vitro fertilization / intracytoplasmic sperm injection (IVF/ICSI) treatment outcomes.METHODS: This retrospective study included patients who underwent IVF/ICSI treatment at the Akdeniz University Reproductive Centre between January 2015 and March 2016. The electronical database was screened to identify the patients with isolated leukospermia detected at the day of oocyte retrieval. Seventy patients whose semen samples had leukospermia (≥1x10(6)/mL) were retrospectively matched for women’s age, metaphase 2 (M2) oocytes and previous unsuccessful attempts at IVF with 70 patients without leukospermia (˂1x10(6)/mL). Fertilization rates, embryo qualities and pregnancy outcomes were compared between groups.RESULTS: The number of M2 oocytes and 2-pronuclei were similar between groups (p>0.05). However, fertilization rate was found to be significantly lower in leukospermia group (%61.4 vs. %69.7, p=0.012). The number of high quality embryos as well as developmental rate of high quality embryos from fertilized oocytes and high quality blastocysts from high quality cleavage stage embryos were comparable between groups (p>0.05). Leukospermia group had increased number of patients with total fertilization failure (%14.3 vs. %2.9, p=0.016) and cycle cancelation (%34.3 vs. %17.1, p=0.020) rates. Although positive beta-human chorionic gonadotropin (β-hCG) rate per cycle was higher in the control group (p=0.033), positive β-hCG and clinical pregnancy rates per embryo transfer were found to be comparable between the groups (p>0.05). DISCUSSION AND CONCLUSION: Leukospermia might affect the fertilization and therefore increase total fertilization failures and cycle cancelations. However, if fertilization occurs successfully, this situation might not have adverse effects on embryo development and pregnancy outcomes.

Amaç: Ardışık kültür ortamı ile kesintisiz tek basamaklı kültür ortamının erken dönemde embriyo kaliteleri üzerine olan etkilerini araştırarak, farklı kültür ortamlarında geliştirilmiş embriyoların olası implantasyon potansiyellerini incelemek. Gereç ve yöntem: Akdeniz Üniversitesi Tıp Fakültesi Üremeye Yardımcı Tedavi Merkezi’nde, Aralık 2014 ve Aralık 2015 tarihleri arasında, in vitro fertilizasyon tedavisi uygulanmış hastalara ait bilgiler elektronik veri tabanı kullanılarak incelendi. Ardışık basamaklı kültür medyumu uygulanan hastaların (n=144) belirlenmesinin ardından, her hasta için indeks olguya en yakın dönemde oosit toplama işlemi gerçekleştirilmiş; yaş ve metafaz-2 oosit sayıları eşleşen ancak tek basamaklı embriyo kültür medyumunun kullanıldığı hastalar (n=144) seçildi. Embriyo kaliteleri ve gebelik sonuçları gruplar arasında karşılaştırıldı. Bulgular:Gruplar arasında fertilize oosit, gelişimin 2-3. gününde yüksek kalite embriyo sayıları ile fertilize oositten yüksek kalitede klivaj embriyo gelişiminde istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Ancak, hasta başına yüksek kalitede blastokist sayısının (p=0.048) ve yüksek kaliteli klivaj evresindeki embriyolardan yine yüksek kaliteli blastokist gelişim oranının (p=0.043) tek basamaklı kültür ortamında daha yüksek olduğu bulundu. Benzer şekilde, blastokist transferi yapılan olgular istatistiksel olarak tek basamaklı kültür grubunda daha fazla idi (p˂0.001). Gebelik sonuçları değerlendirildiğinde, embriyo transferi yapılan hastalarda klinik gebelik (p=0.038) oranı tek basamaklı kültür ortamında daha yüksek bulundu. Ancak implantasyon oranında gruplar arasında istatistiksel olarak anlamlı fark izlenmedi (p>0.05). Sonuç: Çalışmamız tek basamaklı medyum uygulamalarıyla ardışık medyum ile benzer oranlarda yüksek kalitede embriyo gelişimi sağlanabileceğini göstermektedir. Ayrıca, blastokist gelişim oranı artarak olası gebelik sonuçlarında iyileşme sağlanabilir. Pam Tıp Derg 2016;9(3):212-218, Purpose: The aim of this study was to investigate the effect of sequential vs. single-step media on early human embryo development and the embryos’ implantation potential. Materials and methods:This retrospective study included patients who underwent in vitro fertilization (IVF) treatment at the Akdeniz University Reproductive Centre between December 2014 and December 2015. The electronical database was screened to identify the type of culture media used for IVF. A hundred forty four women whose embryos were cultured in sequential media were retrospectively matched for age and metaphase-2 oocytes with 144 women whose embryos were cultured in single-step media. Embryo quality and pregnancy outcomes were compared between sequential and single-step media groups. Results: The number of fertilized oocytes, high quality embryos on day 2-3 and developmental rate of high quality embryos from fertilized oocytes were found to be comparable between the groups (p>0.05). However, the number of high quality blastocysts (p=0.048) and developmental rate of high quality blastocysts from high quality cleavage stage embryos (p=0.043) were significantly higher in single-step media group. Subsequently, singlestep media group had more embryos transferred at blastocyst stage (p˂0.001). Dealing with the pregnancy outcomes, clinical pregnancy per embryo transfer was found to be higher in single-step media group (p=0.038). There was no significant difference in implantation rates between the groups (p>0.05). Conclusion: We have shown that a single step culture media supports high quality embryo development equivalently to established sequential media. Moreover, higher number of blastocysts available for transfer with single step media, might result in a concurrent improve in pregnancy rates. Pam Med J 2016;9(3):212-218

