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1. Using a wearable patch to develop a digital monitoring biomarker of inflammation in response to LPS challenge

Author

Avey, Stefan, primary, Chatterjee, Meenakshi, additional, Manyakov, Nikolay V., additional, Cooper, Philip, additional, Sabins, Nina, additional, Mosca, Kenneth, additional, Mori, Simone, additional, Baribaud, Frédéric, additional, Morris, Mark, additional, Lehar, Joseph, additional, Deiteren, Annemie, additional, Cossu, Marta, additional, Smets, Sophie, additional, Huizer, Tanja, additional, Lamousé‐Smith, Esi, additional, Campbell, Kim, additional, and Pandis, Ioannis, additional

Published
2024
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4. TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

Author

Tomkowicz, Brian, primary, Walsh, Eileen, additional, Cotty, Adam, additional, Verona, Raluca, additional, Sabins, Nina, additional, Kaplan, Fred, additional, Santulli-Marotto, Sandy, additional, Chin, Chen-Ni, additional, Mooney, Jill, additional, Lingham, Russell B., additional, Naso, Michael, additional, and McCabe, Timothy, additional

Published
2015
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6. Differential Expression of Immune Checkpoint Modulators on In Vitro Primed CD4+ and CD8+ T cells.

Author

Sabins, Nina C., Harman, Benjamin C., Barone, Linda R., Shixue Shen, and Santulli-Marotto, Sandra

Subjects
T cells, CD4 antigen, IMMUNOLOGY
Abstract

PD-1, TIM-3, and LAG-3 are molecules shown to have immune modulatory properties, and although initially classified as indicators of T cell hyporesponsiveness, it has become clear that they are also associated with the normal course of T cell activation. Functional studies have focused mainly on CD8+ T cells during chronic inflammation due to interest in co-opting the cellular immune response to eliminate viral or cancerous threats; however, there remains a relative lack of data regarding the expression of these molecules on CD4+ T cells. Here, we report that expression of the immune checkpoint (IC) molecules PD-1, LAG-3, and TIM-3 are differentially expressed on CD4+ and CD8+ T cells in the allogeneic response resulting from a mixed lymphocyte reaction. In these studies, PD-1 expression is higher on CD4+ T cells compared to CD8+ T cells. In contrast, TIM-3 is expressed at higher levels on CD8+ T cells compared to CD4+ T cells with an apparent reciprocity in that PD-1+ CD4+ T cells are frequently TIM-3lo/-, while TIM-3-expressing CD8+ T cells are largely PD-1lo/-. In addition, there is a decrease in the frequency of TIM-3+ CD4+ cells producing IFN-γ and IL-5 compared to TIM-3+ CD8+ cells. Lastly, the memory T cell phenotype within each IC-expressing subset differs between CD4+ and CD8+ T cells. These findings highlight key differences in IC expression patterns between CD4+ and CD8+ T cells and may allow for more effective therapeutic targeting of these molecules in the future. [ABSTRACT FROM AUTHOR]

Published
2016
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