Today, infertility takes a major place in gynecology practice. Non-puerperal uterine inversion is a rare event and usually accompanies submucous myoma, leiomyosarcoma, rhabdomyosarcoma, malignant mixed Mullerian tumour, and endometrial polyp. Herein, we report a 39-year-old woman who suffered from secondary infertility together with uterine inversion, which is an extremely rare co-existence.

Ozet : Gonadotropin serbestlestirici hormon (GnRH) agonisti ile oosit maturasyonunun tetiklendigi ve sonrasinda tum embriyolarin donduruldugu 27 yasindaki olguda luteal destek olmaksizin olusan spontan klinik gebelik sunulmustur. Polikistik over sendromu (PKOS) tanisiyla, oncesinde 3 sefer kontrollu ovaryan stimulasyon ve intrauterin inseminasyon uygulanmis olan hastaya GnRH antagonist protokolu ile intrasitoplasmik sperm enjeksiyonu tedavisi planlandi. Stimulasyonun 11. gununde ≥11 mm 25 adet folikul saptanmasi uzerine GnRH agonisti uygulanarak final oosit maturasyonu saglandi. Blastokist evresine kadar gelisim gosteren yuksek kalitedeki embriyolarin tumu vitrifiye edildi. Taze embriyo transferi planlanmamasi dolayisiyla hastaya luteal faz destegi verilmeyerek yedi gun sureyle cinsel iliski onerilmedi. Ancak, oosit toplanmasinin 5 hafta sonrasinda amenore yakinmasiyla tarafimiza tekrar basvuran hastaya yapilan transvajinal ultrasonografide fetal kalp atimi muspet spontan tekiz gebelik izlendi. Gunumuzde, GnRH agonistlerle tetikleme sonrasi luteal fazin nasil desteklenmesi gerektigine dair yogun tartismalar devam etmektedir. Bu bulgular, ovaryan stimulasyon sonrasi suprafizyolojik steroid seviyelerine ragmen, her hastanin korpus luteum fonksiyonlarinin devaminin farklilik gosterebilecegine isaret etmektedir. Dolayisiyla, PKOS ve beraberinde endojen luteinizan hormon aktivitesinin yuksek oldugu hastalar, korpus luteumun sinirli ancak luteal faz icin yeterli aktivitesinin devam edebilecegi bir alt grubu olusturuyor olabilir. Anahtar kelimeler: GnRH agonist tetikleme, luteal faz destegi, spontan gebelik SPONTANEOUS CLINICAL PREGNANCY FOLLOWING GNRH AGONIST TRIGGERING AND FREEZE ALL POLICY Abstract: We describe a 27 year-old patient undergoing follicle stimulation with gonadotrophin releasing hormone (GnRH) agonist and freeze-all approach, presented with spontaneous clinical pregnancy without supplementation of luteal phase. The patient had three attempts with controlled ovarian hyperstimulation and intrauterine insemination due to polycystic ovary syndrome (PCOS) before referring to our clinic for intracytoplasmic sperm injection. A GnRH antagonist protocol was assigned and ovarian stimulation commenced. After the detection of 25 follicles ≥11 mm, final oocyte maturation was triggered with GnRH agonist on the eleventh day of stimulation. Since freeze all approach was taken, no luteal phase support was administered. High quality blastocysts were vitrified. The couple was advised to refrain from sexual intercourse for seven days. The patient, however, presented with amenorrhea five weeks after the day of oocyte retrieval. A clinical pregnancy with fetal cardiac activity was determined on ultrasound examination. Currently, there is an ongoing debate on how best to counteract the negative impact of agonist triggering on the luteal phase. Our case demonstrates that corpus luteum functions might diverse despite supra-physiological sex steroids resulting from ovarian stimulation. Therefore, in case of PCOS consisting high endogenous LH activity, corpus luteum might be rescued and luteolysis might limit itself in such cycles shortly after implantation. Keywords: GnRH agonist trigger, luteal phase support, spontaneous conception

Objective. To investigate in vitro fertilization (IVF) treatment outcomes of unilateral oocyte retrieval in patients with transvaginally inaccessible ovaries.Study Design. Ninety-two women who underwent unilateral oocyte retrieval were retrospectively matched for age, antral follicle count, and body mass index with 184 women who underwent bilateral oocyte retrieval. Each patient in bilateral oocyte retrieval group had the same number of cumulus oophorus complexes (COCs) from single ovary and had comparable number of follicles (±2) on contralateral site where follicular aspiration was performed.Results. The number of COCs, metaphase-2 oocytes, 2-pronuclei, and top-quality embryos was significantly lower in unilateral oocyte retrieval group. However, proportion of patients with an embryo transfer of at least one top-quality embryo was found to be comparable between unilateral and bilateral oocyte retrieval. Subsequently, clinical pregnancy and live birth rates were found to be similar between the groups. The ROC curve analysis revealed (AUC = 0.74, 95% CI 0.63–0.86,p=0.001) that retrieved COCs ≥ 5 from single ovary had sensitivity of 76.0% and specificity of 64.2% for occurrence of a clinical pregnancy.Conclusion. The patients with unilateral oocyte retrieval have reasonable chance of success with IVF. The retrieval of ≥5 COCs from accessible ovary might result in better treatment outcomes among these patients.

OZET: Hucre siklusunun farkli asamalarinda oosit maturasyon aresti ile karsilasilabilir. Uremeye yardimci tedavi uygulamalarinda tum oositlerin mayozu tamamlayamamalari nadir olarak karsilasilan bir durumdur. Sundugumuz olguda, onceki tedavisinde matur oosit elde edemedigimiz bir vakada, GnRH agonisti (Triptorelin asetat 0.2 mg) ve standart doz hCG’yi (hCG 5000 IU) beraber uygulanarak matur oosit elde etmeye calistik. Buna karsin, “ikili tetikleme” ile yine oosit maturasyonunun metafaz-1 asamasinda duraksadigini saptadik. Her ne kadar olgumuzda “ikili tetikleme” stratejisi etkin olmamissa da, oosit maturasyon aresti farkli nedenlere bagli olabileceginden sonuclarimizin genellenmemesi daha uygun olabilir. Bu hususta, oosit maturasyon aresti ile karsilasilan her olgunun literaturde yer almasinin, yontemler basarisiz olsa dahi, uzun vadede problemin cozumune yonelik katki saglayabilecegini dusunmekteyiz. ANAHTAR KELIMELER: oosit maturasyon aresti, gonadotropin serbestlestirici hormon agonisti, ikili tetikleme DUAL TRIGGERING (GNRH AGONIST AND HCG) IN REPEATED TOTAL OOCYTE MATURATION ARREST ABSTRACT: Maturation arrest of human oocytes might occur at various stages of the cell cycle. A total failure of human oocytes to complete meiosis is rarely observed during assisted conception cycles. We describe here an infertile couple for whom all oocytes failed to mature during their previous in vitro fertilization treatment. Even with the use of dual triggering concept (Triptorelin asetat 0.2 mg plus hCG 5000 IU) oocyte maturation was again arrested at metaphase 1 stage in their next cycle. Since failure to resume meiosis might arise from different etiologies, we cannot conclude that “dual trigger” is not an alternative treatment option for the patients with history of recurrent oocyte maturation arrest. However, we do believe that our observation will guide future researchers. KEYWORDS: oocyte maturation arrest, gonadotrophin releasing hormone agonist, dual trigger

Background The aim of this study was to investigate the influence of body mass index (BMI) on the in vitro fertilization (IVF) treatment outcomes in a cohort of women undergoing their first IVF, using an intracytoplasmic sperm injection (ICSI). Methods This retrospective cohort study included 298 cycles from women younger than 38 years old undergoing IVF-ICSI at a university infertility clinic. The treatment cycles were divided into three groups according to the BMI of the women involved: normal weight (18.5 ≤ BMI 0.05 for each). Additionally, clinical pregnancy, spontaneous abortion, and the ongoing pregnancy rates per transfer were found to be comparable between the normal weight, overweight, and obese women (p >0.05 for each). Conclusion Obese women might require a significantly higher dose of gonadotropins and longer stimulation durations, without greatly affecting the pregnancy outcomes.

Umbilical artery\vein, middle cerebral artery, and ductus venosus Doppler velocimetry were performed at 33 weeks of gestation in the settings of an intrauterine growth restricted fetus during a heart rate deceleration. Interestingly, we recorded a sudden onset redistribution of fetal blood flow with fetal bradycardia. Spontaneous normalization of waveforms was observed once fetal heart rate returned to normal. Our case provides evidence to circulatory variation of a human fetus resulting from an acute incident causing bradycardia.

PubMedID: 24435497 Objective: This study aimed at determining if tumor-free distance (TFD) from outermost layer of cervix predicts surgicopathologic factors and outcome in surgically treated cervical cancer patients. Materials and methods: One hundred sixteen surgically treated cervical squamous cell carcinomas between 1991 and 2010 with FIGO stage IB/2A were identified and reevaluated histologically regarding the TFD. TFD was defined as the distance between outermost layer of cervix and deepest cervical stromal invasion. Depth of invasion (DOI) and TFD were expressed as continuous variables and compared with traditional surgicopathologic variables and survival to determine their prognostic significance. Results: The mean DOI was 10.3 mm and the mean TFD was 4.2 mm. The most common stage was IB1 (60 patients, 51.7%). The mean number of removed pelvic lymph nodes was 32.2 (median 30; range 8-78). Positive pelvic lymph nodes were found in 27 (23%) of the patients. Sixty-eight patients had lymphovascular space involvement (LVSI). Sixty-eight patients (59%) received postoperative radiotherapy where the following items were present: tumor diameter >4 cm, positive lymph nodes, LVSI and positive surgical margins. With the median fol-low- up of 53 months (3-219 months); 14 patients had local and 13 patients had distant metastases (5 of the patients had both at the time of recurrence). With logistic regression analysis, TFD was a predictor of pelvic lymph involvement ( p=0.028) and LVSI (p=0.008) while DOI was a predictor of LVSI (p=0.044). In Cox regression analysis, increased TFD was associated with improved disease-free survival (DFS) (p=0.007). DFS curves (for TFD cut off value 2.5 mm) according to Kaplan-Meier were found to be statistically significant (log rank test=0.002). Conclusion: The results indicate that TFD is predictive of pelvic lymph node involvement, LVSI and patient outcome in surgically treated cervical cancer patients. However, prospective measurement of TFD is still necessary to determine its value in clinical practice. © Springer-Verlag 2014.

This report describes the use of in vitro oocyte maturation in two patients with history of repeated oocyte maturation arrest (OMA) from in vitro fertilization. Based on these two cases, in vitro oocyte maturation from unstimulated cycles seems not an alternative treatment option for the patients with history of OMA. © 2011 Springer-Verlag.

Objectives To examine the effect of copper intrauterine device (Cu-IUD) on female sexual dysfunction (FSD) subtypes. Material and methods There were 159 sexually active women (ninety Cu-IUD users and sixty-nine women with no contraception) who attended the gynecology clinic for routine gynecologic control informed about the study and asked to fill Female Sexual Function Index (FSFI) and Beck Depression Inventory questionnaires. Results The prevalence of FSD was 41.1% ( n = 37) and 37.7% ( n = 26) in Cu-IUD users and control groups, respectively ( p > 0.05). In analyses of mean overall and subgroup scores of FSFI, significantly lower scores for arousal ( p = 0.021), lubrication ( p = 0.021), orgasm ( p = 0.040), pain ( p 0.001), and overall FSFI ( p = 0.031) were noted in Cu-IUD users. When the results for FSFI domains were considered for Cu-IUD users separately, the only difference to reach statistical significance, using a Bonferroni adjustment, was found to be the pain domain. Finally, we determined that Cu-IUD status made the strongest unique contribution to explaining the dependent variable pain in multiple logistic regression model (β = −0.26, p = 0.001). Conclusion Cu-IUD users have increased sexual pain compared to women with no contraception, which in turn possibly causes decreased sexual arousal, lubrication, and orgasm in these women.